Article
Nutrition & Dietetics
Arturo Figueroa, Arun Maharaj, Yejin Kang, Katherine N. Dillon, Mauricio A. Martinez, Masahiko Morita, Dai Nogimura, Stephen M. Fischer
Summary: Postmenopausal women may experience endothelial dysfunction due to arginine deficiency and oxidative stress. Citrulline combined with glutathione improved flow-mediated dilation and attenuated blood pressure reactivity in these women. Baseline flow-mediated dilation and aortic mean arterial pressure response to cold pressor test were associated with the improvements in flow-mediated dilation.
Article
Nutrition & Dietetics
Arun Maharaj, Stephen M. Fischer, Katherine N. Dillon, Yejin Kang, Mauricio A. Martinez, Arturo Figueroa
Summary: This study found that L-CIT supplementation improves endothelial function and aortic blood pressure in hypertensive postmenopausal women through increased availability of L-ARG.
Review
Pharmacology & Pharmacy
Omid Asbaghi, Ghazaleh Shimi, Kaveh Naseri, Saeede Saadati, Mahnaz Rezaei Kelishadi, Saeid Doaei, Neda Haghighat
Summary: This systematic review and meta-analysis revealed an association between conjugated linoleic acid (CLA) supplementation and reduction of intercellular adhesion molecule (ICAM), but no significant effects on blood pressure and vascular cell adhesion molecule (VCAM) were observed.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Thomas Willmott, Laura Ormesher, Andrew J. Mcbain, Gavin J. Humphreys, Jenny E. Myers, Gurdeep Singh, Jon O. Lundberg, Eddie Weitzberg, Carina Nihlen, Elizabeth C. Cottrell
Summary: This study aimed to investigate the role of oral microbiota profiles and oral nitrate-reducing capacity in explaining individual differences in blood pressure (BP) lowering following dietary nitrate supplementation. The results showed that women with hypertension had lower salivary nitrite concentrations and reduced abundance of nitrate-reducing bacteria compared to normotensive women. Oral nitrate reductase (NaR) activity did not differ significantly between pregnant and nonpregnant women, but it tended to be lower in hypertensive women. Oral NaR activity was associated with both baseline diastolic BP and changes in diastolic BP after acute nitrate intake.
Article
Peripheral Vascular Disease
Line Sletner, Sarah R. Crozier, Hazel M. Inskip, Keith M. Godfrey, Pamela Mahon, Scott T. Chiesa, Marietta Charakida, Cyrus Cooper, Mark Hanson
Summary: The study found that postnatal linear and abdominal circumference growth were associated with early markers of atherosclerosis and later cardiovascular disease risk, while prenatal growth was not. Faster postnatal growth was related to higher blood pressure and pulse wave velocity, whereas faster growth in early gestation was associated with greater carotid intima-media thickness in children.
JOURNAL OF HYPERTENSION
(2021)
Article
Pharmacology & Pharmacy
Allison M. Harrison, Manoranjan S. D'Souza, Sarah L. Seeley, Sophocles Chrissobolis
Summary: The study shows that prenatal methamphetamine exposure adversely affects endothelial function in a sex-dependent manner in adult rat offspring. However, there was no significant impact on blood pressure. This suggests that adult males with a history of prenatal methamphetamine exposure may be at greater risk of developing cardiovascular disease due to endothelial dysfunction.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Chi Le-Ha, Lawrence J. Beilin, Sally Burrows, Jeffrey A. Keelan, Martha Hickey, Trevor A. Mori
Summary: The study found a positive association between levels of bioavailable testosterone in umbilical cord blood and systolic and diastolic blood pressure in young adults aged 20 to 27 years. Higher fetal testosterone levels in late pregnancy were associated with higher blood pressure in young adulthood.
Article
Multidisciplinary Sciences
Rosario D'Anna, Francesco Corrado, Saverio Loddo, Giuseppe Gullo, Loretta Giunta, Antonino Di Benedetto
Summary: The combination of myo-inositol and a-lactalbumin has been shown to significantly reduce insulin resistance and excessive fetal growth in women with gestational diabetes mellitus. This treatment also led to a decrease in the need for insulin and pre-term birth rates among the study participants.
SCIENTIFIC REPORTS
(2021)
Review
Multidisciplinary Sciences
Paivi Korhonen, Kati Tihtonen, Jaana Isojarvi, Riitta Ojala, Ulla Ashorn, Per Ashorn, Outi Tammela
Summary: Research suggests that high-dose calcium supplementation during pregnancy may reduce the risk of high blood pressure in offspring at 5-7 years of age, but its effects on growth, metabolic, and neurodevelopmental outcomes remain inconclusive. Limited data from randomized controlled trials do not provide enough evidence to determine the influence of prenatal calcium supplementation on offspring health outcomes beyond the newborn period.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Peripheral Vascular Disease
Surawee Chuaiphichai, Grace Z. Yu, Cheryl M. J. Tan, Christopher Whiteman, Gillian Douglas, Yasmin Dickinson, Edward N. Drydale, Mahesh Appari, Wei Zhang, Mark J. Crabtree, Eileen McNeill, Ashley B. Hale, Adam J. Lewandowski, Nicholas J. Alp, Manu Vatish, Paul Leeson, Keith M. Channon
Summary: Abnormal uteroplacental remodeling resulting from maternal endothelial BH4 deficiency can lead to hypertension and fetal growth restriction during pregnancy. Supplementing with reduced folates can restore endothelial BH4 levels, reduce blood pressure, and normalize fetal growth, suggesting a potential therapeutic target for pregnancy-related hypertension like preeclampsia.
