Article
Gastroenterology & Hepatology
Alberto Zanetto, Elena Campello, Cristiana Bulato, Sabrina Gavasso, Graziella Saggiorato, Sarah Shalaby, Patrizia Burra, Paolo Angeli, Marco Senzolo, Paolo Simioni
Summary: Bacterial infections in patients with decompensated cirrhosis are associated with reduced platelet aggregation and decreased levels of natural anticoagulants, potentially increasing the risk of bleeding and thrombosis.
Article
Gastroenterology & Hepatology
Vivek A. Lingiah, Nikolaos T. Pyrsopoulos
Summary: In this retrospective study involving 192 patients with cirrhosis, the incidence of infections was found to be 54.6%, with a significant number of patients experiencing multiple infections during hospitalization. ICU care was required for some patients due to infection deterioration, and 14.6% of patients died during hospitalization or shortly after discharge.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Javier Martinez, Virginia Hernandez-Gea, Enrique Rodriguez-de-Santiago, Luis Tellez, Bogdan Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibanez-Samaniego, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L. Gluud, Carlos Noronha-Ferreira, Nuria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Remy Schwarzer, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'Era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnoun, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Christian Jansen, Marie Angele Robic, Irene Conejo, Maria Vega Catalina, Marika Rudler, Edilmar Alvarado, Valeria Perez-Campuzano, Maria Anna Guardascione, Petra Fischer, Jaime Bosch, Juan Carlos Garcia-Pagan, Agustin Albillos
Summary: Despite antibiotic prophylaxis, nearly 20% of patients with acute variceal bleeding develop bacterial infections during hospitalization. Respiratory bacterial infections are the most common, occurring early after admission. Respiratory infection is associated with advanced liver disease, severe hepatic encephalopathy, and the use of nasogastric tube, orotracheal intubation for endoscopy, or esophageal balloon tamponade.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Candid Villanueva, Agustin Albillos, Joan Genesca, Joan C. Garcia-Pagan, Anna Brujats, Jose L. Calleja, Carles Aracil, Rafael Banares, Rosa M. Morillas, Maria Poca, Beatriz Penas, Salvador Augustin, Juan G. Abraldes, Edilmar Alvarado, Ferran Torres, Jaume Bosch
Summary: This study found that bacterial infections have a significant impact on the natural history of compensated cirrhosis, significantly increasing the risk of decompensation and death.
JOURNAL OF HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Carlos Terra, Angelo Zambam de Mattos, Marcelo Souza Chagas, Andre Torres, Denusa Wiltgen, Barbara Muniz Souza, Renata Mello Perez
Summary: Patients with cirrhosis have an increased risk of infection, especially from multidrug-resistant organisms (MDRO), which have a significant impact on prognosis and cost. The prevalence of MDR infections has been increasing in recent years, leading to worse outcomes compared to non-resistant bacteria. It is crucial to understand the epidemiological factors, use antibiotics appropriately, and implement preventive measures to effectively manage these infections.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Engineering, Biomedical
Inga S. Shchelik, Joao V. D. Molino, Karl Gademann
Summary: Biohybrid microswimmers designed to carry antibiotics against bacterial infections utilize motile microorganisms and a photo-cleavable linker to release drugs on demand, providing high spatial and temporal precision in inhibiting bacterial growth.
ACTA BIOMATERIALIA
(2021)
Article
Gastroenterology & Hepatology
Wolfgang Maximilian Kremer, Simon Johannes Gairing, Leonard Kaps, Esmeralda Ismail, Vasiliki Kalampoka, Max Hilscher, Maurice Michel, Ekkehard Siegel, Jo euro rn M. Schattenberg, Peter R. Galle, Martin F. Sprinzl, Marcus-Alexander Wo, Michael Nagel, Christian Labenz
Summary: This study investigated bacterial infections in patients with liver cirrhosis in Germany, and the results showed that bacterial infections were common in these hospitalized patients and were associated with short-term mortality. In addition, the study also found that the pathogen spectrum of bacteria varied in different types of infections, and multidrug-resistant bacteria were detected in a small number of infected patients.
