Free radical scavenging abilities of flavonyl-thiazolidine-2,4-dione compounds

Free radical scavenging activity of flavonyl-thiazolidine-2,4-dione compounds has been evaluated using chemiluminescence, electron spin resonance spectroscopy with 5,5-dimethyl-1-pyrroline-1-oxide as spin trap and DPPH (2,2'diphenyl-1-picrylhydrazyl) method. The examined compounds exhibited 28-50% scavenging superoxide anion radical (O-2((center dot) over bar)), 16.7-76.7% hydroxyl radical (HO center dot) and 9-40% DPPH radical. Compounds containing carbonyl group in their structure can be considered as antioxidants with high relevance and great biological importance. Copyright (C) 2009 John Wiley & Sons, Ltd.