Article
Oncology
Michala G. Rolver, Lya K. K. Holland, Muthulakshmi Ponniah, Nanditha S. Prasad, Jiayi Yao, Julie Schnipper, Signe Kramer, Line Elingaard-Larsen, Elena Pedraz-Cuesta, Bin Liu, Luis A. Pardo, Kenji Maeda, Albin Sandelin, Stine Falsig Pedersen
Summary: The mechanisms connecting acidic tumor microenvironments to disease progression are not yet fully understood. This study reveals that cancer cells adapted to an acidic pH environment exhibit increased capacity for acid extrusion and higher intracellular pH at physiological pH levels. This adaptation is associated with metabolic changes favoring oxidative metabolism, increased lipid content, peroxisome proliferation, and mitochondrial fusion. The upregulation of PPAR alpha, stimulated by increased fatty acid uptake, drives the metabolic changes by promoting mitochondrial and peroxisomal energy metabolism while limiting glycolysis. Inhibition of PPAR alpha results in increased sensitivity of acid-adapted cancer cells.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Aisha Rasool, Taysir Mahmoud, Begum Mathyk, Tomoko Kaneko-Tarui, Danielle Roncari, Katharine O. White, Perrie O'Tierney-Ginn
Summary: Placentas of obese women show impaired fatty acid metabolism and lipid accumulation from early pregnancy. The expression of genes associated with fatty acid oxidation, uptake, synthesis, and storage is reduced in these placentas, particularly in placentas of male fetuses. The PPAR alpha pathway is impacted by obesity and PPAR alpha antagonism reduces fatty acid oxidation in 1st trimester placental explants.
SCIENTIFIC REPORTS
(2022)
Article
Sport Sciences
S. E. A. N. A. NEWSOM, H. A. R. R. I. S. O. N. D. STIERWALT, S. A. R. A. H. E. EHRLICHER, M. A. T. T. H. E. W. M. ROBINSON
Summary: In sedentary adults, a single bout of moderate-intensity cycling induces modest increases in intrinsic mitochondrial oxidative phosphorylation that are consistent across multiple substrates.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Multidisciplinary Sciences
Hassan Sadri, Morteza Hosseini Ghaffari, Katharina Schuh, Christian Koch, Helga Sauerwein
Summary: The study compared muscle metabolome and mRNA abundance of genes related to lipogenesis and lipolysis in dairy cows classified as high BCS predicted high, high BCS predicted normal, and normal BCS predicted normal. Results showed that metabolically healthy cows had higher oxidative capacity for fatty acids in muscle.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hai-Xin Chen, Fan Yang, Xin-Qian He, Ting Li, Yong-Zhi Sun, Jian-Ping Song, Xin-An Huang, Wen-Feng Guo
Summary: The study found that Garcinia biflavonoid 1 (GB1) can improve non-alcoholic fatty liver disease by regulating PPAR alpha. GB1 can reduce lipid deposition and oxidative stress, and suppress cell apoptosis. The study revealed the significant role of GB1 in improving lipid metabolism.
Article
Cell Biology
Sharon J. Manley, Appolinaire A. Olou, Jarrid L. Jack, Mariana T. Ruckert, R. McKinnon Walsh, Austin E. Eades, Bailey A. Bye, Joe Ambrose, Fanuel Messaggio, Shrikant Anant, Michael N. VanSaun
Summary: Obesity causes inflammation in adipose tissue, leading to changes in secretion of adipocyte-derived factors and contributing to various pathologies, including cancer. In this study, the synthetic adiponectin receptor agonist AdipoRon was found to affect pancreatic cancer cell metabolism, leading to mitochondrial uncoupling and decreased ATP production, increased glucose uptake and utilization, and inhibition of a factor involved in fatty acid catabolism. Additionally, inhibition of glycolysis impaired the growth and survival of pancreatic cancer cells. These findings suggest that pancreatic cancer cells adapt to suppression of oxidative phosphorylation by upregulating glycolysis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Bailey A. Loving, Maoping Tang, Mikaela C. Neal, Sachi Gorkhali, Robert Murphy, Robert H. Eckel, Kimberley D. Bruce
Summary: As individuals age, dysfunctional microglia may contribute to the onset of neurodegenerative diseases through impaired phagocytosis, cholesterol efflux, and enhanced secretion of pro-inflammatory cytokines. Specifically, microglia lacking lipoprotein lipase exhibit a pro-inflammatory lipid profile, increased cholesterol ester content, and reduced cholesterol efflux, leading to excessive accumulation of lipid droplets. Activation of PPAR pathways by agonists can rescue this phenotype, suggesting a potential therapeutic strategy for aging and neurodegenerative diseases.
