Review
Chemistry, Medicinal
Yichao Wan, Jiabing Long, Han Gao, Zilong Tang
Summary: Cancer is the second leading health killer in human society, and there is an urgent need to develop new anticancer agents with high activity and low toxicity due to multi-drug resistance and side effects. 2-Aminothiazole, as an important scaffold with potential anti-cancer activity, plays a crucial role in the discovery of anti-cancer agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Daniela Secci, Masa Sterle, Stefan Mozina, Ziga Skok, Nace Zidar, Anamarija Zega, Janez Ilas, Lucija Peterlin Masic, Tihomir Tomasic, Diarmaid Hughes, Douglas L. Huseby, Sha Cao, Linnea Garoff, Talia Berruga Fernandez, Paraskevi Giachou, Lisa Crone, Ivailo Simoff, Richard Svensson, Bryndis Birnir, Sergiy V. Korol, Zhe Jin, Francisca Vicente, Maria C. Ramos, Mercedes de la Cruz, Bjorn Glinghammar, Lena Lenhammar, Sara R. Henderson, Julia E. A. Mundy, Anthony Maxwell, Clare E. M. Stevenson, David M. Lawson, Guido V. Janssen, Geert Jan Sterk, Danijel Kikelj
Summary: We have developed compounds that show promising activity against antibiotic-resistant bacteria, Acinetobacter baumannii and Pseudomonas aeruginosa, which are on the WHO priority list. Compound 27, derived from DNA gyrase inhibitor 1, exhibited improved solubility, inhibition of topoisomerase IV, and no cross-resistance to novobiocin. Further optimization steps led to analogs of 27 with improved plasma distribution and retained anti-Gram-negative activity.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Matic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anze Meden, Matej Butala, Stanislav Gobec
Summary: Bacterial resistance is a growing threat to healthcare systems, highlighting the urgent need for discovering new antibacterial agents. Using fragment-based drug discovery, researchers targeted a bacterial enzyme Ddl and identified a potential inhibitor with promising development prospects.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Cheng Shi, Xiangyu Zhang, Xiaowei Chi, Yi Ran Zhou, Weiping Lyu, Tongfei Gao, Jiaxu Zhou, Yanming Chen, Chuxiao Yi, Xiaojiao Sun, Liangren Zhang, Zhenming Liu
Summary: This study identified a series of NLRP3 inhibitors using a self-developed machine learning model. CSC-6 was validated as the hit molecule with optimal activity and it inhibits NLRP3 activation by blocking ASC oligomerization. In vivo experiments demonstrated that CSC-6 effectively reduces the symptoms of NLRP3 overactivation-mediated diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yu Wang, Hongyi Song, Sheng Wang, Qingfeng Cai, Yong Zhang, Yue Zou, Xing Liu, Jixiang Chen
Summary: By testing a series of quinazoline compounds, novel nematicidal activities were discovered with compound K11 showing excellent results. Compound K11 exhibited significant nematicidal activity against multiple nematode species and affected the nematodes' antioxidant capacity and gene expression. Quinazoline can serve as a new nematicidal scaffold, and further research can be conducted based on lead compound K11 for the discovery of novel nematicides.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biology
Alexis Neumann-Mufweba, Serah Kimani, Saif Feroz Khan, Kelly Chibale, Sharon Prince
Summary: Breast cancer is the most common malignancy in women worldwide. Researchers have discovered a compound called MMV652103 that shows potential in the treatment of breast cancer. This compound inhibits oncogenic proteins and displays selective cytotoxicity to breast cancer cells, inhibiting their survival and migration, while also demonstrating a favorable safety profile.
Review
Biochemistry & Molecular Biology
Simran Patel, Khushi Sandha, Anushka Waingankar, Prachi Jain, Arundhati Abhyankar
Summary: Atropisomerism plays a significant role in drug discovery and development, especially in modulating the selectivity of inhibitors for cancer therapy. Considering the impact of stereogenic centers in such compounds is necessary for successful cancer drug development.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Urology & Nephrology
Iris E. Ertl, Ursula Lemberger, Dafina Ilijazi, Melanie R. Hassler, Andreas Bruchbacher, Robert Brettner, Hannah Kronabitter, Michael Gutmann, Petra Vician, Gerhard Zeitler, Anna Koren, Charles-Hugues Lardeau, Thomas Mohr, Andrea Haitel, Eva Comperat, Andre Oszwald, Gabriel Wasinger, Thomas Clozel, Olivier Elemento, Stefan Kubicek, Walter Berger, Shahrokh F. Shariat
Summary: The study aimed to establish a model system for drug identification and repurposing to identify novel therapies for the treatment of bladder cancer. The results showed that clofarabine exhibited inhibitory effects on bladder cancer cells, suggesting potential clinical relevance.