ANNALS OF HEPATOLOGY
(2022)
Article
Cell Biology
Martin P. Alphonse, Jessica H. Rubens, Roger Ortines, Nicholas A. Orlando, Aman M. Patel, Dustin Dikeman, Yu Wang, Ivan Vuong, Daniel P. Joyc, Jeffrey Zhang, Mohammed Mumtaz, Haiyun Liu, Qi Li, Christine Youn, Garrett J. Patrick, Advaitaa Ravipat, Robert J. Miller, Nathan K. Archer, Lloyd S. Miller
Summary: This study investigated a potential host-directed immunotherapy against MRSA and other bacterial skin infections by inhibiting pan-caspase, showing promising efficacy in reducing skin lesions and bacterial burden in mice.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Xiaoning Sun, Chunmei Ding, Meng Qin, Jianshu Li
Summary: Hydrogel-based biosensors are highly promising for the detection and monitoring of bacterial infections. This review summarizes the recent advancements in this field and discusses the challenges and future development of hydrogel biosensors for bacterial infections.
Article
Biology
Fathima Shihana, Mugdha V. Joglekar, Tae-Hwi Schwantes-An, Anandwardhan A. Hardikar, Devanshi Seth
Summary: This study compared the global miRNA profiles of heavy drinking patients with and without liver cirrhosis, and identified specific miRNAs associated with liver disease. The expression of certain miRNAs was found to be inversely correlated with disease severity, suggesting their potential role in monitoring disease progression. Furthermore, miRNAs were associated with pathways involved in cell death, inflammation, fibrosis, and fat metabolism. The study advances knowledge in the field by identifying new miRNAs as potential diagnostic and therapeutic targets.
Article
Oncology
Xiaolei Cheng, Dongdong Jian, Junyue Xing, Cihang Liu, Yong Liu, Cunying Cui, Zhen Li, Shixing Wang, Ran Li, Xiaohan Ma, Yingying Wang, Xiaoping Gu, Zhenwei Ge, Hao Tang, Lin Liu
Summary: This study discovered a group of circulating miRNAs associated with dilated cardiomyopathy (DCM) and identified their important role in regulating myocardial apoptosis and autophagy. These miRNAs could serve as non-invasive diagnostic biomarkers for DCM and provide new insights into the pathogenesis and therapeutic targets of DCM.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Microbiology
Andrea Du Toit
Summary: This study shows that metabolites produced by fungi can support the growth and competitive advantage of pathogenic Salmonella enterica subsp. enterica serovar Typhimurium, highlighting the role of the fungal community during bacterial infection.
NATURE REVIEWS MICROBIOLOGY
(2023)
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
Rui Liu, Yuping Zhong, Rui Chen, Shiyi Chen, Yazhu Huang, Huan Liu
Summary: This study found a strong correlation between the abundance of Escherichia coli (E. coli) in bone marrow and the number of bone lesions in multiple myeloma patients. Further experiments showed that E. coli promotes osteoclast differentiation and inhibits osteoblast differentiation. Mechanism studies revealed that the lipopolysaccharides (LPS) produced by E. coli affect signaling pathways involved in bone formation and resorption. In vivo studies also demonstrated that eliminating E. coli infection helps in the healing of bone lesions in multiple myeloma patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kirsti A. Campbell, Hirsh D. Trivedi, Sanjiv Chopra
