Article
Oncology
Xiangyun Zong, Yang Yu, Hongjian Yang, Wenhu Chen, Xiaowen Ding, Sixuan Liu, Xiaolin Li, Xuan Chen, Chuner Jiang, Xianghou Xia, Run Huang, Meizhen Zhu, Jiejie Hu, Chenlu Liang
Summary: Administering GnRHa during chemotherapy for premenopausal patients with breast cancer can reduce the risk of premature ovarian insufficiency and promote the recovery of ovarian function, especially for patients under the age of 35.
Article
Rheumatology
Miao Shao, Miao Miao, Xia Zhang, Xiaoying Zhang, Yuan An, Huifang Guo, Lingyan Lei, Qing Zhao, Yanjie Ding, Jin Lin, Rui Wu, Feng Yu, Yucui Li, Huali Miao, Liyun Zhang, Yan Du, Ruiying Jiao, Lixia Pang, Li Long, Xueming Yao, Xiaofei Shi, Fei Wang, Luping Cui, Lei Zhang, Shengyun Liu, Fuai Lu, Kangkai Luo, Simeng Zhao, Yongfu Wang, Xiao Wu, Qingwen Wang, Hongjiang Liu, Shulin Song, Xiaoyuan Zhou, Xiaoping Zhang, Shumei Shi, Hong Zhu, Yao Chen, Honglian Yu, Jie Wu, Ruiyun Yu, Wenqiang Fan, Shuang Liu, Jian Xu, Zhibin Chen, Lianjie Shi, Jing He, Xuewu Zhang, Zhanguo Li, Ru Li
Summary: Infection is a major cause of death in patients with SLE. This study found that patients receiving low-dose IV-CYC had a significantly lower infection rate compared to high-dose IV-CYC. Respiratory tract and skin/soft tissue infections were notably decreased in the low-dose group, with infections more likely in SLE patients with leucopenia, pulmonary arterial hypertension, and higher doses of glucocorticoid.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Rheumatology
Mitali Sen, Anu Kurl, Arezou Khosroshahi
Summary: Our study retrospectively reviewed patients who received intravenous cyclophosphamide from 2000-2018. We found that successful pregnancy was associated with a higher cumulative dose of cyclophosphamide, while miscarriage and premature ovarian failure were associated with lower doses. Multiple regressions showed that factors like age, race, serological profile, exposure to steroids, and cumulative dose of cyclophosphamide impacted pregnancy outcomes and development of premature ovarian failure.
Article
Rheumatology
Megan E. B. Clowse, James Oates, April Barnado, Katie Kirchoff, Ashley Blaske, Saira Z. Sheikh, Leslie J. Crofford, Amanda M. Eudy
Summary: This study aimed to investigate disparities in pregnancy outcomes between Black and White women with SLE. The study found that Black women had higher rates of adverse pregnancy outcomes in EMR-derived datasets, and SLE was frequently over-diagnosed in White women, resulting in lower rates of adverse pregnancy outcomes.
Review
Endocrinology & Metabolism
Ning Liu, Haipeng Yang, Liqun Han, Mingxing Ma
Summary: Oxytocin plays different roles in males and females, especially in terms of reproduction. For women, oxytocin is crucial in processes such as menstrual cycle, pregnancy, parturition, lactation, and menopause. Disorders in oxytocin secretion can result in various women's health issues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Rheumatology
Fulvia Ceccarelli, Carmelo Pirone, Carlo Perricone, Aikaterina Selntigia, Valeria Orefice, Viviana Antonella Pacucci, Simona Truglia, Francesca Romana Spinelli, Paola Galoppi, Cristiano Alessandri, Guido Valesini, Roberto Brunelli, Giuseppina Perrone, Fabrizio Conti
Summary: The study found that pregnancy outcomes of SLE patients were not significantly different from the control group of women without autoimmune diseases, except for a higher occurrence of small for gestational age. Disease flares during pregnancy and postpartum were associated with different factors, highlighting the importance of tailored prevention and management strategies. The study emphasized the positive impact of pre-gestational counseling and a multi-disciplinary approach on pregnancy outcomes for SLE patients.
