Article
Medicine, General & Internal
Anais Romero, Fanny Drieux, Arnaud Francois, Alexandra Dervaux, Xiao Li Xu, Dimitri Titeca-Beauport, Dominique Bertrand, Dominique Guerrot
Summary: In adults with IgA vasculitis, glomerular C4d positivity was associated with the severity of the kidney disease at presentation, but not with subsequent renal function deterioration.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Nattawat Klomjit, Mireille El Ters, Benjamin A. Adam, Priya Sampathkumar, Raymund R. Razonable, Sandra J. Taler, Timucin Taner, Mariam Priya Alexander
Summary: Neutralizing monoclonal antibodies like bamlanivimab show promise in treating COVID-19 in kidney transplant recipients, but their impact on kidney allograft histology is unclear. A case study reported diffuse peritubular capillary C4d staining following bamlanivimab treatment in a kidney transplant recipient with stable kidney function at 6 months post-biopsy.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Rheumatology
Shan-Chi Yu, Kung-Chao Chang, Hsuan Wang, Meng-Fang Li, Tsung-Lin Yang, Chun-Nan Chen, Chih-Jung Chen, Ko-Chin Chen, Chieh-Yu Shen, Po-Yen Kuo, Long-Wei Lin, Yueh-Min Lin, Wei-Chou Lin
Summary: Through clinical, histological, and immunohistochemical studies, distinguishing lupus lymphadenitis (LL) from Kikuchi disease (KD) is possible. LL patients tend to be older with broader lesion areas and distinctive histological features. C4d immunohistochemical staining is valuable in this differentiation.
Article
Surgery
Mohamed I. I. El Hag, Hugo Kaneku, Dana Jorgensen, Adriana Zeevi, Heather L. L. Stevenson, Nour Yadak, Mohamed Hassan, Xiaotang Du, Anthony J. J. Demetris
Summary: In this study, CD163, Banff H-score, and diffuse C4d were identified as predictors of serum DSA and facilitated recognition of histopathological features associated with serum DSA and tissue-antibody interaction in liver allograft biopsies.
CLINICAL TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Eva Vonbrunn, Sofya Serikova, Christoph Daniel, Kerstin Amann, Johannes Schoedel, Bjorn Buchholz, Fulvia Ferrazzi, Katharina Heller, Hendrik Apel, Maike Buettner-Herold
Summary: Glomerular immune reactivity is a common finding in time zero biopsies, predominantly determined by donor parameters such as male gender and deceased donor transplants. This immune reactivity does not negatively impact transplant function in a 5-year follow-up.
FRONTIERS IN MEDICINE
(2021)
Review
Cell Biology
Rabab Alkhayyat, Areeg Abbas, Cecily M. Quinn, Emad A. Rakha
Summary: Tumour protein 63 (p63) is a transcription factor that regulates genes involved in the growth and development of ectoderm and derived tissues. p63 immunohistochemical staining has various applications in diagnostic breast pathology, including differentiation of benign and invasive lesions, and characterization of papillary and metaplastic breast carcinomas. This article reviews the applications of p63 in breast pathology and discusses the biology of p63, available antibodies, and interpretation pitfalls.
Article
Urology & Nephrology
Ashwani Kumar, Raja Ramachandran, Amit Rawat, Reena Das, Charan S. Rayat, Deepesh B. Kenwar, Ashish Sharma, Krishan L. Gupta, Ritambhra Nada
Summary: Post-transplant C3G can present with graft dysfunction and proteinuria, accompanied by vascular damage and rejection. Autoantibodies to complement-related proteins are common, while limited genetic analysis did not reveal novel mutations.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Pathology
James B. Maurice, Akudo Nwaogu, Mahmoud Gouda, Olivia Shaw, Alberto Sanchez-Fueyo, Yoh Zen
Summary: This study aimed to examine the clinical utility and impact of the 2016 Banff criteria for acute antibody-mediated rejection (acute AMR) in patients with liver transplantation. The results showed that only a small percentage of DSA-positive patients met the Banff criteria for acute AMR, and combined acute AMR/TCMR cases were more common than isolated acute AMR.
