Article
Gastroenterology & Hepatology
Linhao Zhang, Bo Wei, Zhidong Wang, Huan Tong, Hao Wu
Summary: This study compared the clinical outcomes of embolization of the shunt (ES) and selective embolization of the splenic vein (SESV) for the treatment of spontaneous portosystemic shunt (SPSS)-induced refractory hepatic encephalopathy (HE) in cirrhotic patients. The results showed that the 6-month mortality was significantly lower after SESV compared to ES. Additionally, ES was associated with lower white blood cell and platelet counts, and higher aspartate aminotransferase levels, while SESV led to significant improvements in albumin levels, Child-Pugh score, and grade at 6 months.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Medicine, General & Internal
Jun Li, Dan Wang, Jingping Sun
Summary: Fecal microbiota transplantation (FMT) may be an effective method for treating hepatic encephalopathy (HE) and deserves further research.
Article
Gastroenterology & Hepatology
Marie-Louise Kloster, Albert Ren, Ketan Y. Shah, Murad M. Alqadi, James T. Bui, Andrew J. Lipnik, Matthew M. Niemeyer, Charles E. Ray, Ron C. Gaba
Summary: The study found a high incidence of HE after VCX TIPS. Although HE symptoms may be medically controlled, hospitalization rates are high, and sometimes shunt reduction may be necessary.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Huan Tong, Can Gan, Bo Wei, Zhi Dong Wang, Xiao Dan Li, Shuai Jie Qian, Hui Huan, Lin Hao Zhang, Zhu Yang, Yi Long Chen, Yong Hong Gu, Liu Xiang Chen, Yu Hang Yang, Hao Wu, Cheng Wei Tang
Summary: Alcoholic cirrhosis and notable hydrothorax are independent risk factors for post-TIPS OHE in liver cirrhosis, together with the stent diameter of 10 mm, PPG decrement >= 60%, MELD score >= 10 and blood ammonia. The established risk score is reliable to identify high-risk individuals of developing post-TIPS OHE.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Surbhi Trivedi, Katie Lam, Ashwin Ganesh, Yasir Hasnain, Wassim Hassan, Josi Herren, Ron C. Gaba
Summary: Transjugular intrahepatic portosystemic shunt (TIPS) creation is an effective treatment for decompensated liver cirrhosis, but it can lead to hepatic encephalopathy (HE) due to altered physiology. This review article discusses the epidemiology, diagnosis, and treatment options for post-TIPS HE, including endovascular interventions.
SEMINARS IN INTERVENTIONAL RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
So Yeong Cheon, Juhyun Song
Summary: Hepatic encephalopathy and diabetic encephalopathy are emerging types of neurological diseases characterized by cognitive and motor impairments. The relationship between metabolic organs and the brain plays an important role in the pathogenesis of neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matteo Fantoni, Carla Marcato, Andrea Ciuni, Carlo Pellegrino, Umberto Russo, Riccardo Zannoni, Ilaria Paladini, Andrea Andreone, Massimo De Filippo
Summary: Percutaneous renal artery embolization is an effective technique for treating symptomatic non-functioning renal allograft patients, with a high technical success rate, clinical success rate of 73%, and minor complications that can be resolved on their own. In selected patients, this procedure is a valid treatment option for GIS, with its efficacy, repeatability, minimal invasiveness, and lack of severe complications.
Article
Medicine, General & Internal
Christophe Bureau, Dominique Thabut, Caroline Jezequel, Isabelle Archambeaud, Louis D'Alteroche, Sebastien Dharancy, Patrick Borentain, Frederic Oberti, Aurelie Plessier, Victor De Ledinghen, Nathalie Ganne-Carrie, Nicolas Carbonell, Vanessa Rousseau, Agnes Sommet, Jean Marie Peron, Jean Pierre Vinel
Summary: The study demonstrated that rifaximin significantly reduces the incidence of overt HE after TIPS, with good tolerability. However, the results primarily apply to patients with alcoholic cirrhosis, and further research is needed to evaluate the effects on other types of cirrhosis.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yoji Ishizu, Masataka Sugiyama, Shinji Naganawa
Summary: Diagnosis and severity assessments of portosystemic shunts (PSSs) are crucial, and 4D-flow MRI can be used to evaluate blood flow, aiding in determining the indications for and outcome of PSS embolization.
