Review
Medicine, General & Internal
Zhengyan Hu, Rui Gao, Wanrong Huang, Huiqing Wang, Lang Qin
Summary: The additional use of HCQ may decrease the risk of high lupus activity during pregnancy and the incidence of preeclampsia for SLE patients, but it does not reduce the risk of preeclampsia for APS/aPLs patients or intrauterine growth restriction for SLE and/or APS/aPLs patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Noel Zahr, Saik Urien, Christian Funck-Brentano, Helene Vantomme, Nicolas Garcelon, Isabelle Melki, Margaux Boistault, Olivia Boyer, Brigitte Bader-Meunier
Summary: This study investigated the pharmacokinetics of hydroxychloroquine (HCQ) in pediatric patients with systemic lupus erythematosus (SLE). The results showed that HCQ blood concentration was associated with disease activity and could serve as a significant predictor of disease status.
Article
Medicine, General & Internal
Rene Cordtz, Salome Kristensen, Louise Plank Holm Dalgaard, Rasmus Westermann, Kirsten Duch, Jesper Lindhardsen, Christian Torp-Pedersen, Lene Dreyer
Summary: Patients with systemic lupus erythematosus (SLE) have a higher risk of hospitalisation with COVID-19 infection, and the use of hydroxychloroquine treatment may reduce the risk of hospitalisation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Xian-Bao Li, Nv-Wei Cao, Xiu-Jie Chu, Hao-Yue Zhou, Hua Wang, Si-Jie Yu, Dong-Qing Ye, Bao-Zhu Li
Summary: Antimalarials, especially hydroxychloroquine, may reduce the risk of cancer in patients with systemic lupus erythematosus (SLE), with significant risk reduction seen in Asian populations and SLE patients from multiple centers.
ANNALS OF MEDICINE
(2021)
Article
Immunology
Chiharu Hidekawa, Ryusuke Yoshimi, Yusuke Saigusa, Jun Tamura, Noriko Kojitani, Naoki Suzuki, Natsuki Sakurai, Yuji Yoshioka, Yumiko Sugiyama-Kawahara, Yosuke Kunishita, Daiga Kishimoto, Kana Higashitani, Yuichiro Sato, Takaaki Komiya, Hideto Nagai, Naoki Hamada, Ayaka Maeda, Naomi Tsuchida, Lisa Hirahara, Yutaro Soejima, Kaoru Takase-Minegishi, Yohei Kirino, Nobuyuki Yajima, Ken-ei Sada, Yoshia Miyawaki, Kunihiro Ichinose, Shigeru Ohno, Hiroshi Kajiyama, Shuzo Sato, Yasuhiro Shimojima, Michio Fujiwara, Hideaki Nakajima
Summary: Hydroxychloroquine may help extend the time until the occurrence of infection complications in patients with systemic lupus erythematosus and tends to decrease infection rates.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jon Zubiaur, Alba Herrero-Morant, Adrian Margarida de Castro, Raquel Perez-Barquin, Ivan Ferraz-Amaro, Javier Loricera, Santos Castaneda, Ricardo Blanco
Summary: This retrospective observational study examined the association between cumulative hydroxychloroquine (HCQ) dose and electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE). The results showed that higher cumulative HCQ dose was associated with conduction disturbances, but this association disappeared after multivariate adjustment. There was no significant increase in the development of structural abnormalities.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
Maddalena Larosa, Veronique Le Guern, Gaelle Guettrot-Imbert, Nathalie Morel, Noemie Abisror, Chafika Morati-Hafsaoui, Pauline Orquevaux, Elisabeth Diot, Andrea Doria, Francoise Sarrot Reynauld, Nicolas Limal, Viviane Queyrel, Odile Souchaud-Debouverie, Laurent Sailler, Maelle Le Besnerais, Tiphaine Goulenok, Anna Molto, Emmanuelle Pannier-Metzger, Loic Sentilhes, Luc Mouthon, Estibaliz Lazaro, Nathalie Costedoat-Chalumeau
Summary: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with SLE are unknown. This study found that damage at conception and lupus anticoagulant were significantly associated with adverse pregnancy outcomes, while hypocomplementemia in the first trimester was associated with maternal flares later in pregnancy.
Article
Rheumatology
John A. Reynolds, Mary Gayed, Munther A. Khamashta, Francesca Leone, Veronica Toescu, Ian N. Bruce, Ian Giles, Lee-Suan Teh, Neil McHugh, Mohammed Akil, Christopher J. Edwards, Caroline Gordon
Summary: This study investigated the outcomes of children born to mothers with SLE exposed to HCQ or AZA during pregnancy. The results showed that there were no significant negative outcomes in children exposed to HCQ during pregnancy. However, the use of AZA was associated with an increased reporting of childhood infection, which requires further study.
