Article
Surgery
Jose Luis Campo-Canaveral de la Cruz, Eduardo Minambres, Elisabeth Coll, Maria Padilla, Gloria Sanchez Antolin, Gloria de la Rosa, Joel Rosado, Francisco Javier Gonzalez Garcia, Silvana Crowley Carrasco, Gabriel Sales Badia, Eva Maria Fieria Costa, Jose Alberto Garcia Salcedo, Victor Mora, Carlos de la Torre, Rafael Badenes, Lander Atutxa Bizkarguenaga, Beatriz Dominguez-Gil
Summary: This study aimed to investigate the outcomes of lung and liver transplantation using NRP in cDCD donors and compare them with transplants using DBD grafts. The results showed that simultaneous transplantation of lungs and livers from cDCD donors using NRP offers similar outcomes to transplants using DBD grafts.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Beatriz Dominguez-Gil, Nancy Ascher, Alexander M. Capron, Dale Gardiner, Alexander R. Manara, James L. Bernat, Eduardo Minambres, Jeffrey M. Singh, Robert J. Porte, James F. Markmann, Kumud Dhital, Didier Ledoux, Constantino Fondevila, Sarah Hosgood, Dirk Van Raemdonck, Shaf Keshavjee, James Dubois, Andrew McGee, Galen Henderson, Alexandra K. Glazier, Stefan G. Tullius, Sam D. Shemie, Francis L. Delmonico
Summary: This international collaborative statement aims to promote controlled donation after the circulatory determination of death (cDCDD) programs globally. It emphasizes the importance of determining the prognosis justifying WLST and establishing the standard for determining death based on circulatory criteria.
INTENSIVE CARE MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Sarah E. Scheuer, Paul C. Jansz, Peter S. Macdonald
Summary: Heart transplantation from DCD donors is a rapidly expanding practice with excellent outcomes, and is expected to become a major source of heart donation worldwide. Current protocols and methods have contributed to comparable outcomes to DBD heart transplants.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Allison J. Kwong, W. Ray Kim, John Lake, Peter G. Stock, Connie J. Wang, James B. Wetmore, Marc L. Melcher, Andrew Wey, Nicholas Salkowski, Jon J. Snyder, Ajay K. Israni
Summary: A study found that livers with macrovesicular steatosis are less likely to be transplanted due to their higher risk of graft failure. To facilitate the use of these higher-risk organs, the SRTR now includes the variable of macrovesicular steatosis in their risk-adjustment models.
Article
Surgery
Serena Maria Passamonti, Antonino Cannavo, Mauro Panigada, Valentina Trunzo, Andrea Bottazzi, Antonio Longobardi, Ruggero Buonocore, Andrea Fiorattini, Rosanna Torelli, Giuseppe Piccolo, Tullia Maria De Feo
Summary: This study aimed to assess the association between different types of donation after circulatory death (DCD) and successful organ transplantation. During the study period, livers from type III DCD were more likely to be transplanted, with warm ischemia time potentially explaining this difference.
TRANSPLANT INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Kun Wang, Di Lu, Yuhui Liu, Wangyao Li, Li Zhuang, Zhenyu Ma, Qinfen Xie, Binhua Pan, Yichao Wu, Junli Chen, Lidan Lin, Xiaowen Feng, Qiang Wei, Xuyong Wei, Haiyang Xie, Zhengxin Wang, Shusen Zheng, Xiao Xu
Summary: Early allograft dysfunction (EAD) is a risk factor for decreased graft and patient survival rates after liver transplantation. This study developed predictive models for EAD severity and identified operative time as a potential factor influencing EAD incidence. The novel nomograms effectively predicted the incidence of EAD and its impact on patient outcomes after donation after circulatory death (DCD) liver transplantation.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Shivank Madan, Omar Saeed, Stephen J. Forest, Daniel J. Goldstein, Ulrich P. Jorde, Snehal R. Patel
Summary: This study provides a preliminary analysis of adult donation after circulatory death heart transplantations (DCD-HTs) in the United States, showing favorable early outcomes and suggesting the potential for a substantial increase in adult heart transplant volumes with the use of DCD donors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Surgery
Mark Ly, Michael Crawford, Deborah Verran
Summary: Biliary complications are common in DCD liver recipients, with factors such as higher donor risk index, post-transplant portal vein complications, and elevated peak gamma-glutamyl transferase levels within 7 days post-transplant being associated with their development. Close monitoring for post-transplant biliary complications is recommended when these factors are present.
ANZ JOURNAL OF SURGERY
(2021)
Review
Immunology
Stephen O'Neill, Ellie Asgari, Chris Callaghan, Dale Gardiner, Hermien Hartog, Satheesh Iype, Alex Manara, David Nasralla, Gabi C. Oniscu, Chris Watson
Summary: Recipient outcomes after transplantation with organs from donation after circulatory death (DCD) donors can be as good as or even comparable to those after transplantation with organs from donation after brain death donors. The key to success lies in establishing common practices and accepted protocols to safely utilize DCD organs and maximize the use of the DCD donor pool.
