Article
Oncology
Simon Garinet, Pascal Wang, Audrey Mansuet-Lupo, Ludovic Fournel, Marie Wislez, Helene Blons
Summary: This review discusses the need for improved risk assessment and patient selection for adjuvant and neoadjuvant chemotherapy following resected lung cancer. The current evaluation of recurrence risk is primarily based on TNM classification, but more than 25% of early-stage patients still experience relapse. Validated prognostic and theranostic markers are needed to better stratify patients and guide adjuvant therapies in resected lung cancer.
Editorial Material
Oncology
Jordi Remon, Benjamin Besse
Summary: Efforts are being made to incorporate immune-checkpoint inhibitors into therapy for early stage non-small-cell lung cancer. The IMpower010 trial has demonstrated that this strategy can improve disease-free survival in a subset of patients, opening up a new area of research in the quest for the optimal perioperative strategy to increase overall survival.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Oncology
Maiko Shimosato, Naoki Sakane
Summary: This study aimed to investigate the association of oral dryness with overall survival in palliative care patients, and to determine the threshold points for predicting short-term survival. Results showed that oral dryness at the lingual mucosa was associated with decreased survival, with a moisture degree <19.2% predicting less than 7-day survival. The receiver operating characteristic curve analysis indicated fair predictive performance for 7-, 14-, 21-, and 28-day survival predictions.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Gastroenterology & Hepatology
Kumari Anjali, Tarun Kumar, Amrita Ghosh Kar, Puneet Kumar, Gopeshwar Narayan, Sunita Singh
Summary: This study investigated the association of two polymorphisms of the PARP1 gene with gallbladder cancer risk, as well as the combined effect of multiple SNP sites. Certain haplotypes were found to be significantly associated with the risk of gallbladder cancer. Patients with risk genotypes of rs1805405 had lower overall survival after chemotherapy, while upregulation of PARP1 was associated with higher overall survival in patients with gallbladder cancer.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Chemistry, Medicinal
Lin Wang, Penghui Li, Kun Feng
Summary: The combination of EGCG with chemotherapy drugs can enhance their sensitizing effect on tumors and combat the drug resistance of cancer cells. EGCG can also suppress the adverse effects caused by chemotherapy and improve the quality of life of patients. However, the low bioavailability and off-target effects of EGCG limit its clinical application, and nanomodification shows promise in enhancing its antitumor activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Genetics & Heredity
Xiaoyan Fan, Junye Wen, Lei Bao, Fei Gao, You Li, Dongwei He
Summary: The study found that DEPDC1B is highly expressed in LIHC tissues and is associated with poor prognosis in LIHC patients. Additionally, high expression of DEPDC1B may be associated with multiple signaling pathways and significantly correlated with various cancers.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Yu Mei, Xijia Feng, Tienan Feng, Min Yan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: This retrospective study examined the role of adjuvant chemotherapy (ACT) in patients with pT2N0M0 gastric cancer who underwent radical resection. The study found that ACT was associated with higher 5-year overall survival and disease-specific survival rates. Patients with pT2N0M0 gastric cancer, regardless of high-risk factors, may be suitable for ACT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Sibylle Loibl, Chiun-Sheng Huang, Max S. Mano, Eleftherios P. Mamounas, Charles E. Geyer, Michael Untch, Jean-Christophe Thery, Ingo Schwaner, Steven Limentani, Niklas Loman, Kristina Lubbe, Jenny C. Chang, Thomas Hatschek, David Tesarowski, Chunyan Song, Sanne Lysbet de Haas, Thomas Boulet, Chiara Lambertini, Norman Wolmark
Summary: In HER2-negative breast cancer patients, T-DM1 treatment may be more effective than trastuzumab.
Review
Oncology
Shinji Tsukamoto, Andreas F. Mavrogenis, Lucia Angelelli, Alberto Righi, Giuseppe Filardo, Akira Kido, Kanya Honoki, Yuu Tanaka, Yasuhito Tanaka, Costantino Errani
Summary: The 5-year disease-free survival rate for patients with localized extraskeletal osteosarcoma (ESOS) who underwent surgery combined with (neo)adjuvant chemotherapy was slightly higher than those who underwent surgery alone. Therefore, routine adjuvant chemotherapy for localized ESOS should be avoided.
Article
Oncology
Yuchong Yang, Yao Lu, Hui Tan, Ming Bai, Xia Wang, Shaohua Ge, Tao Ning, Le Zhang, Jingjing Duan, Yansha Sun, Rui Liu, Hongli Li, Yi Ba, Ting Deng
Summary: The timing of postoperative adjuvant chemotherapy has significant effects on the survival rate of colorectal cancer patients. Starting chemotherapy within 8 weeks after surgery leads to better outcomes. There is no noticeable difference in survival benefits between starting chemotherapy within 5-8 weeks and within <= 4 weeks. Delaying chemotherapy for approximately 5-6 months after surgery is still beneficial in improving prognosis compared to patients not receiving chemotherapy.
