Article
Oncology
Peter S. N. van Rossum, Celia Juan-Cruz, Barbara Stam, Maddalena M. G. Rossi, Steven H. Lin, Azadeh Abravan, Jose S. A. Belderbos, Jan-Jakob Sonke
Summary: The study aimed to externally validate lymphopenia prediction models developed at The Christie and MD Anderson Cancer Center in patients with stage III NSCLC. The results showed that the PTV-based MDACC model demonstrated superior performance in predicting severe RIL compared to the dosimetry-based Christie model.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Bae Kwon Jeong, Jin Hyun Kim, Myeong Hee Jung, Ki Mun Kang, Yun Hee Lee
Summary: Analysis of cytokine profiles showed that changes in IL-6, G-CSF, and IFN-gamma levels at 3 weeks after the initiation of radiotherapy could identify patients predisposed to severe RP. Further investigation is needed to understand the mechanism of cytokine variation in relation to RP severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell, Ioannis I. Verginadis
Summary: Radiation therapy is an important modality in cancer treatment, but incidental exposure of the heart to radiation can lead to the development of Radiation-Induced Heart Disease (RIHD), causing various cardiovascular complications. The pathogenesis of radiation-induced myocardial fibrosis (RIMF) is still largely unknown and there are currently no available clinical approaches to reverse it. Therefore, more clinically relevant preclinical models are needed to study the molecular and cellular mechanisms involved in RIMF.
FRONTIERS IN ONCOLOGY
(2022)
Review
Critical Care Medicine
Deepti Singhvi, Jessica Bon
Summary: Comorbidities significantly impact COPD patients, and targeted early screening and treatment may have a significant effect on COPD outcomes. Recent studies suggest that certain radiographic features can serve as surrogate markers for comorbid disease in COPD patients.
Article
Oncology
Hiroshi Mayahara, Kazuyuki Uehara, Aya Harada, Keiji Kitatani, Tomonori Yabuuchi, Shuichirou Miyazaki, Takeaki Ishihara, Hiroki Kawaguchi, Hikaru Kubota, Hideaki Okada, Taira Ninomaru, Chihiro Shindo, Akito Hata
Summary: This study investigated the predictive factors for symptomatic radiation pneumonitis (RP) in patients with locally-advanced non-small cell carcinoma (LA-NSCLC) who received concurrent chemoradiotherapy (CCRT) followed by durvalumab. The results showed that pulmonary fibrosis score and lung V40 were significant predictive factors for symptomatic RP.
RADIATION ONCOLOGY
(2022)
Article
Critical Care Medicine
Miranda Kirby, Benjamin M. Smith
Summary: This article provides an overview of methodologic considerations for implementing quantitative CT scan airway analyses and reviews the scientific literature on quantitative CT scan airway measurements used in clinical trials and observational studies. While observational studies have shown associations between CT scan airway measurements and important clinical outcomes, few such measurements are applied in clinical practice. More research is needed to evaluate the clinical benefit of quantitative CT scan imaging in the clinical setting.
Article
Multidisciplinary Sciences
Tzu-Hui Pao, Ying-Yuan Chen, Wei-Lun Chang, Jeffrey Shu-Ming Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung, Forn-Chia Lin
Summary: The study found that T4 and esophageal stenosis at baseline were independent risk factors for esophageal fistula in ESCC patients treated with definitive CCRT with IMRT. Patients who received repair or stenting for esophageal perforation appeared to have a trend towards improved survival.
Article
Oncology
Romana Wass, Maximilian Hochmair, Bernhard Kaiser, Brane Grambozov, Petra Feurstein, Gertraud Weiss, Raphaela Moosbrugger, Felix Sedlmayer, Bernd Lamprecht, Michael Studnicka, Franz Zehentmayr
Summary: The standard of care for unresectable stage III non-small-cell lung cancer is concurrent chemoradiation followed by durvalumab. However, due to co-morbidities, only about one-third of patients can undergo the concurrent approach. Sequential regimens, especially in a dose-escalated mode, may be safe and feasible while showing better intrathoracic disease control than standard care.
