Article
Microbiology
Ping-Chin Lai, Cheng-Hsu Chen, Long-Bin Jeng, Tung-Min Yu, Shang-Feng Tsai, Ming-Ju Wu, Shao-Bin Cheng, Sheng-Shun Yang, Teng-Yu Lee
Summary: The GZR/EBR single-tablet regimen for 12 weeks is highly effective and well tolerated in GT-1b HCV-infected liver or kidney transplant recipients, with generally easy management of drug-drug interactions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Health Care Sciences & Services
JiHyun An, Dong Ah Park, Min Jung Ko, Sang Bong Ahn, Jeong-Ju Yoo, Dae Won Jun, Sun Young Yim
Summary: DAA therapy has shown safety and efficacy in patients with decompensated cirrhosis. The SVR rate was 86%, with low rates of HCC occurrence and mortality. PI-based treatment demonstrated similar clinical outcomes and adverse events compared to non-PI-based DAA treatment in DC patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yu Jun Wong, Sally Tran, Chung-Feng Huang, Yao-Chun Hsu, Carmen Preda, Hidenori Toyoda, Joanne Liu, Dae Won Jun, Charles Landis, Daniel Q. Huang, Andrei Gila, Livia Negoita, Satoshi Yasuda, Cheng-Hao Tseng, Pei-Chien Tsai, Haruki Uojima, Akito Nozaki, Makoto Chuma, Masanori Atsukawa, Masatoshi Ishigami, Norio Itokawa, Etsuko Iio, Carla Pui-Mei Lam, Tsunamasa Watanabe, Akira Asai, Keisuke Yokohama, Hiroshi Abe, Masaru Enomoto, Norifumi Kawada, Akihiro Tamori, Dong Hyun Lee, Mi Jung Jun, Son Do, Dang K. H. Vo, Li Liu, Junyi Li, Fanpu Ji, Wenjun Wang, Yu Li, Xiaozhong Wang, Fen Guo, Qiang Xu, Liang Jing, Qing Ye, Hongying Pan, JiaJie Zhang, Xie Wen, Qi Wang, Hong Ren, Dachuan Cai, Jia Shang, Junping Liu, Chengzheng Lu, Wenqian Zang, Jia Li, Junqi Niu, Mingyuan Zhang, Chao Wu, Rui Huang, Mayumi Maeda, Akiko Nakanishi, Ming-Lun Yeh, Wan-Long Chuang, Jee-Fu Huang, ChiaYen Dai, Toru Ishikawa, Koichi Takaguchi, Tomonori Senoh, Huy N. Trinh, Hirokazu Takahashi, Yuichiro Eguchi, Sabrina Xin Zi Quek, Hiroaki Haga, Eiichi Ogawa, Grace Wong, Maria Buti, Shinya Fukunishi, Yoshiyuki Ueno, Man-Fung Yuen, Yasuhito Tanaka, Seng Gee Lim, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study compared the tolerability and treatment outcomes of PI-based DAA and non-PI DAA regimens in patients with advanced HCV cirrhosis. The results showed that there was no significant difference in treatment effectiveness and safety between the two groups in the real-world setting. However, further data is needed to evaluate the safety of PI-based DAA in patients with CTP-C or MELD scores beyond 15.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Organic
Arun K. Ghosh, Monika Yadav
Summary: Nirmatrelvir (Paxlovid) is an FDA approved drug that targets SARS-COV-2 3CLprotease. An optically active synthesis of nirmatrelvir was developed to avoid epimerization, which is a crucial step in the synthesis process. A ZnCl2-mediated direct N-trifluroacetylation method was utilized to overcome the epimerization problem and successfully synthesize nirmatrelvir derivatives without significant epimerization.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Kyle R. Kreitman, Jiten P. Kothadia, Satheesh P. Nair, Benedict J. Maliakkal
Summary: The opioid epidemic has increased organ availability for liver transplantation. Direct-acting antiviral therapy for HCV allowed acceptance of HCV viremic donor organs, while NAT led to increased detection of HCV and HBV in donors. Case studies suggest the need for more intensive and prolonged HBV screening in recipients of livers from HCV viremic donors.