Article
Medicine, General & Internal
Samantha L. Dawson, Martin O'Hely, Felice N. Jacka, Anne-Louise Ponsonby, Christos Symeonides, Amy Loughman, Fiona Collier, Margarita Moreno-Betancur, Peter Sly, David Burgner, Mimi L. K. Tang, Richard Saffery, Sarath Ranganathan, Michael A. Conlon, Leonard C. Harrison, Susanne Brix, Karsten Kristiansen, Peter Vuillermin
Summary: The diversity of maternal prenatal gut microbiota and taxa from butyrate-producing families were found to be associated with child internalizing behavior at two years old. A healthy prenatal diet indirectly reduced child internalizing behaviors through higher alpha diversity of maternal fecal microbiota. These findings support animal studies in showing the impact of maternal prenatal gut microbiota on offspring brain development and behavior.
Review
Nutrition & Dietetics
Monica Volino-Souza, Gustavo Vieira de Oliveira, Carlos Adam Conte-Junior, Arturo Figueroa, Thiago Silveira Alvares
Summary: L-arginine is crucial for nitric oxide synthesis and supplementation with its precursor L-citrulline, found in watermelon, can improve vascular function. However, there are differing findings on the effect of watermelon supplementation, possibly due to varying L-citrulline doses. Food technology can be applied to concentrate L-citrulline content and reduce volume for convenient ingestion. Watermelon-derived L-citrulline appears to be an effective supplementation for improving vascular health.
Review
Nutrition & Dietetics
Berner-Andree Sandoval-Ramirez, Ursula Catalan, Elisabet Llaurado, Rosa-Maria Valls, Patricia Salamanca, Laura Rubio, Silvia Yuste, Rosa Sola
Summary: Anthocyanins have significant positive effects on reducing the risks of hypertension and type 2 diabetes, while improving plasma lipids, glucose metabolism, and endothelial function. However, there is no association between anthocyanins and the risks of breast or gastric cancer. Anthocyanin intake provides new pathways for managing glucose metabolism, plasma lipid profiles, and improving endothelial function in humans.
Review
Pharmacology & Pharmacy
Nathan S. Bryan
Summary: Hypertension is a global health crisis, and the loss of nitric oxide production is the primary contributor to its development. Strategies aimed at preventing the loss of nitric oxide production and restoring nitric oxide production have a significant impact on improving patients' health and controlling blood pressure.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Rakhbeer Boparai, Rachel J. Skow, Sauleha Farooq, Craig D. Steinback, Margie H. Davenport
Summary: Structured lower-limb aerobic exercise training intervention during pregnancy did not alter endothelial function and blood flow response significantly, but contributed to improved cardiovascular outcomes, potentially associated with increased reactive hyperemia, indicative of enhanced microcirculatory dilatory capacity.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Review
Peripheral Vascular Disease
Nathanne S. Ferreira, Rita C. Tostes, Pierre Paradis, Ernesto L. Schiffrin
Summary: Excess aldosterone is associated with cardiovascular and metabolic diseases, as it activates immune cells and leads to organ damage. Studies have shown that aldosterone activates various subsets of innate and adaptive immune cells, pointing towards potential new biomarkers and therapeutic targets for diseases associated with elevated aldosterone levels.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Multidisciplinary Sciences
Amanda A. de Oliveira, Fernanda Priviero, Rita C. Tostes, R. Clinton Webb, Kenia P. Nunes
Summary: In this study, it was found that blockade of HSP70 leads to mishandling of Ca2+ during vascular contraction, reducing contraction amplitudes. The results also suggest that HSP70 has a positive effect on IP3r-mediated Ca2+ release and voltage-dependent Ca2+ channels. Additionally, the study indicates that HSP70 does not affect Rho-kinase or SERCA pump in the modulation of vascular contraction.
SCIENTIFIC REPORTS
(2021)
Article
Anthropology
Livia Victorino de Souza, Franciele de Meneck, Giovanna Pachele Parizotto, Maria Franco
Summary: The study found a positive correlation between birth weight and cardiorespiratory fitness, and handgrip strength, suggesting that children with low birth weight had worse performance. This effect remained significant even after adjusting for other factors such as prematurity, sex, age, physical activity, and BMI. High birth weight, older age, and low BMI were identified as predictors for better cardiorespiratory endurance, while high birth weight, male sex, and older age were important determinants for handgrip strength.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Debora Conte Kimura Lichtenecker, Rogerio Argeri, Charlles Heldan de Moura Castro, Magnus Regios Dias-da-Silva, Guiomar Nascimento Gomes
Summary: The study found that female rats undergoing testosterone therapy had changes in renal morphology and function, including increased kidney weight, decreased urine osmolarity, reduced glomerular filtration rate, larger glomerular area, and higher systolic blood pressure. This suggests that testosterone therapy in female rats may lead to adaptations similar to those observed in transmen on long-term testosterone therapy.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Livia Victorino Souza, Sandro Soares de Almeida, Franciele De Meneck, Fernanda Thomazini, Ronaldo Carvalho Araujo, Maria Carmo Franco do
Summary: This study found that the +9/+9 genotype of the BDKRB2 gene was associated with high blood pressure and microvascular dysfunction in prepubescent Brazilian children.