Article
Medicine, Research & Experimental
Jose F. Polanski, Eloise A. Tanaka, Harymy Barros, Adriana G. Chuchene, Patricia T. G. Miguel, Thelma L. Skare
Summary: SLE patients have a higher prevalence of sensorineural hearing loss, unaffected by the use of antimalarial drugs. Pure-tone averages are similar between users and non-users of antimalarials, but non-users perform worse at 8000Hz. Serological and clinical profiles in SLE patients with and without hearing loss are similar.
Article
Medicine, General & Internal
Gang Wang, Ning Zhuo, Zheng Liao, Wei Qi, Feng Tian, Zhenhua Wen, Jingyang Li
Summary: Hydroxychloroquine has excellent anti-inflammatory and immunomodulatory effects, but the risk of retinopathy should be taken seriously. To prevent retinopathy, discontinuation of hydroxychloroquine, better eye protection, and regular vision checks are essential.
Article
Rheumatology
Irene E. M. Bultink, Frank de Vries, Ronald F. van Vollenhoven, Arief Lalmohamed
Summary: Patients with SLE in the UK have a 1.8-fold increased mortality rate compared to the general population, with the highest risk for those aged 18-39 years old; low-dose HCQ reduces the risk of mortality by 45%.
Article
Rheumatology
Jiaoniu Duan, Dan Ma, Xiaoting Wen, Qianyu Guo, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: This meta-analysis suggests that HCQ treatment during pregnancy can reduce the risk of preeclampsia, gestational hypertension, and prematurity in SLE patients. However, the majority of studies included are retrospective and not randomized controlled trials.
Review
Rheumatology
Alina Dima, Ciprian Jurcut, Francois Chasset, Renaud Felten, Laurent Arnaud
Summary: Hydroxychloroquine (HCQ) has shown multiple benefits in the treatment of systemic lupus erythematosus (SLE), including decreasing disease activity, preventing flare-ups, lowering the need for long-term glucocorticoid use, and improving long-term outcomes such as damage accrual and mortality. It also has positive effects on pregnancy and breastfeeding, and may delay progression to SLE in individuals with positive antinuclear antibodies.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Rheumatology
Mai Yoshida, Kentaro Minowa, Hirofumi Amano, Yuki Asai, Ken Yamaji, Naoto Tamura
Summary: The study found that two years of continuous hydroxychloroquine treatment can improve SLE disease activity and corticosteroid dose, as well as increase the achievement rate of LLDAS. Therefore, maintenance dose of hydroxychloroquine is crucial for the management of SLE.
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Woo Jeng Kim, Yoohyun Chung, Jihyun Park, Jae-Young Park, Kyungdo Han, Yonggyu Park, In Yang Park, Hyun Sun Ko
Summary: This study found that elevated pregravid gamma-glutamyl transferase and alanine aminotransferase levels were associated with an increased risk of gestational diabetes mellitus, especially in women with obesity or MetS. However, significant risks were also present in women without obesity or MetS. These results suggest that elevated pregravid liver enzyme levels significantly increase the risk of developing gestational diabetes.
LIVER INTERNATIONAL
(2021)
Article
Obstetrics & Gynecology
Chaewon Kim, Jaeyoung Pae, Woo Jeng Kim, Yuri Jang, Jeong Ha Wie, In Yang Park, Hyun Sun Ko
Summary: The study in Korea found that 67% of pregnant women received pertussis vaccination during pregnancy, but 27.9% did not receive information about pertussis and vaccination. Independent influencing factors for maternal pertussis vaccination included being informed, being informed by OBGYN doctors, and residing in metropolitan areas. Around 56.3% of maternity HCPs routinely recommended pertussis vaccination, with factors affecting routine recommendation being awareness of guidelines and personal pertussis vaccination history within 10 years.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Jung Hee Koh, Hanna Lee, Seung-Geun Lee
Summary: This study investigated the efficacy of intra-articular glucocorticoid injections (IAGI) in short- and long-term treatment of rheumatoid arthritis (RA). Results show that IAGI can help achieve early disease remission, particularly in the wrist joints, which are more prone to joint damage and require more aggressive treatment.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Byung Soo Kang, San Ha Lee, Woo Jeng Kim, Jeong Ha Wie, In Yang Park, Hyun Sun Ko
Summary: This study found that providing information about maternal influenza vaccination, especially by OBGYN doctors, is crucial for increasing vaccination coverage in pregnant women. Closer cooperation between the government and OBGYN academic societies to educate OBGYN doctors might enhance routine recommendations.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Multidisciplinary Sciences
Jae-Young Park, Woo Jeng Kim, Yoo Hyun Chung, Bongseong Kim, Yonggyu Park, In Yang Park, Hyun Sun Ko
Summary: This study found that high levels of pregravid GGT and ALT were associated with an increased risk of GDM + IT in women pregnant with twins, regardless of pregravid obesity or metabolic syndrome. However, there were no significant associations between pregravid ALT and GGT levels and risks for the development of GDM - IT.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jung Hee Koh, Sang Jun Yoon, Mina Kim, Seonghun Cho, Johan Lim, Youngjae Park, Hyun-Sook Kim, Sung Won Kwon, Wan-Uk Kim
Summary: Changes in lipid profile in rheumatoid arthritis can serve as potential biomarkers for tracking and treating the disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biology
Jeong Ha Wie, Se Jin Lee, Sae Kyung Choi, Yun Sung Jo, Han Sung Hwang, Mi Hye Park, Yeon Hee Kim, Jae Eun Shin, Ki Cheol Kil, Su Mi Kim, Bong Suk Choi, Hanul Hong, Hyun-Joo Seol, Hye-Sung Won, Hyun Sun Ko, Sunghun Na
Summary: This study developed an automated machine learning model to predict emergent cesarean section before onset of labor in term nulliparous women. Nine different machine learning methods were applied and compared, with logistic regression showing the best predictive performance. The model identified several significant variables for prediction of emergent cesarean section.