HEPATOLOGY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Therese Bittermann, K. Rajender Reddy
Summary: In the era of direct-acting antivirals (DAAs), listing rates for decompensated HCV cirrhosis have decreased, but delisting of HCV patients due to clinical improvement has increased. However, many patients continue to experience considerable morbidity despite improvements.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Dagmara Przekop, Jakub Klapaczynski, Agnieszka Grytczuk, Ewa Gruszewska, Andrzej Gietka, Anatol Panasiuk, Slawomir Golaszewski, Bogdan Cylwik, Lech Chrostek
Summary: The study evaluated the usefulness of non-invasive indirect biomarkers in the treatment of HCV with the 3D regimen, showing effective levels of liver fibrosis markers post-treatment. The undetectable HCV RNA after 12 weeks indicated 100% virus eradication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Brice Korkmaz, Anne-Sophie Lamort, Roxane Domain, Celine Beauvillain, Artur Gieldon, Ali Oender Yildirim, Georgios T. Stathopoulos, Moez Rhimi, Dieter E. Jenne, Ralph Kettritz
Summary: Cathepsin C plays a crucial role in cancer development and metastasis, and is considered as a potential therapeutic target for various types of cancer. Recent studies have highlighted the important interaction between tumor-associated CatC, NSPs, and NETs in cancer progression, providing new insights for cancer treatment strategies.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Infectious Diseases
Tormod Rebnord, Rolv Terje Lie, Anne Kjersti Daltveit, Ingvild Fossgard Sandoy
Summary: This study found that protease inhibitor (PI)-based combination antiretroviral treatment (cART) and cART initiation before conception may be associated with a slightly increased risk of small-for-gestational-age (SGA) infants. The evidence supporting these findings was of low certainty.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Pharmacology & Pharmacy
Heather S. Snyder, Joshua J. Wiegel, Karen Khalil, Bryant B. Summers, Teresa Tan, Srijana Jonchhe, Tiffany E. Kaiser
Summary: The introduction of safe and highly effective direct acting antivirals (DAAs) has led to improved treatment outcomes for hepatitis C virus (HCV) after transplant. It has been found that treating HCV-negative recipients with HCV-viremic allografts using DAAs is safe and effective, although long-term outcomes are still unknown.
Article
Gastroenterology & Hepatology
Lukas Baumann, Dominique L. Braun, Matthias Cavassini, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, David Haerry, Charles Beguelin, Christoph A. Fux, Gilles Wandeler, Bernard Surial, Andri Rauch
Summary: The study assessed the changes in the prevalence of replicating HCV infection, treatment uptake, and liver-related morbidity and mortality in persons with HIV and hepatitis C. The introduction of direct-acting antiviral therapy was associated with a significant reduction in the prevalence of replicating HCV infection, as well as a decrease in overall mortality and incidence of liver-related events in this population.
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Stefan Kreideweiss, Gerhard Schaenzle, Gisela Schnapp, Viktor Vintonyak, Marc A. Grundl
Summary: A new CatC inhibitor, BI 1291583, was evaluated in this study. It selectively inhibited CatC enzymatic activity, leading to reduced NSP activity associated with chronic airway inflammation. This inhibitor has the potential to restore the protease-antiprotease balance in patients with chronic inflammatory lung diseases such as bronchiectasis.
INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Yasmina Chouik, Claire Francoz, Eleonora De Martin, Olivier Guillaud, Armand Abergel, Mario Altieri, Louise Barbier, Camille Besch, Olivier Chazouilleres, Filomena Conti, Christophe Corpechot, Sebastien Dharancy, Francois Durand, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie-Noelle Hilleret, Pauline Houssel-Debry, Nassim Kamar, Anne Minello, Martine Neau-Cransac, Georges-Philippe Pageaux, Sylvie Radenne, Olivier Roux, Faouzi Saliba, Didier Samuel, Claire Vanlemmens, Marie-Lorraine Woehl-Jaegle, Vincent Leroy, Jean-Charles Duclos-Vallee, Jerome Dumortier
Summary: This study describes the early outcomes of liver transplantation for autoimmune hepatitis (AIH). The prognosis is good for AIH patients after transplantation, and pre-transplant immunosuppression does not affect the outcomes. However, the presence of acute kidney injury at the time of transplantation can negatively impact the prognosis.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Polina I. Selina, Maria A. Karaseva, Alexey A. Komissarov, Dina R. Safina, Nataliya A. Lunina, Marina P. Roschina, Eugene D. Sverdlov, Ilya V. Demidyuk, Sergey V. Kostrov
Summary: Study on developing Danio rerio embryos showed that the 3C protease of human hepatitis A virus can induce lethal effects and specific abnormalities, indicating a significant impact of picornavirus 3C protease at the whole-organism level.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Sana Riaz, Hira Tiwana, Muhammad Adil, Khaver Ali, Tariq Javed
Summary: This study tested the antiviral effects of indigenous medicinal plants from Pakistan on hepatitis C virus (HCV). The methanol extract of Syzgium cumine showed a promising effect against HCV genotypes 1a and 3a. Furthermore, the purified fraction SC14 had a synergistic effect with interferon drugs and suppressed the gene effect of NS3 in Huh-7 cells.
