Article
Rheumatology
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, Michael H. Belmont, Maria Laura Bertolaccini, D. Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M. Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K. Leaf, Nina Kello, Jason S. Knight, Carl Laskin, Alfred I. Lee, Kimberly Legault, Steve R. Levine, Roger A. Levy, Maarten Limper, Michael D. Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L. Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A. Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V. Seshan, Savino Sciascia, Maria G. Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
Summary: This study developed new APS classification criteria with high specificity, including clinical and laboratory domains, and improved classification accuracy through weighting and stratification.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Katja Perdan-Pirkmajer, Polona Zigon, Anja Boc, Eva Podovsovnik, Sasa Cucnik, Alenka Mavri, Ziga Rotar, Ales Ambrozic
Summary: This study suggests that negative aCL and/or anti-beta 2GPI at the time of acute DVT may not require further aPL testing, while LA should be checked after discontinuation of anticoagulant therapy. Positive aCL and/or anti-beta 2GPI at the time of acute DVT have a strong positive predictive value for APS and may impact therapeutic decisions.
Article
Immunology
Michael A. Cole, Gloria F. Gerber, Shruti Chaturvedi
Summary: Complement is a major driver of antiphospholipid syndrome (APS) and a promising therapeutic target. Reliable, rapid-turnaround biomarkers are needed in APS to predict adverse clinical outcomes and determine who will benefit most from complement inhibition. Current studies highlight the inconsistencies in testing, suggesting that cell-based testing or multiplex panels may be most clinically relevant.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alex A. Gandhi, Shanea K. Estes, Christine E. Rysenga, Jason S. Knight
Summary: Antiphospholipid syndrome (APS) is a leading cause of thrombosis, with pathogenic antibodies circulating at stable levels in blood, but thrombotic events often requiring a second hit. Investigators have turned to animal models to explore APS mechanisms, with each model having potential advantages and disadvantages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Gil-Etayo, Sara Garcinuno, Antonio Lalueza, Raquel Diaz-Simon, Ana Garcia-Reyne, Daniel Enrique Pleguezuelo, Oscar Cabrera-Marante, Edgard Alfonso Rodriguez-Frias, Alfredo Perez-Rivilla, Manuel Serrano, Antonio Serrano
Summary: The presence of aPL in COVID-19 patients is significantly associated with thrombosis, with potential mechanisms including early immune dysregulation and delayed aPL-mediated thrombosis. Additionally, aPL found in COVID-19 patients may preexist before the infection.
Article
Medicine, General & Internal
Chun Li, Yu Zuo, Song Zhang, Una E. Makris, David R. Karp, Zhanguo Li
Summary: This study aimed to identify additional clinical and epidemiological risks of arterial thrombosis, venous thrombosis, and pregnancy morbidities in individuals with persistent antiphospholipid antibodies (aPLs)-positive carriers. The study analyzed a large cohort of patients and found that smoking, hypertension, and the presence of underlying autoimmune diseases were additional risk factors for arterial thrombosis. Smoking and the presence of underlying autoimmune diseases were additional risk factors for venous thrombosis, and the presence of underlying autoimmune diseases was significantly associated with pregnancy morbidities. Furthermore, higher levels of cell-free DNA and citrullinated histone H3 were observed in APS patients and aPL patients with autoimmune diseases.
CHINESE MEDICAL JOURNAL
(2022)
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Biochemistry & Molecular Biology
Armando Tripodi
Summary: Lupus anticoagulant (LA) is a crucial laboratory parameter for the diagnosis and management of antiphospholipid syndrome (APS). Proper detection of LA is essential for long-term treatment of patients with thrombotic events, requiring adherence to guidelines and participation in quality assessment schemes.
Article
Immunology
Savino Sciascia, Massimo Radin, Mario Bazzan, Barbara Montaruli, Domenico Cosseddu, Claudio Norbiato, Maria Tiziana Bertero, Renato Carignola, Beatrice Bacco, Silvia Gallo Cassarino, Dario Roccatello
Summary: The presence of antiphospholipid antibodies in COVID-19 patients may contribute to a pro-coagulant state, but differs from patients with overt APS. Therefore, caution is needed in interpreting and generalizing the role of aPL in the management of COVID-19 patients. Additional well-designed clinical studies are necessary before introducing aPL testing as routine in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Simona Truglia, Antonella Capozzi, Silvia Mancuso, Valeria Manganelli, Luca Rapino, Gloria Riitano, Serena Recalchi, Serena Colafrancesco, Fulvia Ceccarelli, Tina Garofalo, Cristiano Alessandri, Agostina Longo, Roberta Misasi, Fabrizio Conti, Maurizio Sorice
Summary: Antiphospholipid syndrome (APS) is more common in women than in men, with male patients often exhibiting high levels of IgM anti-cardiolipin antibodies and a higher incidence of arterial thrombosis and myocardial infarction. Gender appears to influence the serological and clinical profiles of APS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Carla Baleeiro Silva, Camila S. C. Duran, Flavio Signorelli, Gustavo G. M. Balbi, Eloisa Bonfa, Danieli C. O. Andrade
Summary: This study found that youth-onset PAPS patients have a higher frequency of obstetric complications as the first manifestation, with an increased risk of fetal death and preterm delivery. Early recognition of this condition by obstetricians is essential to improve prognosis.
Review
Rheumatology
Savino Sciascia, Massimo Radin, Irene Cecchi, Maria Laura Bertolaccini, Maria Tiziana Bertero, Elena Rubini, Antonella Vaccarino, Mario Bazzan, Osvaldo Giachino, Simone Baldovino, Daniela Rossi, Giulio Mengozzi, Dario Roccatello
Summary: This study identified five clusters of patients with aPL, each exhibiting different clinical and laboratory characteristics. Clusters 1, 2, 3, and 5 corresponded to well-known entities, while cluster 4 may represent a bridging condition between primary APS and SLE. Cluster 4 showed lower thrombotic risk compared to primary APS but higher features such as ANA and cytopenia.
Review
Medicine, General & Internal
Marco Capecchi, Maria Abbattista, Alessandro Ciavarella, Mario Uhr, Cristina Novembrino, Ida Martinelli
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies and thrombosis or obstetrical complications. Anticoagulant therapy is the mainstay of treatment, but its optimal intensity and risk stratification for thrombosis are still unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jin Zhang, Cheng Li, Xiaorong Han, Zhongbo Chen, Binay Kumar Adhikari, Yinghui Wang, Yonggang Wang, Jian Sun
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by vascular thrombosis and pregnancy complications. Digestive system involvement in APS may result from autoimmune or thrombotic mechanisms, with the liver being the most commonly affected organ. This review discusses the clinical manifestations of APS in the digestive system, along with the epidemiology, pathophysiology, and treatment strategies for these patients.
ANNALS OF MEDICINE
(2021)
Article
Hematology
L. Talon, V. Fourneyron, S. Senectaire, M. Tardieu, M. Tillier, A. Trapani, A. Trayaud, A. Vaissade, A. F. Sapin, A. Lebreton, T. Sinegre
Summary: A study was conducted to investigate and compare the results and interpretations of lupus anticoagulant (LA) testing following the ISTH-SSC guidelines or available alternatives. The use of in-house cut-off values and pooled normal plasma (PNP) for ratio normalization, as well as ratio interpretation using the index of circulating anticoagulant, showed comparable testing outcomes. Understanding the characteristics of the mixing test is crucial for maximizing its diagnostic potential.
THROMBOSIS RESEARCH
(2023)