Journal
LEUKEMIA RESEARCH
Volume 37, Issue 11, Pages 1412-1419Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.07.039
Keywords
Mantle cell lymphoma; SOX11; CCND1
Categories
Funding
- National Natural Science Foundation of China [30971296, 81170485, 81170488, 81200360]
- Natural Science Foundation of Jiangsu Province [BK2010584, BK2012484]
- Key Projects of Health Department of Jiangsu Province [K201108]
- Jiangsu Province's Medical Elite Program [RC2011169]
- Priority Academic Program Development of Jiangsu Higher Education Institute [JX10231801]
- National Public Health Grand Research Foundation [201202017]
- Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU
- Jiangsu Province
- Higher Education Institute Foundation of Science and Technology Innovation Team Program
- Project for State Key Clinical Department Construction
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The mechanism of SOX11 function has been widely published recently mainly focused on histone modifications. Besides diagnostic value in mantle cell lymphoma (MCL), SOX11 has also prognostic significance. Although it can also be observed in a fraction of other T and B-cell lymphomas, a monoclonal antibody, called SOX11-C1, may improve the function of SOX11 in both diagnosis and prognosis evaluation. In addition, detection of modified SOX11 cDNA by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) has a higher sensitivity than traditional CCND1 examination in minimal residual disease (MRD) detection, which is an appealing option for predicting disease outcome and status. (C) 2013 Elsevier Ltd. All rights reserved.
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