Article
Multidisciplinary Sciences
Jennifer Q. J. Zhang, Sayanthooran Saravanabavan, Kai Man Cheng, Aarya Raghubanshi, Ashley N. Chandra, Alexandra Munt, Benjamin Rayner, Yunjia Zhang, Katrina Chau, Annette T. Y. Wong, Gopala K. Rangan
Summary: The study found that L-arginine has a mild direct effect on reducing renal cyst growth in vitro, while long-term sodium nitrate supplementation was ineffective in vivo. This suggests that the bioconversion of dietary nitrate to NO through the entero-salivary pathway may not be sufficient to influence the progression of renal cyst growth in ADPKD.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Review
Cell Biology
Morris Karmazyn, Xiaohong Tracey Gan
Summary: Ginseng, an ancient perennial herb, contains bioactive compounds like ginsenosides with potential therapeutic effects. The quantity and type of ginsenosides vary greatly among different ginseng species, and studies have shown their vasodilatating effects, making them potential candidates for treating hypertension.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Nitric oxide (NO) is a gaseous signaling molecule that plays a crucial role in protecting the kidneys. NO can be generated through different pathways, either dependent or independent of NO synthase (NOS). Deficiency of NO is closely associated with chronic kidney disease (CKD). Adverse intrauterine conditions can impact kidney development, increase the risk of CKD, but early reprogramming treatments have the potential to mitigate this risk. This review highlights the relationship between NOS/NO research and renal programming and reprogramming, and suggests potential strategies targeting NO for preventing and treating renal programming.
Article
Peripheral Vascular Disease
Yeyan Zhu, Yufeng Tao, Chunying Wu, Yuting Zeng, Huiting Du, Qunkun Xiang, Yang Chen, Qing Zhu, Lei Wang
Summary: This study demonstrates that renal FXR prevents high-fructose-induced salt-sensitive hypertension by inhibiting DNM3 to promote NO production, providing new insights into the role and potential mechanism of renal FXR in the treatment of hypertension.
JOURNAL OF HYPERTENSION
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wen Zhou, Wanxiang Yang, Keyu Fan, Wuyang Hua, Shaohua Gou
Summary: In this study, a novel hypoxia-activated NO donor (Hano) was designed and prepared, which can increase NO release, dilate blood vessels, and attenuate myocardial hypoxia injury. This drug shows great potential for the treatment of hypoxic heart diseases.
Article
Pharmacology & Pharmacy
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study demonstrates for the first time that the selective eEF2 kinase inhibitor A484954 can induce vasodilatation by inhibiting sympathetic nerve activity-induced vasoconstriction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Ophthalmology
Chunchun Hu, Yu Zhang, Maomao Song, Yonghui Deng, Xinghuai Sun, Yuan Lei
Summary: The study found that sustained use of the NO donor sodium nitroprusside initially reduced intraocular pressure (IOP) but later surprisingly caused IOP elevation, which could not be reversed by drug withdraw but could be reversed by the antioxidant MnTMPyP application. The elevation and normalization of IOP corresponded with changes in protein nitration levels in mouse conventional outflow tissue, suggesting that prolonged use of NO donors may lead to outflow tissue damage by protein nitration. MnTMPyP showed protective effects against nitrative damage and could be considered for co-application with NO donors.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Bozena Badzynska, Ivana Vaneckova, Janusz Sadowski, Silvie Hojna, Elzbieta Kompanowska-Jezierska
Summary: This study investigated the effects of ETA and ETB receptor blockade on blood pressure, medullary blood flow, and tissue NO in different rat models. The results confirmed the dominant role of ETA receptors in regulating blood pressure and renal hemodynamics in both normotensive and hypertensive rats. Additionally, ETB stimulation was found to preserve medullary perfusion under conditions of endothelin system activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ricardo Corro, Carlos Franco Urquijo, Oscar Aguila, Elisa Villa, Jesus Santana, Amelia Rios, Bruno Escalante
Summary: Combining thrombolysis with microbubbles has shown potential as an alternative treatment for patients who cannot receive traditional thrombolytic drugs or surgery. The use of microbubbles as carriers for nitric oxide release agonists allows for controlled release of the agonist, leading to enhanced therapeutic effects and reduced interactions with other tissues.
Review
Biochemistry & Molecular Biology
Marharyta Semenikhina, Mariia Stefanenko, Denisha R. Spires, Dania Ilatovskaya, Oleg Palygin
Summary: Nitric oxide (NO) is an important signaling molecule in the kidney, involved in various physiological and pathophysiological processes. However, the mechanisms of NO production and release in glomerular cells, particularly podocytes, are not well understood. Changes in NO availability have been implicated in diseases such as hypertension and diabetes. Further investigation into these mechanisms will help in developing strategies to prevent or manage kidney damage.
Article
Peripheral Vascular Disease
Yeyan Zhu, Yuting Liu, Chunying Wu, Haonan Li, Huiting Du, Huijing Yu, Cailin Huang, Yating Chen, Weidong Wang, Qing Zhu, Lei Wang
Summary: The experimental results suggest that E. faecalis may contribute to hypertension and renal injury in rats by disturbing lipid metabolism. This sheds light on potential intervention targets for the treatment of gut dysbiosis-induced hypertension.