Article
Rheumatology
Youngjae Park, Mei-Ling Li, Ji-Won Kim, Jung Hee Koh, Yune-Jung Park, Wan-Uk Kim
Summary: Cumulative activity better reflects the radiographic progression of rheumatoid arthritis (RA) than measurement of activity at a single time point, and cumulative swollen joint count (SJC) shows the best predictive performance for radiographic progression.
JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Heesu Yoon, Bo Yun Choi, Won Joon Seong, Geum Joon Cho, Sunghun Na, Young Mi Jung, Ji Hye Jo, Hyun Sun Ko, Joong Shin Park
Summary: Pregnant women were initially excluded from COVID-19 vaccination in South Korea, but their vaccine acceptance and influencing factors were unknown. This study found that receiving vaccine information from obstetrics and gynecology doctors, cohabitant COVID-19 vaccination, and being in the second trimester were independent factors influencing maternal COVID-19 vaccination. Concerns about the vaccine's impact on the fetus and distrust in vaccine effectiveness were the main reasons for vaccine hesitancy among women who did not want to get vaccinated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Subeen Hong, Hyun Sun Ko, Seonok Kim, Yun Sung Jo, In Yang Park
Summary: This study examined the effects of amnioreduction on pregnancy outcomes in women undergoing cerclage operations. The results showed that amnioreduction before cerclage was associated with a shorter time to delivery, but also a higher risk of preterm birth and poor neonatal outcomes. Careful consideration is necessary when deciding to perform amnioreduction before cerclage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Yun Sung Jo, Woo Jeng Kim, Sae Kyung Choi, Su Mi Kim, Jae Eun Shin, Ki Cheol Kil, Yeon Hee Kim, Jeong Ha Wie, Han Wool Kim, Subeen Hong, Hyun Sun Ko
Summary: This study developed a risk scoring model for pregnancy-associated hypertension (PAH) based on maternal pre-pregnancy characteristics. The model included mean arterial pressure (MAP) and pregnancy-associated plasma protein-A (PAPP-A) as predictive factors. The model showed superior performance in predicting PAH and preterm PAH compared to other models. Further studies are needed to validate this scoring model with biomarkers and uterine artery Doppler.
Article
Rheumatology
Jung Hee Koh, Bong-Woo Lee, Wan-Uk Kim
JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Obstetrics & Gynecology
Seon Ui Lee, Gyul Jung, Han Wool Kim, Hyun Sun Ko
Summary: This review article discusses the recent evidence and guidelines on cervical screening and prevention strategies for preterm birth in asymptomatic women without a prior history of preterm birth.
OBSTETRICS & GYNECOLOGY SCIENCE
(2023)
Article
Rheumatology
Jung Hee Koh, Yusun Lee, Hyoun-Ah Kim, Jinhyun Kim, Kichul Shin
Summary: This study investigated and compared remission rates in rheumatoid arthritis (RA) patients treated with different types of biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) from 2013 to 2019. The results showed that using the clinical disease activity index (CDAI), simplified disease activity index (SDAI), or Boolean criteria to assess sustained remission was more stringent, but consistent with the DAS28-based criteria in RA patients treated with b/tsDMARDs.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Rheumatology
J. H. Koh, S-K Lee, J. Kim, H-A Kim, K. Shin, J-K Min
Summary: The study evaluated the clinical outcomes and safety of b/tsDMARDs in elderly RA patients, finding that male sex and non-smoking were associated with better treatment responses. ILD was identified as a key comorbidity affecting adverse events.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