Article
Biology
Franciele De Meneck, Livia Victorino de Souza, Marcos Leal Brioschi, Maria do Carmo Franco
Summary: The study suggests that circulating irisin levels and BAT activity seem to have opposing roles, as normal weight children had greater BAT activity and lower levels of irisin.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
C. L. A. Santana, C. Manfrinato, P. R. P. Souza, A. Marino, V. F. Conde, E. Stedefeldt, L. Y. Tomita, M. do Carmo Franco
Summary: This study evaluated the psychological distress of adult residents in urban shantytown communities in Sao Paulo, Brazil, and found that low-income, younger women residents suffering from food insecurity are at higher risk of psychological distress.
Article
Endocrinology & Metabolism
J. Gusmao-Silva, D. C. K. Lichtenecker, L. G. A. Ferreira, I Gois, R. Argeri, G. N. Gomes, M. R. Dias-da-Silva
Summary: This study assessed the effect of E2EN/DHPA, a commonly used hormone combination, on blood pressure and metabolic outcomes in male rats. The results showed that the treatment reduced body weight and feminized body characteristics, without affecting blood pressure or harmful metabolic parameters.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Public, Environmental & Occupational Health
Lorena Ireno Borges, Simone Forcato, Lays Cristine do Nascimento Olanda, Giovanna Fachetti Frigoli, Camila Borecki Vidigal, Kawane Fabricio Moura, Glaura Scantamburlo A. Fernandes, Maria do Carmo Pinho Franco, Graziela Scalianti Ceravolo, Daniela Cristina Ceccatto Gerardin
Summary: This study aimed to evaluate the effects of topiramate (TOP) treatment during childhood and adolescence on the male rat reproductive system. The results showed that TOP treatment led to decreased seminiferous tubules volume and length, as well as increased interstitial tissue volume and Leydig cells number in adulthood.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Physiology
Leticia M. Monteiro, Celine F. Barbosa, Debora C. K. Lichtenecker, Rogerio Argeri, Guiomar N. Gomes
Summary: The study found that increased fructose consumption during pregnancy and lactation can lead to hypertension and renal dysfunction, with effects lasting for over four weeks after delivery. Increased fructose intake may exacerbate kidney changes during pregnancy, posing a risk factor for maternal health.
PHYSIOLOGICAL REPORTS
(2022)
Article
Cell Biology
Rafael Sobrano Fais, Rafael Menezes da Costa, Allan Carvalho Mendes, Fabiola Mestriner, Simon Gabriel Comerma-Steffensen, Rita C. Tostes, Ulf Simonsen, Fernando Silva Carneiro
Summary: In this study, it was hypothesized that stimulation of endothelin receptors ETA and ETB leads to NLRP3 activation through increased calcium and ROS formation. The experiments conducted on mice demonstrated that ET-1 reduced intracavernosal pressure and the CC ACh and SNP-induced relaxation, while increasing caspase-1 expression. The use of receptor antagonists, genetic deletion, and ROS inhibitors reversed these effects, indicating that ET-1-induced erectile dysfunction involves the activation of NLRP3 via Ca2+-dependent ROS generation mediated by ETA- and ETB-receptors.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Jeimison D. Santos, Rita C. Tostes, Jose T. Oliveira-Neto
Summary: The growing number of transgender individuals has gained attention and will impact clinical practices worldwide. Testosterone, the main hormone used in gender-affirming hormone therapy, can have harmful cardiovascular effects, and thus requires close attention in clinical use.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Medicine, Research & Experimental
Tiago J. Costa, Emily W. Wilson, Milene T. Fontes, Laena Pernomian, Rita C. Tostes, Camilla F. Wenceslau, Cameron G. McCarthy
Summary: O-GlcNAcylation is a widespread and dynamic post-translational modification that affects the function and stability of target proteins. It modulates cellular signaling and transcription regulatory pathways in response to nutrients and stress. It is associated with cardiovascular diseases and has the potential to serve as a novel target for their treatment and prevention.
Meeting Abstract
Biochemistry & Molecular Biology
Tania Plens Shecaira, Amanda Aparecida de Araujo, Camila Paixao, Danielle Dias, Filipe Stoyell-Conti, Nathalia Bernardes, Maria Claudia Irigoyen, Guiomar Gomes, Katia De Angelis
Meeting Abstract
Biochemistry & Molecular Biology
Guiomar Gomes, Debora Kimura, Rogerio Argeri, Magnus Dias-da-Silva
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.