Article
Cardiac & Cardiovascular Systems
Tatjana Josefs, Debapriya Basu, Tomas Vaisar, Britt Arets, Jenny E. Kanter, Lesley-Ann Huggins, Yunying Hu, Jianhua Liu, Noemie Clouet-Foraison, Jay W. Heinecke, Karin E. Bornfeldt, Ira J. Goldberg, Edward A. Fisher
Summary: The study found that hypertriglyceridemia and reduced HDL-C did not affect atherosclerosis lesion size or macrophage content, suggesting that atherosclerosis regression in mice is primarily driven by LDL-C reduction and not impacted by hypertriglyceridemia and plasma HDL-C levels.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anni Kumari, Kristian K. Kristensen, Michael Ploug, Anne-Marie Lund Winther
Summary: LPL plays a crucial role in lipid metabolism by hydrolyzing triglyceride-rich lipoproteins, and its impaired activity can lead to hypertriglyceridemia. In addition to LDL-C, hypertriglyceridemia is also an independent risk factor for atherosclerosis, with LPL and other factors involved in intravascular lipolysis playing a key role in this process.
Article
Biochemistry & Molecular Biology
Liyan Yu, Hongguang Liu, Xiaoxia Ma, Vidya Devanathadesikan Seshadri, Xuan Gao
Summary: The study found that Myrtenal has anti-atherosclerotic activity in high-fat diet-induced atherosclerosis rat models. Myrtenal-treated groups showed the ability to modulate the lipid metabolic pathway, reducing blood lipid levels and inflammatory cytokines.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Stephen G. Young, Wenxin Song, Ye Yang, Gabriel Birrane, Haibo Jiang, Anne P. Beigneux, Michael Ploug, Loren G. Fong
Summary: GPIHBP1 is a crucial partner for LPL in lipolytic processing of lipoproteins, stabilizing LPL structure and preserving activity. It captures LPL and shuttles it to the capillary lumen. The AD of GPIHBP1 accelerates LPL binding, preserves LPL activity, and allows LPL to move across ECs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Iva Klobucar, Lucija Klobucar, Margarete Lechleitner, Matias Trbusic, Gudrun Pregartner, Andrea Berghold, Hansjoerg Habisch, Tobias Madl, Sasa Frank, Vesna Degoricija
Summary: This study found that the serum levels of endothelial lipase (EL) were associated with the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins, and these associations were different between metabolic syndrome (MS) patients and healthy volunteers (HVs). In MS patients, EL levels were negatively correlated with cholesterol levels in large very low-density lipoprotein (VLDL) particles, as well as with total-cholesterol, free-cholesterol, triglyceride, and phospholipid contents of VLDL and intermediate-density lipoprotein particles. In HVs, EL levels were positively correlated with the serum levels of apoB, triglycerides, and phospholipids in large low-density lipoprotein particles. These findings suggest that EL levels are influenced by MS and may play a role in lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The paper "MicroRNA-135a alleviates lipid accumulation and inflammation of atherosclerosis through targeting lipoprotein lipase" by Juan Li et al., published in RSC Advances in 2019, has been retracted.
