Journal
LEUKEMIA RESEARCH
Volume 36, Issue 9, Pages 1179-1184Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.04.027
Keywords
Multidrug resistance; Photodynamic therapy; 5-Aminolevulinic acid; Combined therapy; Leukemic cells
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Funding
- University of Buenos Aires [UBACyT X083]
- National Agency for Science and Technology [PICT-1806]
- National Research Council (CONICET)
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The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant LBR-D160 and LBR-V160 cell lines. Low doses of DOX and VCR increased anti-cancer effect of ALA-PDT in LBR-cells. Decrease in cell survival was higher when the combination VCR + ALA-PDT was used compared to DOX + ALA-PDT. Resistant cell lines LBR-D160 and LBR-V160 were sensitive to ALA-PDT; however, no changes occured when combining therapies. Thus, ALA-PDT can overcome drug resistance and is a good candidate for using treating multidrug resistant (MDR) cells. (c) 2012 Elsevier Ltd. All rights reserved.
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