Article
Medicine, Research & Experimental
Yuchun Wei, Xueting Qin, Xiaoli Liu, Jinsong Zheng, Xiaohui Luan, Yue Zhou, Jinming Yu, Shuanghu Yuan
Summary: This study suggests that evaluating tumor angiogenesis using F-18-Alfatide II may predict the short-term treatment response, progression-free survival, and overall survival in patients with locally advanced non-small cell lung cancer before concurrent chemoradiotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Won Gi Jeong, Yun-Hyeon Kim, Sung-Ja Ahn, Jae-Uk Jeong, Byung Chan Lee, Ick Joon Cho, Yong-Hyub Kim
Summary: This study aimed to evaluate whether pre-treatment fibrotic interstitial lung abnormality (ILA) affects the survival and development of symptomatic radiation pneumonitis (RP) in unresectable stage III non-small cell lung cancer (NSCLC) patients who had undergone definitive concurrent chemoradiotherapy (CCRT). The results showed that pre-treatment fibrotic ILA was an independent risk factor for symptomatic RP and poor survival in unresectable stage III NSCLC patients. Thus, caution should be taken when performing CCRT in patients with pre-treatment fibrotic ILA to prevent adverse outcomes.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Kazuya Takamochi, Masahiro Tsuboi, Morihito Okada, Seiji Niho, Satoshi Ishikura, Shunsuke Oyamada, Takuhiro Yamaguchi, Kenji Suzuki
Summary: This study investigated the use of concurrent chemoradiotherapy followed by surgery for stage IIIA (N2) lung squamous cell carcinoma (LSCC). The results showed promising outcomes, with high 2-year progression-free survival and overall survival rates. The study suggests that this treatment approach is feasible for LSCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ayman Jubran, Domenico Mastrodicasa, Gijs D. van Praagh, Martin J. Willemink, Aya Kino, Jia Wang, Dominik Fleischmann, Koen Nieman
Summary: In this study, a kV-independent coronary artery calcium scoring CT protocol was tested and found to be effective in reducing radiation exposure while maintaining consistent coronary calcium scoring results.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Kuo-Chin Chiu, Wei-Chun Lin, Chia-Lun Chang, Szu-Yuan Wu
Summary: COPD and its severity are significant independent risk factors for all-cause mortality in patients with lung SCC receiving definitive CCRT. Hospitalization for COPDAE within 1 year before CCRT is a significant independent risk factor for lung cancer death in these patients.
Review
Oncology
Yuanhu Yao, Jiaying Lu, Zhaohui Qin, Na Li, Ji Ma, Nan Yao, Wanxi Qu, Li Cui, Shiwang Yuan, Aijun Jiang, Xiaoxiao Liu
Summary: The study aimed to evaluate the effectiveness and safety of high-dose radiotherapy (HD-RT) versus standard-dose radiotherapy (SD-RT) in concurrent chemoradiotherapy for inoperable esophageal cancer patients. The results showed that HD-RT did not provide significant benefits in overall survival and progression-free survival for total esophageal cancer patients compared to SD-RT. However, in the subgroup analysis of esophageal squamous cell carcinoma, HD-RT possibly improved overall survival.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Medicine, General & Internal
Anne-Laure Brun, Marie-Laure Chabi, Clement Picard, Francois Mellot, Philippe A. Grenier
Summary: Chronic lung allograft rejection, also known as CLAD, is a major cause of morbidity and mortality after lung transplantation. It consists of two main phenotypes, Bronchiolitis Obliterans Syndrome (BOS) and Restrictive Allograft Syndrome (RAS), each characterized by specific functional and imaging features. CT plays a crucial role in the diagnosis and follow-up of CLAD patients, helping to exclude identifiable causes, detect early abnormalities, differentiate between obstructive and restrictive phenotypes, and track disease progression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna-Larissa N. Niemeijer, Daniela E. Oprea-Lager, Marc C. Huisman, Otto S. Hoekstra, Ronald Boellaard, Berlinda J. de Wit-van der Veen, Idris Bahce, Danielle J. Vugts, Guus A. M. S. van Dongen, Erik Thunnissen, Egbert F. Smit, Adrianus J. de Langen