Article
Oncology
Peng Jin, Xiaoyan Ji, Shuai Ma, Wenzhe Kang, Hao Liu, Yang Li, Fuhai Ma, Haitao Hu, Weikun Li, Yantao Tian
Summary: This retrospective study analyzed gastric cancer patients with pathological stage pT1N1M0 and found that adjuvant chemotherapy may provide survival benefits for selected patients. Independent risk factors for reduced survival included sex, number of examined lymph nodes, and receiving AC. Patients were divided into three risk categories based on sex and lymph node status, with significant differences in survival observed between the groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Alessandro Silvani, Stefano Vandi, Fabio Pizza, Elena Antelmi, Raffaele Ferri, Giuseppe Plazzi
Summary: The study confirmed the effectiveness of rapid eye movement (REM) sleep latency (REML), the REM sleep atonia index (RAI), and their combination (COM) in automatically identifying pediatric patients with narcolepsy type 1 (NT1). In both the test and validation cohorts, COM performed significantly better in identifying NT1 patients, with high accuracy, sensitivity, and specificity.
Article
Biology
M. Amico, I Van Keilegom, B. Han
Summary: This article introduces a cure model for handling cure fractions in survival data, and proposes a ROC curve estimator to evaluate the classification performance of cured/noncured status. Through simulations and comparisons, the good performance of the proposed method is demonstrated, applied to a breast cancer dataset.
Review
Health Care Sciences & Services
Alex Hall, Elisabeth Boulton, Patience Kunonga, Gemma Spiers, Fiona Beyer, Peter Bower, Dawn Craig, Chris Todd, Barbara Hanratty
Summary: This systematic review aimed to synthesize evidence on the identification of older people with frailty approaching end-of-life and whether intervention improves outcomes. The study found a lack of research using established approaches to assessing frailty and highlighted the need for future research to address this evidence gap and focus on palliative care models.
PALLIATIVE MEDICINE
(2021)
Article
Oncology
Diamantis Tsilimigras, J. Madison Hyer, Anghela Z. Paredes, Dimitrios Moris, Kota Sahara, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Olivier Soubrane, Bas Groot Koerkamp, Itaru Endo, Kazunari Sasaki, Federico Aucejo, Xu-Feng Zhang, Timothy M. Pawlik
Summary: Overall tumor burden (TB) significantly impacts the prognosis of patients with resectable intrahepatic cholangiocarcinoma (ICC), with higher TB associated with worse survival outcomes. TB can serve as a tool to guide post-resection treatment strategies.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Meiling Zhou, Jianlin Li, Zuosen Luo, Jianbin Sun, Feng Xu, Qiao Jiang, Huafeng Deng
Summary: The study found that water-rock interaction leads to an increase in pore size, an initial increase and subsequent decrease in the number of pores, a change in pore shape from oblate to slender, as well as variations in shape factor and fractal dimension. The results provide insights into the damage of rock mesostructure under water-rock interaction.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Mingyue Fu, Zhongcheng Zhou, Xu Yang, Zhongbing Liu, Jiarui Zheng, Xinru Huang, Ling Wang, Jiabao Ye, Weiwei Zhang, Yongling Liao, Feng Xu
Summary: The study revealed that the yellowing Camellia japonica leaves had lower pigment content and weakened photosynthesis compared to its parent. Further analysis showed damaged chloroplast structures and increased Didymella abundance in the mutant leaves, indicating a potential pathogen-induced leaf color variation mechanism.
Article
Agriculture, Multidisciplinary
Jia-Ying Gui, Shen Rao, Yuanyuan Gou, Feng Xu, Shuiyuan Cheng
Summary: The study found that in selenium-rich broccoli cultivation, selenium yeast is preferred for maximizing selenium uptake and nutrient accumulation; selenium yeast and selenite have different influences on the nutrient composition of broccoli florets, with selenium yeast increasing total phenolic acid and glucosinolate content, but reducing total flavonoid content.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Plant Sciences
Mingyue Fu, Shuiyuan Cheng, Feng Xu, Zexiong Chen, Zhongbing Liu, Weiwei Zhang, Jiarui Zheng, Ling Wang
Summary: Leaf color mutation is influenced by various factors including gene mutations, environmental factors, and metabolic basis. These research results will provide theoretical support for the development, improvement, and molecular breeding of leaf color in tree species.
NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
(2021)
Article
Plant Sciences
Xian Zhou, Lanlan Wang, Janping Yan, Jiabao Ye, Shuiyuan Cheng, Feng Xu, Guiyuan Wang, Weiwei Zhang, Yongling Liao, Xiaomeng Liu
Summary: In this study, a novel EMF gene (GbEMF2) was identified and characterized from Ginkgo biloba, which plays a negative regulatory role in flowering development.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
K. Yang, H. Han, Y. Li, J. Ye, F. Xu
Summary: The metabolism of flavonoids in plants is highly plastic in response to development and environmental changes, regulated by various metabolic pathways including miRNA. miRNA plays a significant role in regulating flavonoid formation through direct or indirect mechanisms involving transcription complexes.
