Review
Critical Care Medicine
Deepti Singhvi, Jessica Bon
Summary: Comorbidities significantly impact COPD patients, and targeted early screening and treatment may have a significant effect on COPD outcomes. Recent studies suggest that certain radiographic features can serve as surrogate markers for comorbid disease in COPD patients.
Article
Critical Care Medicine
Paul F. Pinsky, Eric Miller
Summary: This study used the SEER-Medicare database to assess various characteristics of low-dose CT (LDCT) scan lung cancer screening in US clinical practice. The study found that the use of LDCT scans was relatively low but increased over time. Patients with lung cancer who underwent screening had a higher proportion of early-stage cases and higher survival rates.
Article
Critical Care Medicine
Paul Pinsky, Eric Miller, Nick Faris, Raymond Osarogiagbon
Summary: This study explores the relationship between pulmonary nodules and lung cancer, assessing the commonness of nodules in the Medicare population and the rate of lung cancer after their detection. The study finds that pulmonary nodules are relatively common and are associated with a higher occurrence of lung cancer. It also suggests that a larger proportion of early-stage lung cancer is diagnosed through reporting of nodules compared to low-dose CT scan screening.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark M. Hammer, Andrew L. Eckel, Lauren L. Palazzo, Chung Yin Kong
Summary: The study evaluated the cost-effectiveness of different treatment thresholds for subsolid nodules within a lung cancer screening setting using simulation modeling. Treatments for pure ground-glass nodules were not cost-effective, while modifications of Lung-RADS guidelines for part-solid nodules proved to be cost-effective, with an optimal threshold of 4 mm for treatment of the solid component yielding the highest quality-adjusted life years.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Hyuk Lee, Dongheon Lee, Michael T. Lu, Vineet K. Raghu, Chang Min Park, Jin Mo Goo, Seung Ho Choi, Hyungjin Kim
Summary: The externally validated deep learning model showed added value to lung cancer screening in a health check-up sample, reducing the number of screening candidates while maintaining the inclusion rate and positive predictive value.
Article
Oncology
Anton Schreuder, Onno M. Mets, Cornelia M. Schaefer-Prokop, Colin Jacobs, Mathias Prokop
Summary: The study suggests that conducting three additional annual CT screening rounds in the National Lung Screening Trial may lead to substantial reduction in lung cancer mortality, with earlier diagnosis of lung cancer patients compared to original screening methods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yihui Du, Marcel J. W. Greuter, Mathias W. Prokop, Geertruida H. de Bock
Summary: This study aimed to determine appropriate pricing for DL-CAD to be cost-saving and to identify the potentially most cost-effective reading mode for lung cancer screening. The results showed that DL-CAD as a pre-screening reader had the largest potential for cost savings.
INSIGHTS INTO IMAGING
(2023)
Review
Oncology
J. L. Dickson, C. Horst, A. Nair, S. Tisi, R. Prendecki, S. M. Janes
Summary: Lung cancer is the leading cause of cancer death worldwide, with early detection playing a crucial role in improving survival rates. Studies have shown that low-dose computed tomography can significantly reduce lung cancer-specific mortality. Despite some barriers and concerns, this screening method should still be widely promoted.
ANNALS OF ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Xu, Mirza S. Khan, Thomas Z. Li, Riqiang Gao, James G. Terry, Yuankai Huo, Thomas A. Lasko, John Jeffrey Carr, Fabien Maldonado, Bennett A. Landman, Kim L. Sandler
Summary: This study evaluated the added value of CT-based AI-derived body composition measurements in predicting the risk of lung cancer incidence, lung cancer death, cardiovascular disease death, and all-cause mortality. The results showed that these measurements improved the risk prediction for lung cancer death, CVD death, and all-cause mortality, but not for lung cancer incidence.
Article
Oncology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigated the long-term survival effects of colorectal cancer screening based on screening history and interval time since screening. The results showed that colorectal cancer screening was positively associated with favorable prognosis, especially among individuals screened within 1 year before diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carina M. Behr, Hendrik Koffijberg, Koen Degeling, Rozemarijn Vliegenthart, Maarten J. IJzerman
Summary: The study estimated the maximum acceptable cost per screened individual for low-dose computed tomography (LDCT) lung cancer screening and evaluated the impact of additionally screening for chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), or both. The results showed that combined screening for lung cancer and cardiovascular disease is more economically viable than screening for lung cancer alone, primarily due to the benefits of cardiovascular disease screening. Screening high-risk populations for cardiovascular disease is more cost-effective compared to COPD.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Juyoung Kim, Bogeum Cho, Seon-Ha Kim, Chang-Min Choi, Yeol Kim, Min-Woo Jo
Summary: This study evaluates the cost utility of the Korean Lung Cancer Screening Project. The results show that annual low-dose computed tomography screening is cost-effective for high-risk populations.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Critical Care Medicine
Anton Manyak, Luke Seaburg, Kristin Bohreer, Steve H. Kirtland, Michal Hubka, Anthony J. Gerbino
Summary: This retrospective study analyzed a lung cancer screening program conducted at a nonuniversity teaching hospital and found that invasive procedures to resolve false-positive findings were uncommon. While there were some invasive procedures performed to evaluate incidental findings considered benign but clinically important, these procedures often had clinical value.
