Article
Rheumatology
Sophie I. E. Liem, Sam Neppelenbroek, Cynthia M. Fehres, Brigitte A. Wevers, Rene E. M. Toes, Cornelia F. Allaart, Tom W. J. Huizinga, Hans Ulrich Scherer, Jeska K. De Vries-Bouwstra
Summary: Early diagnosis of systemic sclerosis (SSc) is important. The most frequent SSc-specific autoantibodies are anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA). ATA is associated with severe disease course. More detailed characterisation of the ATA-response in SSc might improve prognostication.
Article
Rheumatology
Nobuhiko Kajio, Masaru Takeshita, Katsuya Suzuki, Yukari Kaneda, Humitsugu Yamane, Kazuhiro Ikeura, Hidekazu Sato, Shin Kato, Hiroyuki Shimizu, Kazuyuki Tsunoda, Tsutomu Takeuchi
Summary: This study reveals that serum autoantibodies target the centromere-kinetochore macrocomplex in patients with SS, SSc, and PBC, with similar prevalence rates of each antibody across the three diseases. The specificity of ASCs in SS salivary glands suggests kinetochore complex-driven autoantibody selection, providing insight into the underlying mechanism of ACA acquisition.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Claire F. Beesley, Nina R. Goldman, Taher E. Taher, Christopher P. Denton, David J. Abraham, Rizgar A. Mageed, Voon H. Ong
Summary: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by excessive extracellular matrix deposition. B cells play a fundamental role in the pathogenesis and development of SSc, as they infiltrate lesional sites and produce profibrotic cytokines. B cell counts are increased in SSc patients and show differences in various B cell compartments. B cell signaling is impaired in SSc patients, and B cell depletion therapy has shown therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Robert M. Clancy, Miranda C. Marion, Hannah C. Ainsworth, Miao Chang, Timothy D. Howard, Peter M. Izmirly, Mala Masson, Jill P. Buyon, Carl D. Langefeld
Summary: This study investigates the relationship between the microbiome and anti-SSA/Ro antibodies, and how it affects disease state. Comparing the gut microbiome of healthy controls and anti-SSA/Ro positive women, differences in microbial relative abundances were found to be associated with clinical severity.
Article
Medicine, General & Internal
Alida L. P. Caforio, Anna Baritussio, Renzo Marcolongo, Chun-Yan Cheng, Elena Pontara, Elisa Bison, Maria Grazia Cattini, Nicoletta Gallo, Mario Plebani, Sabino Iliceto, Gianpietro Semenzato, Lisa Maier, Nabeel Hamzeh
Summary: The study revealed that the frequencies of AHAs and AIDAs in cardiac sarcoidosis were significantly higher compared to other cardiac diseases, serving as novel autoimmune markers for the diagnosis of cardiac sarcoidosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Vanessa M. Beutgen, Norbert Pfeiffer, Franz H. Grus
Summary: This study revealed alterations in autoantibody levels in glaucoma patients and identified important subgroup predictors, enhancing prospective glaucoma subtype prediction. Furthermore, it provided insights into the characteristics of glaucoma-related antigens and their role in glaucoma pathogenesis, proposing new diagnostic approaches for glaucoma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Jean-Baptiste Vulsteke, Rita Derua, Sylvain Dubucquoi, Frederic Coutant, Sebastien Sanges, David Goncalves, Greet Wuyts, Petra De Haes, Daniel Blockmans, Wim A. Wuyts, Kristl G. Claeys, Ellen De Langhe, Nicole Fabien, Xavier Bossuyt
Summary: New and known antisynthetase autoantibodies (ASAs) were discovered and detected through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). The dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity was identified. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Dermatology
R. Toosi, A. Teymourzadeh, H. Mahmoudi, K. Balighi, M. Daneshpazhooh
Summary: By evaluating the changes in antibody levels in PV patients before and after RTX treatment, it was found that the reduction in anti-gamma/epsilon nAchR Abs during clinical improvement may suggest a synergic role with anti-Dsg1,3 Abs.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Cristina Arnaldos-Perez, Albert Perez-Isidro, Uma Bolos, Carmen Domenech, Judit Ballus, Sergio Rodriguez-Tajes, Maria Carlota Londono, Odette Vinas, Estibaliz Ruiz-Ortiz
Summary: This study aimed to determine if using separated E2 subunits can confirm patients with low positive or discordant results. The results showed that autoantibodies against E2 subunits of PDC, BCOADC, and OGDC were detected in all patients, except for one case in the low positive or discordant results group, using the Dot-blot with separated subunits. Therefore, it is recommended to use methods that include these three E2 subunits, and a Dot-blot with separated subunits can confirm cases with discordant results.
