Article
Cardiac & Cardiovascular Systems
Syed S. Razi, Karishma Kodia, Ahmed Alnajar, Mark Block, Francisco Tarrazzi, Dao Nguyen, Nestor Villamizar
Summary: In patients aged 80 years or older with stage I NSCLC, lobectomy offers better survival outcomes compared to SBRT, especially in those with no comorbidities. The number of lymph nodes examined during lobectomy, as well as age, sex, high grade, and tumor size, were found to be independent predictors of survival.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Rashid Al-Umairi, Usman Tarique, Rahim Moineddin, Laura Jimenez-Juan, Lan Chau Kha, Patrick Cheung, Anastasia Oikonomou
Summary: This study evaluated CT patterns of lung injury post-SBRT and identified predictable time points and durations. Familiarity with these patterns and timeframes aids in distinguishing them from local recurrence.
Article
Medicine, General & Internal
Annaig Bertho, Morgane Dos Santos, Sarah Braga-Cohen, Valerie Buard, Vincent Paget, Olivier Guipaud, Georges Tarlet, Fabien Milliat, Agnes Francois
Summary: By utilizing three-fraction schedules delivered over a period of 1 week with doses per fraction of 20, 28, 40, and 50 Gy, only 3 x 40 Gy or 3 x 50 Gy generated focal lung fibrosis after 6 months. The study suggests that a fractionation schedule using an arc-therapy-delivered three fractions/1 week regimen with 3 x 3 mm beam requires 40 Gy per fraction for lung fibrosis to develop within 6 months.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Lirong Wu, Jun Zhu, Nils-Petter Rudqvist, James Welsh, Percy Lee, Zhongxing Liao, Ting Xu, Ming Jiang, Xiangzhi Zhu, Xuan Pan, Pansong Li, Zhipeng Zhou, Xia He, Rong Yin, Jifeng Feng
Summary: This study evaluated the T cell receptor (TCR) repertoire before and after stereotactic body radiotherapy (SBRT) for early-stage non-small-cell lung cancer (NSCLC). The analysis showed that quantitative assessments of TCRs can help predict prognosis in NSCLC patients. Patients who had a lower change in Shannon Entropy in TCR repertoire after SBRT had poorer metastasis-free survival, indicating a potential correlation between immune function and treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Shujun Zhang, Bo Lv, Xiangpeng Zheng, Ya Li, Weiqiang Ge, Libo Zhang, Fan Mo, Jianjian Qiu
Summary: The study aimed to evaluate the accuracy and feasibility of a lung SBRT treatment plan with ITVpredict as the target. ITVpredict was generated using a deep learning model based on CBCT images, and its geometric accuracy was verified. The results showed that the dosimetric parameters of the treatment plan based on ITVpredict were comparable to the original 4DCT plan.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Eleni Gkika, Elke Firat, Sonja Adebahr, Erika Graf, Ilinca Popp, Gianluca Radicioni, Simon S. Lo, Ursula Nestle, Nils H. Nicolay, Gabriele Niedermann, Dan G. Duda, Anca-L. Grosu
Summary: We conducted a prospective study to investigate the changes in circulating immune cells after stereotactic body radiotherapy (SBRT) in early-stage NSCLC patients. We found no significant increase in CD8(+) cytotoxic T lymphocytes at the first follow-up, but observed a significant expansion in Ki-67(+)CD8(+) and Ki-67(+)CD4(+) T-cell fractions in patients receiving 10 Gy or less per fraction. Our findings suggest that SBRT can induce immediate expansion of circulating effector T-cells.
NPJ PRECISION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. Mcgee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Summary: Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). A phase I study tested the addition of atezolizumab to SABR in high risk, medically inoperable, early-stage NSCLC, and found that it was well tolerated and showed efficacy signals.
NATURE COMMUNICATIONS
(2023)
Article
Critical Care Medicine
Yusef A. Syed, William Stokes, Manali Rupji, Yuan Liu, Onkar Khullar, Nikhil Sebastian, Kristin Higgins, Jeffrey D. Bradley, Walter J. Curran, Suresh Ramalingam, James Taylor, Manu Sancheti, Felix Fernandez, Drew Moghanaki
Summary: Facilities with higher use of SBRT for surgery in patients with early stage NSCLC showed lower rates of postoperative mortality. These findings suggest that the availability and use of SBRT may improve the selection of patients predicted to be at high risk of postoperative mortality.