Summary: Cirrhosis is a significant contributor to morbidity and mortality worldwide, with infections impacting quality of life. Understanding immune dysfunction and managing infections in cirrhosis has become more nuanced with increasing rates of drug-resistant organisms. This review discusses cirrhosis-associated immune deficiency, common infections, and techniques for prevention and treatment in high-risk populations.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Mariantonietta Pisaturo, Carmine Minichini, Mario Starace, Mara Caroprese, Margherita Macera, Giuseppina Brancaccio, Stefania De Pascalis, Antonella Santonicola, Alfonso Galeota Lanza, Rosa Zampino, Gaetano Cotticelli, Evangelista Sagnelli, Giovanni Battista Gaeta, Nicola Coppola
LIVER INTERNATIONAL
(2019)
Review
Rheumatology
Marco Sebastiani, Laura Milazzo, Fabiola Atzeni, Caterina Vacchi, Andreina Manfredi, Luca Quartuccio, Carlo Scire, Giovanni Battista Gaeta, Giovanni Lapadula, Orlando Armignacco, Marcello Tavio, Salvatore D'Angelo, Pierluigi Meroni, Laura Bazzichi, Walter Grassi, Alessandro Mathieu, Claudio Mastroianni, Evangelista Sagnelli, Teresa Santantonio, Caterina Uberti Foppa, Massimo Puoti, Loredana Sarmati, Paolo Airo, Oscar Massimiliano Epis, Rossana Scrivo, Miriam Gargiulo, Agostino Riva, Giovanni Ciancio, Gianguglielmo Zehender, Gloria Taliani, Luca Meroni, Salvatore Sollima, Piercarlo Sarzi-Puttini, Massimo Galli
MODERN RHEUMATOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Valentina Marchese, Anna Beltrame, Andrea Angheben, Stefania Marocco, Giovanni Battista Gaeta, Zeno Bisoffi
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2020)
Article
Infectious Diseases
L. Onorato, M. Macera, F. Calo, C. Monari, F. Russo, M. R. Iovene, G. Signoriello, R. Annibale, M. C. Pace, C. Aurilio, G. B. Gaeta, N. Coppola
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Letter
Gastroenterology & Hepatology
Giuseppina Brancaccio, Giovanni B. Gaeta
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Letter
Hematology
S. Martini, S. Ferrara, C. Bellacosa, B. M. Celesia, F. Taccari, G. Di Filippo, A. Tartaglia, G. Gaeta, P. Maggi
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2020)
Article
Biotechnology & Applied Microbiology
Alekos Simoni, Andrew M. Hammond, Andrea K. Beaghton, Roberto Galizi, Chrysanthi Taxiarchi, Kyros Kyrou, Dario Meacci, Matthew Gribble, Giulia Morselli, Austin Burt, Tony Nolan, Andrea Crisanti
NATURE BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Ruggiero Seccia, Daniele Gammelli, Fabio Dominici, Silvia Romano, Anna Chiara Landi, Marco Salvetti, Andrea Tacchella, Andrea Zaccaria, Andrea Crisanti, Francesca Grassi, Laura Palagi
Article
Infectious Diseases
Giuseppina Brancaccio, Alessandro Vitale, Giuseppe Signoriello, Giovanni B. Gaeta, Umberto Cillo
INFECTIOUS DISEASES
(2020)
Review
Surgery
Giuseppina Brancaccio, Giovanni B. Gaeta
ANNALS OF TRANSPLANTATION
(2020)
Article
Infectious Diseases
Mariantonietta Pisaturo, Mario Starace, Carmine Minichini, Stefania De Pascalis, Margherita Macera, Laura Occhiello, Vincenzo Messina, Vincenzo Sangiovanni, Ernesto Claar, Davide Precone, Gianfranca Stornaiuolo, Maria Stanzione, Ivan Gentile, Giuseppina Brancaccio, Salvatore Martini, Addolorata Masiello, Angelo Salomone Megna, Carmine Coppola, Alessandro Federico, Evangelista Sagnelli, Marcello Persico, Alfonso Galeota Lanza, Aldo Marrone, Giovanni Battista Gaeta, Nicola Coppola
Article
Multidisciplinary Sciences
William T. Garrood, Nace Kranjc, Karl Petri, Daniel Y. Kim, Jimmy A. Guo, Andrew M. Hammond, Ioanna Morianou, Vikram Pattanayak, J. Keith Joung, Andrea Crisanti, Alekos Simoni
Summary: The study shows that off-target mutations induced by CRISPR-Cas9 in mosquitoes can be reduced to undetectable levels, with judicious design of the guide RNA and strict temporal control of Cas9 expression in the germline being key factors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)