HEPATOLOGY RESEARCH
(2021)
Article
Surgery
Ramsey Sitta, John Roberts, James Gardner, Nancy Ascher, Merisa Piper
Summary: This is a case report on the successful salvage of a living donor graft with complex arterial dissection in liver transplantation, highlighting the importance of collaboration with a microvascular surgeon.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Stefania Gioia, Lorenzo Ridola, Ludovica Cristofaro, Manuela Merli, Jessica Faccioli, Oliviero Riggio, Silvia Nardelli
Summary: This study found that after TIPS procedure, not only muscle mass but also adipose tissue underwent changes. Improvement in subcutaneous adipose tissue, sarcopenia, and myosteatosis were associated with cognitive impairment improvement, independently of liver function. The correlation between adipose tissue and ammonia modification suggests a potential role of adipose tissue in ammonia trafficking between organs.
LIVER INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Yang, Xueqing Liang, Shirui Yang, Xiaofeng He, Mingsheng Huang, Wenfeng Shi, Junyang Luo, Chongyang Duan, Xinghui Feng, Sirui Fu, Ligong Lu
Summary: Preoperative prediction of OHE in patients with variceal bleeding treated using TIPS procedure was performed. A prediction model combining clinical and radiological factors was developed, which showed satisfactory performance in both training and validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Dominique Thabut, Charlotte Bouzbib, Lucy Meunier, Manon Haas, Nicolas Weiss, Alexandre Louvet, Francois Imbert-Bismut, Fanny Mochel, Yann Nadjar, Antoine Santiago, Thierry Thevenot, Veronique Duhalde, Frederic Oberti, Claire Francoz, Audrey Coilly, Marie-Noelle Hilleret, Pascal Lebray, Amelie Liou-Schischmanoff, Louise Barbier, Christophe Duvoux, Georges-Philippe Pageaux, Michael Bismuth, Damien Galanaud, Thomas De Broucker, Jean-Francois Cadranel, Vincent Leroy, Vincent Di Martino, Dominique Larrey, Christophe Camus, Olivier Scatton, Victor De Ledinghen, Ariane Mallat, Marika Rudler, Christophe Bureau
Summary: Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease that often goes undiagnosed due to a lack of understanding and consensus on diagnosis. Non-specific symptoms and comorbidities in cirrhotic patients make differential diagnosis challenging. Guidelines are provided to assist clinicians in diagnosing and treating HE. Liver transplantation may be indicated for HE, but its reversibility post-transplantation and the consequences in patients with other neurological disorders remain controversial.
LIVER INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Nardelli, Oliviero Riggio, Laura Turco, Stefania Gioia, Marta Puzzono, Marcello Bianchini, Lorenzo Ridola, Francesca Aprile, Stefano Gitto, Giuseppe Pelle, Michele Di Martino, Guido Marzocchi, Cristian Caporali, Alessandra Spagnoli, Arianna Di Rocco, Filippo Schepis
Summary: This study investigated the characteristics of patients with cirrhosis and SPSS, finding that the presence of SPSS was associated with higher mortality and complications. Variables independently associated with SPSS included portal vein thrombosis and Child-Pugh C class.
