Article
Peripheral Vascular Disease
Jessica Barochiner, Lucas S. Aparicio, Rocio Martinez, Jose Alfie, Marcos J. Marin
Summary: The study identifies a phenomenon called masked uncontrolled apparent resistant hypertension (MUCRH) in hypertensive patients, which is associated with cardiovascular mortality and cerebrovascular events. MUCRH may be an independent predictor for these events.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: The higher difference in morning and evening home systolic blood pressure (MEdif: morning minus evening home SBP >= 20 mmHg) is associated with higher cardiovascular disease (CVD) risk compared to other MEdif groups. Those in both elevated MEave (>= 135 mmHg) and MEdif (>= 20 mmHg) groups have higher CVD risk compared to controlled groups. These findings suggest that monitoring MEdif in home BP can predict future CVD incidence.
HYPERTENSION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Kazuomi Kario, Naoyuki Hasebe, Ken Okumura, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita, Hiroshi Inoue
Summary: The study evaluated the blood pressure control in elderly patients with non-valvular atrial fibrillation, finding that morning home blood pressure was poorly controlled in these patients, and masked uncontrolled morning hypertension was still significant.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Hiroaki Watanabe, Satoshi Hoshide, Hisoshi Kanegae, Kazuomi Kario
Summary: Obesity with increased high-sensitive cardiac troponin T (hs-cTnT) is associated with a higher risk of cardiovascular disease events. hs-cTnT may identify a malignant phenotype of obesity.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Jia-Hui Xia, Dong-Yan Zhang, Yuan-Yuan Kang, Qian-Hui Guo, Yi-Bang Cheng, Jian-Feng Huang, Qi-Fang Huang, Wei Zhang, Li-Juan Zhang, Yu Dou, Yan-Lun Su, Hua-Ling Liu, Mei-Sheng Zheng, Xin-Juan Xu, Jian-Jun Mu, Yan Li, Ji-Guang Wang
Summary: Overweight and obesity are significantly associated with a higher prevalence of masked uncontrolled hypertension, indicating that clinic blood pressure might overestimate the effectiveness of antihypertensive treatment in patients with overweight and obesity.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: The study analyzed the association between home blood pressure and cardiovascular events occurring in different seasons, finding that morning home blood pressure may be a superior predictor of cardiovascular events in winter.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: This study analyzed the association between home and ambulatory blood pressure monitoring and cardiovascular risk in hypertensive outpatients, and found that both home blood pressure and ambulatory blood pressure were independently associated with cardiovascular risk. Home blood pressure had a modest superiority to predict cardiovascular prognosis compared to ambulatory blood pressure.
Article
Cardiac & Cardiovascular Systems
Ming-Hui Hung, Ling-Chieh Shih, Yu-Ching Wang, Hsin-Bang Leu, Po-Hsun Huang, Tao-Cheng Wu, Shing-Jong Lin, Wen-Harn Pan, Jaw-Wen Chen, Chin-Chou Huang
Summary: This study developed machine learning-based prediction models to predict masked hypertension and masked uncontrolled hypertension using clinical characteristics. The models showed high sensitivity and negative predictive value, with the random forest model performing the best in both internal and external validation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Corey K. Bradley, Eunhee Choi, Marwah Abdalla, Hiroyuki Mizuno, Michael Lam, Maria Cepeda, Dona Sangapalaarachchi, Justin Liu, Paul Muntner, Kazuomi Kario, Anthony J. Viera, Joseph E. Schwartz, Daichi Shimbo
Summary: For most people, high home blood pressure can be identified or ruled out with a high degree of confidence within 3 days or less of monitoring.
Article
Peripheral Vascular Disease
Claudia R. L. Cardoso, Gil F. Salles
Summary: Home blood pressure monitoring is increasingly used in managing hypertension. This study found that higher/uncontrolled HBP levels are predictive of adverse cardiovascular outcomes and mortality in patients with resistant hypertension. Morning HBP was associated with the highest risks, and HBP parameters improved risk discrimination in comparison with office and ambulatory blood pressures.