TRANSPLANTATION REVIEWS
(2023)
Article
Immunology
Raphael P. H. Meier, Miguel Nunez, Shareef M. Syed, Sandy Feng, Mehdi Tavakol, Chris E. Freise, John P. Roberts, Nancy L. Ascher, Ryutaro Hirose, Garrett R. Roll
Summary: Donation after circulatory death (DCD) liver transplantation is feasible and can achieve comparable survival to donation after brain death (DBD) liver transplantation in selected recipient/donor pairs. However, without selection criteria, the outcomes of DCDLTs remain worse than those of DBD-LTs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Christopher M. Bobba, Bryan A. Whitson, Matthew C. Henn, Nahush A. Mokadam, Brian C. Keller, Justin Rosenheck, Asvin M. Ganapathi
Summary: The use of lungs donated after circulatory death (DCD) has increased, with similar survival rates compared to lungs donated after brain death (DBD). This supports further utilization of DCD lungs in transplantation, expanding the donor pool.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Melissa A. Lyle, Stephen W. English, Rohan M. Goswami, Juan C. Leoni Moreno, Jose Nativi-Nicolau, Daniel S. Yip, Parag C. Patel
Summary: As the utilization of DCD in heart transplantation increases, transplant cardiologists face challenges in donor selection, including predicting the survival time of donors and determining the standards for these predictions. The current scoring systems lack standardization and there are variations in the time windows set.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Margarita Fernandez-de la Varga, Pablo del Pozo-del Valle, Sergio Bejar-Serrano, Rafael Lopez-Andujar, Marina Berenguer, Martin Prieto, Eva Montalva, Victoria Aguilera
Summary: This study compared the incidence of complications between liver transplant recipients receiving donors after circulatory death (DCD) and those receiving donors after brain death (DBD). The results showed that DCD recipients had a higher rate of biliary complications, postoperative bleeding, and reinterventions. However, there were no significant differences in graft and patient survival rates between the two groups at 1, 2, 3, and 4 years.
ANNALS OF HEPATOLOGY
(2022)
Article
Medicine, General & Internal
S. Dhanani, L. Hornby, A. van Beinum, N. B. Scales, M. Hogue, A. Baker, S. Beed, J. G. Boyd, J. A. Chandler, M. Chasse, F. D'Aragon, C. Dezfulian, C. J. Doig, F. Duska, J. O. Friedrich, D. Gardiner, T. Gofton, D. Harvey, C. Herry, G. Isac, A. H. Kramer, D. J. Kutsogiannis, D. M. Maslove, M. Meade, S. Mehta, L. Munshi, L. Norton, G. Pagliarello, T. Ramsay, K. Rusinova, D. Scales, M. Schmidt, A. Seely, J. Shahin, M. Slessarev, D. So, H. Talbot, W. N. K. A. van Mook, P. Waldauf, M. Weiss, J. T. Wind, S. D. Shemie
Summary: This study investigated the timing of resumption of cardiac activity in patients after planned withdrawal of life-sustaining measures. It found that 14% of patients experienced transient resumption of cardiac activity after pulselessness, with only 1% of resumptions being identified at the bedside. These events occurred within 4 minutes 20 seconds after a period of pulselessness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Robert Qaqish, Yui Watanabe, Konrad Hoetzenecker, Jon Yeung, Manyin Chen, Andrew Pierre, Kazuhiro Yasufuku, Laura Donahoe, Marc de Perrot, Tom Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: Short- and long-term outcomes are similar between recipients of lungs from donation after neurologic determination of death and donation after circulatory determination of death. Different intervals between withdrawal of life-sustaining therapies and cardiac arrest did not impact recipient outcomes, and the maximum acceptable duration of this interval remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Ivica Grgurevic, Anita Madir, Vladimir Trkulja, Tonci Bozin, Gorana Aralica, Kristian Podrug, Ivana Mikolasevic, Emmanuel Tsochatzis, James O'Beirne, Massimo Pinzani
Summary: The use of 2D shear wave elastography (2DSWE) appears to be equally effective as transient elastography (TE) for diagnosing clinically significant portal hypertension and ruling out high-risk varices in patients with chronic liver disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Sara Cococcia, Priti Dutta, Melika Moghim, Brian Hogan, Sudeep Tanwar, Aileen Marshall, Douglas Macdonald, Dominic Yu, James O'Beirne, William M. Rosenberg, Paul M. Trembling
Summary: This study aimed to investigate the incidence of hepatocellular carcinoma (HCC) arising from indeterminate liver lesions using MRI surveillance and explore its associations with baseline factors. The results showed that approximately one fifth of indeterminate liver lesions developed into HCC over a mean follow-up of 4.6 years, and this was significantly associated with a low platelet count at the time of initial diagnosis of an indeterminate lesion.
