Article
Pharmacology & Pharmacy
Zeyu Zhang, Chunlei Liu, Yongyi Bai, Xin Li, Xiaojian Gao, Chen Li, Ge Guo, Si Chen, Mingzhuang Sun, Kang Liu, Yang Li, Kunlun He
Summary: A novel endothelin receptor antagonist, pipersentan, has been synthesized and shown to effectively treat ET-1 system activation-related pulmonary arterial hypertension, making it a potential new therapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Gerd Wallukat, Stephan Mattecka, Katrin Wenzel, Wieland Schroedl, Birgit Vogt, Patrizia Brunner, Ahmed Sheriff, Rudolf Kunze
Summary: This study found that C-reactive protein (CRP) affects intracellular calcium signaling and blood pressure. When CRP is combined with GPCR agonists in cardiomyocytes, it can interfere with the desensitization of GPCRs, regardless of the type of GPCR, but dependent on the concentration of CRP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ruiqi Liu, Tianyi Yuan, Ranran Wang, Difei Gong, Shoubao Wang, Guanhua Du, Lianhua Fang
Summary: This paper reviews the regulation of endothelin receptors and their pathways in normal physiological processes and disease processes, and describes the mechanistic roles of ET receptor antagonists that are currently approved and used in clinical studies. Current clinical researches on ET are focused on the development of multi-target combinations and novel delivery methods to improve efficacy and patient compliance while reducing side effects. Future research directions and trends of ET targets, including monotherapy and precision medicine, are also described in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yaritza Inostroza-Nieves, Alicia Rivera, Jose R. Romero
Summary: A study found that Major Histocompatibility Complex (MHC) molecules play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules after exposure to cytokines. SCD is characterized by vascular endothelial cell activation, oxidative stress, sickle cell adhesion, and excess levels of endothelin-1 (ET-1). The study suggests that ET-1 is a novel regulator of MHC class II molecules and ET-1 receptor blockade may be a promising therapeutic approach for regulating immune and vascular responses in SCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Hiddo J. L. Heerspink, Arihiro Kiyosue, David C. Wheeler, Min Lin, Emma Wijkmark, Glenn Carlson, Anne-Kristina Mercier, Magnus Astrand, Sebastian Ueckert, Peter J. Greasley, Phil Ambery
Summary: This study evaluated the efficacy and safety of the ERA zibotentan combined with the SGLT2 inhibitor dapagliflozin in reducing albuminuria and protecting kidney function.
Review
Health Care Sciences & Services
Marwa Saadaoui, Manoj Kumar, Souhaila Al Khodor
Summary: The COVID-19 pandemic is a global public health challenge, with pregnant women potentially facing the risk of vertical transmission of the virus to their fetus or infant. However, limited data and information on the impact of maternal infection during pregnancy are available, highlighting the importance of understanding the effects on pregnant women and their offspring.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jee Yoon Park, Huiyoung Yun, Seung-been Lee, Hyeon Ji Kim, Young Hwa Jung, Chang Won Choi, Jong-Yeon Shin, Joong Shin Park, Jeong-Sun Seo
Summary: This study comprehensively characterizes the microbiomes of pregnant women and their neonates, revealing microbial colonization in previously considered sterile intrauterine environments. The microbiome distribution is primarily determined by sample collection site rather than mother-neonate pairs. The distinct bacterial composition in meconium supports microbial colonization during normal pregnancy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jee Yoon Park, Huiyoung Yun, Seung-been Lee, Hyeon Ji Kim, Young Hwa Jung, Chang Won Choi, Jong-Yeon Shin, Joong Shin Park, Jeong-Sun Seo
Summary: This study aimed to comprehensively characterize the microbiomes of pregnant women and their neonates, exploring similarities and associations between different samples, sample collection sites, and obstetrical factors. The findings suggest evidence of microbial colonization in traditionally considered sterile intrauterine environments and fetal gastrointestinal tract. Microbiome distribution was strongly grouped by sample collection site, rather than mother-neonate pairs.
SCIENTIFIC REPORTS
(2023)
Review
Urology & Nephrology
Donald E. Kohan, Jonathan Barratt, Hiddo J. Heerspink, Kirk N. Campbell, Mariannne Camargo, Ike Ogbaa, Ruth Haile-Meskale, Dana V. Rizk, Andrew King
Summary: Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephritis worldwide. New therapies, including endothelin-A receptor (ETAR) blockade, show promise for mitigating renal deterioration and reducing proteinuria in patients with IgAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Kim N. N. Cajachagua-Torres, Sophia M. M. Blaauwendraad, Hanan El Marroun, Hans Demmelmair, Berthold Koletzko, Romy Gaillard, Vincent W. V. Jaddoe
Summary: Fetal tobacco exposure is associated with changes in neonatal metabolite profiles, with different effects observed during different stages of maternal smoking.
Article
Immunology
Garima Singh, Bradley J. Segura, Michael K. Georgieff, Tate Gisslen
Summary: Research shows that prenatal LPS exposure-induced FIRS attenuates the hippocampal immune response to postnatal LPS in premature infants, without evidence of immune tolerance.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Yash Pandya, Alexander Marta, Andre Barateiro, Carla Leticia Bandeira, Jamille Gregorio Dombrowski, Joao Costa, Claudio Romero Farias Marinho, Carlos Penha-Goncalves
Summary: Pregnancy-associated malaria may affect placental endothelin gene expression and endothelin receptor B protein levels by interfering with maternal and fetal TLR4 alleles. Fetal protection during Plasmodium infection is mediated by fetal TLR4 signaling, which controls trophoblast motility and vasoregulatory responses in the placenta. These findings highlight the importance of fetal innate immune sensing in protecting against adverse pregnancy outcomes associated with malaria.
INFECTION AND IMMUNITY
(2021)
Review
Pharmacology & Pharmacy
Martine Clozel
Summary: Endothelin plays a key role in systemic hypertension and resistant hypertension may depend on endothelin. Aprocitentan, a novel ERA, shows potential for the treatment of difficult-to-treat hypertension.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yui Kuroda, Miki Nonaka, Yuji Kamikubo, Haruo Ogawa, Takashi Murayama, Nagomi Kurebayashi, Hakushun Sakairi, Kanako Miyano, Akane Komatsu, Tetsushi Dodo, Kyoko Nakano-Ito, Keisuke Yamaguchi, Takashi Sakurai, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono
Summary: The research found that the endothelin A receptor may affect pain mechanisms by heterodimerization with the mu opioid receptor, and the ETAR antagonist Compound-E can enhance the analgesic effects of morphine. These findings provide a new approach to reducing opioid use.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Noha Abdel-Aziz Nassef, Manal S. S. Abd-El Hamid, Samy A. A. Abusikkien, Asmaa Ibrahim Ahmed
Summary: This study investigated the protective effect of quercetin on acute lung injury in a BDL model. The results showed that quercetin can alleviate lung injury induced by hepatopulmonary syndrome through its anti-inflammatory, antioxidative, and antifibrotic effects.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.