Article
Biochemistry & Molecular Biology
Syed Benazir Alam, Ashley Wagner, Steven Willows, Marianna Kulka
Summary: Quercetin and resveratrol have differential inhibitory effects on mast cells, potentially through modulation of FcεRI expression, signaling, and mediator release.
Article
Biochemistry & Molecular Biology
Tsubasa Ashikari, Masakazu Hachisu, Kazuki Nagata, Daisuke Ando, Yuki Iizuka, Naoto Ito, Kandai Ito, Yuki Ikeda, Hiroki Matsubara, Takuya Yashiro, Kazumi Kasakura, Chiharu Nishiyama
Summary: Mast cells play a significant role in IgE-mediated immunoresponses, and salicylaldehyde, identified as an inhibitor of mast cell activation, shows potential as an antiallergic compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Donald MacGlashan
Summary: This study found that released FceRI-alpha accounted for 7% of total surface FceRI before the reaction, with a molecular weight of approximately 54 kD. The release of FceRI-alpha was found to be independent of internalized processing and starting density of FceRI, and was more effective with non-IgE-dependent stimuli.
Article
Allergy
Cynthia Kanagaratham, Tahereh Derakhshan, Yasmeen S. El Ansari, Kameryn N. Furiness, Eleanor Hollers, Mats Keldsen, Hans C. Oettgen, Daniel F. Dwyer
Summary: In this study, the inhibitory effects of IgG:Fc?RIIb signaling on MC responses to IgE were assessed using complementary transcriptomic and functional approaches. The results showed that IgG signaling via Fc?RIIb has a suppressive effect on IgE-induced MC transcription, especially genes related to bone marrow-derived MCs activation. These findings are important for understanding the regulatory mechanisms of IgG on IgE-induced MC responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O'Sullivan
Summary: Mast cells are tissue-resident cells that contribute to allergic diseases through excessive or inappropriate cellular activation and degranulation. Siglec-6, a receptor selectively expressed by mast cells, could be a promising target for therapeutic intervention. This study found that Siglec-6 is highly expressed by human mast cells and has a potent inhibitory effect on mast cell activation, making it a potential therapeutic target for mast cell-driven diseases.
Review
Oncology
Mohammad Fereydouni, Mona Motaghed, Elnaz Ahani, Tal Kafri, Kristen Dellinger, Dean D. Metcalfe, Christopher L. Kepley
Summary: The role of mast cells in cancer pathologies is controversial, but they could serve as a platform for developing novel mechanisms of tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Yuka Nagata, Ryo Suzuki
Summary: Mast cells (MCs) have different roles in allergic responses, and the interactions between antigens and immunoglobulin E (IgE) can trigger diverse responses in MCs. The clustering of high-affinity IgE receptor Fc epsilon RI is crucial for signal transduction and determines the quality of MC responses. Antigen properties precisely regulate Fc epsilon RI dynamics, which can result in different outcomes by switching the intracellular signaling pathway, suggesting that antigen properties can control MC responses both qualitatively and quantitatively.
Article
Critical Care Medicine
Angelica Tiotiu, Yusef Badi, Nazanin Zounemat Kermani, Marek Sanak, Johan Kolmert, Craig E. Wheelock, Philip M. Hansbro, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Yike Guo, Sharon Mumby, Ian M. Adcock, Kian Fan Chung
Summary: By analyzing gene signatures of MC activation, we can identify phenotypes of severe asthma and indicate that MCs can have distinct transcriptional phenotypes associated with specific clinical phenotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Ashley Wagner, Syed Benazir Alam, Marianna Kulka
Summary: This study compared the response of different mast cell models to common stimuli and found that factors such as source, age, and biological sex play an important role in phenotypic outcomes and may explain the variability in their function.
