Article
Pharmacology & Pharmacy
Tong Zhou, Ke Yan, Yuhan Zhang, Linfangzi Zhu, Yi Liao, Xiaoxiang Zheng, Yongxiong Chen, Xiaoxin Li, Zuguo Liu, Zhaoqiang Zhang
Summary: This study explored the potential mechanism of fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, against corneal neovascularization by investigating changes in lipid metabolism. The findings suggest that lipid metabolism disorder may contribute to suture-induced corneal neovascularization, and fenofibrate exerts anti-neovascularization and anti-inflammatory effects by regulating key enzymes in lipid metabolism and reducing lipid peroxidation damage through the PPAR alpha signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chen Sun, Shuyu Mao, Siyu Chen, Wenxiang Zhang, Chang Liu
Summary: PPARs have been identified as crucial regulators of lipid and glucose homeostasis and have the potential to improve metabolic syndromes. Adipose tissue plays a significant role in insulin resistance and metabolic syndromes, with PPARs playing essential roles in adipocyte biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Zijian Xu, Limei Shi, Daochuan Li, Qincheng Wu, Ying Zhang, Mengyu Gao, Andong Ji, Qixiao Jiang, Rui Chen, Rong Zhang, Wen Chen, Yuxin Zheng, Lianhua Cui
Summary: The study found that exposure to particulate matter can lead to lipid metabolism disorders. In this experiment, mice were exposed to real-ambient particulate matter for six weeks using an individually ventilated cage system. The results showed that particulate matter exposure caused dyslipidemia, liver steatosis, increased size of white adipocytes, and whitening of brown adipose tissue. Additionally, the expression of lipid metabolism-related genes was affected by particulate matter exposure. Treatment with the PPAR alpha agonist WY14,643 alleviated the symptoms of particulate matter-induced dyslipidemia, liver steatosis, and whitening of brown adipose tissue.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Lianggong Ding, Wenfei Sun, Miroslav Balaz, Anyuan He, Manuel Klug, Stefan Wieland, Robert Caiazzo, Violeta Raverdy, Francois Pattou, Philippe Lefebvre, Irfan J. Lodhi, Bart Staels, Markus Heim, Christian Wolfrum
Summary: The study elucidates a cellular mechanism for sensing cellular fatty acid levels and adjusting lipolysis as needed, involving peroxisomal degradation of fatty acids, production of reactive oxygen species, and post-translational regulation of adipose triglyceride lipase.
Article
Endocrinology & Metabolism
Tingwan Du, Lian Xiang, Jingjing Zhang, Chunmei Yang, Wenxin Zhao, Jialu Li, Yong Zhou, Ling Ma
Summary: This study aimed to explore the association between serum 25(OH)D-3 and hepatic steatosis in NAFLD patients and investigate whether vitamin D has an effect on activating the PPAR alpha pathway. The study consisted of a case-control study, in vivo experiments with rats, and in vitro experiments with HepG2 cells. The results showed that NAFLD patients had impaired liver function, dyslipidemia, and insulin resistance. Adequate vitamin D levels were found to have a protective effect on NAFLD patients. In addition, vitamin D treatment ameliorated hepatic steatosis in both rats and cells. MK886, a PPARa antagonist, inhibited the anti-steatosis effect of vitamin D. These findings suggest that vitamin D may protect against NAFLD and alleviate hepatic steatosis through the PPAR alpha signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jungu Lee, Suyeon Jeon, Mijeong Lee, Michung Yoon
Summary: The study investigated the effects of fenofibrate on insulin resistance and tissue inflammation in HFD-fed OVX mice. Results showed that fenofibrate treatment reduced body weight gain, adipose tissue mass, and the size of visceral adipocytes in these mice. It also improved hyperglycemia, hyperinsulinemia, and glucose tolerance. Fenofibrate reduced pancreatic islet size, insulin-positive beta-cell area, pancreatic lipid accumulation, and CD68-positive macrophages in both the pancreas and visceral adipose tissue. It also decreased TNF alpha expression levels in adipose tissue and serum.