Article
Cardiac & Cardiovascular Systems
Danica H. Chang, Sandra M. Dumanski, Sofia B. Ahmed
Summary: Cardiovascular disease is the leading cause of death in women, yet females are underrepresented in cardiovascular research, leading to poorer health outcomes. A framework is proposed to address this issue by including female models, considering sex as a biological variable, and increasing female participation in clinical trials. It is essential to collect sex-specific data and stratify data by sex to ensure reproducibility and relevance of findings. Increasing female representation and considering female-specific cardiovascular risk factors will improve cardiovascular health for all.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Mizuki Ohashi, Katsuyuki Miura, Naoyuki Takashima, Aya Kadota, Yoshino Saito, Shunichiro Tsuji, Takashi Murakami, Yuka Kadomatsu, Mako Nagayoshi, Megumi Hara, Keitaro Tanaka, Takashi Tamura, Asahi Hishida, Toshiro Takezaki, Ippei Shimoshikiryo, Etsuko Ozaki, Isao Watanabe, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Sho Yamasaki, Hiroaki Ikezaki, Isao Oze, Yuriko N. Koyanagi, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai
Summary: This study evaluated the association of reproductive history with hypertension and obesity and found that this association differed among premenopausal and postmenopausal women.
HYPERTENSION RESEARCH
(2022)
Article
Environmental Sciences
Roberto Gonzalez-Martin, Maria Grau-Perez, Patricia Sebastian-Leon, Patricia Diaz-Gimeno, Carmen Vidal, Maria Tellez-Plaza, Francisco Dominguez
Summary: Cadmium and lead exposure can affect hormonally regulated processes and increase reproductive lifespan and prevalence of pregnancy loss in post-menopausal women. This study evaluated the association between blood cadmium and lead levels with reproductive lifespan and personal history of pregnancy loss in a sample of 5317 post-menopausal women. The results showed that higher blood cadmium and lead levels were associated with longer reproductive lifespan and increased prevalence of pregnancy loss, especially in smokers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sahra Hefzollesan, Nasrin Sharififard, Zeinab Mahboobi, Elnaz Faramarzi
Summary: This study investigated the relationship between reproductive history and the DMFT index in women, finding that while pregnancy frequency did not significantly impact DMFT, women with four or more pregnancies had higher DMFT rates. Factors such as brushing frequency, age, and oral health education were found to have significant effects on oral health.
Article
Obstetrics & Gynecology
Marthe S. Gottschalk, Anne Eskild, Solveig Hofvind, Elisabeth K. Bjelland
Summary: A study in Norway found that age at natural menopause increases with increasing number of childbirths up to three, but does not further increase beyond three childbirths. This suggests a complex relationship between childbirth and menopause age.
HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Ram B. Jain, Alan Ducatman
Summary: Sex hormones influence excretion of PFAS in rodents, but their influence in humans is unclear. This study analyzed data from NHANES and found that in US females aged ≥20 years, those who took hormonal replacement therapy had higher serum PFAS concentrations compared to nonusers, regardless of hysterectomy or natural menopause status. The results suggest that estrogen hormones may be associated with higher serum PFAS in postmenopausal women.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Sharayu Mhatre, Ben Lacey, Paul Sherliker, Nilanjan Chatterjee, Preetha Rajaraman, Mahesh Goel, Shraddha Patkar, Vikas Ostwal, Prachi Patil, Shailesh Shrikhande, Garvit Chitkara, Rajendra Badwe, Sarah Lewington, Rajesh Dikshit
Summary: In India, the incidence of gall-bladder cancer is higher in women than in men. This study found a positive association between parity and GBC risk, suggesting that reproductive and hormonal factors play an important role in the development of GBC.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maddalena Larosa, Nathalie Costedoat-Chalumeau, Gaelle Guettrot-Imbert, Veronique Le Guern, Nathalie Morel, Diogo Jesus, Luca Iaccarino, Luis Ines, Andrea Doria
Summary: This study observed 158 pregnant women with SLE and found a significant correlation between SLE-DAS and SLEPDAI. The use of SLE-DAS in the first trimester predicted maternal flares in the 2nd and 3rd trimester, demonstrating its reliability in measuring SLE activity during pregnancy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Clinical Neurology