Article
Pharmacology & Pharmacy
Tianduanyi Wang, Otto I. Pulkkinen, Tero Aittokallio
Summary: Most drug molecules have the ability to modulate multiple target proteins, which can lead to both therapeutic effects and unwanted side effects. Evaluating the selectivity of a compound is an important factor in drug development and repurposing efforts. Traditional methods for characterizing selectivity fall short in quantifying how selective a compound is against a particular target protein. In this study, we propose an optimization-based selectivity scoring method that allows for the identification of potent and selective compounds against given kinase targets. We demonstrate the effectiveness of this method in finding highly selective compounds in computational experiments using a large-scale kinase inhibitor dataset.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Wendy A. Warr, Marc C. Nicklaus, Christos A. Nicolaou, Matthias Rarey
Summary: Designing new medicines more cheaply and quickly is closely related to exploring chemical space more widely and efficiently. This review focuses on the collection of millions or even billions of enumerated chemical structures, as well as larger chemical spaces that are not fully enumerated. New technologies for searching large libraries and combinatorially in chemical space are discussed, along with space navigation techniques and the impact of autonomous laboratories on synthesis of designed compounds. Challenges and opportunities for the future are summarized.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Review
Immunology
Sangmi Oh, Lena Trifonov, Veena D. Yadav, Clifton E. Barry, Helena I. Boshoff
Summary: Despite over two decades since the first genome sequence of Mycobacterium tuberculosis (Mtb) was published, target-based approaches have not yielded successful drugs in clinical testing. Whole-cell screening combined with elucidation of the mechanism of action remains the most effective method for progressing inhibitors into the tuberculosis drug discovery pipeline. This review discusses scaffolds identified in the past decade from screenings of small molecule libraries against Mtb, and describes the pharmacophore through structure-activity relationship studies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pau Nadal Rodriguez, Ouldouz Ghashghaei, Andrea Bagan, Carmen Escolano, Rodolfo Lavilla
Summary: This article introduces a synthetic approach for dealing with the structural complexity of molecules, which offers advantages in terms of synthetic economy and the preparation of larger amounts of drugs. The article summarizes the scientific methodology and main results of the research, provides a general appraisal of the current situation, and offers perspectives on future research directions.
Article
Pharmacology & Pharmacy
Ellie Esfandiari Nazzaro, Fahad Y. Sabei, Walter K. Vogel, Mohamad Nazari, Katelyn S. Nicholson, Philip R. Gafken, Olena Taratula, Oleh Taratula, Monika A. Davare, Mark Leid
Summary: Ewing's sarcoma is a rare and aggressive cancer of bone and soft tissue characterized by specific chromosomal translocations. Current cytotoxic chemotherapies effectively treat localized disease but can lead to treatment-related morbidities, and the survival rate for patients with relapsed or metastatic disease remains low. A new compound, ML111, was identified through high-throughput screening and showed promising inhibitory effects on Ewing's sarcoma cells in vitro and in vivo, suggesting its potential as a new drug lead for further preclinical studies.
Review
Chemistry, Medicinal
Rongfeng Zhu, Guangqian Jiang, Wanyu Tang, Xiaobao Zhao, Fan Chen, Xiaoya Zhang, Na Ye
Summary: Aporphine alkaloids embedded in 4H-dibenzo[de,g]quinoline four-ring structures are a major subclass of isoquinoline alkaloids. Aporphine is a privileged scaffold used in organic synthesis and medicinal chemistry for discovering new therapeutic agents for CNS diseases, cancer, metabolic syndrome, and other diseases. It has been widely studied as selective or multitarget directed ligands (MTDLs) targeting various CNS receptors and enzymes, serving as valuable pharmacological probes and potential leads for drug discovery.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Cell Biology
Sara Santos Bernardes, Mauro Cunha Xavier Pinto, Jaime Henrique Amorim, Vasco Ariston de Carvalho Azevedo, Rodrigo Ribeiro Resende, Akiva Mintz, Alexander Birbrair
Summary: This article introduces a research finding that periostin expressed by pericytes in the glioma microenvironment is crucial for glioma angiogenesis. This new discovery will contribute to the development of therapies for gliomas.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemical Research Methods
Stephanie Deville-Foillard, Anne Billet, Rose-Marie Dubuisson, Ludger Johannes, Philippe Durand, Frederic Schmidt, Andreas Volk
