Article
Agriculture, Dairy & Animal Science
Jinsol Jeong, Kwang-Hwan Choi, Seung-Hun Kim, Dong-Kyung Lee, Jong-Nam Oh, Mingyun Lee, Gyung Cheol Choe, Chang-Kyu Lee
Summary: In this study, pig embryonic fibroblasts were transdifferentiated into skeletal muscle through overexpression of the MYOD1 gene and modulation of signaling pathways. The use of signaling molecules with MYOD1 overexpression led to the formation of myotubes and activation of muscle markers in PEFs. This myogenic reprogramming protocol could be valuable for muscle disease models and cultured meat production in regenerative medicine and cellular agriculture.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Benjamin Gellhaus, Kai O. Boeker, Marlene Gsaenger, Eyck Rodenwaldt, Marc A. Hueser, Arndt F. Schilling, Dominik Saul
Summary: Sarcopenia, a prevalent condition among the elderly, has significant socioeconomic importance due to its association with falls, hospitalization, increased healthcare costs, and diminished quality of life. The transcription factor FOXO3 plays a crucial role in muscle equilibrium and can upregulate the expression of Fbxo32, a key driver of muscle protein degradation. This study explored the hypothesis that targeting FOXO3 could regulate this detrimental pathway.
Article
Dermatology
Min Zhou, Hao Zhang, Hairen Chen, Baiwen Qi
Summary: This study reveals that adiponectin protects skeletal muscle from ischemia-reperfusion injury through the miR-21/PI3K/Akt signaling pathway by inhibiting inflammatory response, apoptosis, and autophagy.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Physiology
Arkady Uryash, Alfredo Mijares, Carlos E. Lopez, Jose A. Adams, Jose R. Lopez
Summary: Chronic elevated muscle Ca2+ levels may decrease insulin-stimulated glucose uptake, leading to hyperglycemia. By reducing muscle Ca2+ levels, muscle glucose uptake can be improved, alleviating hyperglycemia. This phenomenon may be related to the expression and subcellular fractionation of GLUT4.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yan He, Miao Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu, Bin Li
Summary: The PI3K/Akt signaling pathway plays a crucial role in cancer, and targeting inhibitors against it may aid in drug discovery. Additionally, combining pathway inhibitors with other cancer treatment strategies could be an effective approach to solving therapeutic dilemmas.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Food Science & Technology
Bingting Chen, Yilzera Abaydula, Delong Li, Huiwen Tan, Xiaoli Ma
Summary: The study showed that taurine can alleviate insulin resistance in HepG2 cells and improve blood glucose levels and oxidative stress in T2DM rats. Taurine's effects are partly attributed to its activation of the PI3K/Akt/GLUT4 pathway, suggesting potential benefits in treating diabetes-related dysfunction.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Endocrinology & Metabolism
Pablo Panico, Myrian Velasco, Ana Maria Salazar, Patricia Ostrosky-Wegman, Marcia Hiriart
Summary: This study evaluated the effects of sucrose and arsenic exposure on the pathways involved in insulin-stimulated GLUT4 translocation in muscle. The results showed that sucrose and arsenic exposure induced systemic insulin resistance, with defects in GLUT4 retention and docking in the quadriceps muscle, and impacts on the Akt pathway and proteolytic pathway in the gastrocnemius muscle.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samaneh Eickelschulte, Sonja Hartwig, Ben Leiser, Stefan Lehr, Viola Joschko, Manopriya Chokkalingam, Alexandra Chadt, Hadi Al-Hasani
Summary: TBC1D4 is a multidomain Rab GTPase-activating protein that plays a role in GLUT4 trafficking. Phosphorylation by AKT and AMPK does not affect enzymatic activity but disrupts interaction with other proteins. Insulin and contraction regulate TBC1D4 primarily by disrupting recruitment to GLUT4 vesicles.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Selvaraj Jayaraman, Kalaiselvi Krishnamoorthy, Monisha Prasad, Vishnu Priya Veeraraghavan, Rajapandiyan Krishnamoorthy, Mohammad A. Alshuniaber, Mansour K. Gatasheh, Mohamed Elrobh, Gunassekaran
Summary: Herbicides, particularly glyphosate, have been found to increase the risk of developing diabetes by negatively affecting insulin signaling pathways in skeletal muscle. Glyphosate exposure leads to hyperglycemia, dyslipidemia, and oxidative stress, while reducing antioxidant enzymes. It alters the expression of key molecules involved in insulin metabolism and shows a high binding affinity with them. These findings provide experimental evidence linking glyphosate exposure to insulin resistance and the development of type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mira Oh, Seo-Young Kim, SeonJu Park, Kil-Nam Kim, Seung Hyun Kim
Summary: Chinese chive contains compounds that can promote skeletal muscle cell proliferation, with newly isolated flavonoid and 5-aminouridine showing positive effects on skeletal muscle growth by up-regulating PI3K/Akt/mTOR pathways. Additionally, the isolated compound 1 down-regulated the Smad pathways, which are negative regulators of skeletal muscle growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mirko Magnone, Sonia Spinelli, Giulia Begani, Lucrezia Guida, Laura Sturla, Laura Emionite, Elena Zocchi
Summary: This study demonstrates that the plant hormone ABA can improve glycemic control and enhance muscle insulin sensitivity and glucose uptake in a murine model of T1D.