NUTRITION & DIABETES
(2023)
Article
Integrative & Complementary Medicine
Cui Shuang, Pan Xiao-Jie, Ge Chao-Liang, Guo Yi-Tong, Zhang Peng-Fei, Yan Ting-Ting, Zhou Ji-Yu, He Qing-Xian, Cheng Long-Hao, Wang Guang-Ji, Hao Hai-Ping, Wang Hong
Summary: Silymarin protects against NAFLD by activating PPARα to reduce lipid accumulation in mice, and it is not recommended to take silymarin and classical PPARα agonists simultaneously for NAFLD therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Selin Gencer, Yvonne Doering, Yvonne Jansen, Soyolmaa Bayasgalan, Olga Schengel, Madeleine Mueller, Linsey J. F. Peters, Christian Weber, Emiel P. C. van der Vorst
Summary: This study reveals that adipocyte-specific ACKR3 plays a key role in regulating lipid levels in hyperlipidemic mice, potentially impacting the health of adipose tissue. On the other hand, hepatic ACKR3 deficiency did not show comparable effects on lipid levels in adipose tissue. Further research is needed to explore the systemic or metabolic effects of adipocyte ACKR3 in disease models.
Article
Cell Biology
Oliver Stohr, Rongya Tao, Ji Miao, Kyle D. Copps, Morris F. White
Summary: Fgf21 plays a crucial role in regulating metabolism during hepatic insulin resistance, as shown by studies where modestly reduced Fgf21 due to hepatic FoxO1 suppression contributed to metabolic dysregulation in LDKO mice. Restoring Fgf21 through adenoviral infection corrected metabolic issues in the mice, highlighting the importance of Fgf21-dependent plasticity and BAT function in metabolic health.
Article
Biochemistry & Molecular Biology
Rosaria Scandiffio, Sara Bonzano, Erika Cottone, Sujata Shrestha, Simone Bossi, Silvia De Marchis, Massimo E. Maffei, Patrizia Bovolin
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease without approved pharmacological therapy. The study investigated the effects of (E)-beta-caryophyllene (BCP), a phytocannabinoid, on HepG2 steatotic hepatocytes. BCP was found to decrease lipid accumulation and change the lipid profile in steatotic conditions by reducing saturated fatty acids. The action of BCP was mediated by CB2 cannabinoid receptor, peroxisome proliferator-activated receptor alpha (PPAR alpha), and gamma (PPAR gamma). The results suggest potential applications of BCP in the treatment of NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Elisa Felix-Soriano, Kristin I. Stanford
Summary: Longer duration of breastfeeding in rodents leads to an adult phenotype that is resistant to diet-induced obesity and has increased brown adipose tissue activity, which is dependent on hypothalamic FGF21 signaling.
Article
Biochemistry & Molecular Biology
Longkai Shi, Emad Karrar, Xingguo Wang
Summary: The study shows that sesamol has a significant effect on improving hepatic steatosis by regulating hepatic lipid metabolism and reducing oxidative stress, making it a potential agent for treating NAFLD. Sesamol-rich sesame oil could be used in functional foods and nutraceutical applications in the future.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jinsoo Song, In-Jeoung Baek, Sujeong Park, Jinjoo Oh, Deokha Kim, Kyung Song, Mi Kyung Kim, Hye Won Lee, Byoung Kuk Jang, Eun-Jung Jin
Summary: The aberrant expression of peroxisomal NUDT7 leads to typical features of non-alcoholic fatty liver disease, including increased levels of hepatic triglycerides and fatty acids, infiltration of inflammatory cells, impaired glucose tolerance and insulin sensitivity, and stimulation of adipose tissue lipolysis. The deficiency of Nudt7 enhances de novo lipogenesis in hepatocytes and activates PPAR signaling pathway. Liraglutide can reduce the typical features of non-alcoholic fatty liver disease caused by NUDT7 deficiency.
