Article
Oncology
Maosen Dou, Dan Li, Mengchan Zhu, Wei Guo, Changhong Miao, Min Li, Ying Xue, Ruiping He, Nan Jiang, Di Ge, Qin Hu, Yue Shao, Yingyong Hou, Xuefei Wang, Xingxu Huang, Tianshu Liu, Qi Wang, Yuehong Wang, Jiayuan Sun, Weibing Wang, Yuanlin Song, Jie Hu, Qihong Huang
Summary: Non-diagnostic findings are commonly found in transbronchial lung biopsy (TBLB) and endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB). To improve lung cancer detection, a study used an 850 K methylation chip to identify methylation sites that can differentiate malignant from benign lung nodules. The findings showed that a combination of HOXA7, SHOX2, and SCT methylation analysis was most effective in diagnosing lung cancer using bronchial washing and brushing samples.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Caichen Li, Huiting Wang, Yu Jiang, Wenhai Fu, Xiwen Liu, Ran Zhong, Bo Cheng, Feng Zhu, Yang Xiang, Jianxing He, Wenhua Liang
Summary: Lung cancer screening is burdened with physical and mental health issues for patients worldwide. This review summarizes recent studies on lung cancer screening from the US, Europe, and Asia, and discusses risk-based selection for screening, novel techniques for differential diagnosis of pulmonary nodules, and current strategies for suspected malignancy.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Yan Hu, Qing Yu, Cuiyan Guo, Guangfa Wang
Summary: DNA-ICM can be used as an adjunct method for the detection of lung cancer, and its combination with basic bronchoscopy techniques can significantly increase the sensitivity, especially for patients suspected of peripheral lung cancer.
Article
Cell Biology
Jing Ning, Tao Ge, Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He
Summary: The research focuses on various early diagnosis methods for lung cancer, aiming to improve early diagnosis rates and explore feasible and effective strategies. This includes imaging screening, bronchoscopy, and emerging potential liquid biopsies, as well as volatile organic compounds and autoantibodies.
Article
Biotechnology & Applied Microbiology
Qinsi Yang, Jiaxin Luo, Hao Xu, Liu Huang, Xinxi Zhu, Hengrui Li, Rui Yang, Bo Peng, Da Sun, Qingfu Zhu, Fei Liu
Summary: Lung cancer is commonly diagnosed at an advanced stage, leading to poor prognosis. However, recent evidence suggests that extracellular vesicles (EVs) may serve as potential biomarkers for early cancer detection. In this study, we analyzed the metabolomic signatures of urinary EVs in lung cancer patients and identified a marker panel with a diagnostic potency of 96% for the testing cohort and 84% for the validation set. These findings suggest that metabolomic analysis of urinary EVs could provide non-invasive markers for lung cancer diagnostics and improve patient outcomes.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pathology
Joanna K. M. Ng, Wing Cheung, Joshua J. X. Li, Ka Pang Chan, Wing Ho Yip, Gary M. Tse
Summary: This study retrospectively reviews sputum and bronchial cytology paired with resection-confirmed lung cancers. The findings suggest that sputum cytology has lower sensitivity for T1 lesions and caution should be taken in interpreting negative and indeterminate cytology results.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2023)
Article
Oncology
Xinyu Zhang, Chun Li, Maosong Ye, Qin Hu, Jie Hu, Ziying Gong, Jieyi Li, Xiaokai Zhao, Yiqing Xu, Daoyun Zhang, Yingyong Hou, Xin Zhang
Summary: BWF demonstrates high sensitivity in detecting EGFR mutations in LC patients, showing high concordance with histologic samples, and providing the advantage of rapid EGFR mutation detection. In EGFR testing, the diameter of the target lesion and its contact degree with BWF are significant predictive factors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Shaohua Zheng, Shaohua Kong, Zihan Huang, Lin Pan, Taidui Zeng, Bin Zheng, Mingjing Yang, Zheng Liu
Summary: This paper proposes a two-stage nodule detection method for low-dose computed tomography (LDCT), which generates nodule candidates using a multi-scale feature detection network and reduces false positives through a candidate scoring network. Experimental results show that the proposed method achieves good detection performance on the LUNA16 dataset.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Xu, Mirza S. Khan, Thomas Z. Li, Riqiang Gao, James G. Terry, Yuankai Huo, Thomas A. Lasko, John Jeffrey Carr, Fabien Maldonado, Bennett A. Landman, Kim L. Sandler
Summary: This study evaluated the added value of CT-based AI-derived body composition measurements in predicting the risk of lung cancer incidence, lung cancer death, cardiovascular disease death, and all-cause mortality. The results showed that these measurements improved the risk prediction for lung cancer death, CVD death, and all-cause mortality, but not for lung cancer incidence.