Review
Medicine, Research & Experimental
Aqib B. Chowdhury, Kosha J. Mehta
Summary: This review emphasizes the importance of liver biopsy in evaluating chronic liver disease (CLD) and explains the commonly used scoring systems. It also discusses the utility of liver biopsy in examining alcohol-related liver disease, non-alcoholic fatty liver disease, viral hepatitis, haemochromatosis, and hepatocellular carcinoma.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Surgery
Anna Buxeda, Laura Llinas-Mallol, Javier Gimeno, Dolores Redondo-Pachon, Carlos Arias-Cabrales, Carla Burballa, Adrian Puche, Miguel Lopez-Botet, Jose Yelamos, Carlos Vilches, Maarten Naesens, Maria Jose Perez-Saez, Julio Pascual, Marta Crespo
Summary: Isolated microvascular inflammation (iMVI) is a rare phenotype that cannot be classified as antibody-mediated rejection (ABMR) in recent Banff classifications because it lacks HLA donor-specific antibodies or C4d deposition. In this study, we compared peripheral blood leukocyte distribution and inflammatory infiltrates in kidney transplant biopsies among ABMR, iMVI, and normal cases. We found that iMVI had fewer lymphocytes and peripheral T cells compared to ABMR and normal cases, but more NKG2A+ NK cells. iMVI also showed decreased plasma cell infiltration and increased cytotoxic T cell infiltration compared to ABMR.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Zeno Sparchez, Rares Craciun, Iuliana Nenu, Lavinia Patricia Mocan, Mihaela Sparchez, Tudor Mocan
Summary: In recent years, the field of hepatocellular carcinoma has seen significant changes, emphasizing different HCC phenotypes and the emergence of novel, specific therapies that pave the way for personalized treatment of primary liver cancer. The role of liver biopsy has slowly shifted from a confirmatory method to a technique capable of providing in-depth characterization of nodules. It is expected that liver biopsy will regain its position in HCC, and combining it with other available methods could improve treatment selection and outcomes.
Article
Pathology
Sarojini Raman, Pallavi Mishra, Ansuman Panigrahi, Nikunj K. Rout, Kanakalata Dash
Summary: This study evaluated the immunohistochemical expression of C4d in proliferative glomerular diseases, finding a high prevalence of C4d positivity, significantly associated with IgG and IgM staining. The findings suggest that C4d staining, along with immunoglobulin markers and complement proteins, can help delineate different complement activation pathways and understand the pathogenesis of glomerular diseases.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2021)
Article
Obstetrics & Gynecology
George Tocu, Ioana Teodora Popa, Iuliana Ivan, Lucretia Anghel, Luiza A. Nechita, Carmina Liana Musat, Laura Florentina Rebegea, Dana Tutunaru
Summary: Liver metastases are a common clinical manifestation of mammary cancer. This case report presents the diagnosis and treatment of a 52-year-old female patient with liver and lung metastases. Laboratory investigations and imaging exams played a crucial role in revealing the extent and origin of the metastases, leading to the final diagnosis of cholangiocarcinoma with liver metastases and lung tumor with lung and bone metastases.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Francesca Lunardi, Daniela Isabel Abbrescia, Luca Vedovelli, Federica Pezzuto, Francesco Fortarezza, Giovanni Maria Comacchio, Vincenza Guzzardo, Pia Ferrigno, Monica Loy, Chiara Giraudo, Anna Sara Fraia, Eleonora Faccioli, Fausto Braccioni, Emanuele Cozzi, Dario Gregori, Geert M. Verleden, Fiorella Calabrese, Francesco Paolo Schena, Federico Rea
Summary: Chronic rejection is the leading cause of reduced survival and quality of life in lung transplant patients. This study identified a distinct molecular signature in lung biopsies of patients with histological signs of chronic rejection, with LCN2 gene playing a central role. The findings suggest that LCN2 gene may be crucial in the pathophysiology of chronic rejection.
Article
Surgery
Takahiro Ito, Bita V. Naini, Daniela Markovic, Antony Aziz, Stephanie Younan, Michelle Lu, Hirofumi Hirao, Kentaro Kadono, Hidenobu Kojima, Joseph DiNorcia, Vatche G. Agopian, Hasan Yersiz, Douglas G. Farmer, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski, Fady M. Kaldas
Summary: This study investigated the correlation between the severity of IRI and short-term graft outcomes, demonstrating that severe IRI was associated with higher incidence of EAD and inferior survival. Independent risk factors for moderate to severe IRI and EAD were identified, providing valuable insights for optimizing donor-recipient matching and patient management in liver transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