Article
Gastroenterology & Hepatology
Feng-Zhi Xin, Ze-Hua Zhao, Xiao-Lin Liu, Qin Pan, Zi-Xuan Wang, Lin Zeng, Qian-Ren Zhang, Lin Ye, Meng-Yu Wang, Rui-Nan Zhang, Zi-Zhen Gong, Lei-Jie Huang, Chao Sun, Feng Shen, Lu Jiang, Jian-Gao Fan
Summary: The expansion of Escherichia-Shigella in NAFLD patients was found to be associated with disease severity, independent of obesity. Escherichia fergusonii induced nonobese NAFLD in rats characterized by hepatic steatosis and hepatocyte ballooning, disrupting host lipid metabolism. Additionally, E fergusonii-derived msRNA 23487 down-regulated host hepatic peroxisome proliferator-activated receptor alpha expression, contributing to liver lipid accumulation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Vanessa Barbosa Veronesi, Mariana Rodrigues Pioli, Dailson Nogueira de Souza, Caio Jordao Teixeira, Gilson Masahiro Murata, Junia Carolina Santos-Silva, Fernanda Ballerini Hecht, Julia Modesto Vicente, Silvana Bordin, Gabriel Forato Anhe
Summary: The study suggests that Agomelatine mimics the metabolic benefits of melatonin in fructose-treated rats, resulting in reduced body weight gain, improved liver lipid levels, and decreased circulating triglyceride levels. Additionally, Agomelatine also decreases hepatic fatty acid synthesis and intestinal lipoprotein production in fructose-treated rats.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Psychology, Clinical
Edna M. Sant'Anna, Sara P. C. Paiva, Raphael P. Santos, Ana M. S. Rodrigues, Nakita A. Davis, Simone F. Nery, Fernanda P. Maia, Adaliene V. M. Ferreira, Fernando M. Reis
Summary: In the short term, the mindfulness-based program did not lead to weight loss in infertile women, but it did contribute to a reduction in waist circumference, possibly due to a decrease in food energy intake.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2022)
Article
Cell Biology
Camila P. Almeida, Camila O. Silveira, Enio F. Ferreira, Marcia C. Ferreira, Gabriella G. Oliveira, Emerson S. Veloso, Felipe H. S. Silva, Santuza S. Coelho, Leonardo M. Moraes, Fernando M. Reis, Helen L. Del Puerto
Summary: The study revealed that pro-caspase-3 is constitutively expressed in human luteinized granulosa cells (LGC), while cleaved caspase-3 is found in only a small percentage of cells. The expression of pro-caspase-3 was independent of CASP3 mRNA levels and did not correlate with the amount of cleaved caspase-3. These findings suggest that pro-caspase-3 may play a role in quick cleavage into active caspase-3 and triggering apoptosis during gonadotropin-induced follicular development.
Article
Biochemistry & Molecular Biology
Flavia R. Oliveira, Maira Casalechi, Marcia M. Carneiro, Ivete de Avila, Cynthia Dela Cruz, Helen L. Del Puerto, Aroldo F. Camargos, Mauricio S. Abrao, Fernando M. Reis
Summary: The study found that Oct-4, C-kit and Musashi-1 are widely expressed in normal and endometriosis patients' endometrium, as well as in endometriotic lesions. However, these markers are not suitable for the characterization of endometrial SPCs.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Neurosciences
Lais Bhering Martins, Jenneffer Rayane Braga Tibaes, Ana Maria dos Santos Rodrigues, Ammar Hassanzadeh Keshteli, Carolina Karam Vono, Julia Borges e Borges, Paula Martins Horta, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: This study found that patients with migraine have lower diet quality and higher Dietary Inflammatory Index (DII) compared to healthy controls. However, the scores of diet quality and DII were not correlated with migraine frequency and severity.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Veterinary Sciences
Tatiany L. Silveira, Lisa Y. Pang, Alexandra Di Domenico, Emerson S. Veloso, Istefani L. D. Silva, Helen L. Del Puerto, Enio Ferreria, David J. Argyle
Summary: Metastatic melanoma is an aggressive form of cancer in humans and dogs, with COX-2 potentially playing a critical role in malignant behavior. The study on canine melanomas showed that COX-2 is overexpressed in both oral and cutaneous melanomas, correlating with poor prognosis markers. The research also established a direct relationship between COX-2 expression and malignant behavior in canine melanoma, providing a powerful molecular tool for further understanding melanoma progression.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Neurosciences
Mariele Lino Silva, Lais Bhering Martins, Luana Caroline dos Santos, Gilberto Simeone Henriques, Antonio Lucio Teixeira, Ana Maria dos Santos Rodrigues, Adaliene Versiani Matos Ferreira
Summary: This study suggests that patients with migraine have lower plasma levels of minerals and lower dietary intake of minerals compared to individuals without migraine. It highlights the importance of dietary intervention to ensure adequate mineral intake as a therapeutic strategy for migraine.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
Camila O. Silveira, Rafaela M. Oliveira, Leonardo M. Moraes, Gabriella G. Oliveira, Luciana P. T. Aguiar, Felipe H. S. Souza, Santuza S. Coelho, Pedro H. D. M. Prazeres, Helen L. Del Puerto, Marcia C. F. Ferreira
Summary: This study investigated the in vitro effects of clomiphene citrate and letrozole on apoptosis in human cumulus cells. The results showed that these drugs did not significantly affect cell viability but modulated the expression of genes involved in apoptosis. Co-treatment with estradiol reversed the effects on gene expression.