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Chuting Li, Xuting Zhang, Jie Li, Liyin Liang, Jingran Zeng, Min Wen, Linjie Pan, Dongxin Lv, Min Liu, Yuanyuan Cheng, Heqing Huang
Summary: The purpose of this study was to investigate the effects of GRb1 on heart failure (HF) and cardiac energy metabolism. The results showed that GRb1 could improve cardiac function by protecting mitochondrial function, inhibiting oxidative stress, and promoting ATP synthesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyan Chen, Wenjie Shi, Yong Xie, Yunwu Wang, Qian Yao, Huajing Ke, Xuan Xu, Hui Liu, Pi Liu, Xiaojiang Zhou
Summary: This study investigates the role of Kruppel-like factor 14 (KLF14) in hepatic lipid metabolism in nonalcoholic steatohepatitis (NASH). The expression of KLF14 was found to be decreased in NASH patients and mice fed a high-fat diet. Knockdown of KLF14 promoted the progression of hepatic steatosis by downregulating fatty acid oxidation genes.
Article
Biochemistry & Molecular Biology
Xiaoyan Chen, Wenjie Shi, Yong Xie, Yunwu Wang, Qian Yao, Huajing Ke, Xuan Xu, Hui Liu, Pi Liu, Xiaojiang Zhou
Summary: This study investigated the role of Kruppel-like factor 14 (KLF14) in hepatic lipid metabolism and its mechanism in nonalcoholic steatohepatitis (NASH). The expression of KLF14 was found to be decreased in NASH patients and mice fed a high-fat diet. Overexpression of KLF14 alleviated lipid accumulation and oxidative stress in the mouse model of NASH through the activation of the PPARa pathway.
Article
Food Science & Technology
Qian-Wen Zheng, Xu-Fen Ding, Hui-Jun Cao, Qian-Zhi Ni, Bing Zhu, Ning Ma, Feng-Kun Zhang, Yi-Kang Wang, Sheng Xu, Tian-Wei Chen, Ji Xia, Xiao-Song Qiu, Dian-Zhen Yu, Dong Xie, Jing-Jing Li
Summary: Ochratoxin A (OTA) is a major contaminant in food and feed that can induce hepatic steatosis by activating the PPAR gamma-CD36 axis, leading to lipid accumulation and triglyceride deposition in the liver, which may increase the risk of metabolic diseases.
Article
Nutrition & Dietetics
Liali Aljouda, Laura Nagy, Andreas Schulze
Summary: This study investigated the effectiveness of a diet restricted in long-chain triglycerides (LCTs) and supplemented with medium-chain triglycerides (MCTs) in reducing triglyceride levels and symptoms in children with lipoprotein lipase (LPL) deficiency. Results showed that the diet led to a significant drop in triglyceride levels in LPL patients and no disease-specific manifestations or complications. The study suggests that the LCT-restricted and MCT-supplemented diet is a feasible, well-tolerated, and clinically effective long-term management option for pediatric patients with LPL deficiency.
Article
Environmental Sciences
Hu Zhang, Chao Zhao, Ying Zhang, Lu Lu, Wei Shi, Qian Zhou, Yuepu Pu, Shizhi Wang, Ran Liu, Lihong Yin
Summary: This study investigated the tumorigenic mechanism of N-nitrosomethylbenzylamine (NMBA) exposure using both cell and rat models. It was found that NMBA exposure induced malignant transformation of esophageal cells and promoted the development of esophageal carcinoma through the activation of the fatty acid-associated PPAR alpha signaling pathway. Animal studies also confirmed the association between accelerated fatty acid decomposition and the progression of NMBA-induced esophageal carcinoma. These findings provide valuable insights into the carcinogenic risk assessment of N-nitrosamines.
ENVIRONMENTAL POLLUTION
(2023)
Article
Endocrinology & Metabolism
Jiesi Xu, Zhenglong Liu, Jianxin Zhang, Siyu Chen, Wei Wang, Xuefan Zhao, Mei Zhen, Xun Huang
Summary: Cellular lipid storage is regulated by the balance of lipogenesis and lipolysis. In this study, we showed that the protein stability of ATGL is regulated by the N-end rule in cultured cells and in mice. Our findings reveal the N-end rule-mediated proteasomal regulation of ATGL, which may have potential implications for the treatment of obesity.
