Article
Infectious Diseases
Si-Ho Kim, Seok Jun Mun, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh, Kyong Ran Peck
Summary: Early recurrent bloodstream infection (ER-BSI) after living-donor liver transplantation (LDLT) significantly affects the one-year survival rate of patients, with ER-BSI being the most important risk factor for mortality. Intra-abdominal and/or biliary complications and early allograft dysfunction are risk factors for both early single BSI and ER-BSI.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Genetics & Heredity
Negin Farzamikia, Seyyedeh Mina Hejazian, Mehdi Haghi, Seyyed Sina Hejazian, Sepideh Zununi Vahed, Mohammadreza Ardalan
Summary: Despite immunosuppression after organ transplantation, NK cells play a crucial role in defending against viral infections. Research suggests that the presence of the activating gene KIR2DS1 may reduce the incidence of CMV infection in kidney transplant recipients.
Review
Immunology
Silvia Martini, Francesco Tandoi, Renato Romagnoli, Mario Rizzetto
Summary: Hepatitis D, caused by the hepatitis D virus, is the most severe form of viral hepatitis in humans. Liver transplantation is currently the only therapeutic option for terminal HDV disease, but it is not accessible in poor countries. In high-income countries, hepatitis B virus vaccination has significantly reduced the prevalence of HDV infection, but there is still a demand for liver transplantation among aging cirrhotics who acquired hepatitis D decades ago.
Review
Pediatrics
Victoria Dimitriades, Lavjay Butani
Summary: Infections are a common cause of hospitalization after kidney transplantation, with immunoglobulins potentially playing a protective role. However, there is limited awareness among pediatric nephrologists about this. Abnormalities in immunoglobulins are associated with poorer outcomes, highlighting the need for interventions.
PEDIATRIC NEPHROLOGY
(2023)
Article
Immunology
Anna-Maria Hitz, Kim-Alina Blaesing, Bettina Wiegmann, Ramon Bellmas-Sanz, Evgeny Chichelnitskiy, Franziska Wandrer, Lisa-Marie Horn, Christine Neudoerfl, Jana Keil, Kerstin Beushausen, Fabio Ius, Wiebke Sommer, Murat Avsar, Christian Kuehn, Igor Tudorache, Jawad Salman, Thierry Siemeni, Axel Haverich, Gregor Warnecke, Christine S. Falk, Jenny F. Kuehne
Summary: In the early post-transplant period after double lung transplantation, higher frequencies of donor NK and T cells expressing KIR in the recipient blood suggest a potential regulatory role in immune balance and graft survival. Higher activation levels of donor NK and T cells also indicate their pre-activation status during the transplantation process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Edoardo Giussani, Andrea Binatti, Giulia Calabretto, Vanessa Rebecca Gasparini, Antonella Teramo, Cristina Vicenzetto, Gregorio Barila, Monica Facco, Alessandro Coppe, Gianpietro Semenzato, Stefania Bortoluzzi, Renato Zambello
Summary: Large granular lymphocyte leukemias (LGLL) are sustained by proliferating cytotoxic T cells or NK cells, with the etiology partly related to viral agents. Different hypotheses have been proposed regarding the role of viruses, such as the presence of Epstein Barr Virus (EBV) in aggressive NK leukemias but not in indolent CLPD-NK. New data analysis failed to identify viral sequences in CLPD-NK, suggesting a complex relationship between viral agents and NK cell activation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Wiwat Chancharoenthana, Asada Leelahavanichkul, Wassawon Ariyanon, Somratai Vadcharavivad, Weerapong Phumratanaprapin
Summary: In this retrospective study of kidney transplant recipients with recurrent IgA nephropathy, the combination of rituximab and standard therapy effectively reduced proteinuria and maintained renal allograft function. Patients treated with rituximab showed less severe renal allograft pathology despite strong IgA deposition. Further mechanistic studies with longer follow-up periods are recommended.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Woo Yeong Park, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han
Summary: Gd-IgA1 can be utilized as a diagnostic biomarker for predicting recurrent IgAN in kidney transplantation, while the level of Gd-IgA1 does not affect the survival rates of grafts or patients.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Konstantinos Sfakianoudis, Anna Rapani, Sokratis Grigoriadis, Agni Pantou, Evangelos Maziotis, Georgia Kokkini, Chrysanthi Tsirligkani, Stamatis Bolaris, Konstantinos Nikolettos, Margarita Chronopoulou, Konstantinos Pantos, Mara Simopoulou
Summary: Current evidence regarding the role of uterine natural killer (uNK) cells in recurrent implantation failure (RIF) and recurrent miscarriages (RM) is conflicting, with a definitive causative relationship still missing. Possible treatments for addressing uNK-related RIF and RM include glucocorticoids, intralipids, and intravenous immunoglobulin administration, but solid evidence on their efficiency and safety is needed before recommendation. Further studies are necessary to determine a causative relationship between uNK cells and RIF-RM pathologies before considering them as biomarkers or targets for therapeutic purposes.