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Oncology
Anna Kerpel-Fronius, Martin Tammemagi, Milena Cavic, Claudia Henschke, Long Jiang, Ella Kazerooni, Choon-Taek Lee, Luigi Ventura, Dawei Yang, Stephen Lam, Rudolf M. Huber
Summary: The feasibility and effectiveness of lung cancer screening for individuals who never smoked are uncertain due to current screening guidelines typically excluding this group. Evaluation in each country considering various factors, including risk assessment accuracy and cost-effectiveness, is necessary. Current evidence supporting widespread implementation of screening for never smokers is lacking.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Review
Oncology
Christine D. Berg, Joan H. Schiller, Paolo Boffetta, Jing Cai, Casey Connolly, Anna Kerpel-Fronius, Andrea Borondy Kitts, David C. L. Lam, Anant Mohan, Renelle Myers, Tejas Suri, Martin C. Tammemagi, Dawei Yang, Stephen Lam
Summary: Air pollution is the second leading cause of lung cancer and has a synergistic effect with smoking. This study summarizes the association between air pollution and lung cancer, as well as the identification and measurement methods of air pollutants. Assessing cumulative exposure to air pollution presents challenges in accurately collecting long-term data.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medical Laboratory Technology
Ye Sun, Yan L. Ge, Li Q. Li, Yang Liu, Yang Lu, Qin Jing, Yi Chen, Wen Q. Li, Lin L. Hou, Pei Min
Summary: Tracheobronchial foreign body aspiration is a potentially risky event that requires early detection and rapid intervention. Elevated CEA and bronchial obstruction are not typical manifestations of lung cancer, emphasizing the importance of bronchoscopy in making a reliable diagnosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Rudolf M. Huber, Milena Cavic, Anna Kerpel-Fronius, Lucia Viola, John Field, Long Jiang, Ella A. Kazerooni, Coenraad F. N. Koegelenberg, Anant Mohan, Ricardo Sales Dos Santos, Luigi Ventura, Murry Wynes, Dawei Yang, Javier Zulueta, Choon-Taek Lee, Martin C. Tammemagi, Claudia Henschke, Stephen Lam
Summary: This report discusses the importance of global implementation of lung cancer screening and the impact of respiratory infections such as COVID-19 on screening. It highlights the risk of false positive results due to respiratory infections and provides guidance and recommendations for these situations, while also calling for further research and discussions.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Critical Care Medicine
David S. Gierada, Paul F. Pinsky
Summary: The study found that low-dose CT screening can improve the survival rate of stage I lung cancer, especially for smaller primary tumor size and surgical treatment.
Article
Physiology
Gali Epstein Shochet, Elizabetha Brook, Omer Eyal, Evgeny Edelstein, David Shitrit
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Ruth Rahamimov, Hagit Tifti-Orbach, Boris Zingerman, Hefziba Green, Shira Schneider, Avry Chagnac, Eytan Mor, Benjamin D. Fox, Benaya Rozen-Zvi
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Oncology
Matthew Koslow, David Shitrit, Lilach Israeli-Shani, Orit Uziel, Einat Beery, Alexandra Osadchy, Yael Refaely, Gali Epstein Shochet, Aliza Amiel
Letter
Critical Care Medicine
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
Article
Physiology
David Langleben, Stylianos E. Orfanos, Michele Giovinazzo, Robert D. Schlesinger, Robert Naeije, Benjamin D. Fox, Ali O. Abualsaud, Fay Blenkhorn, Lawrence G. Rudski, John D. Catravas
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Letter
Critical Care Medicine
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
Article
Health Care Sciences & Services
Alexander Guber, Gali Epstein Shochet, Sarah Kohn, David Shitrit
JOURNAL OF MEDICAL SYSTEMS
(2019)
Letter
Critical Care Medicine
Ori Wand, Avraham Unterman, Gali Epstein Shochet, David Shitrit
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Respiratory System
Benjamin D. Fox, Yael Shostak, Barak Pertzov, Baruch Vainshelboim, Shimon Itzhakian, Irit Terner, Mordechai R. Kramer
BMC PULMONARY MEDICINE
(2019)
Article
Respiratory System
Benjamin Daniel Fox, Marina Bondarenco, Isaac Shpirer, Noam Natif, Sivan Perl
Summary: The study suggests that transitioning to home NIV after a hypercapnic hospitalisation may be useful for younger, cooperative patients with chronic respiratory disease, but may not be beneficial and potentially harmful for older patients or those with cardiac failure.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Sivan Perl, Marina Bondarenco, Noam Natif, Yitschak Shpirer, Sharon Enghelberg, Benjamin Fox
RESPIRATORY RESEARCH
(2020)
Article
Medicine, General & Internal
Daniel Erez, Matthew Koslow, Gali Epstein Shochet, Zamir Dovrish, Lilach Lsraeli-Shani, David Dahan, Daniel King, David Shitrit
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2019)
Article
Respiratory System
Benjamin Daniel Fox, Nadav Sheffy, Baruch Vainshelboim, Leonardo Fuks, Mordechai R. Kramer
BMJ OPEN RESPIRATORY RESEARCH
(2018)
Article
Medicine, General & Internal
David Dahan, Gali Epstein Shochet, Ester Fizitsky, Miriam Almagor, David Shitrit
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2018)
Article
Respiratory System
Ori Wand, Benjamin D. Fox, Osnat Shtraichman, Osnat Moreh-Rahav, Mordechai R. Kramer
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2020)