Article
Psychology, Clinical
Edna M. Sant'Anna, Sara P. C. Paiva, Raphael P. Santos, Ana M. S. Rodrigues, Nakita A. Davis, Simone F. Nery, Fernanda P. Maia, Adaliene V. M. Ferreira, Fernando M. Reis
Summary: In the short term, the mindfulness-based program did not lead to weight loss in infertile women, but it did contribute to a reduction in waist circumference, possibly due to a decrease in food energy intake.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2022)
Article
Neurosciences
Mariele Lino Silva, Lais Bhering Martins, Luana Caroline dos Santos, Gilberto Simeone Henriques, Antonio Lucio Teixeira, Ana Maria dos Santos Rodrigues, Adaliene Versiani Matos Ferreira
Summary: This study suggests that patients with migraine have lower plasma levels of minerals and lower dietary intake of minerals compared to individuals without migraine. It highlights the importance of dietary intervention to ensure adequate mineral intake as a therapeutic strategy for migraine.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Agriculture, Multidisciplinary
J. R. Oliveira, J. M. O. Andrade, D. de F. Lelis, A. F. Paraiso, A. M. B. de Paula, A. L. S. Guimaraes, J. P. Lima, J. Cota, D. da Costa, S. H. S. Santos
Summary: The aim of this study was to evaluate the impact of Madagascar cockroach flour on body composition, biochemistry, and inflammation in the liver of obese mice. The results showed that the group treated with HFD-CF had lower levels of fasting glucose, total cholesterol, triglycerides, and pyruvic transaminase/aspartate aminotransferase compared to the HFD group. Additionally, the HFD+CF group exhibited reduced levels of liver interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) expression. These findings suggest that Madagascar cockroach flour may serve as a beneficial dietary supplement to improve biochemical and inflammatory alterations caused by obesity.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Nursing
Ana Paula dos Santos Xavier Braga, Diana Matos Silva, Deborah de Farias Lelis, Rogerio Estevam Farias, Alanna Fernandes Paraiso, Sergio Henrique Sousa Santos, Andrea Maria Eleuterio de Barros Lima Martins, Joao Marcus Oliveira Andrade
Summary: This study evaluated the expression levels of apelin and visfatin mRNA in placental tissue of women with preeclampsia and overweight/obesity and correlated it with maternal and fetal variables. The main findings showed lower levels of apelin expression in overweight/obese women, and a negative correlation with BMI and pre-pregnancy weight. Higher expression levels of apelin were observed in women with late PE and no personal history of PE. Higher visfatin expression levels were observed in women with late PE and term delivery, and a positive correlation was observed between visfatin levels and fetal anthropometric parameters.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Review
Biochemistry & Molecular Biology
Victor Hugo Dantas Guimaraes, Barbhara Mota Marinho, Daisy Motta-Santos, Gabriela da Rocha Lemos Mendes, Sergio Henrique Sousa Santos
Summary: Obesity and metabolic disorders are significant global health problems, and the gut microbiota plays a crucial role in regulating systemic homeostasis. Recent evidence suggests that the microbiota and its signaling pathways can influence overall metabolism and the Renin-Angiotensin System (RAS), which, in turn, may impact the microbiota. This review aims to explore the nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome. It discusses the metabolic changes associated with obesity, diabetes, and hepatic steatosis based on relevant scientific literature, as well as the molecular and physiological mechanisms that affect the human microbiome. The review also analyzes the interaction and modulation of the RAS. Strategies such as the use of prebiotics, symbiotics, probiotics, and biotechnology may have an impact on gut microbiota and human health.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gabriela C. Cerri, Sergio H. S. Santos, Michael Bader, Robson A. S. Santos
Summary: Alamandine is a newly described component of the renin-angiotensin system (RAS) and its effects are mediated by the receptor Mas-related G protein-coupled receptor D (MrgD). This study aimed to assess the metabolic consequences of MrgD genetic ablation in mice by evaluating brown adipose tissue RNA sequencing. The results showed that MrgD-KO mice have diminished brown adipose tissue and a high-glucose diet decreased both circulating alamandine levels and MrgD expression in BAT from wild-type mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Psychology, Multidisciplinary
Luana Lemos Leao, Weslley Gomes de Araujo Valadares, Nayra Suze Souza e Silva, Stenio Fernando Pimentel Duarte, Alfredo Mauricio Batista de Paula, Desiree Sant'Ana Haikal, Sergio Henrique Sousa Santos, Jeane Soares, Joelton Cruz, Jordana Santos, Gustavo Leal Teixeira, Renato Sobral Monteiro-Junior
Summary: The COVID-19 pandemic has led to increased depression and other mental disorders in the general population, influenced by various individual and contextual factors. Physical activity interventions, both before and during the pandemic, are associated with a lower risk of depressive symptoms.
BEHAVIORAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Kavaljit H. Chhabra, Siresha Bathina, Tumininu S. Faniyan, Dennis J. Samuel, Muhammad Ummear Raza, Leticia Maria de Souza Cordeiro, Gonzalo Viana Di Prisco, Brady K. Atwood, Jorge Robles, Lauren Bainbridge, Autumn Davis
Summary: This study identifies ADGRL1 as a glucose receptor in the mouse hypothalamus, which is involved in energy and glucose homeostasis in a sex-dependent manner. Targeting ADGRL1 may lead to the development of new drugs for the treatment of type 2 diabetes and obesity.
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Review
Plant Sciences
Barbhara Mota Marinho, Caroline Honaiser Lescano, Sergio Henrique Sousa Santos
Summary: Brazilian arnicas, belonging to the Asteraceae family, are mainly found in the Brazilian biome Cerrado but also in other regions such as Caatinga, Atlantic Forest, Pampa, Pantanal, and Amazonia Forest. Recent studies have demonstrated the high medicinal potential of the plant's leaves, roots, inflorescences, and flowers. The selected species of Brazilian arnicas have shown various pharmacological activities, including anti-inflammatory, analgesic, antimicrobial, antioxidant, and trypanocidal effects.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Plant Sciences
Barbhara Mota Marinho, Victor Hugo Dantas Guimara, Daniel Silva Moraes, Guilherme Henrique Mendes Ribeiro, Rodrigo Moreira da Silva, Norberto Peporine Lopes, Andre Luiz Sena Guimara, Alfredo Mauricio Batista de Paula, Sergio Henrique Sousa Santos
Summary: The present study investigated the effects of Lychnophora ericoides ethanolic extract (EELE) on cutaneous wound healing and the underlying mechanisms. The results revealed that EELE significantly reduced the wound area, improved anatomical skin features, promoted collagen production and angiogenesis, and decreased the number of mast cells at the injury site. Real-time PCR data showed that EELE increased important factors for wound healing, such as FGF, VEGF, collagen formation, and the expression of the proliferative axis of the renin-angiotensin system.
Article
Food Science & Technology
Caroline Honaiser Lescano, Fernando Freitas de Lima, Taline Baganha Stefanello Catelan, Victor Hugo Dantas Guimaraes, Ulisses Alves Pereira, Charles Martins Aguilar, Claudia Andrea Lima Cardoso, Sergio Henrique Sousa Santos, Alexandre Borges, Ivan Pires de Oliveira
Summary: Campomanesia guazumifolia, a plant from the Brazilian Cerrado, is used in traditional medicine for its medicinal properties. This study investigated the effects of the leaf infusion of Campomanesia guazumifolia on platelet activity, specifically focusing on the role of the cyclooxygenase (COX) pathway. The results showed that the infusion inhibits platelet aggregation and reduces intracellular calcium discharge, without involving the cyclic nucleotide pathways. Furthermore, the study identified that the infusion inhibits COX-1, reducing thromboxane A2 levels and PKCβ2 phosphorylation, suggesting its therapeutic potential for platelet-associated cardiovascular disease.
Article
Biochemistry & Molecular Biology
Victor Hugo Dantas Guimaraes, Deborah de Farias Lelis, Luis Paulo Oliveira, Luciana Mendes Araujo Borem, Felipe Alberto Dantas Guimaraes, Lucyana Conceicao Farias, Alfredo Mauricio Batista de Paula, Andre Luiz Sena Guimaraes, Sergio Henrique Sousa Santos
Summary: The high-lard/high-sugar diet significantly impacts liver metabolism, inducing hepatic steatosis and glucose intolerance, leading to metabolic disorders and decreased insulin sensitivity.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