Article
Multidisciplinary Sciences
Wenxin Song, Anne P. Beigneux, Thomas A. Weston, Kai Chen, Ye Yang, Le Phuong Nguyen, Paul Guagliardo, Hyesoo Jung, Anh P. Tran, Yiping Tu, Caitlyn Tran, Gabriel Birrane, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Peter Tontonoz, Haibo Jiang, Michael Ploug, Loren G. Fong, Stephen G. Young
Summary: This study reveals that the GPIHBP1-transported LPL can detach and move into the EC glycocalyx, where it plays a role in the intravascular processing of triglyceride-rich lipoproteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Peripheral Vascular Disease
Patricia Hernandez, Neena Passi, Taher Modarressi, Vivek Kulkarni, Meshal Soni, Fran Burke, Archna Bajaj, Daniel Soffer
Summary: Hypertriglyceridemia (HTG) is a common condition associated with atherosclerosis and pancreatitis risk. Novel therapies may reduce atherosclerosis risk and are likely to benefit patients with moderate to severe HTG. Dietary modifications, weight control, and specific drug therapy are key in managing HTG.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Pei-Yi Chen, Wan-Yun Gao, Je-Wen Liou, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen
Summary: Dyslipidemia, characterized by elevated levels of LDL-C, TGs, and TGRLs, is a major risk factor for ASCVDs. ANGPTL3, synthesized exclusively in the liver, plays a critical role in regulating lipoprotein metabolism and its downregulation is associated with reduced risk of cardiovascular events. Therapies targeting ANGPTL3 show promise for managing dyslipidemia and ASCVDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
John E. Le Lay, Qun Du, Minal B. Mehta, Nicholas Bhagroo, B. Timothy Hummer, Judith Falloon, Glenn Carlson, Anton Rosenbaum, ChaoYu Jin, Holly Kimko, Lan-Feng Tsai, Steven Novick, Bill Cook, David Han, Chang Yeop Han, Tomas Vaisar, Alan Chait, Sotirios K. Karathanasis, Christopher J. Rhodes, Boaz Hirshberg, Melissa M. Damschroder, Judith Hsia, Joseph S. Grimsby
Summary: HDL levels play a crucial role in cardiovascular disease, and inhibiting endothelial lipase can increase HDL-C, improve lipoprotein profiles, and reduce cardiovascular risk when combined with other medications.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Ellen Thiemann, Gerburg K. Schwaerzer, Ioannis Evangelakos, Marceline M. Fuh, Michelle Y. Jaeckstein, Janina Behrens, Stefan K. Nilsson, Manju Kumari, Ludger Scheja, Alexander Pfeifer, Joerg Heeren, Markus Heine
Summary: Cold-induced activation of BAT has a significant impact on systemic lipoprotein metabolism. LPL plays a crucial role in vascular lipoprotein processing. The absence of Lpl exclusively in endothelial cells does not impair lipid and energy metabolism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei-Yi Chen, Tzu-Ya Chao, Hao-Jen Hsu, Chih-Yang Wang, Ching-Yen Lin, Wan-Yun Gao, Ming-Jiuan Wu, Jui-Hung Yen
Summary: Tangeretin modulates the LXRα-ANGPTL3-LPL pathway to exert a lipid-lowering effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and storage, facilitated by lipoprotein lipase (LPL) which acts as a gatekeeper for fatty acid uptake. LPL activity is regulated by extracellular proteins including members of the angiopoietin-like family of proteins. This review delves into how ANGPTL3, ANGPTL4, and ANGPTL8 regulate LPL activity and coordinate triglyceride metabolism and fat partitioning.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Food Science & Technology
Yee-Ying Lee, Teck-Kim Tang, Eng-Seng Chan, Eng-Tong Phuah, Oi-Ming Lai, Chin-Ping Tan, Yong Wang, Nur Azwani Ab Karim, Noorlida Habi Mat Dian, Joo Shun Tan
Summary: Structured lipids are a modified form of lipid aimed at improving the nutritional and functional properties of conventional fats and oils. Examples of this new generation of healthful lipids, such as MCT and MLCT, are mainly composed of MCFA and have shown multiple physiological and functional properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Svetlana Schekatolina, Viktoriia Lahovska, Aleksandr Bekshaev, Sergey Kontush, Wilfried Le Goff, Anatol Kontush
Summary: This study investigates the mechanism of free cholesterol (FC) transfer to high-density lipoprotein (HDL) during lipolysis of triglyceride-rich lipoprotein (TGRL). The researchers propose a reverse remnant-cholesterol transport (RRT) hypothesis and develop a mathematical model to study the transfer process. The results suggest that FC accumulation in HDL during lipolysis is influenced by competitive fluxes and mediated by specific proteins. These findings offer new insights into the understanding of HDL in the framework of RRT.