Lindsay Ross, Huah Shin Ng, Julia O'Mahony, Maria Pia Amato, Jeffrey A. Cohen, Mary Pat Harnegie, Kerstin Hellwig, Mar Tintore, Sandra Vukusic, Ruth Ann Marrie
Summary: This scoping review maps the literature related to women's health in multiple sclerosis (MS) and identifies important knowledge gaps, particularly in terms of race and ethnicity diversity and inclusion of women with progressive MS. Future studies should aim to include participants from a broader range of races and ethnicities, with progressive MS, and living in the Asia-Pacific and African regions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Ashley L. Artese, Andrea Sitlinger, Grace MacDonald, Michael A. Deal, Erik D. Hanson, Carl F. Pieper, J. Brice Weinberg, Danielle M. Brander, David B. Bartlett
Summary: The study aimed to investigate the effects of a 12-week high-intensity interval training and resistance training intervention on health-related quality of life (HRQOL) in adults with treatment naive chronic lymphocytic leukemia (CLL). The results showed significant improvements in physical, emotional, social, and overall well-being in the group that participated in the intervention, compared to the control group who only had improvements in lymphoma-specific symptoms.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Neurosciences
Daniel C. Parker, William E. Kraus, Heather E. Whitson, Virginia B. Kraus, Patrick J. Smith, Harvey Jay Cohen, Carl F. Pieper, Richard A. Faldowski, Katherine S. Hall, Janet L. Huebner, Olga R. Ilkayeva, James R. Bain, L. Kristin Newby, Kim M. Huffman
Summary: This study found that an increasing KYN/TRP ratio is associated with greater concentrations of ADRD biomarkers (pTau181, GFAP, and NfL) in older adults, but not with cognitive performance (MoCA score) or the A beta(42)/ beta(40) ratio. There were no significant associations of KA/KYN with MoCA score or plasma ADRD biomarkers.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Health Care Sciences & Services
David A. Leiman, Harrison N. Jones, Rebecca North, Kathryn N. Porter Starr, Carl F. Pieper, Seth M. Cohen
Summary: This study assessed the associations between self-reported dysphagia and psychosocial health among older adults. The results showed a significant association between dysphagia and anxiety symptoms, as well as a decreased sense of well-being, but no association with social isolation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Coralei E. Neighbors, Richard Sloane, Carl F. Pieper, Douglas Wixted, Christopher W. Woods, L. Kristin Newby
Summary: This study aimed to identify groups of individuals based on their self-reported compliance with COVID-19 mitigation behaviors and explored the associations between compliance classes and important study and public health outcomes. Through latent class analysis, the participants were categorized into three classes: most compliant, moderately compliant, and least compliant. These compliance classes had distinct characteristics, such as age, sex, medical history, and ethnicity, and were associated with important outcomes. Targeted public health policies and interventions based on compliance group characteristics may help increase compliance.
Article
Mathematical & Computational Biology
Megan L. Neely, Carl F. Pieper, Bida Gu, Natalia O. Dmitrieva, Jane F. Pendergast
Summary: Modeling longitudinal trajectories and identifying latent classes of trajectories is important in biomedical research. Different models can be used, such as latent class trajectory analysis (LCTA), growth mixture modeling (GMM), and covariance pattern mixture models (CPMM). The level of within-person correlation is non-negligible in biomedical applications, which can affect the model choice and interpretation. LCTA does not consider this correlation, while GMM incorporates random effects and CPMM specifies a model for within-class covariance matrix. This study highlights the importance of considering correlation in obtaining appropriate model interpretations and provides insights into model choice.
STATISTICS IN MEDICINE
(2023)
Article
Medicine, General & Internal
William U. Meyerson, Carl F. Pieper, Rick H. Hoyle
Summary: A secondary analysis of FDA clinical trial data showed that antidepressant therapy can effectively reduce depressive symptoms in patients with severe depression, but the response varies among individuals.