Summary: In this study, a targeted contrast agent for magnetic resonance imaging (MRI) was developed using Shiga toxin B-subunit (STxB) as a targeting agent that binds to a glycosphingolipid overexpressed on tumor cells. The study found that the conjugate between cyclic peptide and nine monoamide DO3A[Gd(III)] exhibited higher longitudinal relaxivity (r(1)) compared to the pure cyclic peptide contrast agent. The conjugate also showed specific accumulation and cellular distribution in Gb3-expressing cancer cells, indicating its potential for in vivo tumor detection using MRI.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tatiane Cristina Silva Maiolini, Welton Rosa, Daniel Oliveira Miranda, Thais A. Costa-Silva, Andre G. Tempone, Paula Carolina Pires Bueno, Danielle Ferreira Dias, Daniela Aparecida Chagas de Paula, Patricia Sartorelli, Joao Henrique G. Lago, Marisi Gomes Soares
Summary: This study extracted and evaluated the essential oils from 18 Myrtaceae species for their anti-T. cruzi activity. The results suggested that eight essential oils showed potential as sources of bioactive compounds against T. cruzi. Several active components were also identified.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Cell Biology
Andressa Brito Lira, Gabrieli Lessa Parrilha, Gabriela Tafaela Dias, Fernanda Samara de Sousa Saraiva, Gabriel Correa Verissimo, Rayane Siqueira de Sousa, Teresinha Goncalves da Silva, Abrahao Alves de Oliveira Filho, Adriano Francisco Alves, Elaine Maria de Souza-Fagundes, Heloisa Beraldo, Maria Aparecida Gomes, Margareth de Fatima Formiga Melo Diniz
Summary: This study investigated the toxicity and oxidative stress of 2-acetylpyridine-N(4)-orthochlorophenyl thiosemicarbazone (TSC01) in silico, in vitro, and in vivo. The results showed that TSC01 had good absorption by biological membranes in silico and no theoretical toxicity. It did not exhibit cytotoxicity against Hep-G2 and HT-29 cells. In the acute nonclinical toxicological test, TSC01 caused behavioral changes and depressive signs at higher doses, but all changes disappeared after 24 hours with no deaths. Biochemical parameters showed no toxicity relevance, and histopathological analysis revealed no organ changes. These findings suggest that TSC01 has low toxicological potential.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Obstetrics & Gynecology
Camila O. Silveira, Rafaela M. Oliveira, Leonardo M. Moraes, Gabriella G. Oliveira, Luciana P. T. Aguiar, Felipe H. S. Souza, Santuza S. Coelho, Pedro H. D. M. Prazeres, Helen L. Del Puerto, Marcia C. F. Ferreira
Summary: This study investigated the in vitro effects of clomiphene citrate and letrozole on apoptosis in human cumulus cells. The results showed that these drugs did not significantly affect cell viability but modulated the expression of genes involved in apoptosis. Co-treatment with estradiol reversed the effects on gene expression.
REPRODUCTIVE SCIENCES
(2022)
Article
Chemistry, Medicinal
Mario F. C. Santos, Marcela A. M. Moreira, Tatiane C. S. Maiolini, Danielle F. Dias, Daniela A. Chagas-Paula, Luciana Azevedo, Marisi G. Soares
Summary: This study investigated the anti-inflammatory properties of extracts, fractions, and isolated compound ergosterol peroxide from Sclerotinia sclerotiorum. The results showed that the hexane fraction and ergosterol peroxide exhibited significant inhibition of ear edema and neutrophil recruitment, indicating anti-inflammatory activity.
NATURAL PRODUCTS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Albert Katchborian-Neto, Mario Ferreira Conceicao Santos, Diego Fernandes Vilas-Boas, Elda Goncalves dos Santos, Marcia Paranho Veloso, Paula Carolina Pires Bueno, Ivo Santana Caldas, Marisi Gomes Soares, Danielle Ferreira Dias, Daniela Aparecida Chagas-Paula
Summary: Ayahuasca, composed mainly of Banisteriopsis caapi and Psychotria viridis, is a natural medicine used by indigenous communities in South America. It has shown potential against internal parasites and the Trypanosoma cruzi parasite. The compounds in Ayahuasca have multi-targeted effects, including controlling parasitaemia and modulating the immune response, making it beneficial for Chagas' disease treatment.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Applied
Mario F. C. Santos, Karen de J. Nicacio, Albert Katchborian-Neto, Miller S. Ferreira, Daniel de Oliveira Miranda, Joao Andrade, Herinque de A. Pereira, Ester Goncalves de Jesus, Thamires B. Silva Souza, Raquel P. Morais-Urano, Danielle Ferreira Dias, Daniela A. Chagas-Paula, Marisi G. Soares
Summary: The phytochemical investigation of Aniba firmula led to the isolation of undescribed bicyclic octane neolignans, as well as two other known bicyclic neolignans. These compounds showed significant anti-inflammatory activity by inhibiting the production of the inflammatory mediator PGE2, suggesting their potential as anti-inflammatory agents.