CELLULAR IMMUNOLOGY
(2023)
Article
Allergy
Yang Li, Patrick S. C. Leung, M. Eric Gershwin, Junmin Song
Summary: Mast cells originate from hematopoietic progenitors in the bone marrow and migrate to peripheral tissues. Microbiota/metabolites and immune cells play a key role in immune tolerance. Activation of allergen-specific IgE on mast cells triggers intracellular signal cascade, leading to degranulation and release of pro-inflammatory mediators. Multiple signal components in the allergic cascade can be targeted for therapeutic purposes.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Review
Allergy
Daniel Elieh-Ali-Komi, Martin Metz, Pavel Kolkhir, Emek Kocatuerk, Joerg Scheffel, Stefan Frischbutter, Dorothea Terhorst-Molawi, Lena Fox, Marcus Maurer
Summary: The signs and symptoms of chronic urticaria (CU) are caused by the activation and degranulation of skin mast cells (MCs). Recent studies have contributed to our understanding of the involvement and differences of skin MCs in CU. Moreover, novel mechanisms of MC activation in CU have been identified and characterized. The use of MC-targeted and MC mediator-specific treatments has also provided insights into the role of the skin environment and the relevance of MC crosstalk in CU pathogenesis. This review summarizes these recent findings and their impact on our understanding of CU, specifically focusing on chronic spontaneous urticaria (CSU). It also highlights unresolved questions, controversial issues, and future research directions.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Deisy Segura-Villalobos, Monica Lamas, Claudia Gonzalez-Espinosa
Summary: This study found that the localization of mast cells within cyclic hypoxia regions in tumors can modify their transcriptional profile and activation parameters. Cyclic hypoxia causes important phenotypic changes in mast cells.
Review
Immunology
Edward S. Schulman, Haruhisa Nishi, Amir Pelleg
Summary: Since the late 1970s, there has been a significant increase in the incidence and mortality of asthma. This review focuses on the role of endogenous purine nucleotide ATP in mast cells' physiology, particularly in allergic reactions. ATP activates P2 purinergic cell-surface receptors to trigger heightened inflammatory responses. It is the most potent enhancer of IgE-mediated mast cell degranulation described to date. The reviewed studies provide insights into the unpredictability and intensity of clinical reactions to minimal allergen exposures and potential therapeutic approaches targeting ATP-related enhancement of allergic reactions are discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sathisha Upparahalli Venkateshaiah, Madhavi Rayapudi, Hemanth Kumar Kandikattu, Chandra Sekhar Yadavalli, Anil Mishra
Summary: This study demonstrates that IL-15 responsive T cells and IgE receptors can serve as novel non-invasive biomarkers for distinguishing between EoE and GERD. Additionally, analysis of blood mRNA levels reveals certain receptors significantly reduced in EoE patients, which can be used as predictors for EoE.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Satomi Mishima, Marin Sakamoto, Hikaru Kioka, Yuka Nagata, Ryo Suzuki
Summary: This study comprehensively examined the role of VAMP3 in mast cell function and the molecular mechanisms underlying it. The results suggest that VAMP3 mediates granule fusion and promotes granule exocytosis in mast cells. The loss of VAMP3 disrupts plasma membrane homeostasis and enhances Fc epsilon RI-mediated signal transduction. VAMP3 plays a multifunctional role in complex secretory responses in mast cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yasuhiro Nanri, Satoshi Nunomura, Yasuhiro Terasaki, Tomohito Yoshihara, Yusuke Hirano, Yasuyuki Yokosaki, Yukie Yamaguchi, Carol Feghali-Bostwick, Keiichi Ajito, Shoichi Murakami, Simon J. Conway, Kenji Izuhara
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Oncology
Ryuichiro Kimura, Tetsuro Yoshimaru, Yosuke Matsushita, Taisuke Matsuo, Masaya Ono, Jae-Hyun Park, Mitsunori Sasa, Yasuo Miyoshi, Yusuke Nakamura, Toyomasa Katagiri
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Review
Allergy
Yasutaka Mitamura, Satoshi Nunomura, Masutaka Furue, Kenji Izuhara
ALLERGOLOGY INTERNATIONAL
(2020)
Article
Medicine, General & Internal
