Journal
LEUKEMIA RESEARCH
Volume 37, Issue 3, Pages 341-348Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.10.003
Keywords
Salmonella; Lymphoma; Interleukin-2; Immunotherapy; Co-stimulatory molecules; Antigen presenting cells
Categories
Funding
- Agencia Nacional de Investigacion e Innovacion (ANII), Uruguay
- ProInBio, Uruguay
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Therapeutic vaccination holds potential as complementary treatment for non-Hodgkin's lymphoma (NHL). B-NHL cells are antigen-presenting cells, but they cannot elicit proper antitumor responses because they lack expression of co-stimulatory molecules. Here, we report a novel approach to design improved whole tumor cell vaccines for B-NHL. We demonstrated that Salmonella infection significantly up-regulates CD80, CD86, CD40 and MHC II expression in lymphoma cells, and that therapeutic vaccination with infected and then irradiated lymphoma cells combined with IL-2 elicits strong anti-tumor specific immunity and extended survival in lymphoma-bearing mice. This may represent the basis of an effective immunotherapy against B-NHL that could be easily translated into the clinics. (C) 2012 Elsevier Ltd. All rights reserved.
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