Article
Multidisciplinary Sciences
Noor Ulain, Asif Ali, Momin Khan, Zakir Ullah, Lubna Shaheen, Naveed Shareef, Muhammad Yasir, Tehmina Mustafa
Summary: Immunohistochemistry detection of MPT64 antigen is a reliable and rapid method for diagnosing tuberculous lymphadenitis, with better performance compared to ZN staining and cytomorphology.
Review
Endocrinology & Metabolism
Anna Crescenzi, Zubair Baloch
Summary: The use of immunohistochemistry is crucial in thyroid pathology, going beyond the confirmation of thyroid origin to include molecular profiling and prediction of clinical behavior. It has also influenced the classification scheme of thyroid tumors. Immunostains should be interpreted in conjunction with cytologic and architectural features, and their validation is essential for specimens with limited cellularity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jiali Gong, Ying Fan, Hongyang Lu
Summary: PEAC is an exceptionally rare subtype of lung cancer with features similar to colorectal adenocarcinoma. It has unique mutation expression and immune characteristics, with potential for targeted therapy in the future.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Balazs Gieszer, Zsolt Megyesfalvi, Viktoria Dulai, Judit Papay, Ilona Kovalszky, Jozsef Timar, Janos Fillinger, Tunde Harko, Orsolya Pipek, Vanda Teglasi, Eszter Regos, Gergo Papp, Zoltan Szallasi, Viktoria Laszlo, Ferenc Renyi-Vamos, Gabriella Galffy, Csaba Bodor, Balazs Dome, Judit Moldvay
Summary: This study suggests that high EGFR-aVAF in tumoral tissue predicts benefit from EGFR-TKI treatment in advanced LADC, and that exon 19 EGFR mutation is associated with high EGFR-aVAF and improved survival outcomes.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Brant G. Wang, Haresh Mani, Zoe Q. Wang, Wenping Li
Summary: Pancreatic solid-pseudopapillary neoplasm (SPN) is a rare tumor that mainly affects young females. While the cytological diagnosis is usually straightforward in typical cases, atypical clinical presentations and cytological features can make it challenging. This study provides insights into both typical and atypical features of SPN, emphasizing the importance of recognizing unusual clinical and cytological features to avoid misdiagnosis.
Article
Oncology
Liang Shi, Junfang Tang, Hong Tao, Lili Guo, Weihua Wu, Hongbo Wu, Zichen Liu, Li Tong, Wei Wu, Hongxia Li, Qiyi Meng, Liyan Xu, Nanying Che, Zhe Liu
Summary: The study demonstrates the feasibility of detecting EGFR mutations in cerebrospinal fluid and plasma. In patients with brain metastases from LADC, cerebrospinal fluid can serve as a liquid biopsy specimen to guide treatment strategy by monitoring EGFR mutation status.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Giulio Rossi, Fabio Davoli, Venerino Poletti, Alberto Cavazza, Filippo Lococo
Summary: This article highlights the wide spectrum of clinical and radiological presentation of malignant mesothelioma, the possibility of using cytology for continuous diagnosis, and proposes some alternative and more unbiased approaches to diagnosing MPM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Po-Yen Chen, Chin-Chou Wang, Chien-Ning Hsu, Chung-Yu Chen
Summary: This study compared the relative survival rate of gefitinib, erlotinib, and afatinib in EGFR-mutated advanced lung adenocarcinoma patients in Taiwan. Afatinib showed better overall survival and time to treatment failure outcomes compared to gefitinib and erlotinib, especially in patients with initial brain metastases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Guodong Fu, Ronald S. Chazen, Christina MacMillan, Ian J. Witterick
Summary: This diagnostic study developed a sensitive molecular assay for detection and quantification of BRAF V600E variation in residual tissue from thyroid FNA biopsies to identify patients with cancer harboring BRAF V600E in a cost-effective manner, highlighting the clinical value of molecular assay of the remaining FNA tissue in the management of thyroid nodules.
Article
Oncology
Wensheng Zhou, Zhichao Liu, Yanan Wang, Yanwei Zhang, Fangfei Qian, Jun Lu, Huimin Wang, Ping Gu, Minjuan Hu, Ya Chen, Zhengyu Yang, Ruiying Zhao, Yuqing Lou, Baohui Han, Wei Zhang
Summary: This study investigated the profile of concomitant alterations in EGFR-mutant LUAD with a size of 3 cm or less and found that TP53 mutation and EGFR amplification were poor prognostic factors for recurrence-free survival.
Article
Genetics & Heredity
Yan Chen, Bo Jiang, Yuange He, Chu Zhang, Wenjie Zhou, Cheng Fang, Dejian Gu, Minxia Zhang, Mei Ji, Juntao Shi, Xin Yang
Summary: MET exon 14 skipping mutation is a potential therapeutic target in NSCLC, which is mutually exclusive with EGFR sensitive mutations. However, the coexistence of MET exon 14 mutations with EGFR exon 20 insertion mutations has not been reported and the management approach for this subtype is unknown.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgaeuer, Mark Kriegsmann, Claus-Peter Heussel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Torsten Goldmann, Stefan Froehling, Martin Wermke, Cornelius F. Waller, Amanda Tufman, Martin Reck, Solange Peters, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger
Summary: The study found specific immunosuppressive characteristics in ALK- and EGFR-positive lung adenocarcinoma, supporting further clinical evaluation of immune-modulators as partners of immune checkpoint blockade in such tumors. The targeted gene expression profiling is a promising tool to analyze tumor microenvironment characteristics from routine diagnostic lung cancer biopsies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Li Xu, Kang Li, Xiaoyan Chen, Bolin Chen, Jia Li, Lin Wu
Summary: EGFR mutation is common in Asian NSCLC patients, which is the main cause of malignant tumor-related death worldwide. While distant metastases often occur in NSCLC, uterine cervical metastasis is rare. The use of NGS in diagnosing uterine cervical metastasis represents a significant clinical application beyond medication guidance and identification of drug resistance mechanisms.
Article
Oncology
Hayato Koba, Hideharu Kimura, Taro Yoneda, Naohiko Ogawa, Kota Tanimura, Yuichi Tambo, Takashi Sone, Kazuyoshi Hosomichi, Atsushi Tajima, Kazuo Kasahara
Summary: The study found that after EGFR-TKI treatment, some patients originally diagnosed with adenocarcinoma underwent histological transformation to small-cell carcinoma, with the detection of common variants. The Notch and ASCL1 signaling pathways may play an important role in the transformation of small-cell carcinoma under TP53 and RB1 inactivation.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Pathology
Seung-Hee Cho, Byung-Joon Seung, Soo-Hyeon Kim, Min-Kyung Bae, Ha-Young Lim, Jung-Hyang Sur
Summary: This study evaluated EGFR expression levels in canine intestinal adenocarcinomas, finding that they were higher than in non-neoplastic tissue at both protein and mRNA levels. Additionally, wild-type sequences were observed in the EGFR, KRAS, and BRAF genes in all 13 samples, aiding in the development of anti-EGFR agents for canine intestinal adenocarcinoma.
VETERINARY PATHOLOGY
(2021)