Takeshi Nakahara, Kenji Izuhara, Daisuke Onozuka, Satoshi Nunomura, Risa Tamagawa-Mineoka, Koji Masuda, Susumu Ichiyama, Hidehisa Saeki, Yudai Kabata, Riichiro Abe, Mamitaro Ohtsuki, Koji Kamiya, Tatsuro Okano, Tomomitsu Miyagaki, Yozo Ishiuji, Akihiko Asahina, Hiroshi Kawasaki, Keiji Tanese, Hiroshi Mitsui, Tatsuyoshi Kawamura, Takuya Takeichi, Masashi Akiyama, Emi Nishida, Akimichi Morita, Kyoko Tonomura, Yukinobu Nakagawa, Koji Sugawara, Chiharu Tateishi, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Michihiro Hide, Natsuko Aoki, Shigetoshi Sano, Haruna Matsuda-Hirose, Yutaka Hatano, Motoi Takenaka, Hiroyuki Murota, Norito Katoh, Masutaka Furue
Article
Biochemistry & Molecular Biology
Satoshi Nunomura, Yasuhiro Nanri, Veronique Lefebvre, Kenji Izuhara
Summary: SOX11 deficiency in epithelial cells impairs the extension of the leading edge of eyelids, resulting in embryonic eyelid closure failure. The transcription factor c-Jun downstream of FGF10 is required for this extension and its levels are decreased in SOX11-deficient embryos.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Genetics & Heredity
Tetsuro Yoshimaru, Yusuke Nakamura, Toyomasa Katagiri
Summary: Breast cancer is a heterogeneous disease with treatment options including surgery, radiotherapy, chemotherapy, and molecular-targeted drugs, but resistance often leads to treatment failure. Understanding molecular mechanisms can help improve treatment outcomes.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Allergy
Satoshi Nunomura, Isao Kitajima, Yasuhiro Nanri, Midori Kitajima, Naoko Ejiri, I-Shuan Lai, Naoko Okada, Kenji Izuhara
Summary: The FADS mouse model, generated by specifically deleting Ikk2 in facial skin fibroblasts, exhibits similar ocular lesions to AKC in patients and can be used to examine the therapeutic effects of anti-AKC agents. Tear periostin, a novel biomarker for allergic conjunctival disease, is valuable for evaluating the efficacy of such treatments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Letter
Dermatology
Yasuhiro Nanri, Satoshi Nunomura, Tomoya Watanabe, Shoichiro Ohta, Yukie Yamaguchi, Kenji Izuhara
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Pediatrics
Hayato Go, Junya Ono, Hitoshi Ohto, Kenneth E. Nollet, Kenichi Sato, Yohei Kume, Hajime Maeda, Mina Chishiki, Kentaro Haneda, Hirotaka Ichikawa, Nozomi Kashiwabara, Yuji Kanai, Kei Ogasawara, Maki Sato, Koichi Hashimoto, Satoshi Nunomura, Kenji Izuhara, Mitsuaki Hosoya
Summary: This study found higher serum periostin levels at birth in preterm infants subsequently diagnosed with bronchopulmonary dysplasia, and the serum periostin levels at birth significantly correlated with gestational age and birth weight.
PEDIATRIC RESEARCH
(2022)
Article
Respiratory System
Takashi Yoshida, Tetsutaro Nagaoka, Yuichi Nagata, Yoshifumi Suzuki, Takeo Tsutsumi, Sachiko Kuriyama, Junko Watanabe, Shinsaku Togo, Fumiyuki Takahashi, Masakazu Matsushita, Yusuke Joki, Hakuoh Konishi, Satoshi Nunomura, Kenji Izuhara, Simon J. Conway, Kazuhisa Takahashi
Summary: Periostin plays an important role in the development of pulmonary hypertension (PH) and is involved in the pathogenesis of both experimental PH and human PH.
Article
Medical Laboratory Technology
Masayuki Takai, Junya Ono, Masaki Okamoto, Kiminori Fujimoto, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Shoichiro Ohta, Tomoaki Hoshino, Arata Azuma, Kenji Izuhara
Summary: The formation of an IgA complex affects the measurement of periostin. The EMI and R1 domains of periostin contribute to the formation of the complex with IgA. A novel ELISA system that combines the R3 and R4 domains allows for independent measurement of periostin.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Letter
Allergy
Naoko Okada, Hiroyuki Yazu, Eisuke Shimizu, Kazumi Fukagawa, Satoshi Nunomura, Hirohisa Saito, Kenji Matsumoto, Atsushi Kawaguchi, Kenji Izuhara, Hiroshi Fujishima
Letter
Allergy
Takeshi Nakahara, Kenji Izuhara, Daisuke Onozuka, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Michihiro Hide, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Makiko Kido-Nakahara, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Keiji Tanese, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Norito Katoh, Masutaka Furue
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Respiratory System
Takuma Isshiki, Hisayo Matsuyama, Tetsuo Yamaguchi, Toshisuke Morita, Junya Ono, Satoshi Nunomura, Kenji Izuhara, Susumu Sakamoto, Sakae Homma, Kazuma Kishi
RESPIRATORY INVESTIGATION
(2020)
Article
Respiratory System
Tomohito Yoshihara, Yasuhiro Nanri, Satoshi Nunomura, Yukie Yamaguchi, Carol Feghali-Bostwick, Keiichi Ajito, Shoichi Murakami, Masaaki Mawatari, Kenji Izuhara
RESPIRATORY RESEARCH
(2020)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