Article
Horticulture
Xiao-Meng Liu, Jun-Ping Tan, Shui-Yuan Cheng, Ze-Xiong Chen, Jia-Bao Ye, Jia-Rui Zheng, Feng Xu, Wei-Wei Zhang, Yong-Ling Liao, Xiao-Yan Yang
Summary: Berberine is the primary medicinal component of Coptis chinensis, with pharmacological effects such as heat-clearing and detoxifying. The content and gene expression levels of alkaloids in C. chinensis were investigated to reveal the molecular regulation of berberine accumulation in the plant. The study provides resources and technical support for enhancing the medicinal value of C. chinensis through genetic engineering.
SCIENTIA HORTICULTURAE
(2022)
Article
Immunology
Chao Lv, Shukun Han, Baokang Wu, Zhiyun Liang, Yang Li, Yizhou Zhang, Qi Lang, Chongli Zhong, Lei Fu, Yang Yu, Feng Xu, Yu Tian
Summary: This study developed immune scoring systems focusing on B7-H3, B7-H4, and HHLA2, and demonstrated their potential in predicting survival and immunotherapeutic efficacy for gallbladder cancer (GBC). The results showed that these immune scoring systems were associated with worse clinicopathological stage and unfavorable prognosis in postoperative survival. Additionally, novel prediction models based on immune stratification and TNM staging showed excellent discrimination ability in predicting survival and immunotherapeutic efficacy for GBC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Plant Sciences
Juan Xiang, Shen Rao, Qiangwen Chen, Weiwei Zhang, Shuiyuan Cheng, Xin Cong, Yue Zhang, Xiaoyan Yang, Feng Xu
Summary: Selenium is an essential trace element for humans and animals, and tea leaves contain beneficial organic selenium. Exogenous selenium treatment can significantly improve the growth of tea trees and the nutritional quality of tea leaves, providing theoretical and technical support for breeding selenium-rich tea.
Review
Plant Sciences
Wei Chao, Shen Rao, Qiangwen Chen, Weiwei Zhang, Yongling Liao, Jiabao Ye, Shuiyuan Cheng, Xiaoyan Yang, Feng Xu
Summary: Selenium is an essential trace element for human immune regulation and disease prevention. In plants, organic selenium compounds promote plant growth, improve nutritional quality, and play important roles in plant ecosystems. Selenium accumulation plants release selenium-containing compounds that promote the growth of selenium accumulators but inhibit the growth and distribution of non-selenium accumulators.
Article
Forestry
Ke Yang, Zhongbing Liu, Xueyin Chen, Xian Zhou, Jiabao Ye, Feng Xu, Weiwei Zhang, Yongling Liao, Xiaoyan Yang, Qijian Wang
Summary: As the most significant transformation stage of plants, the flowering process has been a focus of research. This study identified 26 MADS-box genes from Ginkgo biloba and analyzed their gene structures, protein features, and expression patterns. The findings suggest that these genes may play an important role in the development and differentiation of G. biloba flowers.
Article
Horticulture
Li Yu, Qiangwen Chen, Xiaoli Liao, Xiaoyan Yang, Wei Chao, Xin Cong, Weiwei Zhang, Yongling Liao, Jiabao Ye, Hua Qian, Yang Zhao, Shuiyuan Cheng, Feng Xu
Summary: Selenium is an important trace element for human and animal health. Approximately 0.5-1 billion people worldwide suffer from selenium deficiency, leading to various endemic diseases. Cabbage, as a popular vegetable, can accumulate selenium through biofortification. Therefore, producing selenium-enriched cabbage may be an effective solution to alleviate selenium deficiency.
Review
Horticulture
Hanbin Wu, Ke Yang, Liwei Dong, Jiabao Ye, Feng Xu
Summary: Matricaria chamomilla is a versatile aromatic medicinal plant used for treating flatulence, inflammation, and pain, with terpenes and flavonoids as its main active components.
Article
Biochemistry & Molecular Biology
Li Yu, Qiangwen Chen, Jiarui Zheng, Feng Xu, Jiabao Ye, Weiwei Zhang, Yongling Liao, Xiaoyan Yang
Summary: Plant-specific TCP transcription factors play a crucial role in the growth and development of Ginkgo biloba. This study identified 13 TCP genes in G. biloba and found that they are regulated by multiple signals, including phytohormones and miRNAs, and are involved in the biosynthesis of flavonoids. The findings provide a theoretical foundation for understanding the potential functions of TCPs in G. biloba.
PLANT SIGNALING & BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Xiaoli Liao, Shen Rao, Tian Yu, Zhenzhou Zhu, Xiaoyan Yang, Hua Xue, Yuanyuan Gou, Shuiyuan Cheng, Feng Xu
Summary: The application of Se yeast as a source of selenium significantly improves the growth and quality indices of Se-rich cabbage, leading to increases in total plant weight, head weight, and head size. Furthermore, the appropriate concentration of 8 mg/kg Se yeast enhances cabbage quality and antioxidant system indices.
PLANT SIGNALING & BEHAVIOR
(2021)
