Article
Geriatrics & Gerontology
Alpna Tyagi, Carol Mirita, Iman Shah, P. Hemachandra Reddy, Subbiah Pugazhenthi
Summary: This study suggests that Sirt3 deficiency exacerbates the harmful effects of lipotoxicity on BMECs, leading to aggravated neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Guang Zhong Liu, Wei Xu, Yan Xiang Zang, Qi Lou, Peng Zhou Hang, Qiang Gao, Hang Shi, Qi Yun Liu, Hong Wang, Xin Sun, Cheng Liu, Peng Zhang, Hua Dong Liu, Shao Hong Dong
Summary: The study revealed that Sirt3 was significantly down-regulated in AF patients and models, but restored by HL treatment. Sirt3 could regulate the acetylated modification of key metabolic enzymes, and increasing Sirt3 levels rescued AF-induced atrial metabolic remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Rui-Cheng Yang, Kun Huang, Hui-Peng Zhang, Liang Li, Yu-Fei Zhang, Chen Tan, Huan-Chun Chen, Mei-Lin Jin, Xiang-Ru Wang
Summary: The study found that SARS-CoV-2 infection can cause dysfunction of the blood-brain barrier, increasing its permeability, which provides new insights into the neuropathogenesis of SARS-CoV-2.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Integrative & Complementary Medicine
Jingxin Liu, Tian Zhang, Jianzhong Zhu, Shuangchen Ruan, Rongsong Li, Bing Guo, Ligen Lin
Summary: The study found that honokiol can alleviate lipid accumulation by promoting SIRT3-AMPK-mediated autophagy, mainly targeting lipid droplets. Honokiol interacts hydrophobically with amino acid residues (PHE294, GLU323, and VAL324) and NAD(+). Additionally, honokiol improves mitochondrial function for enhanced lipolysis by reducing acetylated long-chain acyl-CoA dehydrogenase levels. In CDHFD-fed mice, honokiol treatment significantly prevented liver lipid accumulation, and co-treatment with the AMPK inhibitor Compound C almost abolished these effects.
Article
Chemistry, Medicinal
Jun Li, Shouyin Shen, Haiyan Shen
Summary: HSPA12A is downregulated in hBMECs induced by oxygen-glucose deprivation/reoxygenation (OGD/R). Overexpression of HSPA12A protects hBMECs from OGD/R-induced cell injury, preserves blood-brain barrier integrity, inhibits leukocyte adhesion, and reduces inflammation.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Microbiology
Anita Kovacs-Kasa, Abdelrahman A. Zaied, Silvia Leanhart, Murat Koseoglu, Supriya Sridhar, Rudolf Lucas, David J. Fulton, Jose A. Vazquez, Brian H. Annex
Summary: This study found that plasma from patients with SARS-CoV-2 infection can cause lung vascular endothelial injury. Analysis revealed significant variability in cytokine elevations among SARS-CoV-2 patients. Considering the destructive effect of SARS-CoV-2 plasma on vascular permeability, further research is needed to explore the underlying mechanisms of this phenomenon.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Xiandong Zhu, Feixiang Duan, Yan Zhang, Xiaowu Wang, Yongqiang Wang, Jiawei Chen, Lanyu Zhang, Minmin Wu, Zhuo Pan, Bicheng Chen
Summary: This study discovered that acadesine can alleviate inflammation and tissue damage in SAP-ALI by modulating the Nrf2-dependent antioxidant pathway through activating AMPK. These findings are of great significance for the treatment of SAP-related lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Huy Q. Ta, Nicholas R. Teman, Irving L. Kron, Mark E. Roeser, Victor E. Laubach
Summary: This study found that the use of Steen solution can significantly improve the pulmonary endothelial barrier function of patients with acute respiratory distress syndrome, reduce inflammation, and protect the connections of endothelial cells. These findings are of great significance for improving the treatment of severe acute respiratory distress syndrome.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Gastroenterology & Hepatology
Xiaotian Chen, Mingming Zhang, Fan Zhou, Zhengrong Gu, Yuan Li, Ting Yu, Chunyan Peng, Lixing Zhou, Xiangrui Li, Dandan Zhu, Xiaoqi Zhang, Chenggong Yu
