Article
Surgery
Wei-Feng Li, Yi-Hao Yen, Yueh-Wei Liu, Chih-Chi Wang, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng, Jing-Houng Wang, Sheng-Nan Lu
Summary: This study aimed to predict early recurrence of hepatocellular carcinoma after liver resection by assessing preoperative image tumor characteristics and alpha-fetoprotein levels. The study identified AFP level, tumor size, vascular invasion, and multiple tumors as predictive factors for early recurrence. A simple diagnostic model was developed to successfully predict early recurrence.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Wencui Li, Lizhu Han, Bohan Xiao, Xubin Li, Zhaoxiang Ye
Summary: This study aimed to identify the independent risk factors for AFP-NHCC and construct an individual prediction nomogram of early recurrence. The researchers found several independent predictors for early recurrence of AFP-NHCC and developed an effective nomogram. This nomogram could assist physicians in making more accurate personalized treatment decisions for AFP-NHCC patients.
Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Liting Wen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Lili Zhou, Lanmei Gao, Yueming Li
Summary: This study found that preoperative platelet count and rad-score are associated with early recurrence of small HCC. The radiomics nomogram developed in this study can accurately predict the probability of early recurrence of small HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Daniel Hoffman, Amy Shui, Ryan Gill, Shareef Syed, Neil Mehta
Summary: AFP >= 1000 ng/mL, multinodularity, and vascular invasion were found to be independent risk factors for HCC recurrence. The researchers developed the RESTORE index to predict HCC recurrence risk, which can stratify the risk into different levels based on patient's scores.
Article
Surgery
Tomoaki Yoh, Takamichi Ishii, Satoshi Ogiso, Hiroto Nishino, Takahiro Nishio, Yukinori Koyama, Yoichiro Uchida, Takashi Ito, Etsuro Hatano
Summary: This study retrospectively analyzed patients with intermediate and advanced-stage hepatocellular carcinoma who underwent liver resection. The results showed that although liver resection alone may not lead to remission in most patients, active salvage therapy can potentially prolong survival. Further research is warranted to decrease recurrence rates and increase salvageability for these patients.
Article
Multidisciplinary Sciences
Nanping Lin, Lei Wang, Qizhen Huang, Weiping Zhou, Xiaolong Liu, Jingfeng Liu
Summary: This study developed a nomogram model to predict the overall survival of hepatocellular carcinoma patients who underwent R0 resection. The model showed good calibration and discriminatory power, and it was found that p-TACE could significantly prolong the median overall survival in high-risk patients.
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Oncology
Yao Huang, Hengkai Chen, Yongyi Zeng, Zhiqiang Liu, Handong Ma, Jingfeng Liu
Summary: A machine learning prognostic model was developed to identify high-risk patients after surgical resection, with variable importance reviewed in different time intervals. Tumor characteristics contribute more to HCC relapse in 0 to 1 year, while HBV infection and smoking largely affect patients' outcome in 3 to 5 years.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Liming Zheng, Xi Gu, Guojun Zheng, Xin Li, Meifang He, Longgen Liu, Xike Zhou
Summary: The study constructed a predictive model using various analysis methods to successfully identify high-risk patients for early HCC recurrence, and predict patients' response to adjuvant sorafenib treatment. The model can optimize risk stratification for early HCC recurrence and evaluate patient response to adjuvant sorafenib after liver resection.
Article
Oncology
Qu Xie, Zeyin Zhao, Yanzhen Yang, Dan Long, Cong Luo
Summary: This study aimed to construct models using radiomics derived from enhanced computed tomography (CT) imaging to predict the risk of postoperative recurrence in early-stage hepatocellular carcinoma patients. Clinical, radiomic, and combined models were built using four algorithms and evaluated through cross-validation. The results showed that the combined models outperformed those relying solely on clinical or radiomic features. This research provides clinicians with a valuable tool to predict postoperative recurrence and inform early preventive strategies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Shih-Yu Yang, Chih-Chi Wang, Kuang-Den Chen, Yueh-Wei Liu, Chih-Che Lin, Ching-Hui Chuang, Yu-Chieh Tsai, Chih-Chien Yao, Yi-Hao Yen, Chang-Chun Hsiao, Tsung-Hui Hu, Ming-Chao Tsai
Summary: This study revealed that statin use may have a chemopreventive effect on HCC recurrence after curative resection. Factors such as age, liver cirrhosis, diabetes, number of tumors, tumor size, and vascular invasion were identified as independent risk factors for HCC recurrence, while statin use and antiviral therapy significantly reduced the risk of recurrence.
Article
Health Care Sciences & Services
Yu-Syuan Chen, Shih-Yu Yang, Pei-Ming Wang, Chih-Chi Wang, Chee-Chien Yong, Ding-Wei Chen, Yueh-Wei Liu, Ching-Hui Chuang, Pao-Yuan Huang, Chih-Chien Yao, Yen-Po Lin, Ming-Chao Tsai
Summary: Concurrent cholecystectomy may reduce recurrence in early-stage HCC after curative resection, but does not significantly impact overall survival. Further studies are needed to confirm these results.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Lanxin Mu, Luhe Qi, Haitao Long, Jing Huang, Zibiao Zhong, Xiaowen Shi, Chaoji Chen, Qifa Ye
Summary: A novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, using a photothermal fibrous chitosan/polydopamine sponge, which effectively addresses bleeding and inhibits tumor recurrence and metastasis, offering significant promise for improving liver cancer surgery.