Article
Medicine, General & Internal
Raquel Morales, Jose Miguel Bolarin, Manuel Muro, Isabel Legaz
Summary: This study aimed to investigate the impact of various factors on death from sepsis, multiorgan failure, and graft failure in patients with alcoholic liver disease undergoing liver transplantation. The study found that certain gene mutations, such as KIR2DL2/S2+, KIR2DL5+, and KIR3DL1+, increased the frequency of death from multiorgan failure and graft failure.
Article
Urology & Nephrology
Chloe Schwarz, Antoine Morel, Marie Matignon, Philippe Grimbert, Eric Rondeau, Nacera Ouali, Helene Francois, Laurent Mesnard, Camille Petit-Hoang, Cedric Rafat, Karine Dahan, Yosu Luque
Summary: Hepatitis B virus (HBV) reactivation was found to be high in kidney transplant recipients receiving belatacept, but did not impact patient survival. Further studies are needed to confirm these results.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Oncology
Takeji Umemura, Satoru Joshita, Hiromi Saito, Shun-ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Masao Ota
Summary: Natural killer cells, mediated through KIR-HLA interactions, play a role in hepatocellular carcinoma (HCC) development. In patients with hepatitis C virus-associated cirrhosis, the presence of HLA-Bw4 and the KIR3DL1 + HLA-Bw4 pair was significantly associated with HCC onset, suggesting a potential risk factor for HCC development in HCV cirrhosis.
Article
Medicine, General & Internal
Dominika Deborska-Materkowska, Agnieszka Perkowska-Ptasinska, Anna Sadowska-Jakubowicz, Joanna Pazik, Marta Serwanska-Swietek, Natalia Mikolajczyk, Robert Swider, Jacek Nowak, Magdalena Durlik
Summary: This study reveals that the killer-cell immunoglobulin-like receptor (KIR) genotype of kidney transplant recipients is associated with polyomavirus-associated nephropathy (PyVAN). In addition, acute rejection, male sex, and lack of antiviral prophylaxis are also risk factors for PyVAN.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Multidisciplinary Sciences
Paolo Maggi, Federica Calo, Vincenzo Messina, Gianfranca Stornaiuolo, Maria Stanzione, Luca Rinaldi, Stefania De Pascalis, Margherita Macera, Nicola Coppola
Summary: Liver transplant recipients with viral hepatitis are at high risk of cardiovascular disease and subclinical vascular damage. Risk assessment tools may underestimate the cardiovascular risk, and chronic inflammatory status may play a key role.
Article
Medical Laboratory Technology
Azam Khamseh, Vahdat Poortahmasebi, Saber Soltani, Mohsen Nasiritoosi, Ali Jafarian, Azam Ghaziasadi, Mehdi Norouzi, Saied Ghorbani, Narges Eslami, Seyed Mohammad Jazayeri
Summary: This study investigated the prevalence of occult hepatitis B infection (OBI) among Iranian liver transplant recipients. The results showed that the prevalence of OBI in this population was relatively low, but further research is needed to fully understand its significance.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Immunology
Amit Nair, Laia Coromina Hernandez, Shimul Shah, Xaralambos Zervos, Michael Zimmerman, Kazunari Sasaki, Teresa Diago, Koji Hashimoto, Masato Fujiki, Federico Aucejo, Jessica Bollinger, Tiffany L. Kaiser, Charles M. Miller, Cristiano Quintini, John J. Fung, Bijan Eghtesad
Summary: In liver transplantation, delaying the initiation of calcineurin inhibitors (CNI) and using induction rabbit antithymocyte globulin (rATG) may help preserve early kidney function, especially when CNI initiation is delayed beyond 10 days or target tacrolimus levels are lower.
Article
Surgery
Angelica Perez-Gutierrez, Umar Siddiqi, Gene Kim, Govind Rangrass, Aalok Kacha, Valluvan Jeevanandam, Yolanda Becker, Lisa Potter, John Fung, Talia B. Baker
Summary: This paper presents the best practices for successful execution of combined heart-liver-kidney transplantation, including patient selection, perioperative planning, and coordination among transplant teams. By careful selection and collaboration, this highly challenging operation can be successfully performed.
