Journal
LIPIDS IN HEALTH AND DISEASE
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12944-018-0833-2
Keywords
Apolipoprotein A5; Lipoprotein metabolism; Obesity; Metabolic syndrome; Adipocytes
Funding
- National Natural Science Foundation of China [81370393, 81670426]
- Graduate Self-Exploration and Innovation Project of Central South University of China [2018zzts923]
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Apolipoprotein A5 (apoA5) has been identified to play an important role in lipid metabolism, specifically in triglyceride (TG) and TG-rich lipoproteins (TRLs) metabolism. Numerous evidence has demonstrated for an association between apoA5 and the increased risk of obesity and metabolic syndrome, but the mechanism remains to be fully elucidated. Recently, several studies verified that apoA5 could significantly reduce plasma TG level by stimulating lipoprotein lipase (LPL) activity, and the intracellular role of apoA5 has also been proved since apoA5 is associated with cytoplasmic lipid droplets (LDs) and affects intrahepatic TG accumulation. Furthermore, since adipocytes provide the largest storage depot for TG and play a crucial role in the development of obesity, we could infer that apoA5 also acts as a novel regulator to modulate TG storage in adipocytes. In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders.
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