Article
Gastroenterology & Hepatology
Montse Pauta, Noemi Rotllan, Ana Fernandez-Hernando, Cedric Langhi, Jordi Ribera, Mingjian Lu, Loreto Boix, Jordi Bruix, Wladimiro Jimenez, Yajaira Suarez, David A. Ford, Angel Baldan, Morris J. Birnbaum, Manuel Morales-Ruiz, Carlos Fernandez-Hernando
Article
Cell Biology
Bo Wang, Xin Rong, Mark A. Duerr, Daniel J. Hermanson, Per Niklas Hedde, Jinny S. Wong, Thomas Q. de Aguiar Vallim, Benjamin F. Cravatt, Enrico Gratton, David A. Ford, Peter Tontonoz
Article
Biochemistry & Molecular Biology
Elisa N. D. Palladino, Wen-yi Wang, Carolyn J. Albert, Cedric Langhi, Angel Baldan, David A. Ford
JOURNAL OF LIPID RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
David A. Ford, Jaideep Honavar, Carolyn J. Albert, Mark A. Duerr, Joo Yeun Oh, Stephen Doran, Sadis Matalon, Rakesh P. Patel
JOURNAL OF LIPID RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Daniel P. Pike, Celine L. Hartman, Gregory J. Weissler, Elisa N. D. Palladino, Carolyn J. Albert, David A. Ford
Article
Biochemistry & Molecular Biology
Thomas Q. de Aguiar Vallim, Elinor Lee, David J. Merriott, Christopher N. Goulbourne, Joan Cheng, Angela Cheng, Ayelet Gonen, Ryan M. Allen, Elisa N. D. Palladino, David A. Ford, Tisha Wang, Angel Baldan, Elizabeth J. Tarling
JOURNAL OF LIPID RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Narmadaa Thyagarajan, Jenika D. Marshall, Arthur T. Pickett, Clemens Schumacher, Yanbo Yang, Sherri L. Christian, Robert J. Brown
Article
Multidisciplinary Sciences
Sherri L. Christian, Nikitha K. Pallegar, Robert J. Brown, Alicia M. Viloria-Petit
Article
Biochemistry & Molecular Biology
Breanne M. Coady, Jenika D. Marshall, Luke E. Hattie, Alexander M. Brannan, Madeline N. Fitzpatrick, Kala E. Hickey, Stefan Wallin, Valerie Booth, Robert J. Brown
JOURNAL OF PEPTIDE SCIENCE
(2018)
Article
Multidisciplinary Sciences
Jenika D. Marshall, Emily R. Courage, Ryan F. Elliott, Madeline N. Fitzpatrick, Anne D. Kim, Andrea F. Lopez-Clavijo, Bronwyn A. Woolfrey, Mireille Ouimet, Michael J. O. Wakelam, Robert J. Brown
Editorial Material
Biochemistry & Molecular Biology
David A. Ford
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biology
Alexandria J. Tobin, Nicholas P. Noel, Sherri L. Christian, Robert J. Brown
Summary: The study found that lipoprotein hydrolysis products can increase secretion of multiple cytokines in breast cancer cells, with different responses observed in different cell lines. The changes in cytokine secretion profiles were independent of increased cell metabolic activity, providing insight into how these products may affect breast cancer cell viability and progression in the tumor microenvironment.
BMC RESEARCH NOTES
(2021)
Article
Biochemistry & Molecular Biology
Kaushalya Amunugama, Matthew J. Jellinek, Megan P. Kilroy, Carolyn J. Albert, Valerio Rasi, Daniel F. Hoft, Michael G. S. Shashaty, Nuala J. Meyer, David A. Ford
Summary: This study identified novel very long carbon chain plasmalogens in human neutrophils, which undergo oxidation during activation to produce chlorolipid products. Elevated levels of these chlorolipids were found in septic patients, indicating their potential role in the pathophysiology of sepsis.
Article
Biochemistry & Molecular Biology
Makayla M. Bavis, Allison M. Nicholas, Alexandria J. Tobin, Sherri L. Christian, Robert J. Brown
Summary: The energy demand of breast cancers is partly met by the oxidation of exogenous fatty acids. Fatty acids also play a role in cell signaling and membrane construction for tumor cells. Lipoprotein lipase (LPL) hydrolyzes lipoprotein triacylglycerols and phospholipids to provide fatty acids, which may promote breast tumor growth in the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Shubha Shakya, Kelly D. Pyles, Carolyn J. Albert, Rakesh P. Patel, Kyle S. McCommis, David A. Ford
Summary: This study reveals a novel distribution of plasmalogen molecular species in airway epithelial cells that are targeted by myeloperoxidase-derived hypochlorous acid, resulting in the formation of electrophilic 2-ClFALD. Furthermore, the proteomics analysis shows distinct protein enrichments in metabolic pathways, particularly in pyruvate metabolism, in epithelial cells compared to endothelial cells modified by 2-ClFALD.