ARCHIVES OF MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Abby B. Siegel, Sonja K. Olsen, Arthur Magun, Robert S. Brown
Article
Gastroenterology & Hepatology
Ser Yee Lee, Michael A. Mooney, Matthew L. Inra, Krishna Juluru, Alyson N. Fox, Sonja K. Olsen, Robert S. Brown, Jean C. Emond, Daniel Cherqui, Michael D. Kluger
Article
Gastroenterology & Hepatology
Matthew S. Chang, Sonja K. Olsen, Elsa M. Pichardo, Scott Heese, Jessica B. Stiles, Rita Abdelmessih, Elizabeth C. Verna, James V. Guarrera, Jean C. Emond, Robert S. Brown
LIVER TRANSPLANTATION
(2012)
Letter
Gastroenterology & Hepatology
Matthew S. Chang, Sonja K. Olsen, Elsa M. Pichardo, Scott Heese, Jessica B. Stiles, James V. Guarrera, Jean C. Emond, Robert S. Brown
LIVER TRANSPLANTATION
(2013)
Article
Gastroenterology & Hepatology
Michael D. Kluger, Karim J. Halazun, Ryan T. Barroso, Alyson N. Fox, Sonja K. Olsen, David C. Madoff, Abby B. Siegel, Joshua L. Weintraub, Jonathan Sussman, Robert S. Brown, Daniel Cherqui, Jean C. Emond
LIVER TRANSPLANTATION
(2014)
Article
Immunology
Michael D. Kluger, James V. Guarrera, Sonja K. Olsen, Robert S. Brown, Jean C. Emond, Daniel Cherqui
Article
Immunology
Matthew S. Chang, Sonja K. Olsen, Elsa M. Pichardo, Jessica B. Stiles, Lori Rosenthal-Cogan, William D. Brubaker, James V. Guarrera, Jean C. Emond, Robert S. Brown
News Item
Education, Scientific Disciplines
Daniel J. Sartori, Sonja Olsen, Elizabeth Weinshel, Sondra R. Zabar
Article
Radiology, Nuclear Medicine & Medical Imaging
Chenyang Zhan, Sonja Olsen, Hoi Cheung Zhang, Stephan Kannengiesser, Hersh Chandarana, Krishna Prasad Shanbhogue
ABDOMINAL RADIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Azadeh Sharafi, Rahman Baboli, Marcelo Zibetti, Krishna Shanbhogue, Sonja Olsen, Tobias Block, Hersh Chandarana, Ravinder Regatte
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Saamia Faruqui, Fidelis C. Okoli, Sonja K. Olsen, David M. Feldman, Harmit S. Kalia, James S. Park, Carmen M. Stanca, Viviana Figueroa Diaz, Sarah Yuan, Nabil N. Dagher, Suparna A. Sarkar, Neil D. Theise, Sooah Kim, Krishna Shanbhogue, Ira M. Jacobson
Summary: Cholangiopathy is a late complication of severe COVID-19, characterized by marked elevation in ALP and bile duct injury. Further studies are needed to understand its pathogenesis, natural history, and therapeutic interventions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Chenyang Zhan, Vinay Prabhu, Stella K. Kang, Clayton Li, Yuli Zhu, Sooah Kim, Sonja Olsen, Ira M. Jacobson, Nabil N. Dagher, Brendan Carney, Ryan M. Hickey, Bedros Taslakian
Summary: This study found that compared to anticoagulation or no treatment, TIPS had a better effect on reducing portomesenteric thrombus burden in cirrhotic patients, and both treatments were safe options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Alexander M. Sy, Maureen Whitsett, Xiaodong Li, Neil D. Theise, Nabil N. Dagher, Sonja Olsen
JOURNAL OF GASTROINTESTINAL CANCER
(2019)
Letter
Immunology
Nino Khetsuriani, Suxiang Tong, Xiaoyan Lu, Shannon Reed, Dean Erdman, Angela Campbell, Krongkaew Supawat, Sahas Liamsuwan, Narayanan Jothikumar, Sonja Olsen
EMERGING INFECTIOUS DISEASES
(2009)