Journal
LEUKEMIA RESEARCH
Volume 34, Issue 4, Pages 483-486Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.06.026
Keywords
T-cell acute lymphoblastic leukemia; SIL-TAL1; HOX11L2; MLL; NOTCH1
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Funding
- CNPq [309091/2007-1]
- INCA-FAF/Swiss Bridge Foundation [230150-4]
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T-cell acute lymphoblastic leukemia (T-ALL) may affect children in very early age. However, the critical events leading to this brief latency is still unclear. We used standard methods to explore NOTCH1 mutations and other specific molecular markers in 15 early childhood T-ALL cases. Most of them consisted of immature differentiation subtype. Despite being found in a lower frequency than that described for overall pediatric T-ALL, NOTCH1 alterations were the most frequent ones. Other alterations included MLL+ (n = 4), SIL-TAL1(+) (n = 3), FLT3 mutation (n = 1) and HOX11L2(+) (n = 1). Our results suggest that NOTCH1 and MLL abnormalities are primary leukemogenic hits in early T-ALL. (C) 2009 Elsevier Ltd. All rights reserved.
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