Article
Multidisciplinary Sciences
Hyunmin Ko, Hyo Kee Kim, Chris Chung, Ahram Han, Seung-Kee Min, Jongwon Ha, Sangil Min
Summary: In this post hoc analysis, there was no significant association found between medication adherence and intrapatient variability (IPV) of tacrolimus concentrations among kidney transplant recipients. Both electronic monitoring and self-reported adherence did not affect the IPV of tacrolimus levels in this study.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Amelia R. Cossart, Christine E. Staatz, Nicole M. Isbel, Scott B. Campbell, W. Neil Cottrell
Summary: Older adult kidney transplant recipients face challenges in managing their medication regimen, but prioritize medication taking above all else. Support networks and gratitude to their donor serve as motivators for adherence, but strategies to support medication taking may be ineffective when daily routines change. Future interventions should focus on fostering adaptable medication taking behaviors that can withstand changes in routine.
Article
Pharmacology & Pharmacy
Pengpeng Zhang, Xiao Zhu, Jin Yan, Jia Liu
Summary: The study aimed to enhance the predictive ability of the Theory of Planned Behavior (TPB) by incorporating variables from the Health Belief Model (HBM) in renal transplant patients. Factors such as marital status, household income, preoperative drinking history, time after transplantation, and religion were independently associated with immunosuppressive medication nonadherence. Adding HBM variables to the TPB model significantly improved prediction accuracy, with perceived barriers and seriousness playing a crucial role in medication adherence.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Mikaela Katz, Scott Gillespie, James P. Stevens, Lori Hall, Vasantha Kolachala, Ryan Ford, Keri Levin, Nitika A. Gupta
Summary: A retrospective study revealed that pediatric liver transplant recipients have higher mortality rates after transferring to adult care, with African Americans experiencing disproportionately higher mortality. This transition period is a vulnerable time for patients, and measures need to be taken to ensure the safe transfer of young adults with chronic health care needs.
JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
George V. Mazariegos, Benjamin L. Shneider, Eyal Shemesh, Deborah Schady, Hector Melin-Aldana, Soo-Jin Cho, Ravinder Anand, Jinson Erinjeri, Rachel Annunziato, Miguel Reyes-Mugica
Summary: The study evaluated interrater reliability of readings of rejection in liver transplant clinical trials using digitized slides, showing substantial disagreement initially among experienced pathologists but improved reliability with a unique study-specific procedure. This suggests the potential for such procedures to increase reliability in histopathologic determinations in future research and possibly in clinical settings.
LIVER TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Jeffrey J. Gaynor, Giselle Guerra, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Mariella Ortigosa-Goggins, Marina M. Tabbara, Lissett Moni, George W. Burke, Gaetano Ciancio
Summary: Graft failure due to nonadherence (GFNA) is a major cause of graft loss in kidney transplantation, especially among African-American and Hispanic recipients under 50 years of age. These patients have a higher risk of developing GFNA and other graft failures. Nonadherent behavior can lead to graft loss and can persist for a long time after transplantation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Lei Dong, Xiao Zhu, Hongyu Zhao, Qin Zhao, Shan Liu, Jia Liu, Lina Gong
Summary: This study aimed to establish a prediction model based on a combined theory framework to predict immunosuppressive medication nonadherence in kidney transplant recipients. The LASSO model was developed with eight predictors, including age, preoperative drinking history, education, marital status, perceived barriers, social support, perceived behavioral control, and perceived susceptibility. The model demonstrated acceptable discrimination and predictive ability in both internal and external validation sets.
Article
Surgery
Regina van Zanten, Annelies de Weerd, Michiel Betjes, Marieken Boer-Verschragen, Emma K. Massey
Summary: After kidney transplantation, simplification of the immunosuppressive medication regimen can improve medication adherence without affecting fear of rejection.
TRANSPLANT INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Prerana Baranwal, Mihika Sathe, Steven J. Lobritto, Jennifer Vittorio
Summary: This study aimed to investigate the impact of health literacy on transition readiness, adherence, health-related quality of life, and medical outcomes in pediatric liver transplant recipients and their caregivers. The results showed that limited health literacy may decrease the level of transition readiness, but it does not affect health-related quality of life, adherence, and medical outcomes.
LIVER TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Charles D. Varnell Jr, Kristin L. Rich, Avani C. Modi, David K. Hooper, Mark H. Eckman, M. H. Eckman
Summary: The study shows that the adherence promotion strategy MAPS is more effective and cost-effective than usual care in reducing rejection rates after kidney transplants among adolescent patients. Strategies with similar costs that reduce rejection rates by at least 3% can also be cost-effective, indicating the importance of adherence promotion interventions in improving outcomes for kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Medical Laboratory Technology
Ragnhild H. Skauby, Marte T. Gustavsen, Anders M. Andersen, Anna Bjerre, Anders Asberg, Karsten Midtvedt, Nils T. Vethe, Stein Bergan
Summary: This study characterized the pharmacokinetics of PL and PN in renal Tx recipients, revealing a wide variability in PL exposure and suppression of endogenous CL. Therapeutic drug monitoring may be necessary due to this variability. An abbreviated profile within the first 4 hours after PL dosing was found to provide a good prediction of PL exposure, with a potential surrogate marker for drug exposure being morning CL levels.
THERAPEUTIC DRUG MONITORING
(2021)
Review
Medicine, General & Internal
Hani Oweira, Ali Ramouz, Omid Ghamarnejad, Elias Khajeh, Sadeq Ali-Hasan-Al-Saegh, Rajan Nikbakhsh, Christoph Reissfelder, Nuh Rahbari, Arianeb Mehrabi, Mahmoud Sadeghi
Summary: Multiple factors influence graft rejection after kidney transplantation, including donor and recipient characteristics, as well as pre- and post-operative parameters. Identifying these risk factors helps reduce the risk of rejection and improve graft survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Wouter W. Woud, Dennis A. Hesselink, Martin J. Hoogduijn, Carla C. Baan, Karin Boer
Summary: Extracellular vesicles (EVs) are tissue-specific particles containing valuable diagnostic information. This study assesses the applicability of a calibrated Imaging Flow Cytometry (IFCM)-based methodology to directly detect and characterize tissue-specific EV subsets in clinical kidney transplantation.
SCIENTIFIC REPORTS
(2022)
Article
Transplantation
Yasar Caliskan, Gonca Karahan, Sebahat Usta Akgul, Safak Mirioglu, Yasemin Ozluk, Halil Yazici, Erol Demir, Ahmet B. Dirim, Aydin Turkmen, John Edwards, Fatma Oguz Savran, Mehmet S. Sever, Krzysztof Kiryluk, Ali Gharavi, Krista L. Lentine
Summary: The study revealed that recipients with the GG genotype of LIMS1 have a higher risk of TCMR after kidney transplantation, suggesting the importance of LIMS1 in allograft rejection. However, the GG genotype was not significantly associated with allograft loss.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Ruvistay Gutierrez-Arias, Maria Jose Martinez-Zapata, Monica C. Gaete-Mahn, Dimelza Osorio, Luis Bustos, Joel Melo Tanner, Ricardo Hidalgo, Pamela Seron
Summary: Due to the limited number of studies and heterogeneity in interventions and outcomes, the effects of exercise training in lung transplant patients are uncertain with a high risk of bias.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)