Summary: This study found that Honokiol (HKL), an active compound in magnolia bark, can inhibit the differentiation of Th17 cells in ulcerative colitis by activating SIRT3. The results of the experiments showed that HKL can regulate Th17 cell differentiation by activating SIRT3 and inhibiting the STAT3/ROR gamma t signaling pathway, thus partially alleviating the symptoms of colitis.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Physiology
Carla Roberta Peachazepi Moraes, Ivanio Teixeira Borba-Junior, Franciele De Lima, Jessica Ribeiro Alves Silva, Bruna Bombassaro, Andre C. Palma, Eli Mansour, Licio Augusto Velloso, Fernanda Andrade Orsi, Fabio Trindade Maranhao Costa, Erich Vinicius De Paula
Summary: In this study, the researchers found that the serum from COVID-19 patients can disrupt the endothelial barrier integrity in cell monolayers. They also observed that the levels of soluble Tie2 were increased and soluble VE-cadherin were decreased in these patients compared to healthy individuals. Furthermore, the magnitude of this disruption was proportional to disease severity and levels of VEGF-A and Ang-2. These findings provide important insights into the pathogenesis of acute lung injury in COVID-19 and may contribute to the development of new biomarkers and therapeutic targets.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Xuecheng Zheng, Junling Gao, Manman Zhao, Lingling Han, Dexin Zhang, Kaijie Wang, Jianzhong Cui
Summary: This study demonstrated that HKL could alleviate neurological deficits and cell apoptosis induced by ICH through the activation of Sirt3. HKL improved cell survival rate, suppressed cell apoptosis, and inhibited mitochondrial fission. The results also showed that HKL reversed the phosphorylation and mitochondrial translocation of Drp1. These findings suggest that HKL has great potential for the treatment of ICH.
CHINESE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Makiko Konda, Masahiro Kitabatake, Noriko Ouji-Sageshima, Rei Tonomura, Ryutaro Furukawa, Shota Sonobe, Chiyoko Terada-Ikeda, Maiko Takeda, Masahiko Kawaguchi, Toshihiro Ito
Summary: Acute respiratory distress syndrome (ARDS) lacks specific and effective treatment, making it crucial to understand its pathogenesis. This study reveals that ADAMTS4 plays a role in regulating vascular endothelial cell (VEC) permeability in ARDS and may serve as a significant predictive marker and therapeutic target for ARDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanli Wu, Mei Li, Jijia Bai, Xigang Ma
Summary: This study investigates the regulatory effect of long non-coding RNA SNHG3 on the function of pulmonary microvascular endothelial cells (PMVECs) in sepsis-related acute lung injury (ALI). Knockdown of SNHG3 promotes PMVEC proliferation, reduces apoptosis and barrier permeability, and increases the expression of tight junction proteins claudin-5 and ZO-1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Anatomy & Morphology
Ping Liu, Yifei Bian, Jia Zhong, Yang Yang, Xiang Mu, Zhongjie Liu
Summary: The newly established rat intestinal microvascular endothelial cell line RIMVEC-11, characterized by endothelial features, maintained fundamental physiological function, and possessed potential for capillary formation and cell migration.
Article
Microbiology
Soumya Panigrahi, Tamal Goswami, Brian Ferrari, Christopher J. Antonelli, Douglas A. Bazdar, Hannah Gilmore, Michael L. Freeman, Michael M. Lederman, Scott F. Sieg
Summary: SARS-CoV-2 infection leads to reduced ACE2 expression on cells, potentially causing compromised respiratory function and thrombotic events. Increased levels of molecules like angiotensin II and bradykinin may contribute to inflammation, while spike protein and bradykinin can induce dysfunction in endothelial cells.
MICROBIOLOGY SPECTRUM
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.