Summary: This study investigated the response of NSCLC patients to pembrolizumab monotherapy and the uptake of Zr-89-pembrolizumab in tumors, finding that patients with higher uptake had better responses to treatment. Although no significant correlation was found with PD-L1 or PD-1 immunohistochemistry, the injection of Zr-89-pembrolizumab was deemed safe in the study.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasper Smit, Frank J. Borm, Anna-Larissa N. Niemeijer, Marc C. Huisman, Otto S. Hoekstra, Ronald Boellaard, Daniela E. Oprea-Lager, Danielle J. Vugts, Guus A. M. S. van Dongen, Berlinda J. de Wit-van der Veen, Erik Thunnissen, Egbert F. Smit, Adrianus J. de Langen
Summary: Zr-89-durvalumab is safe and may provide a better way to assess tumor PD-L1 expression in NSCLC patients treated with immunotherapy. However, further research is needed to validate its utility.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Oncology
Andrew G. Shuman, Matti S. Aapro, Benjamin Anderson, Katherine Arbour, Pedro C. Barata, Aditya Bardia, Eduardo Bruera, Bruce A. Chabner, Herbert Chen, Edwin Choy, Pierfranco Conte, Giuseppe Curigliano, Don Dizon, Eileen O'Reilly, Antonio Tito Fojo, Hans Gelderblom, Timothy A. Graubert, Jayne S. Gurtler, Evan Hall, Fred R. Hirsch, Ahmed Idbaih, David H. Ilson, Michael Kelley, Carlo La Vecchia, Heinz Ludwig, Beverly Moy, Hyman Muss, Frans Opdam, Rebecca D. Pentz, Marshall R. Posner, Jeffrey S. Ross, Adrian Sacher, Suresh Senan, Enrique Soto Perez de Celis, Kenneth K. Tanabe, Jan B. Vermorken, Eric Wehrenberg-Klee, Susan E. Bates
Summary: In this editorial, the authors discuss the potential implications of the recent Supreme Court decision in Dobbs v. Jackson Women's Health Organization for patients with cancer, in the context of the difficult decision of whether or not to choose pregnancy termination.
Article
Radiology, Nuclear Medicine & Medical Imaging
Helen J. Ball, Lakshmi Santanam, Suresh Senan, James A. Tanyi, Marcel van Herk, Paul J. Keall
Summary: A survey was conducted to assess the clinical practice of respiratory motion management in radiation oncology. The results showed that 84% of respondents used deep inspiration breath hold for left-sided breast cancer. 83% of respondents considered respiratory motion management very important or required for thoracic and abdominal cancer patients. 95% of respondents used respiratory motion management for thoracic and abdominal sites.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: A workflow involving preplanning on diagnostic CT imaging and online plan adaption using cone-beam CT scan was developed for single-visit radiotherapy. The study showed that this workflow can meet clinical goals and outperform initial treatment plans based on daily CT scan.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Oncology
Gregory J. Riely, Egbert F. Smit, Myung-Ju Ahn, Enriqueta Felip, Suresh S. Ramalingam, Anne Tsao, Melissa Johnson, Francesco Gelsomino, Raymond Esper, Ernest Nadal, Michael Offin, Mariano Provencio, Jeffrey Clarke, Maen Hussain, Gregory A. Otterson, Ibiayi Dagogo-Jack, Jonathan W. Goldman, Daniel Morgensztern, Ann Alcasid, Tiziana Usari, Paul Wissel, Keith Wilner, Nuzhat Pathan, Svitlana Tonkovyd, Bruce E. Johnson
Summary: The combination of encorafenib and binimetinib showed clinical efficacy and acceptable safety in patients with BRAF(V600E)-mutant metastatic NSCLC.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moritz Rabe, Miguel A. Palacios, John van Sornsen R. de Koste, Chukwuka Eze, Martin Hillbrand, Claus Belka, Guillaume Landry, Suresh Senan, Christopher Kurz
Summary: This study compared the accumulated doses of MRgRT, non-adaptive IMPT, and online adaptive IMPT for central lung tumors, with a focus on the bronchial tree dose. The results showed that non-adaptive and online adaptive proton therapy achieved significant dose sparing for organs in close proximity to central lung tumors compared to MRgRT. Online adaptive IMPT achieved significantly lower doses to the bronchial tree compared to MRgRT.