Article
Gerontology
Harrison N. Jones, David A. Leiman, Kathryn N. Porter Starr, Rebecca North, Carl F. Pieper, Raele D. Robison, Seth M. Cohen
Summary: This study examines the relationship between dysphagia and social determinants of health in older adults. It found that older adults with dysphagia had higher odds of experiencing food insecurity and being homebound.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Review
Rheumatology
BrianJ. Andonian, Leanna M. Ross, Alyssa M. Zidek, Liezl B. Fos, Lucy W. Piner, Johanna L. Johnson, Kelsey B. Belski, Julie D. Counts, Carl F. Pieper, Ilene C. Siegler, Connie W. Bales, Kathryn N. Porter N. Starr, William E. Kraus, Kim M. Huffman
Summary: In a 2014 study, it was found that weight loss and increased physical activity are important factors in reducing cardiovascular disease (CVD) risk in patients with rheumatoid arthritis (RA). By controlling diet and exercising, both weight and fat can be reduced, leading to improved cardiovascular health and decreased RA-related CVD risk.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Maria J. Marquine, Adam Parks, Jaime Perales-Puchalt, David A. Gonzalez, Monica Rosado-Bruno, Rebecca North, Carl Pieper, Amy E. Werry, Andrew Kiselica, Silvia Chapman, Hiroko Dodge, Kathryn Gauthreaux, Walter A. Kukull, Katya Rascovsky
Summary: Researchers developed normative data for the National Alzheimer's Coordinating Center Uniform Data Set Neuropsychological Battery (UDS3-NB) for Latino individuals in the US. Younger age and higher education were associated with better cognitive test scores, especially among Spanish-speakers. Sex effects varied across tests and language groups. These data can improve the diagnostic accuracy of the UDS3-NB among Latinos.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Thomas J. Farrer, Terri G. Monk, David L. McDonagh, Gavin Martin, Carl F. Pieper, Deborah Koltai
Summary: This study aimed to investigate the relationship between anesthesia type and the development of Post Operative Cognitive Decline (POCD) in older adults. The results showed that anesthesia type did not predict the development of POCD, while preoperative cognitive function was the only variable predictive of POCD development and activities of daily living (ADLs) were predictive of post-operative delirium.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Immunology
Coralei E. Neighbors, Richard A. Faldowski, Carl F. Pieper, Joshua Taylor, Megan Gaines, Richard Sloane, Douglas Wixted, Christopher W. Woods, L. Kristin Newby
Summary: This study identified factors associated with COVID-19 vaccination promptness, including older age, lower education levels, lower household incomes, and vaccine hesitancy. The most common reasons for not being vaccinated were concerns about vaccine safety, side effects, and vaccine effectiveness.
Correction
Cell Biology
R. Waziry, C. P. Ryan, D. L. Corcoran, K. M. Huffman, M. S. Kobor, M. Kothari, G. H. Graf, V. B. Kraus, W. E. Kraus, D. T. S. Lin, C. F. Pieper, M. E. Ramaker, M. Bhapkar, S. K. Das, L. Ferrucci, W. J. Hastings, M. Kebbe, D. C. Parker, S. B. Racette, I. Shalev, B. Schilling, D. W. Belsky
Article
Anesthesiology
Corey B. Simon, Gregory E. Hicks, Carl F. Pieper, Virginia Byers Kraus, Francis J. Keefe, Cathleen Colon-Emeric
Summary: This study tested a new Movement-Evoked Provocation Test for Low Back Pain in Older Adults (MEPLO), and compared associations between movement-evoked pain and disability-associated outcomes. The results showed that MEPLO is a safe and feasible method in older adults with persistent LBP, and it is more strongly associated with self-reported physical function and usual gait speed compared to traditional pain measures.
CLINICAL JOURNAL OF PAIN
(2023)
Article
Health Policy & Services
Richard Sloane, Carl F. Pieper, Richard Faldowski, Douglas Wixted, Coralei E. Neighbors, Christopher W. Woods, L. Kristin Newby
Summary: A prognostic model for COVID-19 was developed using readily obtainable clinical variables. The model identified health insurance, race, household size, and the frequency of practicing three mitigation behaviors as important predictors of incident COVID-19 infection.
HEALTH SERVICES RESEARCH AND MANAGERIAL EPIDEMIOLOGY
(2023)
Article
Cell Biology
R. Waziry, C. P. Ryan, D. L. Corcoran, K. M. Huffman, M. S. Kobor, M. Kothari, G. H. Graf, V. B. Kraus, W. E. Kraus, D. T. S. Lin, C. F. Pieper, M. E. Ramaker, M. Bhapkar, S. K. Das, L. Ferrucci, W. J. Hastings, M. Kebbe, D. C. Parker, S. B. Racette, I. Shalev, B. Schilling, D. W. Belsky
Summary: The geroscience hypothesis suggests that slowing down or reversing molecular changes associated with aging can delay or prevent chronic diseases and extend healthy lifespan. A post hoc analysis of the CALERIE trial showed that caloric restriction intervention can slow down the pace of aging, but did not significantly affect biological age estimates. Despite small effect sizes, even modest slowdown of aging can have profound effects on population health. This finding supports the geroscience hypothesis and provides a basis for future long-term follow-up trials to establish the effects of intervention on primary healthy-aging endpoints.