NATURAL PRODUCT RESEARCH
(2022)
Article
Multidisciplinary Sciences
Emerson Soares Veloso, Barbara Andrade de Carvalho, Felipe Henrique de Souza Silva, Thais Salviana Ribeiro, Bruna Mendes Lima, Camila Pereira Almeida, Vitor Henrique Soares Romao da Silva, Sara Aparecida Rocha, Marina Rios de Araujo Campos, Helen Lima Del Puerto, Enio Ferreira
Summary: Metformin can inhibit EMT and reduce the metastatic potential of melanoma cells, suggesting its potential role in the prevention and treatment of melanoma.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Thaynan Cunha Vieira, Evelyn Ane Oliveira, Barbara Jaime dos Santos, Fernanda Rezende Souza, Emerson Soares Veloso, Cristiana Buzelin Nunes, Helen Lima Del Puerto, Geovanni Dantas Cassali
Summary: Pure human and canine mammary invasive micropapillary carcinoma is a rare and aggressive tumor with a high rate of lymphatic invasion and metastasis, leading to a poor prognosis. COX-2 protein is overexpressed in both types of carcinoma, while COX-2 mRNA expression is significantly higher in canine tumors and is associated with negative estrogen receptor and high Ki67.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Physical
Minh-Duc Hoang, Farah Savina, Philippe Durand, Pr Rachel Meallet-Renault, Gilles Clavier, Arnaud Chevalier
Summary: This study presents the synthesis, photophysical characterization, and application for cell imaging of 14 fluorophores derived from a hybrid Naphthalimide/Cinnoline fused backbone called CinNapht. The photophysical properties of these fluorophores have been recorded and theoretical calculations have been conducted. Some of these analogues have been tuned for imaging of cell organelles, confirming their potential as alternatives for cell imaging tools.
Article
Chemistry, Medicinal
Luiz P. M. O. Leao, Natalie de B. Vieira, Paula P. S. Oliveira, Daniela A. Chagas-Paula, Marisi G. Soares, Thiago B. Souza, Joao L. Baldim, Thais A. Costa -Silva, Andre G. Tempone, Danielle F. Dias, Joao Henrique G. Lago
Summary: Gibbilimbol B and analogues, derived from Piper malacophyllum, showed activity against Trypanosoma cruzi trypomastigote forms and reduced toxicity against NCTC cells. A series of 24 chemically related analogues were prepared to investigate their potential against T. cruzi trypomastigotes and explore structure-activity relationships. These structurally-related analogues demonstrated promising activity against trypomastigote forms and no mammalian cytotoxicity to fibroblasts. The presence of t-butyl or nitro groups at the p-position with appropriate side chains was found to be essential for biological activity against T. cruzi parasites.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Organic
Steven Vertueux, Alexandre Haefele, Kathleen Solmont, Philippe Durand, Pierre-Yves Renard
Summary: A series of chemiluminescent cassettes based on adamantyl stabilized 1,2-dioxetanes linked to a fluorophore by a conjugated linker were synthesized in this study. The chemiluminescent decomposition and photoluminescence properties of their respective emissive species were investigated.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ana Luisa Almeida Lage, Juliana Martins Ribeiro, Tairine Fernanda da Silva Magalhaes, Elaine Maria de Souza-Fagundes, Mateus Fernandes Venancio, Michelle Fernanda Brugnera, Dayse Carvalho da Silva Martins
Summary: This paper presents an approach to degrade atrazine, an environmentally harmful herbicide. Different types of porphyrins were studied and their effects on degradation were evaluated. The formed products were found to be equally or more toxic than the original atrazine, highlighting the importance of verifying the products and determining their toxicities.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Multidisciplinary
Eleonore Tacke, Minh-Duc Hoang, Kevin Tatoueix, Benoit Keromnes, Elsa Van Eslande, Philippe Durand, Gregory Pieters, Arnaud Chevalier
Summary: This study describes a simple and easy-to-implement process based on a nucleophilic aromatic substitution reaction with a wide variety of nucleophiles on a fluorinated CinNapht. The key advantage of this process is the ability to introduce multiple functionalities at a very late stage, allowing for the synthesis of new applications such as photostable and bioconjugatable large Stokes shift red emitting dyes and selective organelle imaging agents. The synthesis of bench-stable CinNapht-F has been optimized and can be reproduced on a large scale, making it a convenient starting material for preparing new molecular imaging tools.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.