Article
Oncology
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Barbara Rijksen, Marjan Admiraal, Jorrit Visser, Sarah Barink, Amy L. de la Fuente, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: We developed a rapid palliative radiotherapy workflow using diagnostic imaging for pre-planning and on-couch target and plan adaptation based on a synthetic CT obtained from CBCT. The adapted treatment plans showed significant improvements in target coverage compared to the original plans. Most patients were satisfied with the workflow. The average treatment time, including consultation and on-couch adaptive treatment, was 85 minutes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Miguel A. Palacios, Georgi Gerganov, Paul Cobussen, Shyama U. Tetar, Tobias Finazzi, Berend J. Slotman, Suresh Senan, Cornelis J. A. Haasbeek, Iwan Kawrakow
Summary: This study evaluated the accuracy of automatic tumor segmentation in MR-guided radiotherapy (MRgRT) by comparing it to manual delineations performed by experienced observers. The results showed a high level of agreement between automatic segmentation and manual delineation.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Koichi Goto, Yasushi Goto, Toshio Kubo, Kiichiro Ninomiya, Sang-We Kim, David Planchard, Myung-Ju Ahn, Egbert F. Smit, Adrianus Johannes de Langen, Maurice Perol, Elvire Pons-Tostivint, Silvia Novello, Hidetoshi Hayashi, Junichi Shimizu, Dong-Wan Kim, Chih-Hsi Kuo, James Chih-Hsin Yang, Kaline Pereira, Fu-Chih Cheng, Ayumi Taguchi, Yingkai Cheng, Wenqin Feng, Zenta Tsuchihashi, Pasi A. Janne
Summary: T-DXd demonstrates clinically meaningful responses in patients with previously treated HER2-positive non-small-cell lung cancer, with favorable safety at a dosage of 5.4 mg/kg.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zofia Piotrowska, Daniel Shao-Weng Tan, Egbert F. Smit, Alexander I. Spira, Ross A. Soo, Danny Nguyen, Victor Ho-Fun Lee, James Chih-Hsin Yang, Vamsidhar Velcheti, John M. Wrangle, Mark A. Socinski, Marianna Koczywas, John E. Janik, Jeffrey Jones, Helena Alexandra Yu
Summary: This study demonstrates that Zipalertinib has encouraging antitumor activity in heavily pretreated patients with EGFR ex20ins-mutant NSCLC, with an acceptable safety profile and low frequency of high-grade diarrhea and rash.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Hilal Tekatli, Miguel A. Palacios, Famke L. Schneiders, Cornelis J. A. Haasbeek, Ben J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: This study investigated the long-term clinical outcomes of MR-guided SF-SABR on a 0.35 T linac for lung tumors. The results showed that SF-SABR, using automatic beam gating during breath-holds, achieved good tumor control and low toxicity.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Famke L. Schneiders, Claire van Vliet, Nicolas Giraud, Anna M. E. Bruynzeel, Ben J. Slotman, Miguel A. Palacios, Suresh Senan
Summary: This study retrospectively reviewed the outcomes of MR-guided adrenal SABR and found that this approach is well tolerated and achieves high local control rates. Further research using deformable dose accumulation is needed to better understand the dose-response relationship.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Respiratory System
Rolof G. P. Gijtenbeek, Vincent van der Noort, Joachim G. J. Aerts, Jeske A. Staal-van den Brekel, Egbert F. Smit, Frans H. Krouwels, Frank A. Wilschut, T. Jeroen N. Hiltermann, Wim Timens, Ed Schuuring, Joost D. J. Janssen, Martijn Goosens, Paul M. van den Berg, A. Joop de Langen, Jos A. Stigt, Ben E. E. M. van den Borne, Harry J. M. Groen, Wouter H. van Geffen, Anthonie J. van der Wekken
Summary: This study found that in patients with EGFR-mutated NSCLC, intercalated erlotinib with cisplatin-pemetrexed chemotherapy significantly prolonged progression-free survival compared to erlotinib monotherapy, but at the cost of increased toxicity.