Article
Multidisciplinary Sciences
Kengo Yoshida, Yasunari Satoh, Arikuni Uchimura, Munechika Misumi, Seishi Kyoizumi, Masataka Taga, Yukiko Matsuda, Asao Noda, Yoichiro Kusunoki
Summary: Radiation exposure has been found to induce clonal hematopoiesis (CH) in elderly individuals, which is associated with hematologic malignancy and cardiovascular disease. This study used a mouse model to investigate the effects of radiation exposure on CH. The results showed that radiation exposure led to an increase in peripheral blood myeloid cells and red blood cell distribution width, and recurrent somatic mutations were observed specifically in the hematopoietic system. These findings highlight the development of massive CH due to radiation exposure and provide insights into the mutations involved in radiation-induced CH.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Xinmiao Wang, Weinian Liao, Jun Chen, Yiding Wu, Chaonan Liu, Shilei Chen, Yang Xu, Song Wang, Yongping Su, Changhong Du, Junping Wang
Summary: Mitochondrial oxidative damage is rapidly induced in hematopoietic stem cells (HSCs) after exposure to ionizing radiation, leading to apoptosis. The induction of 5-lipoxygenase (5-LOX) plays a key role in this process, while the natural antioxidant caffeic acid (CA) can protect against HSC apoptosis by suppressing 5-LOX-mediated mitochondrial oxidative damage.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Stephanie Hasapis, Isibel Caraballo, Timothy J. Sears, Kennedy D. Brock, John B. Cart, Everett J. Moding, Chang-Lung Lee
Summary: The transcription factor p53 plays a crucial role in controlling the toxicity and malignant transformation of hematopoietic cells induced by genotoxic stress. The gene Phlda3 is robustly induced by radiation and its role in response to radiation in hematopoietic cells is unknown.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Kimberly J. Jurgensen, William K. J. Skinner, Bryan Oronsky, Nacer D. Abrouk, Andrew E. Graff, Reid D. Landes, William E. Culp, Thomas A. Summers, Lynnette H. Cary
Summary: The present studies demonstrate that systemic administration of RRx-001 prior to total body irradiation significantly improves overall survival and bone marrow regeneration in mice, suggesting potential applications in radiation protection.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Adam Institoris, Ciaran Murphy-Royal, Stefano Tarantini, Andriy Yabluchanskiy, Jordan N. Haidey, Anna Csiszar, Zoltan Ungvari, Grant R. Gordon
Summary: Whole brain irradiation (WBI) therapy is a key treatment for brain metastases, but can lead to cognitive decline. This study investigated the impact of WBI on astrocytic Ca2+ signaling and gap junctional coupling, finding that while the latter remained unaffected, there was a long-lasting reduction in synaptic-evoked astrocyte Ca2+ signals, potentially contributing to cognitive impairment post-WBI.
Article
Biochemistry & Molecular Biology
Hao Luan, Jinkun Yang, Yemei Wang, Xing Shen, Xuewen Zhang, Zizhi Qiao, Shuang Xing, Zuyin Yu
Summary: This study found that recombinant human thrombopoietin (rhTPO) can improve long-term bone marrow suppression and promote hematopoietic recovery. RhTPO reduces long-term myelosuppression by enhancing the self-renewal capacity of hematopoietic stem cells, reducing DNA damage, suppressing cell senescence, and regulating hematopoietic remodeling and HSC cycle disorder through the ROS/p53/p21/p16 pathway long term after ionizing radiation.