Article
Medicine, General & Internal
Iakovos Toumazis, Pianpian Cao, Koen de Nijs, Mehrad Bastani, Vidit Munshi, Mehdi Hemmati, Kevin ten Haaf, Jihyoun Jeon, Martin Tammemagi, G. Scott Gazelle, Eric J. Feuer, Chung Yin Kong, Rafael Meza, Harry J. de Koning, Sylvia K. Plevritis, Summer S. S. Han
Summary: In their 2021 update, the USPSTF emphasized the need for further research on the benefits and harms of risk model-based lung cancer screening strategies. This comparative modeling analysis found that risk model-based screening strategies were more cost-effective than the USPSTF recommendation, with a 6-year risk threshold of 1.2% or greater being the most cost-effective.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Ophthalmology
Stine Dahl Vest, Sarah E. Coupland, Bita Esmaeli, Paul T. Finger, Gerardo F. Graue, Hans E. Grossniklaus, Tine Gadegaard Hindso, Frederik Holm, Santosh G. Honavar, Jwu Jin Khong, Marina Knudsen Kirkegaard, Penelope A. McKelvie, Lauge Hjorth Mikkelsen, Kaustubh Mulay, Peter Kristian Rasmussen, Volkert Siersma, Lene Dissing Sjo, Matthew C. Sniegowski, Bradley A. Thuro, Geeta K. Vemuganti, Steffen Heegaard
Summary: The specific location of ocular adnexal lymphoma (OAL) and the AJCC TNM tumour stage are prognostic factors for mortality in different OAL subtypes. Eyelid lymphoma has the highest disease-specific mortality in all subtypes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Christina Sadolin Damhus, John Brandt Brodersen, Mette Bech Risor
Summary: The implementation of the Non-specific Symptoms and Signs of Cancer-Cancer Patient Pathway (NSSC-CPP) in Denmark has increased awareness of potential cancer symptoms and referrals. Through participant observation and interviews, this study explores the affective state of anticipation among patients in the NSSC-CPP. The findings suggest that although participants may not explicitly express worry about cancer, their increased healthcare use and interpretation of bodily sensations indicate underlying concerns.
Article
Obstetrics & Gynecology
Ruth Kirk Ertmann, Dagny Ros Nicolaisdottir, Jakob Kragstrup, Gritt Overbeck, Margit Kriegbaum, Volkert Siersma
Summary: There seems to be little association between common pregnancy symptoms in the first trimester and the risk of future pregnancy and birth complications, although some symptoms such as pain and bleeding may cause concern.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Medicine, General & Internal
Emma Grundtvig Gram, Volkert Siersma, John Brandt Brodersen
Summary: This study compares the long-term psychosocial consequences of mammography screening among women with breast cancer, normal results, and false-positive results. Through a 12-14 year follow-up of 1170 women who participated in the Danish mammography screening program from 2004-2005, it was found that women with false-positive results reported higher psychosocial consequences compared to women with normal findings. The findings also indicate that women diagnosed with breast cancer experienced a greater impact than those with false-positive results.
Article
Medicine, General & Internal
Elvira Isaeva, Joakim Bloch, Anja Poulsen, Jorgen Kurtzhals, Susanne Reventlow, Volkert Siersma, Azamat Akylbekov, Talant Sooronbaev, Rune Munck Aabenhus, Jesper Kjaergaard
Summary: In Kyrgyzstan, healthcare workers often prescribe antibiotics as a precautionary measure when there is clinical uncertainty. This study aims to assess whether the use of a CRP test can safely reduce antibiotic prescription for children with acute respiratory symptoms in primary healthcare centers in Kyrgyzstan.
Article
Oncology
Emma Grundtvig Gram, Tulia Filipa Roberto Manso, Bruno Heleno, Volkert Siersma, Jessica A. Rogvi, John Brandt Brodersen
Summary: The study compared the psychosocial consequences of early-stage breast cancer (DCIS) and invasive breast cancer (IBC), and found that they may have different long-term effects. It suggests renaming DCIS to exclude cancer nomenclature.