JOURNAL OF HYPERTENSION
(2021)
Review
Pharmacology & Pharmacy
Elizabeth C. Cottrell
Summary: Hypertension in pregnancy is common and poses risks for mothers and babies. Current treatments are limited, so new approaches are needed. Dietary nitrate supplementation has shown potential benefits for hypertension, but more research is needed.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Lucas M. Kangussu, Vania C. Olivon, Raquel D. do N. Arifa, Natalia Araujo, Daniela Reis, Marieta T. de A. Assis, Frederico M. Soriani, Daniele da G. de Souza, Lusiane M. Bendhack, Daniella Bonaventura
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Bruna S. Terra, Aura M. B. Osorio, Aline de Oliveira, Rebeca P. M. Santos, Andressa P. Mouro, Natalia F. de Araujo, Cameron C. da Silva, Felipe T. Martins, Luciene B. Vieira, Daniella Bonaventura, Heitor A. de Abreu, Antonio F. C. Alcantara, Angelo de Fatima
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2017)
Article
Medicine, Research & Experimental
Mariana C. Diniz, Vania C. Olivon, Livia D. Tavares, Janaina A. Simplicio, Natalia A. Gonzaga, Daniele G. de Souza, Lusiane M. Bendhack, Carlos R. Tirapelli, Daniella Bonaventura
Article
Biochemistry & Molecular Biology
Daniella Bonaventura, Carlos R. Tirapelli, Ana Maria de Oliveira
Article
Pharmacology & Pharmacy
Ulisses V. Hipolito, Gerson J. Rodrigues, Claure N. Lunardi, Daniella Bonaventura, Sergio R. Ambrosio, Ana M. de Oliveira, Lusiane M. Bendhack, Fernando B. da Costa, Carlos R. Tirapelli
EUROPEAN JOURNAL OF PHARMACOLOGY
(2009)
Article
Pharmacology & Pharmacy
Ulisses V. Hipolito, Juliana T. Rocha, Nathalia B. Palazzin, Gerson J. Rodrigues, Carlos C. Crestani, Fernando M. Correa, Daniella Bonaventura, Sergio R. Ambrosio, Lusiane M. Bendhack, Leonardo B. Resstel, Carlos R. Tirapelli
EUROPEAN JOURNAL OF PHARMACOLOGY
(2011)
Article
Immunology
Fatima Brant, Aline S. Miranda, Lisia Esper, David Henrique Rodrigues, Lucas Miranda Kangussu, Daniella Bonaventura, Frederico Marianetti Soriani, Vanessa Pinho, Danielle G. Souza, Milene Alvarenga Rachid, Louis M. Weiss, Herbert B. Tanowitz, Mauro Martins Teixeira, Antonio Lucio Teixeira, Fabiana Simao Machado
INFECTION AND IMMUNITY
(2014)
Article
Immunology
Vivian V. Costa, Caio T. Fagundes, Deborah F. Valadao, Thiago V. Avila, Daniel Cisalpino, Rebeca F. Rocha, Lucas S. Ribeiro, Fernando R. Ascencao, Lucas M. Kangussu, Celso M. Q. Junior, Ruiz G. Astigarraga, Frederico L. Gouveia, Tarcilia A. Silva, Daniela Bonaventura, Divaldo de Almeida Sampaio, Ana Cristina L. Leite, Mauro M. Teixeira, Danielle G. Souza
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Alice V. Araujo, Camila Z. Ferezin, Amanda de C. Pereira, Gerson J. Rodrigues, Marcella D. Grando, Daniella Bonaventura, Lusiane M. Bendhack
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2012)
Review
Pharmacology & Pharmacy
Carlos R. Tirapelli, Daniella Bonaventura, Luis F. Tirapelli, Ana M. de Oliveira
Article
Pharmacology & Pharmacy
Alice V. Araujo, Camila Z. Ferezin, Gerson J. Rodrigues, Claure N. Lunardi, Juliana A. Vercesi, Marcella D. Grando, Daniella Bonaventura, Lusiane M. Bendhack
VASCULAR PHARMACOLOGY
(2011)
Article
Infectious Diseases
Vivian V. Costa, Caio T. Fagundes, Deborah F. Valadao, Daniel Cisalpino, Ana Carolina F. Dias, Katia D. Silveira, Lucas M. Kangussu, Thiago V. Avila, Maria Rosa Q. Bonfim, Daniela Bonaventura, Tarcilia A. Silva, Lirlandia P. Sousa, Milene A. Rachid, Leda Q. Vieira, Gustavo B. Menezes, Ana Maria de Paula, Alena Atrasheuskaya, George Ignatyev, Mauro M. Teixeira, Danielle G. Souza
PLOS NEGLECTED TROPICAL DISEASES
(2012)
Article
Biochemistry & Molecular Biology
Natalia Nobrega, Natalia Ferreira Araujo, Daniela Reis, Larissa Moreira Facine, Claudiane Aparecida S. Miranda, Gianne Campos Mota, Rosaria Dias Aires, Luciano dos Santos Aggum Capettini, Jader dos Santos Cruz, Daniella Bonaventura
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Article
Immunology
Roberta Cristelli Fonseca, Gabriel Shimizu Bassi, Camila Carvalho Brito, Lorena Barreto Rosa, Bruna Araujo David, Alan Moreira Araujo, Natalia Nobrega, Ariane Barros Diniz, Itamar Couto Guedes Jesus, Luciola Silva Barcelos, Marco Antonio Peliky Fontes, Daniella Bonaventura, Alexandre Kanashiro, Thiago Mattar Cunha, Silvia Guatimosim, Valbert Nascimento Cardoso, Simone Odilia Antunes Fernandes, Gustavo Batista Menezes, Guillaume de lartigue, Andre Gustavo Oliveira
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.