Article
Endocrinology & Metabolism
Julio Sevillano, Aileen Liang, Brenda Strutt, Thomas G. Hill, Sandra Szlapinski, Maria Pilar Ramos-Alvarez, David J. Hill
Summary: PTN is expressed in mouse pancreatic beta-cells during both young and adult stages, potentially contributing to adaptive increases in beta-cell mass during early life or pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Erin M. MacFarlane, Jennifer E. Bruin
Summary: The prevalence of diabetes is increasing globally, with a reported association between diabetes and environmental pollutant exposure. Identifying chemicals that disrupt metabolism, particularly those affecting pancreatic endocrine cells, is a high priority. Human pluripotent stem cells show promise as a tool for in vitro toxicity testing and screening for chemicals influencing endocrine cell formation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Romina J. Bevacqua, Jonathan Y. Lam, Heshan Peiris, Robert L. Whitener, Seokho Kim, Xueying Gu, Mollie S. H. Friedlander, Seung K. Kim
Summary: This study found that SIX2 and SIX3 play important roles in the functional maturation of human pancreatic beta cells, particularly in insulin secretion. SIX2 primarily regulates genes governing insulin processing and output, while SIX3 affects genes normally expressed in fetal cells and non-beta cells.
GENES & DEVELOPMENT
(2021)
Review
Endocrinology & Metabolism
Danielle L. Overton, Teresa L. Mastracci
Summary: Diabetes mellitus, affecting nearly 536.6 million people worldwide, is primarily caused by the death or dysfunction of beta cells in the pancreas. Studies suggest that interactions between neighboring cells in the pancreas play a crucial role in supporting beta cell function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Amaara Marzook, Alejandra Tomas, Ben Jones
Summary: GLP-1R is a GPCR that mediates the effects of GLP-1, important in the treatment of T2D. Biased GLP-1R agonists have been discovered, showing altered trafficking profiles and selective engagement with different intracellular effectors for studying the mechanisms and physiological importance of these processes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Skornitzke, Neha Vats, Philipp Mayer, Hans-Ulrich Kauczor, Wolfram Stiller
Summary: This study provides a quantitative meta-analysis of pancreatic CT perfusion studies, investigating the choice of study parameters, the ability to differentiate pancreatic diseases quantitatively, and the influence of acquisition and reconstruction parameters on reported results. The results showed significant differences in perfusion measurements between different pathologies despite the heterogeneity of study parameters. Statistical analysis identified the most influential parameters for future optimization and standardization of acquisition protocols.
INSIGHTS INTO IMAGING
(2023)
Review
Endocrinology & Metabolism
Zhe Jin, Sergiy V. Korol
Summary: The pancreatic islets play a vital role in regulating blood glucose levels through cell communication using molecules like gamma-aminobutyric acid (GABA). GABA not only affects islet function and hormone secretion, but also immune cell interactions in both normal and pathological conditions, particularly in type 1 diabetes. In recent years, research interest in GABA signaling in islets has increased, spanning from molecular studies to clinical implications. This mini-review aims to provide an overview of the current state of research on islet GABA, focusing on human islets, identifying knowledge gaps, and exploring clinical implications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Moonhyung Choi, Seungbae Yoon, Youngjoon Lee, Dongyeob Han
Summary: Pancreas MRI can differentiate focal lesions by evaluating the enhancement pattern and can be helpful in understanding microscopic changes in the pancreas. This study confirms perfusion changes in the pancreas with pancreatic cancer using dynamic contrast-enhanced MRI and identifies correlations between perfusion and morphological changes in the pancreas.
Article
Cell Biology
Tayde Quiroz-Acosta, Karina Bermeo, Isabel Arenas, David E. Garcia
Summary: Our study supports the hypothesis that GPCRs tonically inhibit HVA Ca2+ channels in pancreatic beta-cells. A voltage-clamp protocol with a strong depolarizing prepulse was used to unmask voltage-dependent inhibition of Ca2+ channels. The novelty of these results strengthens the critical role of GPCRs in Ca2+ channel regulation, highlighting kinetic slowing and increased facilitation ratio. Together, HVA Ca2+ channels of pancreatic beta-cells are constitutively inhibited by GPCRs underlying fine-tuning modulation of insulin secretion.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorge Yassen Diaz-Blancas, Ismael Dominguez-Rosado, Carlos Chan-Nunez, Jorge Melendez-Zajgla, Vilma Maldonado
Summary: This study analyzed the effects of platelets on pancreatic cancer cells and found that platelets can increase the proliferation and migration capacity of cancer cells, enhance clonogenicity, and induce higher expression of stem cell markers. Differential expression of microRNAs in platelets from pancreatic cancer patients and healthy subjects was also discovered, with clear differences between the two groups. Furthermore, differences between blood-derived and pancreatic juice-derived platelets in the cancer patients suggest the presence of distinct platelet subpopulations, warranting further analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Huan Zhao, Xiuzhen Huang, Zixin Liu, Wenjuan Pu, Zan Lv, Lingjuan He, Yan Li, Qiao Zhou, Kathy O. Lui, Bin Zhou
Summary: The study uses genetic lineage tracing to demonstrate that pancreatic endocrine and exocrine progenitor cells do not generate new beta cells, thus arguing against beta-cell neogenesis in the adult mouse pancreas.