REPRODUCTIVE SCIENCES
(2022)
Article
Nutrition & Dietetics
Jenneffer Rayane Braga Tibaes, Lais Bhering Martins, Ana Maria dos Santos Rodrigues, Matheus Henrique Alves Amaral, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: This study evaluated the effect of long-term consumption of dry ginger extract on the resting energy expenditure (REE) of female adults with high body adiposity. The results showed that continuous consumption of ginger extract for 3 months did not change the REE, anthropometric, and clinical data of female adults with excess adiposity.
Article
Endocrinology & Metabolism
Anna Paula Marcal, Nicia Soares, Laila Asth, Fabricio A. Moreira, Adaliene V. M. Ferreira, Daniele C. Aguiar
Summary: This study investigated the effects of cannabidiol (CBD) treatment on behavior problems induced by a high-refined carbohydrate diet. The results demonstrated that sub-chronic treatment with CBD could alleviate the compulsive-like and anxiogenic-like behavior caused by long-term consumption of a high-refined carbohydrate diet.
METABOLIC BRAIN DISEASE
(2022)
Article
Multidisciplinary Sciences
Emerson Soares Veloso, Barbara Andrade de Carvalho, Felipe Henrique de Souza Silva, Thais Salviana Ribeiro, Bruna Mendes Lima, Camila Pereira Almeida, Vitor Henrique Soares Romao da Silva, Sara Aparecida Rocha, Marina Rios de Araujo Campos, Helen Lima Del Puerto, Enio Ferreira
Summary: Metformin can inhibit EMT and reduce the metastatic potential of melanoma cells, suggesting its potential role in the prevention and treatment of melanoma.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Marina C. Zicker, Carina C. Montalvany-Antonucci, Debora R. Lacerda, Marina C. Oliveira, Tarcilia A. Silva, Soraia Macari, Mila F. M. Madeira, Adaliene V. M. Ferreira
Summary: This study found that supplementation of virgin coconut oil (VCO) can attenuate the osteopenic effects induced by obesity. VCO supplementation increases trabecular bone and improves the microarchitecture of the femur and alveolar bone.
Article
Veterinary Sciences
Thaynan Cunha Vieira, Evelyn Ane Oliveira, Barbara Jaime dos Santos, Fernanda Rezende Souza, Emerson Soares Veloso, Cristiana Buzelin Nunes, Helen Lima Del Puerto, Geovanni Dantas Cassali
Summary: Pure human and canine mammary invasive micropapillary carcinoma is a rare and aggressive tumor with a high rate of lymphatic invasion and metastasis, leading to a poor prognosis. COX-2 protein is overexpressed in both types of carcinoma, while COX-2 mRNA expression is significantly higher in canine tumors and is associated with negative estrogen receptor and high Ki67.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Article
Oncology
Felipe Henrique de Souza Silva, Adam Underwood, Camila Pereira Almeida, Thais Salviana Ribeiro, Elaine M. Souza-Fagundes, Almir S. Martins, Marcos Eliezeck, Silvia Guatimosim, Luciana O. Andrade, Luisa Rezende, Hipacia Werneck Gomes, Cleida Aparecida Oliveira, Raquel Cristina Rodrigues, Isabella Terra Borges, Geovanni Dantas Cassali, Enio Ferreira, Helen Lima Del Puerto
Summary: The study suggests that the SOX3 transcription factor can promote apoptosis in the breast cancer cell line MDA-MB-231, while its nuclear expression is downregulated in cases of invasive ductal carcinoma. Further research is needed to investigate its role as a tumor suppressor protein and its regulation of genes involved in apoptosis.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.