BMC GASTROENTEROLOGY
(2022)
Article
Health Care Sciences & Services
Lucy Gracen, Kelly L. Hayward, Melanie Aikebuse, Anthony Russell, James O'Beirne, Steven McPhail, Katharine M. Irvine, Suzanne Williams, Patricia C. Valery, Elizabeth E. Powell
Summary: This prospective cohort study aims to incorporate liver fibrosis screening into routine care for type 2 diabetes patients, providing early targeted detection of advanced fibrosis and reducing unnecessary referrals. The findings will help direct spending and resource allocation for NAFLD in a high-risk population and establish a reliable and sustainable community care pathway in primary care.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Joanne M. Carson, Behzad Hajarizadeh, Josh Hanson, James O'Beirne, David Iser, Phillip Read, Anne Balcomb, Jane Davies, Joseph S. Doyle, Jasmine Yee, Marianne Martinello, Philippa Marks, Gail Matthews, Gregory J. Dore
Summary: This study evaluated retreatment for virological failure in patients with hepatitis C virus, and found that retreatment can be effectively done in primary care, with the potential for improving retreatment uptake and reducing mortality through simplified regimens.
JOURNAL OF VIRAL HEPATITIS
(2022)
Article
Gastroenterology & Hepatology
Saad Khan, Rajit Gilhotra, Caroline Di Jiang, David Rowbotham, Andre Chong, Avik Majumdar, Campbell White, Alex Huelsen, Jim Brooker, James O'Beirne, Cameron Schauer, Marios Efthymiou, Rhys Vaughan, Sujievvan Chandran
Summary: This retrospective analysis evaluated the efficacy and safety of SX-ELLA Danis SEMS for control of refractory variceal bleeding. The results showed that SEMS placement had a high technical success rate and achieved immediate bleeding control in the majority of cases. The SEMS was relatively easy to use and had low rates of serious adverse events.
ENDOSCOPY INTERNATIONAL OPEN
(2022)
Article
Gastroenterology & Hepatology
Lucy Gracen, Withma Muthukumara, Melanie Aikebuse, Anthony Russell, James O'Beirne, Katharine M. Irvine, Suzanne Williams, Gaurav Puri, Patricia C. Valery, Kelly L. Hayward, Elizabeth E. Powell
Summary: The prevalence of using SGLT2 inhibitors and GLP-1 receptor agonists in people with T2D and co-existent NAFLD is high and is associated with the prevalence of clinically significant liver disease. Further clinical trials are needed to assess the efficacy of these medications in reducing the progression of NAFLD.
ANNALS OF HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Michelle J. Allen, Rachael Doran, David Brain, Elizabeth E. Powell, James O'Beirne, Patricia C. Valery, Adrian Barnett, Ruvini Hettiarachchi, Ingrid J. Hickman, Sanjeewa Kularatna
Summary: This study aimed to identify the attributes and levels for preference research on chronic liver disease screening programs to understand patient preferences.
BMC HEALTH SERVICES RESEARCH
(2023)
Letter
Gastroenterology & Hepatology
Rajiv Kurup, Melissa Day, Rohit Gupta, James O'Beirne
LIVER TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
James O'Beirne, Richard Skoien, Barbara A. Leggett, Gunter F. Hartel, Louisa G. Gordon, Elizabeth E. Powell, Patricia C. Valery
Summary: The study aimed to determine the incidence of decompensated cirrhosis and associated risk factors in patients hospitalized with NAFLD or NASH. The results showed that patients with diabetes, aged 70 years or older, a history of other cancers or major cardiovascular events had a higher risk of decompensated cirrhosis. Additionally, patients with both diabetes and cirrhosis had a higher risk of decompensation. The study emphasized the importance of timely diagnosis and treatment to prevent disease progression in patients with NAFLD/NASH.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Melissa Day, Jocelyne Desoe, Sakinah Zulkifli, Lucinda Vaux, Jonathan Mitchell, James Patrick O'Beirne
Meeting Abstract
Gastroenterology & Hepatology
Stuart Keith Roberts, Ashika Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jenny Philip, Simone I. Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibbals, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Mark Goodwin, Christos Karapetis, Miriam T. Levy, Kate Muller, James Patrick O'Beirne, David Pryor, James Seow, Caroline J. Tallis, Nick Butler, John K. Olynyk, John Zalcberg
Meeting Abstract
Gastroenterology & Hepatology
Melissa Day, Jocelyne Desoe, Sakinah Zulkifli, Lucinda Vaux, James Patrick O'Beirne
Article
Gastroenterology & Hepatology
Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jennifer Philip, Simone Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts
Summary: This study aimed to develop a core set of quality indicators for the management of hepatocellular carcinoma (HCC). Through a Delphi consensus study, 23 specific indicators were identified, covering aspects such as diagnosis, staging, and treatment of HCC. Adherence to these indicators can improve the quality of care and patient outcomes, including survival.
HEPATOLOGY COMMUNICATIONS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Day, J. Desoe, L. Vaux, S. Zulkifli, J. Mitchell, J. O'Beirne
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Day, F. Waldie, N. S. Zulkifli, L. Vaux, J. O'Beirne
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)