Article
Oncology
Javad Hashemi, Abdol-Mohammad Kajbafzadeh, Fariba Ghorbani, Masoud Soleimani, Ehsan Arefian, Reza Khorramirouz, Seyed Ehsan Enderami, Parvin Pasalar
Summary: This study aimed to engineer pancreatic tissue by decellularizing intact rat pancreases and reseeding them with human-induced pluripotent stem cells using different growth factors. The differentiated cells in Exp2 3D culture exhibited significant upregulation of pancreatic endocrine markers and glucose transporter, with the highest insulin and C-peptide concentrations. The presence of decellularized pancreas as a scaffold for hiPSCs and growth factors shows potential for applications.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Aedan Brown, Emmanuel S. Tzanakakis
Summary: Insulin and glucagon play important roles in blood sugar homeostasis. Glucagon increases glucose levels by acting on the liver, while insulin promotes sugar uptake by peripheral tissues. However, the interaction between alpha- and beta-cells in the pancreas is not fully understood. This study developed a model to investigate the response of pancreatic cells to glucose under different conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Daniel Oropeza, Valentina Cigliola, Agustin Romero, Simona Chera, Santiago A. Rodriguez-Segui, Pedro L. Herrera
Summary: The research demonstrates that alpha-cells undergo stage-specific transcriptional changes at 5 and 15 days post-beta-cell ablation through diphtheria toxin (DT). At day 5, alpha-cells transiently upregulate genes related to interferon signaling and proliferation, while at day 15 they experience a temporary downregulation of genes involved in insulin receptor, mTOR, and MET signaling, indicating potential novel markers and modulated signaling pathways in alpha-cells following acute beta-cell loss.
Article
Medicine, Research & Experimental
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Rana Melhem, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
Summary: Spatially-organized increases in Ca2+ within pancreatic beta cells under high glucose stimulation were found to be mediated by leader cells, which possess unique molecular features and localized signaling with delta cells. Single cell RNA sequencing revealed differential gene expression related to cilium biogenesis and transcriptional regulation between leader and follower cells.
Article
Endocrinology & Metabolism
Stephan C. Collins, Hyun Woong Do, Benoit Hastoy, Alison Hugill, Julie Adam, Margarita V. Chibalina, Juris Galvanovskis, Mahdieh Godazgar, Sheena Lee, Michelle Goldsworthy, Albert Salehi, Andrei I. Tarasov, Anders H. Rosengren, Roger Cox, Patrik Rorsman
Article
Endocrinology & Metabolism
Pontus Duner, Israa Mohammad Al-Amily, Arvind Soni, Olof Asplund, Fateme Safi, Petter Storm, Leif Groop, Stefan Amisten, Albert Salehi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Multidisciplinary Sciences
Ingmar Lundquist, Israa Mohammed Al-Amily, Sandra Meidute Abaraviciene, Albert Salehi
Article
Biochemistry & Molecular Biology
Mengyin Cai, Pradeep Bompada, Albert Salehi, Juan R. Acosta, Rashmi B. Prasad, David Atac, Markku Laakso, Leif Groop, Yang De Marinis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Patricio Atanes, Inmaculada Ruz-Maldonado, Ross Hawkes, Bo Liu, Min Zhao, Guo Cai Huang, Israa Mohammed Al-Amily, Albert Salehi, Stefan Amisten, Shanta J. Persaud
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Endocrinology & Metabolism
Alexander Hamilton, Quan Zhang, Albert Salehi, Mara Willems, Jakob G. Knudsen, Anna K. Ringgaard, Caroline E. Chapman, Alejandro Gonzalez-Alvarez, Nicoletta C. Surdo, Manuela Zaccolo, Davide Basco, Paul R. V. Johnson, Reshma Ramracheya, Guy A. Rutter, Antony Galione, Patrik Rorsman, Andrei I. Tarasov
Article
Endocrinology & Metabolism
Stefan Amisten, Pontus Duner, Olof Asplund, Israa Mohammed Al-Amily, Leif Groop, Albert Salehi
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2018)
Article
Multidisciplinary Sciences
Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Stefan Amisten, Patricio Atanes, Ross Hawkes, Inmaculada Ruz-Maldonado, Bo Liu, Fariborz Parandeh, Min Zhao, Guo Cai Huang, Albert Salehi, Shanta J. Persaud
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Enming Zhang, Israa Mohammed Al-Amily, Sarheed Mohammed, Cheng Luan, Olof Asplund, Meftun Ahmed, Yingying Ye, Danya Ben-Hail, Arvind Soni, Neelanjan Vishnu, Pradeep Bompada, Yang De Marinis, Leif Groop, Varda Shoshan-Barmatz, Erik Renstrom, Claes B. Wollheim, Albert Salehi
Article
Multidisciplinary Sciences
Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
NATURE COMMUNICATIONS
(2019)
Article
Physiology
Israa Mohammad Al-Amily, Pontus Duner, Leif Groop, Albert Salehi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Jalal Taneera, Abdul Khader Mohammed, Sarah Dhaiban, Mawieh Hamad, Rashmi B. Prasad, Nabil Sulaiman, Albert Salehi
Article
Genetics & Heredity
Jalal Taneera, Sarah Dhaiban, Abdul Khader Mohammed, Debasmita Mukhopadhyay, Hayat Aljaibeji, Nabil Sulaiman, Joao Fadista, Albert Salehi
Article
Endocrinology & Metabolism
Stefan Amisten, Israa Mohammad Al-Amily, Arvind Soni, Ross Hawkes, Patricio Atanes, Shanta Jean Persaud, Patrik Rorsman, Albert Salehi
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.