Article
Health Care Sciences & Services
Lihong Gu, Xiaochun Yin, Yang Cheng, Xixuan Wang, Ming Zhang, Xiaoping Zou, Lei Wang, Yuzheng Zhuge, Feng Zhang
Summary: The study investigated the impact of body mass index (BMI) on the occurrence of overt hepatic encephalopathy (OHE) after the transjugular intrahepatic portosystemic shunt (TIPS) procedure in decompensated cirrhotic patients. A retrospective observational cohort study of 145 cirrhotic patients receiving TIPS was conducted, and the relationship between BMI and clinical outcomes, as well as risk factors for post-TIPS OHE, was analyzed. The results showed that overweight/obese patients had a higher frequency of OHE compared to normal weight patients, and overweight/obesity and older age were identified as independent risk factors for post-TIPS OHE according to the logistic regression analysis. The study concludes that overweight/obesity and older age may increase the risk of post-TIPS OHE in cirrhotic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Cesar Prieto-Frias, Marian Conchillo, Marina Payeras, Mercedes Inarrairaegui, Delia Davola, Gema Fruehbeck, Javier Salvador, Macarena Rodriguez, Jose A. Richter, Carmen Mugueta, Maria J. Gil, Ignacio Herrero, Jesus Prieto, Bruno Sangro, Jorge Quiroga
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2016)
Article
Oncology
Hidenori Toyoda, Paul B. S. Lai, James O'Beirne, Charing C. Chong, Sarah Berhane, Helen Reeves, Derek Manas, Richard P. Fox, Winnie Yeo, Frankie Mo, Anthony W. H. Chan, Toshifumi Tada, Mercedes Inarrairaegui, Arndt Vogel, Nora Schweitzer, Stephen L. Chan, Bruno Sangro, Takashi Kumada, Philip J. Johnson
BRITISH JOURNAL OF CANCER
(2016)
Article
Engineering, Biomedical
Jorge Aramburu, Raul Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro, Jose Ignacio Bilbao
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2016)
Article
Engineering, Biomedical
Jorge Aramburu, Raul Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro, Jose Ignacio Bilbao
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2017)
Article
Biophysics
Jorge Aramburu, Raul Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro, Jose Ignacio Bilbao
JOURNAL OF BIOMECHANICS
(2016)
Article
Biophysics
Jorge Aramburu, Raid Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro, Jose Ignacio Bilbao
JOURNAL OF BIOMECHANICS
(2016)
Review
Gastroenterology & Hepatology
Bruno Sangro, Diego Martinez-Urbistondo, Lourens Bester, Jose I. Bilbao, Douglas M. Coldwell, Patrick Flamen, Andrew Kennedy, Jens Ricke, Ricky A. Sharma
Article
Medicine, General & Internal
Carlos Rodriguez de Lope, Maria Reig, Ana Matilla, Maria Teresa Ferrer, Eva Duenas, Beatriz Minguez, Javier F. Castroagudin, Inmaculada Ortiz, Sonia Pascual, Jose Luis Lledo, Adolfo Gallego, Juan I. Arenas, Caries Aracil, Montserrat Forne, Carolina Munoz, Fernando Pons, Margarita Sala, Mercedes Inarrairaegui, Marta Martin-Llahi, Victoria Andreu, Carmen Garre, Paloma Rendon, Javier Fuentes, Javier Crespo, Manuel Rodriguez, Jordi Bruix, Maria Varela
Article
Medical Laboratory Technology
Delia D'Avola, Veronica Fernandez-Ruiz, Francisco Carmona-Torre, Miriam Mendez, Javier Perez-Calvo, Felipe Prosper, Enrique Andreu, Jose Ignacio Herrero, Mercedes Inarrairaegui, Carmen Fuertes, Jose Ignacio Bilbao, Bruno Sangro, Jesus Prieto, Jorge Quiroga
TRANSLATIONAL RESEARCH
(2017)
Article
Immunology
Fernando Rotellar, Fernando Pardo, Alberto Benito, Gabriel Zozaya, Pablo Marti-Cruchaga, Francisco Hidalgo, Luis Lopez, Mercedes Inarrairaegui, Bruno Sangro, Ignacio Herrero
Article
Biotechnology & Applied Microbiology
Nerea Zabaleta, David Salas, Maria Paramo, Mirja Hommel, Valerie Sier-Ferreira, Ruben Hernandez-Alcoceba, Jesus Prieto, Jose I. Bilbao, Gloria Gonzalez-Aseguinolaza
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2017)
Article
Surgery
Diego Aguiar, Diego Martinez-Urbistondo, Delia D'Avola, Mercedes Inarrairaegui, Fernando Pardo, Fernando Rotellar, Bruno Sangro, Jorge Quiroga, Jose Ignacio Herrero
ANNALS OF TRANSPLANTATION
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. Paramo, P. Garcia-Barquin, M. Carrillo, M. Millor Muruzabal, I. Vivas, J. I. Bilbao
Article
Oncology
Imam Waked, Sarah Berhane, Hidenori Toyoda, Stephen L. Chan, Nicholas Stern, Daniel Palmer, Toshifumi Tada, Winnie Yeo, Frankie Mo, Dominik Bettinger, Martha M. Kirstein, Mercedes Inarrairaegui, Asmaa Gomaa, Arndt Vogel, Tim Meyer, Bruno Sangro, Paul Lai, Takashi Kumada, Philip J. Johnson
BRITISH JOURNAL OF CANCER
(2017)