Article
Pharmacology & Pharmacy
Meirong Yu, Shuang Wu, Chao Gong, Lianhua Chen
Summary: This study investigated whether Neuregulin-1 beta increased glucose uptake and GLUT4 translocation in palmitate-treated C2C12 myotubes. The results showed that Neuregulin-1 beta not only promoted glucose uptake in palmitate-treated myotubes, but also facilitated GLUT4 translocation to the plasma membrane. This effect was associated with the activation of the PI3K/AKT signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ewa Swiderska, Justyna Strycharz, Adam Wroblewski, Piotr Czarny, Janusz Szemraj, Jozef Drzewoski, Agnieszka Sliwinska
Summary: Chronic and intermittent hyperglycemia affect insulin signaling in visceral pre/adipocytes by upregulating analyzed PI3K/AKT pathway molecules. Both mRNA and protein expression levels are more dependent on stage-specific events than the length of the period of high glucose exposure. Additionally, changes in miR expression seem to be involved in the regulation of PI3K/AKT expression in response to hyperglycemic stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Automation & Control Systems
Yara Hamshawi, Florin-Daniel Bilbie, Andrei Paun, Assaf Malka, Ron Piran
Summary: Membrane computing, a subfield of natural computing, models living systems using mathematical tools. Researchers have developed a new conceptual tool to better fit P-systems to higher-order organisms and successfully simulated glucose homeostasis in health and disease.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2022)
Article
Plant Sciences
Minna Huang, Yan Yan, Zihao Deng, Lingli Zhou, Meiling She, Yajun Yang, Meng Zhang, Dongtao Wang
Summary: Saikosaponin A and D, two emerging antioxidants extracted from Bupleurum chinense DC, were found to alleviate muscle atrophy in chronic kidney disease (CKD) by reducing oxidative stress through the PI3K/AKT/Nrf2 pathway.
Letter
Sport Sciences
Leonardo Vidal Andreato, Braulio Henrique Magnani Branco, Joao Victor Esteves
JOURNAL OF SPORTS SCIENCES
(2019)
Article
Endocrinology & Metabolism
Daniele Pereira Santos-Bezerra, Sharon Nina Admoni, Rosana Cristina Mori, Tatiana Souza Pelaes, Ricardo Vesoni Perez, Cleide Guimaraes Machado, Maria Beatriz Monteiro, Maria Candida Parisi, Elizabeth Joao Pavin, Marcia Silva Queiroz, Marisa Passarelli, Ubiratan Fabres Machado, Maria Lucia Correa-Giannella
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Cell Biology
Caio Y. Yonamine, Ana B. Alves-Wagner, Joao Esteves, Maristela M. Okamoto, Maria L. Correa-Giannella, Daniel Giannella-Neto, Ubiratan F. Machado
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Letter
Endocrinology & Metabolism
Joao J. Garavelo, Liandro R. Altimari, Juliano M. Gabardo, Adalberto Ferreira-Junior, Luis A. G. Freitas, Cosme F. Buzzachera, Joao V. D. C. Esteves, Sergio G. da Silva, Solange M. F. de Moraes
OBESITY RESEARCH & CLINICAL PRACTICE
(2019)
Article
Hospitality, Leisure, Sport & Tourism
Ursula F. Julio, Valeria L. G. Panissa, Rubiana L. Cury, Marcus F. Agostinho, Joao V. D. C. Esteves, Emerson Franchini
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2019)
Article
Medicine, Research & Experimental
Rosana Cristina Mori, Thais Pocas da Silva, Raquel Saldanha Campello, Ubiratan Fabres Machado
Editorial Material
Medicine, Research & Experimental
Joao V. Esteves, Caio Y. Yonamine, Ubiratan F. Machado
BIOMARKERS IN MEDICINE
(2020)
Article
Endocrinology & Metabolism
Rosana Cristina Mori, Daniele Pereira Santos-Bezerra, Tatiana Souza Pelaes, Sharon Nina Admoni, Ricardo Vessoni Perez, Maria Beatriz Monteiro, Cleide Guimaraes Machado, Marcia Silva Queiroz, Ubiratan Fabres Machado, Maria Lucia Correa-Giannella
Summary: The study revealed an association between SNPs in the HSD11B1 gene and susceptibility to DKD and IR in individuals with T1D. Certain SNPs were found to be associated with diabetic retinopathy, overt diabetic kidney disease, and arterial hypertension, suggesting a role in microvascular complications and insulin resistance.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Endocrinology & Metabolism
Aline David-Silva, Joao Victor Esteves, Mychel Raony P. T. Morais, Helayne Soares Freitas, Telma Maria Zorn, Maria Lucia Correa-Giannella, Ubiratan Fabres Machado
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Letter
Sport Sciences
Joao Victor Esteves, Leonardo Vidal Andreato
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2020)
Letter
Endocrinology & Metabolism
Leonardo Vidal Andreato, Alexandro Andrade, Joao Victor Esteves
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Meeting Abstract
Endocrinology & Metabolism
J. V. Esteves, L. S. Amendola, M. M. Okamoto, U. F. Machado
Article
Sport Sciences
Adalberto Ferreira Junior, Joao Julio Garavelo, Leandro Ricardo Altimari, Juliano Moro Gabardo, Luis Alberto Garcia Freitas, Cosme Franklim Buzzachera, Joao Victor Del Conti Esteves, Sergio Gregorio da Silva, Solange Marta Franzoi de Moraes
SPORT SCIENCES FOR HEALTH
(2020)
Letter
Geriatrics & Gerontology
Joao Victor Esteves, Sonia Maria Marques Gomes Bertolini, Leonardo Vidal Andreato
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.