Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth

Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors

(2013) A Mariño-Enríquez et al.   ONCOGENE

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

(2013) J R Smith et al.   ONCOGENE

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Targeting CDC37: An alternative, kinase-directed strategy for disruption of oncogenic chaperoning

(2011) Jennifer R. Smith et al.   CELL CYCLE

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth

(2010) Serif Senturk et al.   HEPATOLOGY

Proliferating Cell Nuclear Antigen Is Protected from Degradation by Forming a Complex with MutT Homolog2

(2009) Yu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted therapy for hepatocellular carcinoma

(2009) Hans Christian Spangenberg et al.   Nature Reviews Gastroenterology & Hepatology

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

(2008) J. L. Holmes et al.   CANCER RESEARCH

Molecular targeted therapies in hepatocellular carcinoma

(2008) Josep M. Llovet et al.   HEPATOLOGY

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

(2008) J R Smith et al.   ONCOGENE