Article
Peripheral Vascular Disease
Hiroaki Watanabe, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
Summary: In obese patients, atrial fibrillation was found to be an independent predictor of cardiovascular events after adjusting for home blood pressure. Among non-obese individuals, there was no significant difference in cardiovascular event rates between atrial fibrillation patients and those with sinus rhythm. Additionally, home systolic blood pressure was also identified as a predictor of cardiovascular events in obese patients independent of atrial fibrillation risk.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Marco A. M. Alves, Audes D. M. Feitosa, Marco A. Mota-Gomes, Annelise M. G. Paiva, Weimar S. Barroso, Roberto D. Miranda, Eduardo C. D. Barbosa, Andrea A. Brandao, Paulo G. S. Diniz, Otavio Berwanger, Jose L. Lima-Filho, Andrei C. Sposito, Antonio Coca, Wilson Nadruz
Summary: This study found that the accuracy of guideline-proposed office blood pressure screening thresholds in identifying individuals at high risk of having masked hypertension in an office setting is limited and is inferior to that yielded by scores derived from simple clinical variables.
HYPERTENSION RESEARCH
(2023)
Article
Critical Care Medicine
Ghaleb Khirfan, Celia A. Melillo, Sami Al Abdi, James E. Lane, Raed A. Dweik, Robert L. Chatburn, Umur Hatipoglu, Adriano R. Tonelli
Summary: This study shows that adjusting pulmonary hemodynamics for esophageal pressure (P-es) in patients with obesity significantly reduces the number of diagnoses of postcapillary pulmonary hypertension (PH). Measuring P-es should be considered in obese patients, especially those with elevated PAWP.
Review
Endocrinology & Metabolism
Hyun-Jin Kim, Kwang-il Kim
Summary: This review discusses the optimal blood pressure targets for patients with diabetes mellitus and summarizes the recommendations from different guidelines. A target blood pressure of <140/90 mm Hg is recommended, and <130/80 mm Hg for patients with diabetes mellitus who have high-risk clinical features.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Medicine, General & Internal
Edward J. . Filippone, Andrew J. . Foy, Gerald V. Naccarelli
Summary: A comprehensive approach for managing hypertension requires monitoring blood pressure at home or outside the clinic. Different phenotypes of patients (treated and untreated) have been identified, including normotension, hypertension, white-coat phenomena, and masked phenomena. Out-of-office pressure components, such as nighttime pressures, play an equally important role as mean values. Abnormalities in nighttime pressure have been associated with increased cardiovascular risk. It is important to determine the justification of altering therapy based solely on abnormal dipping, isolated nocturnal hypertension, or an abnormal surge through randomized trials.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Koichi Nagashima, Takafumi Hiro, Daisuke Fukamachi, Yasuo Okumura, Ichiro Watanabe, Atsushi Hirayama, Masashi Tanaka, Tomofumi Tanaka, Itaru Takamisawa, Isao Taguchi, Akira Sato, Kazutaka Aonuma, Seiji Fukamizu, Akihiro Nakada, Atsuyuki Watanabe, Naofumi Amioka, Yasuyuki Suzuki, Naoya Matsumoto, Junichi Koizumi, Kazuya Kumagai, Masanao Naya, Yoshiharu Higuchi, Yoshiro Naito, Tohru Masuyama, Mitsuharu Kawamura, Ryusuke Tsunoda, Susumu Suzuki, Hideki Ishii, Toyoaki Murohara, Takeshi Shimizu, Yasuchika Takeishi, Kazuki Shiina, Jun Yamashita, Tomohiko Imamura, Naokata Sumitomo, Teruo Noguchi, Toshihide Aso, Kojiro Furukawa, Yasuteru Yamauchi, Kaoru Okishige, Kenji Sakata, Masakazu Yamagishi, Shigeo Shimizu, Masakazu Ohno, Teruyasu Sugano, Koichiro Matsumura, Kensuke Matsumoto, Kazuyuki Ozaki, Shunji Hayashidani, Hiroshi Meno, Atsushi Iwata, Takumi Higuma, Hirofumi Tomita, Hideaki Yoshino, Seiichi Taniai, Koki Shishido, Masato Murakami, Koji Negishi, Masaki Nii, Daisuke Wakatsuki, Hiroshi Suzuki, Yuji Motoike, Yukio Ozaki, Jun Nakazato, Hidemori Hayashi, Satoshi Higuchi, Morio Shoda