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Uhlig, Sumarth Mehta, Meaghan Dendy Case, Andrew Dhanasopon, Justin Blasberg, Robert J. Homer, Stephen B. Solomon, Hyun S. Kim
Summary: The study found that the overall survival following TA and SBRT for stage I lung cancer is comparable for most histological subtypes, except for non-small cell NETs where TA showed longer overall survival.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Oncology
Yuanjun Qi, Jianbin Li, Yingjie Zhang, Qian Shao, Xijun Liu, Fengxiang Li, Jinzhi Wang, Zhenxiang Li, Wei Wang
Summary: Abdominal compression has minimal impact on tumour motion analysis, but can reduce tumor target volume and decrease PTV margins. The use of abdominal compression can effectively reduce tumor target volume and decrease PTV margins in SBRT treatment.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Tomoyuki Hida, Akinori Hata, Junwei Lu, Vladimir I. Valtchinov, Takuya Hino, Mizuki Nishino, Hiroshi Honda, Noriyuki Tomiyama, David C. Christiani, Hiroto Hatabu
Summary: In this study of 231 stage I NSCLC patients, ILA was present in 9.5% of patients and was significantly associated with shorter overall survival, serving as an imaging marker for shorter survival in stage I NSCLC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Zhu, Li-Li Chen, Ying-Wei Luo, Li Zhang, Hui-Yun Ma, Hao-Shuai Yang, Bao-Cong Liu, Lu-Jie Li, Wen-Biao Zhang, Xiang-Min Li, Chuan-Miao Xie, Jian-Cheng Yang, De-ling Wang, Qiong Li
Summary: The study evaluated the performance of an automatic deep learning (DL) algorithm for measuring size, mass, and volume in predicting prognosis of lung adenocarcinoma (LUAD) and compared it with manual measurements. The results showed that the DL algorithm can replace human measurements for more accurate T-staging of LUAD and can better predict prognosis for ground glass nodules (GGNs) than manual measurements. This demonstrates the clinical relevance of DL algorithm in patients with lung adenocarcinoma.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Takaya Inagaki, Hiroshi Doi, Masahiro Inada, Naoko Ishida, Aritoshi Ri, Saori Tatsuno, Yutaro Wada, Takuya Uehara, Kiyoshi Nakamatsu, Makoto Hosono, Yasumasa Nishimura
Summary: Clinical T stage is associated with progression-free survival after SBRT for lung cancer, and there are differences in failure patterns according to T stage. 4D-CT can be used to assess chest wall invasion.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Pierre Tremolieres, Ana Gonzalez-Moya, Amaury Paumier, Martine Mege, Julien Blanchecotte, Christelle Theotime, Damien Autret, Stephane Dufreneix
Summary: This study characterizes the motion of pulmonary tumors during SBRT and evaluates different margins when creating the PTV on a single 4DCT scan. The results suggest that using a 4-mm margin to generate the PTV appears feasible for upper lobe lesions located above the carina.
RADIATION ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Samuel P. Heilbroner, Eric P. Xanthopoulos, Donna Buono, Daniel Carrier, Ben Y. Durkee, Michael Corradetti, Tony J. C. Wang, Alfred I. Neugut, Dawn L. Hershman, Simon K. Cheng
Summary: This study examined the cost effectiveness of hfIGRT in elderly patients with stage III NSCLC using Medicare claims data. The results showed that hfIGRT did not affect clinical outcomes but increased radiation costs, indicating the need for further scrutiny through a randomized controlled trial.
Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Michael T. Milano, Jimm Grimm, Scott G. Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A. Tome, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D. Solberg, John P. Kirkpatrick, Louis S. Constine, John C. Flickinger, Lawrence B. Marks, Issam El Naqa
Summary: This study analyzed dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy after single-fraction stereotactic radiosurgery or hypofractionated radiosurgery. The results showed that the maximum point dose to the optic apparatus was related to RION risk, providing insight into NTCP risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Ariel E. Marciscano, Adriana Haimovitz-Friedman, Percy Lee, Phuoc T. Tran, Wolfgang A. Tome, Chandan Guha, Feng-Ming (Spring) Kong, Arjun Sahgal, Issam El Naqa, Andreas Rimner, Lawrence B. Marks, Silvia C. Formenti, Theodore L. DeWeese
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Percy Lee, Billy W. Loo Jr, Tithi Biswas, George X. Ding, Issam M. El Naqa, Andrew Jackson, Feng-Ming Kong, Tamara LaCouture, Moyed Miften, Timothy Solberg, Wolfgang A. Tome, An Tai, Ellen Yorke, X. Allen Li
Summary: Based on the evaluation of published experiences with SBRT, a steep dose-response relationship exists with high rates of durable local control for early-stage non-small cell lung cancer when physical doses of 43-50 Gy are delivered.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia M. Pakela, Huan-Hsin Tseng, Martha M. Matuszak, Randall K. Ten Haken, Daniel L. McShan, Issam El Naqa
Review
Oncology
Paul Martin Putora, Michael Baudis, Beth M. Beadle, Issam El Naqa, Frank A. Giordano, Nils H. Nicolay
Editorial Material
Oncology
Issam El Naga
Summary: Artificial intelligence and machine learning have the potential to improve cancer care accessibility, efficiency, cost-effectiveness, and personalization, but carefully planned deployment strategies are needed to validate their performance in real-world clinical settings and overcome the trust barrier.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Engineering, Biomedical
Julia M. Pakela, Martha M. Matuszak, Randall K. Ten Haken, Daniel L. McShan, Issam El Naqa
Summary: The study investigates the feasibility of predicting patient anatomical changes using two different methods during fractionated treatment, and results show that the MRNN framework performs slightly better than the QRNN framework on a dataset of 125 head and neck cancer patients.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Ibrahim Chamseddine, Yejin Kim, Brian De, Issam El Naqa, Dan G. Duda, John Wolfgang, Jennifer Pursley, Harald Paganetti, Jennifer Wo, Theodore Hong, Eugene J. Koay, Clemens Grassberger
Summary: This study developed machine learning models to predict treatment failure and radiation-induced toxicities in patients with hepatocellular carcinoma after radiotherapy. The models demonstrated excellent performance, particularly in high-risk patients, and could be used for patient stratification and treatment selection.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyung-Wook Jee, Thomas Bortfeld, Issam El Naqa, Lei Dong
Summary: This special issue collects and presents research and developmental works in the forefront of particle radiotherapy (pRT) investigations. It focuses on seven subfields that represent recent advances in medical physics communities, including ultrahigh dose rate (FLASH) particle therapy, online adaptive particle therapy, MR-particle RT systems, compact, affordable, and accessible particle RT systems, range uncertainty reduction, range verification, and artificial intelligence in particle therapy. The editorial provides visionary perspectives on each subfield's present activities and future research directions, along with a synopsis of the published articles pertaining to each subfield.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2022)
Article
Computer Science, Interdisciplinary Applications
Wenbo Sun, Dipesh Niraula, Issam El Naqa, Randall K. Ten Haken, Ivo Dinov, Kyle Cuneo, Judy (Jionghua) Jin
Summary: This paper presents a systematic method to integrate expert human knowledge with AI recommendations for optimizing clinical decision making. It combines Gaussian process models with deep neural networks to quantify the uncertainty of treatment outcomes given by physicians and AI recommendations, providing guidance for clinical physicians and improving AI models performance.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Engineering, Biomedical
Naveena Gorre, Eduardo Carranza, Jordan Fuhrman, Hui Li, Ravi K. Madduri, Maryellen Giger, Issam El Naqa
Summary: The objective of this study is to develop a modular and user-friendly software tool for clinical applications of machine learning models. This tool allows clinicians, researchers, and early AI developers to explore, train, and test AI algorithms, and provides visualization and interpretability of otherwise blackbox AI algorithms.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Islam Eljilany, Payman Ghasemi Saghand, James Chen, Aakrosh Ratan, Martin McCarter, John Carpten, Howard Colman, Alexandra P. Ikeguchi, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, Jose Conejo-Garcia, William S. Dalton, George J. Weiner, Issam M. El Naqa, Ahmad A. Tarhini
Summary: In this study, the prognostic value of immunoscore calculated from real-world transcriptomic data was evaluated in patients with advanced malignancies treated with immune checkpoint inhibitors. The results demonstrated that the immunoscore could predict patients at risk of death, with better overall survival observed in patients with intermediate-high immunoscore.
Review
Oncology
Rossybelle Amorrortu, Melany Garcia, Yayi Zhao, Issam El Naqa, Yoganand Balagurunathan, Dung-Tsa Chen, Thanh Thieu, Matthew B. Schabath, Dana E. Rollison
Summary: This narrative review summarizes existing literature on approaches to estimate real-world disease progression in lung cancer patients. Five approaches were identified, including manual abstraction, natural language processing, treatment-based algorithms, changes in tumor volume, and delta radiomics-based approaches. The accuracy of these approaches was assessed using different methods.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Mark Farha, Neil K. Jairath, Theodore S. Lawrence, Issam El Naqa
JCO CLINICAL CANCER INFORMATICS
(2020)