Article
Medicine, General & Internal
Moug Al-Bakri, Anne Mette Skovgaard, Daniella Bach-Holm, Dorte Ancher Larsen, Volkert Siersma, Line Kessel
Summary: This study aimed to investigate the influence of childhood cataract on academic development by comparing school performance in reading and mathematics in children with cataract to a matched control group. The study found that children with cataract, especially those who underwent bilateral cataract surgery, have lower scores in mathematics.
Article
Clinical Neurology
Sofie Olsgaard Bergien, Volkert Dirk Siersma, Maria Kristiansen, Lasse Skovgaard
Summary: This study examines how social relations and engagement in leisure activities predict wellbeing among older adults with MS in Denmark. The findings show that emotional and instrumental social support are associated with better wellbeing, while strained social relations are associated with lower levels of wellbeing. Engagement in leisure activities is also found to be a predictor of wellbeing.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Health Care Sciences & Services
Kristine Henderson Bissenbakker, Anne Moller, Alexandra Brandt Ryborg Jonsson, John Brandt Brodersen
Summary: This study aims to develop the MultiMorbidity Questionnaire (MMQ), a multimorbidity-specific PROM for the assessment of Needs-based QoL. Through 17 qualitative content validity questionnaire interviews, items and domains for the MMQ were developed. The results showed the relevance of supplementing the Needs-based approach with Self-perceived health inequity. The final MMQ draft will be further assessed for its psychometric properties.
PATIENT-RELATED OUTCOME MEASURES
(2023)
Article
Health Care Sciences & Services
Kristine Bissenbakker, Volkert Siersma, Alexandra Brandt Ryborg Jonsson, Anne Moller, Karl Bang Christensen, John Brandt Brodersen
Summary: The aim of this study was to assess the psychometric properties of the draft MultiMorbidity Questionnaire (MMQ) and adjust it accordingly to ensure its content and construct validity. Through analyzing the responses from 390 patients with multimorbidity, the measurement tools of MMQ1 and MMQ2 were found to have acceptable psychometric properties.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
Article
Primary Health Care
Emil Ronn Sorensen, Ida Scheel Rasmussen, Gritt Overbeck, Volkert Siersma, Clara Lundmark Appel, Philip Wilson
Summary: This study assesses the uptake and use of a web-based psychoeducational intervention in primary care. The results show that higher parity and the absence of a nurse or midwife in the practice are important factors associated with decreased use of the intervention. On the other hand, being a student or living outside the capital city are important factors associated with increased use of the intervention.
Article
Pharmacology & Pharmacy
Grimur Hognason Mohr, Carlo Alberto Barcella, Mia Klinten Grand, Margit Kriegbaum, Volkert Siersma, Margaret K. Hahn, Sri Mahavir Agarwal, Catrine Bakkedal, Lone Baandrup, Filip Krag Knop, Christen Lykkegaard Andersen, Bjorn Hylsebeck Ebdrup
Summary: This study compared the management of dyslipidaemia in patients with severe mental illness (SMI) and healthy controls (HCs). The results showed differences in lipid-profile measurements, presence of dyslipidaemia and redemption of lipid-lowering pharmacotherapy between the two groups. It suggests that patients with SMI have an increased awareness of managing dyslipidaemia in the primary prophylaxis of cardiovascular disease, but there may be a lack of lipid-lowering drugs for secondary prevention in high-risk SMI patients.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2023)
Article
Primary Health Care
A. B. R. Jonsson, F. H. J. Martiny, M. K. Sondergaard, J. B. Brodersen, T. D. Due, M. H. Nielsen, C. Bakkedal, J. E. Bardram, K. Bissenbakker, I. Christensen, K. Doherty, P. Kjellberg, S. W. Mercer, S. Reventlow, M. P. Rozing, A. Moller
Summary: In northern Denmark, seven general practices introduced extended consultations for patients with severe mental illness (SMI), which were found to be beneficial despite the study being terminated early due to the COVID-19 pandemic.
Article
Primary Health Care
Katrine Tranberg, Alexandra Jonsson, Tina Due, Volkert Siersma, John Brandt Brodersen, Kristine Bissenbakker, Frederik Martiny, Annette Davidsen, Pia Kuerstein Kjellberg, Kevin Doherty, Stewart W. Mercer, Maria Haahr Nielsen, Susanne Reventlow, Anne Moller, Maarten Rozing
Summary: This study evaluated the feasibility and fidelity of implementing and assessing the SOFIA coordinated care program in general practice in Denmark, aimed at improving somatic health care for patients with severe mental illness. While the program was implemented with a high level of fidelity, improvements are needed in the recruitment methodology.