Article
Rheumatology
Hajar El Kamouni, Darya S. Jalaledin, Alexandra Albert, Sabrina Hoa, Caroline Vo, Josiane Bourre-Tessier, Eric Rich, Jean-Richard Goulet, Martial Koenig, Gemma Perez, May Y. Choi, Yves Troyanov, Minoru Satoh, Marvin J. Fritzler, Jean-Luc Senecal, Oceane Landon-Cardinal
Summary: This study aimed to compare the phenotypic features of anti-U1RNP+ mixed connective tissue disease patients with and without anti-SMN autoantibodies.
Article
Immunology
Kerensa E. Ward, Lora Steadman, Abid R. Karim, Gary M. Reynolds, Matthew Pugh, Winnie Chua, Sian E. Faustini, Tonny Veenith, Ryan S. Thwaites, Peter J. M. Openshaw, Mark T. Drayson, Adrian M. Shields, Adam F. Cunningham, David C. Wraith, Alex G. Richter
Summary: Post-acute cardiac sequelae are recognized complications of COVID-19, and autoantibodies against heart antigens have been found in individuals with severe COVID-19. Elevated levels of DSG2 protein and autoantibodies were observed in convalescent sera of severe COVID-19 patients, suggesting DSG2 as a potential biomarker for cardiac damage in COVID-19.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Rheumatology
Ryan M. Close, Laura M. Close, Patrick Galdun, Stefanie Gerstberger, Matthew Rydberg, Lisa Christopher-Stine
Summary: Statin-associated autoimmune myopathy is a rare condition in American Indians, with potential risk factors requiring further investigation. Healthcare providers need to be aware of this possibility and familiarize themselves with its presentation for effective treatment.
Article
Medicine, General & Internal
Alida Linda Patrizia Caforio, Giacomo De Luca, Anna Baritussio, Mara Seguso, Nicoletta Gallo, Elisa Bison, Maria Grazia Cattini, Elena Pontara, Luna Gargani, Alessia Pepe, Corrado Campochiaro, Mario Plebani, Sabino Iliceto, Giovanni Peretto, Antonio Esposito, Lorenzo Tofani, Alberto Moggi-Pignone, Lorenzo Dagna, Renzo Marcolongo, Marco Matucci-Cerinic, Cosimo Bruni
Summary: The study found that the frequencies of AHA and AIDA in SSc were significantly higher compared to other cardiac disease groups and normal blood donors, suggesting a high burden of underdiagnosed autoimmune heart involvement in SSc. AHA was associated with interstitial lung disease, chest pain history, abnormal troponin, AIDA, and current immunosuppression, as well as death and overall cardiac events during follow-up.
Article
Multidisciplinary Sciences
Maurizio Bruschi, Andrea Cavalli, Solange Moll, Giovanni Candiano, Leonardo Scapozza, Jigar J. Patel, John C. Tan, Ken C. Lo, Andrea Angeletti, Gian Marco Ghiggeri, Marco Prunotto
Summary: Evidence has shown that autoantibodies targeting podocytes can cause membranous nephropathy. In this study, a high-density peptide array was used to identify a panel of proteins reactive to sera of membranous nephropathy patients. The protein FMNL1, expressed by macrophages in the tissues of membranous nephropathy patients, was found to have high levels of anti-FMNL1 IgG4 in the sera of these patients. This autoantibody was associated with lack of remission of proteinuria and was also observed in other glomerular disease conditions. These findings suggest a broader role of this autoantibody in different glomerular diseases.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Corrie M. Wortel, Sophie I. E. Liem, Nina M. van Leeuwen, Maaike Boonstra, Cynthia M. Fehres, Lauran Stoeger, Tom W. J. Huizinga, Rene E. M. Toes, Jeska De Vries-Bouwstra, Hans U. Scherer
Summary: This study investigates the autoreactive B cell responses in ATA-positive and ACA-positive SSc patients. The results show that ATA-positive patients exhibit a more active B cell response, which is associated with the presence and severity of ILD. This may explain the differential responsiveness to B cell depleting therapy.