Review
Biochemistry & Molecular Biology
Huidan Luo, Bin Yi
Summary: Exosomes, as nanoscale membrane vesicles, are important for cell communication and can serve as non-invasive liquid biopsy biomarkers in nasopharyngeal carcinoma. They play a role in regulating physiological processes of the tumor and have implications in cell growth, angiogenesis, metastasis, immunosuppression, radiation resistance, and chemotherapy resistance in NPC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Immunology
Ali Hazrati, Kosar Malekpour, Zahra Mirsanei, Arezou Khosrojerdi, Nasim Rahmani-Kukia, Neda Heidari, Ardeshir Abbasi, Sara Soudi
Summary: Cancer-associated mesenchymal stem/stromal cells (CA-MSCs) play a crucial role in tumor growth, immune evasion, metastasis, drug resistance, and angiogenesis by interacting with tumor and non-tumor cells in the tumor microenvironment. These cells affect the function of tumor cells and non-tumor cells through the production of cytokines, chemokines, and growth factors. Understanding these interactions is essential for targeted tumor therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Mario Rosario D'Andrea, Vittore Cereda, Luigi Coppola, Guido Giordano, Andrea Remo, Elena De Santis
Summary: Neoangiogenesis and various components of the tumor microenvironment are crucial in early metastatic spreading of breast cancer. Understanding the characteristics of the breast tumor environment, especially in correlation with hormone receptors and HER2 status, is important for diagnostic algorithms. The tumor microenvironment, including immune and non-immune cells, as well as cytokines, plays a critical role in breast cancer biology, impacting prognosis and treatment response.
Review
Oncology
Domenico Ribatti
Summary: The chick embryo chorioallantoic membrane (CAM) is commonly used in vivo experimental model for studying the angiogenic and metastatic capabilities of malignant cell lines or tumor tissues. Due to the natural immunodeficiency of chick embryos, CAM can support the engraftment of tumor cells and faithfully recapitulate most characteristics of the carcinogenic process, including growth, invasion, angiogenesis, and colonization. This review focuses on recent literature data regarding the use of CAM in investigating the metastatic process.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lavinia Raimondi, Alessia Gallo, Nicola Cuscino, Angela De Luca, Viviana Costa, Valeria Carina, Daniele Bellavia, Matteo Bulati, Riccardo Alessandro, Milena Fini, Pier Giulio Conaldi, Gianluca Giavaresi
Summary: This study reveals a novel role of miR-CT3 in regulating tumor angiogenesis and progression in osteosarcoma cells, as well as its association with the modulation of epithelial-mesenchymal transition proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sebastian A. Wohlfeil, Verena Haefele, Bianca Dietsch, Celine Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Geraud
Summary: This study investigates the efficiency and vascularization patterns of different mouse melanoma cell lines in liver metastasis. The highly and moderately metastatic melanomas are associated with gene clusters involved in cell migration and angiogenesis. Sorafenib shows a strong inhibitory effect on vascularization in liver metastasis of melanoma.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Kun Ding, Xia Liu, Luman Wang, Lu Zou, Xuqian Jiang, Aiping Li, Jianwei Zhou
Summary: This review summarizes the tumor suppressive functions of the JWA gene and its role in anti-cancer drug development. It focuses on elucidating the key regulatory proteins up and downstream of JWA and their signaling networks. JWA is low expressed in various malignancies and acts as a tumor suppressor by inhibiting oncogenes or activating tumor suppressor genes.
Article
Chemistry, Analytical
Chun-Hao Huang, Kin Fong Lei
Summary: Tumor angiogenesis plays a crucial role in cancer metastasis and the development of new therapeutic strategies. A microfluidic device developed by researchers allows for quantitative monitoring of tumor angiogenesis and evaluation of drug efficacy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Meicen Zhou, Wenbao Lu, Bingwei Li, Xiaochen Yuan, Mingming Liu, Jianqun Han, Xueting Liu, Ailing Li
Summary: Roquin2 is identified as a novel breast cancer suppressor that inhibits tumor angiogenesis by selectively downregulating the expression of proangiogenic genes. Overexpression of Roquin2 can inhibit breast tumor-induced angiogenesis, while silencing Roquin2 enhances tumor angiogenesis. In vivo induction of Roquin2 significantly suppresses breast tumor growth, metastasis, and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Xupeng Mu, Kebang Hu, Anhui Wei, Jinping Bai, Li Feng, Jinlan Jiang
Summary: Nanoparticles can trigger tumor-derived extracellular vesicles with enhanced pro-metastatic capacity, potentially promoting tumor progression. One mechanism is that miR-301a-3p released by nanoparticles can affect vascular endothelial cells, leading to increased vascular permeability and angiogenesis, promoting the formation of pre-metastasis niches. Therefore, the impact of nanoparticles on extracellular vesicles needs to be considered when designing nanodrugs for cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shashank Kumar, Kumari Sunita Prajapati, Sanjay Gupta
Summary: Signal peptide, CUB, and EGF-like domain-containing proteins (SCUBE) are secretory cell surface glycoproteins that play key roles in the developmental process. SCUBE proteins participate in the progression of several diseases, including cancer, and are recognized for their oncogenic and tumor suppressor functions depending on the cellular context. SCUBE proteins promote cancer cell proliferation, angiogenesis, invasion, or metastasis, stemness or self-renewal, and drug resistance. SCUBE proteins have potential prognostic and diagnostic value for breast cancer, renal cell carcinoma, endometrial carcinoma, and nasopharyngeal carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chen Chen, Yang Liu, Lin Liu, Chaohua Si, Yanxin Xu, Xiaoke Wu, Chengzeng Wang, Zhenqiang Sun, Qiaozhen Kang
Summary: This study found that exosomes derived from colorectal cancer cells carry circTUBGCP4, which induces tip cell formation in vascular endothelial cells, promoting angiogenesis and tumor metastasis through the activation of the Akt signaling pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Engineering, Biomedical
Afeng Yang, Shupei Sheng, Yun Bai, Guozheng Xing, Xuya Yu, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Summary: Vascular abnormalities are a major obstacle to effective immunotherapy, and the combination of antiangiogenesis therapy and immunotherapy can enhance the effectiveness of immunotherapy. This study proposes a hydrogel/nanosystem-mediated antiangiogenesis combined immunotherapy strategy to regulate the tumor microenvironment and achieve synergistic effects in tumor treatment.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Luopei Guo, Chunbo Li, Jingjing Guo, Junjun Qiu, Keqin Hua
Summary: This study aimed to investigate the promotion of cervical cancer progression by CKAP2 through modulating the tumor microenvironment (TME) via NF-κB signaling. The interaction between cervical cancer cells and the TME was tested. Gain- and loss-of-function assays were performed to elucidate the role of CKAP2. Western blot analysis revealed the underlying mechanism involved. It was found that cervical cancer tissues were enriched with macrophages and microvessels. CKAP2 increased the tumor-promoting macrophage population. The overexpression of CKAP2 not only promoted endothelial cell viability and tube formation but also increased vascular permeability, and vice versa. Moreover, CKAP2 promoted cervical cancer progression via NF-κB signaling, which could be blocked by the NF-κB signaling inhibitor JSH-23. The findings indicated that CKAP2 could promote cervical cancer progression by modulating the TME via NF-κB signaling.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