Article
Gastroenterology & Hepatology
Kenji Yamaoka, Satoshi Saitoh, Keiichi Kinowaki, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Toshio Fukusato, Hiromitsu Kumada
Summary: This study aimed to compare the clinicopathological features of typical steatohepatitic HCC (SH-HCC) with other HCCs. The results showed significant differences between SH-HCC and other HCCs in terms of age, hepatitis B virus (HBV) infection, nonalcoholic steatohepatitis (NASH), diabetes, and hyperlipidemia. Tumor size and background steatosis were also significantly different between the two groups. The combined use of ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) improved the diagnostic accuracy of SH-HCC. According to LI-RADS, 87% of SH-HCC cases were classified as malignant tumors.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Tetsuya Hosaka
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Tetsuya Hosaka, Fumitaka Suzuki, Masahiro Kobayashi, Shunichirou Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Norio Akuta, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada
Summary: This study found that switching from TDF or ADV to TAF resulted in favorable renal safety over 2 years. In the CKD stage 3a-4 subgroup, eGFR recovered within the first 12 weeks after TAF and then stabilized.
HEPATOLOGY RESEARCH
(2022)
Article
Oncology
Nozomu Muraishi, Yusuke Kawamura, Norio Akuta, Junichi Shindoh, Masaru Matsumura, Satoshi Okubo, Shunichiro Fujiyama, Tetsuya Hosaka, Satoshi Saitoh, Hitomi Sezaki, Fumitaka Suzuki, Yoshiyuki Suzuki, Kenji Ikeda, Yasuji Arase, Masaji Hashimoto, Ichiro Yasuda, Hiromitsu Kumada
Summary: In this study, the effect of lenvatinib on tumor blood vessel diameter in patients with hepatocellular carcinoma was investigated. It was found that lenvatinib can reduce the diameter of tumor blood vessels, which may be considered as a process of normalization. The decrease in tumor blood vessels in imaging analysis may be associated with improved prognosis, but further studies are still required.
Article
Oncology
Norio Akuta, Hitomi Sezaki, Shunichiro Fujiyama, Yusuke Kawamura, Tetsuya Hosaka, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Yoshiyuki Suzuki, Fumitaka Suzuki, Hiromitsu Kumada
Summary: This study found that a combination of simple markers can help non-specialized doctors evaluate the risk of PLC following HCV clearance with DAAs. However, regular imaging studies are still recommended for the early detection of PLC.
Article
Gastroenterology & Hepatology
Yusuke Kawamura, Norio Akuta, Junichi Shindoh, Masaru Matsumura, Satoshi Okubo, Licht Tominaga, Shunichiro Fujiyama, Tetsuya Hosaka, Satoshi Saitoh, Hitomi Sezaki, Fumitaka Suzuki, Yoshiyuki Suzuki, Kenji Ikeda, Yasuji Arase, Masaji Hashimoto, Takuyo Kozuka, Hiromitsu Kumada
Summary: This study showed that curative-intent subsequent treatment is more beneficial for HCC patients with better liver function (mALBI grade 1 and 2a) and intrahepatic target nodules who have received lenvatinib treatment.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Norio Akuta, Yusuke Kawamura, Shunichiro Fujiyama, Kenichi Nakamichi, Eiji Saegusa, Hidetoshi Ogura, Masaki Kato, Etsuko Doi, Naoko Inoue, Hitomi Sezaki, Tetsuya Hosaka, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Yoshiyuki Suzuki, Hiromitsu Kumada, Fumitaka Suzuki
Summary: This retrospective cohort study evaluated the treatment efficacy and predictive factors of a combined diet and exercise program for fatty liver. The program improved liver function tests and body weight, and the etiology of non-NAFLD, presence of diabetes mellitus, and large waist circumference were identified as independent predictors of decreased hemoglobin A1c levels.
HEPATOLOGY RESEARCH
(2023)
Article
Oncology
Yusuke Kawamura, Norio Akuta, Junichi Shindoh, Masaru Matsumura, Satoshi Okubo, Licht Tominaga, Shunichiro Fujiyama, Tetsuya Hosaka, Satoshi Saitoh, Hitomi Sezaki, Fumitaka Suzuki, Yoshiyuki Suzuki, Kenji Ikeda, Yasuji Arase, Masaji Hashimoto, Takuyo Kozuka, Hiromitsu Kumada
Summary: This study analyzed the data of 64 BCLC stage C patients with intrahepatic target nodules who received systemic therapy. The results showed that the combined use of multiple treatment procedures improved the overall survival of patients with hepatocellular carcinoma.
Article
Gastroenterology & Hepatology
Norio Akuta, Yusuke Kawamura, Shunichiro Fujiyama, Satoshi Saito, Nozomu Muraishi, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Hiromitsu Kumada
Summary: This study investigated the impact of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on nonalcoholic fatty liver disease (NAFLD) with type 2 diabetes mellitus (T2DM) after 5 years of treatment. The results showed that, after 5 years, 50% of patients had histological improvement, 17% had no change, and 33% had worsening. Insulin resistance and serum ferritin levels also significantly decreased at 5 years. In addition, patients who added another treatment after long-term use of SGLT2i showed minimal worsening. This study provides important insights for understanding the long-term effects of SGLT2i in treating NAFLD with T2DM.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Tetsuya Hosaka, Fumitaka Suzuki, Mariko Kobayashi, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Summary: The study found that measuring HBcrAg using an ultrasensitive assay has a better potential for predicting the development of hepatocellular carcinoma in patients with chronic hepatitis B undergoing antiviral treatment.
HEPATOLOGY COMMUNICATIONS
(2022)