CLINICAL TRANSPLANTATION
(2022)
Editorial Material
Gastroenterology & Hepatology
John J. Fung
LIVER TRANSPLANTATION
(2022)
Article
Immunology
Mohamed Rela, Jesus Quintero, Mureo Kasahara, Paolo Muiesan, Francisco Hernandez-Oliveros, Rajesh Rajalingam, Sadhana Shankar, Blayne Amir Sayed, Diego di Sabato, Ashwin Rammohan, John Fung, Itxarone Bilbao
Summary: The incidence and distribution of cancers in children are different from adults. Nonhepatic cancers should be considered in pediatric liver transplantation. With longer post-transplant survival and increased risk of new cancers, guidelines and best practices are needed for nonhepatic cancers in pediatric liver transplantation.
Editorial Material
Gastroenterology & Hepatology
John Fung, Diego DiSabato, Chih-Yi Liao, Osmanuddin Ahmed, Anjana Pillai
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Oncology
Aditya Juloori, Rohan R. Katipally, Jeffrey M. Lemons, Anurag K. Singh, Renuka Iyer, Jared R. Robbins, Ben George, William A. Hall, Sean P. Pitroda, Fauzia Arif, John Fung, Anjana Pillai, Chih-Yi Liao, Manish Sharma, Stanley L. Liauw
Summary: This study investigated the safety and efficacy of stereotactic body radiation therapy (SBRT) with immunotherapy in patients with hepatocellular carcinoma (HCC). The results showed that the combination of SBRT with nivolumab plus ipilimumab had better survival and efficacy compared to immunotherapy alone in HCC patients, suggesting the need for further investigation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Osman Ahmed, Qian Yu, Mikin Patel, Gloria Hwang, Anjana Pillai, Chih-yi Liao, John Fung, Talia Baker
Summary: A combination therapy of yttrium-90 transarterial radioembolization (TARE) and systemic gemcitabine, cisplatin, and capecitabine is safe and effective for the first-line treatment of locally advanced intrahepatic cholangiocarcinoma (iCCA), resulting in high rates of downstaging and favorable overall survival.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Surgery
Jesse D. Schold, Anne M. Huml, S. Ali Husain, Emilio D. Poggio, R. Blake Buchalter, Rocio Lopez, Bruce Kaplan, Sumit Mohan
Summary: In the United States, over 20% of procured kidneys for transplantation are not utilized. This study examined the factors associated with nonutilization and found that deceased donors from higher distressed communities were more likely to have their kidneys not utilized. The study also found regional variations in kidney nonutilization rates and minimal impact on recipient outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Kumar Jayant, Thomas G. Cotter, Isabella Reccia, Francesco Virdis, Mauro Podda, Nikolaos Machairas, Ramesh P. Arasaradnam, Diego Di Sabato, John C. LaMattina, Rolf N. Barth, Piotr Witkowski, John J. Fung
Summary: This study compared the outcomes of high-MELD and low-MELD living-donor liver transplant recipients and found no significant differences in patient survival, graft survival, and most complications between the two groups. However, the high-MELD group had a higher risk of pulmonary infection, abdominal fluid collection, and prolonged ICU stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Immunology
Mateusz Ogledzinski, Piotr J. Bachul, Braden Juengel, Yaser Al-Salmay, Jayant Kumar, Angelica Perez-Gutierrez, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Rolf Barth, John Fung, Piotr Witkowski
Meeting Abstract
Immunology
Angelica Perez-Gutierrez, Braden Juengel, Piotr J. Bachul, Yaser AlSalmay, Piotr Witkowski, John Fung, Yolanda T. Becker, Rolf N. Barth
Meeting Abstract
Gastroenterology & Hepatology
Tiffany C. L. Wong, Shirley T. L. Chiu, James Fung, Chung Mau Lo
Meeting Abstract
Surgery
Angelica Perez-Gutierrez, Piotr Bachul, Yaser AlSalmay, Piotr Witkowski, Rolf Barth, Diego DiSabato, John Fung, Yolanda Becker
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
Piotr Bachul, Angelica Perez-Guetierrez, Yaser Al-Salmay, Braden Juengel, Kumar Jayant, Lindsay Basto, Ling-Jia Wang, Laurencia Perea, Martin Tibudan, Celeste Thomas, Rolf Barth, John Fung, Piotr Witkowski
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
Angelica Perez-Gutierrez, Thomas Cotter, Mathew Odenwald, Kumar Jayant, Diego DiSabato, Michael Charlton, John Fung
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