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Toru Adachi, Akira Sato, Kenji Kuroki, Tomoko Terai, Daisuke Hanaoka, Daigo Hiraya, Takeshi Machino, Akihiko Nogami, Masaki Ieda, Kazutaka Aonuma
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Medicine, General & Internal
Robert Haase, Peter Schlattmann, Pascal Gueret, Daniele Andreini, Gianluca Pontone, Hatem Alkadhi, Joerg Hausleiter, Mario J. Garcia, Sebastian Leschka, Willem B. Meijboom, Elke Zimmermann, Bernhard Gerber, U. Joseph Schoepf, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Akira Sato, Kristian A. Ovrehus, Axel C. P. Diederichsen, Shona M. M. Jenkins, Juhani Knuuti, Ashraf Hamdan, Bjorn A. Halvorsen, Vladimir Mendoza-Rodriguez, Carlos E. Rochitte, Johannes Rixe, Yung Liang Wan, Christoph Langer, Nuno Bettencourt, Eugenio Martuscelli, Said Ghostine, Ronny R. Buechel, Konstantin Nikolaou, Hans Mickley, Lin Yang, Zhaqoi Zhang, Marcus Y. Chen, David A. Halon, Matthias Rief, Kai Sun, Beatrice Hirt-Moch, Hiroyuki Niinuma, Roy P. Marcus, Simone Muraglia, Reda Jakamy, Benjamin J. Chow, Philipp A. Kaufmann, Jean-Claude Tardif, Cesar Nomura, Klaus F. Kofoed, Jean-Pierre Laissy, Armin Arbab-Zadeh, Kakuya Kitagawa, Roger Laham, Masahiro Jinzaki, John Hoe, Frank J. Rybicki, Arthur Scholte, Narinder Paul, Swee Y. Tan, Kunihiro Yoshioka, Robert Roehle, Georg M. Schuetz, Sabine Schueler, Maria H. Coenen, Viktoria Wieske, Stephan Achenbach, Matthew J. Budoff, Michael Laule, David E. Newby, Marc Dewey
BMJ-BRITISH MEDICAL JOURNAL
(2019)
Article
Clinical Neurology
Hiroki Watanabe, Akira Koike, Yo Joon Pak, Longmei Wu, Hiroshi Kubota, Hirotomo Konno, Akira Sato, Hiroaki Kawamoto, Akira Matsumura, Kazutaka Aonuma, Yoshiyuki Sankai, Masaki Leda
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Daigo Hiraya, Akira Sato, Tomoya Hoshi, Masaki Ieda
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Daigo Hiraya, Akira Sato, Hiroaki Watabe, Tomoya Hoshi, Masaki Ieda
Article
Cardiac & Cardiovascular Systems
Tomoya Hoshi, Daigo Hiraya, Akira Sato, Masaki Ieda
Summary: Careful antithrombotic management is crucial for minimizing the risk of thromboembolism and bleeding in patients with Antiphospholipid syndrome undergoing surgical treatments.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Shunsuke Sakai, Akira Sato, Tomoya Hoshi, Masaki Ieda
EUROPEAN HEART JOURNAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Manabu Uematsu, Ryota Yamada, Akira Sato
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Koji Sudo, Kenji Kuroki, Akira Sato
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Koji Sudo, Kenji Kuroki, Kazuya Nakagawa, Tetsuya Asakawa, Kazutaka Aonuma, Akira Sato
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Koji Sudo, Manabu Uematsu, Jumpei Suzuki, Kenji Kuroki, Akira Sato
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Kenji Kuroki, Masayoshi Yamamoto, Akira Sato
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Takeo Horikoshi, Tsuyoshi Kobayashi, Akira Sato
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Peripheral Vascular Disease
Tomomi Koizumi, Hideaki Kaneda, Shunsuke Sakai, Akira Sato, Kazutaka Aonuma
ANNALS OF VASCULAR DISEASES
(2019)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