Article
Chemistry, Multidisciplinary
Hang Li, Mian Jiang, Shu-ya Zhao, Shu-qin Zhang, Lu Lu, Xin He, Guo-xing Feng, Xin Wu, Sai-jun Fan
Summary: This study revealed the involvement of exosomes in TBI-induced intestinal injury in mice, providing a new target for protecting patients against irradiation-induced intestinal injury during radiotherapy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Yan Qi, Shilei Chen, Yukai Lu, Zihao Zhang, Song Wang, Naicheng Chen, Mingqiang Shen, Fang Chen, Mo Chen, Yong Quan, Lijing Yang, Yang Xu, Yongping Su, Mengjia Hu, Junping Wang
Summary: The research demonstrates that grape seed proanthocyanidin extract can ameliorate IR-induced HSPC injury by upregulating the expression of Foxo1 and its target antioxidant genes, thereby reducing ROS production and DNA damage while increasing HSC reconstituting ability and survival in irradiated mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell & Tissue Engineering
Han-Sol So, Min-Guk Kim, Jeong-Chae Lee, Sung-Ho Kook
Summary: The study found that using glucose oxidase (GO) can effectively promote the mobilization of hematopoietic stem progenitor cells (HSPCs) from the bone marrow to peripheral blood, even in animal models. Through combined use with granulocyte colony-stimulating factor (G-CSF) and/or AMD3100, the mobilization of HSPCs can be greatly enhanced.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Mitchell Sabloff, Steven Tisseverasinghe, Mustafa Ege Babadagli, Rajiv Samant
Summary: Total body irradiation (TBI) plays a crucial role in hematopoietic cell transplantation by eliminating disease and suppressing the immune system to prevent rejection of donor cells. Compared to chemotherapy, TBI may offer greater tumor cytotoxicity and tissue penetration capabilities.
Article
Cell & Tissue Engineering
Zenghua Lin, Maile K. Hollinger, Zhijie Wu, Wanling Sun, Kaylind Batey, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young
Summary: It was found that sirolimus enhanced the regeneration of hematopoietic stem and progenitor cells in mice exposed to sublethal total body irradiation and other regenerative stressors. The effects were associated with increased expression of hematopoietic genes, reduced DNA damage and clearance of cellular reactive oxygen species. Sirolimus also showed potential clinical applications for the treatment and prevention of hematopoietic injury.
Article
Multidisciplinary Sciences
M. H. Yashavarddhan, Ajay Kumar Sharma, Pankaj Chaudhary, Sania Bajaj, Sukhvir Singh, Sandeep Kumar Shukla
Summary: Researchers have developed a mouse model for studying hematopoietic syndrome in non-uniform or partial body exposure scenarios using cobalt(60) gamma radiation. They found significant changes in cytokines and stem cell markers in irradiated mice compared to untreated controls, indicating the potential usefulness of the model in understanding non-uniform body exposure scenarios.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sajeev Wagle, Hyun-Jaung Sim, Govinda Bhattarai, Ki-Choon Choi, Sung-Ho Kook, Jeong-Chae Lee, Young-Mi Jeon
Summary: Ferulic acid, as a dietary antioxidant, can protect against systemic damages caused by TBI by restoring disorders in bone formation, osteoclast activation, and adipocyte activation, thereby preventing stem cell senescence and bone mass loss.
Article
Oncology
Brita Singers Sorensen, Mateusz Krzysztof Sitarz, Christina Ankjaergaard, Jacob Johansen, Claus E. Andersen, Eleni Kanouta, Cathrine Overgaard, Cai Grau, Per Poulsen
Summary: This study validated the effectiveness of proton FLASH technology in a mouse leg model and quantified the FLASH factor through full dose response curves.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Lue Sun, Yohei Inaba, Yu Sogo, Atsuo Ito, Mahesh Bekal, Koichi Chida, Takashi Moritake
Summary: Exposure to ionizing radiation can lead to chronic oxidative stress and long-term reduction in antioxidant capacity and red blood cell glutathione levels. This study found that chronic reduction in antioxidants may contribute to the pathogenesis of radiation-induced late effects. Interestingly, glutathione and the GSH/GSSG ratio were more sensitive markers of radiation exposure compared to whole-blood antioxidant capacity and complete blood counts.
SCIENTIFIC REPORTS
(2021)