Article
Medicine, Research & Experimental
Yi-Jia Lin, Chiung-Ju Chen, Shu-Ching Hsueh, Mei-Hui Lee, Shu-Fen Peng, Hsu-Feng Lu, Kung-Wen Lu, Wen-Wen Huang, Kuo-Ching Liu, Yung-Liang Chen, Yung-Luen Shih, Jin-Cherng Lien
Summary: DMC increased macrophage phagocytosis in leukemia mice in vivo.
Article
Biochemistry & Molecular Biology
Zahra Changizi, Azam Moslehi, Ali Haeri Rohani, Akram Eidi
Summary: Chlorogenic acid (CGA) shows significant effects in inducing apoptosis and treating 4T1 breast cancer tumors in BALB/c mice, reducing tumor weight and volume, decreasing metastatic nodules, promoting apoptosis, and increasing the expression levels of specific genes.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Veterinary Sciences
Beibei Zhang, Guanggang Qu, Yuchen Nan, En-Min Zhou
Summary: The study found that infertility caused by ZP3 vaccination is associated with ovarian oxidative stress and follicle loss. Antioxidant stress drugs can reduce oxidative stress and apoptosis levels, restore follicle numbers, and improve fertility.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Nutrition & Dietetics
Julia Spielmann, Wiebke Naujoks, Matthias Emde, Martin Allweyer, Johannes Faender, Heike Kielstein, Dagmar Quandt, Ina Baehr
Summary: This study found that ad libitum feeding of a high-fat diet in BALB/c mice does not affect body weight gain, visceral fat mass, plasma cytokine concentrations, immune cell populations, or the number, frequency, and phenotype of NK cells. However, compared to a normal-fat diet, restrictive feeding of a high-fat diet leads to significantly higher body weights, visceral fat mass, and plasma interferon-gamma concentrations, as well as changes in the frequencies of granulocytes and NK cell subsets, and in the surface expression of NK cell maturation markers.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Physical
Haroon Iqbal, Anam Razzaq, Bushra Uzair, Noor Ul Ain, Shamaila Sajjad, Norah Ayidh Althobaiti, Aishah Eid Albalawi, Bouzid Menaa, Muhammad Haroon, Muslim Khan, Naveed Ullah Khan, Farid Menaa
Summary: The study synthesized TiO2 nanoparticles in an environmentally friendly manner and found them to exhibit promising ex vivo and in vivo anti-tumor efficacy, with a safer profile compared to the conventional drug doxorubicin.
Article
Parasitology
Zeyu Tang, Hang Li, Suzhu Xie, Shaowei Zhao, Shuang Zhang, Hao Wang, Nanli Li, Xuancheng Zhang, Fanglin Zhao, Lijun Jia
Summary: Neospora caninum, a protozoan parasite, was found to cause decreased litter size and live pup numbers in infected pregnant mice compared to non-infected mice. The infected mice exhibited trophoblast cell shrinkage, increased apoptosomes, and higher parasite load in placental tissue with time after infection.
PARASITOLOGY RESEARCH
(2023)
Article
Veterinary Sciences
Qian Li, Shufan He, Yuantong Zou, Hua Yue, Cheng Tang, Jie Liu
Summary: A novel Bovine adenovirus type 3 (BAdV-3) strain with a natural deletion partial fiber gene, named BO/YB24/17/CH, was isolated. The study showed that this virus caused mild clinical signs in mice and could be detected in multiple organs. This research provides valuable insights into the pathogenicity of this virus and is important for the prevention, control, and vaccine development against BAdV-3.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria Consiglia Trotta, Sami Gharbia, Hildegard Herman, Bianca Mladin, Andrei Hermenean, Cornel Balta, Coralia Cotoraci, Victor Eduard Peteu, Carlo Gesualdo, Francesco Petrillo, Marilena Galdiero, Roberto Alfano, Mihaela Gherghiceanu, Michele D'Amico, Settimio Rossi, Anca Hermenean
Summary: The study found that aged mice had decreased endogenous levels of RvD1 in the retina, as well as sex-related differences in neuroinflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Katherine J. L. Jackson, Justin T. Kos, William Lees, William S. Gibson, Melissa Laird Smith, Ayelet Peres, Gur Yaari, Martin Corcoran, Christian E. Busse, Mats Ohlin, Corey T. Watson, Andrew M. Collins
Summary: The poorly characterized immunoglobulin genes in inbred mouse strains commonly used in models of antibody-mediated human diseases could compromise data analysis. This study used long-read SMRT sequencing to amplify VDJ-C sequences from BALB/c mice and identified strain variations in specific immunoglobulin genes. By computationally retrieving IGHV haplotypes, a set of expressed BALB/c IGHV germline gene sequences was established. The study also assessed the suitability of assemblies from the Mouse Genome Project for the determination of IGH loci genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amanda Virtuoso Jacques, Natalia Marceli Stefanes, Laura Otto Walter, Daiane Mari Perondi, Fernanda da Luz Efe, Luiz Felipe Schmitz de Souza, Larissa Sens, Stephanie Milis Syracuse, Ana Carolina Rabello de Moraes, Aldo Sena de Oliveira, Carolina Teixeira Martins, Luma Godoy Magalhaes, Adriano Defini Andricopulo, Lisandra de Oliveira Silva, Ricardo Jose Nunes, Maria Claudia Santos-Silva
Summary: The study found that chalcones F07, F09, and F10 exhibit cytotoxicity against K562 and Jurkat cells, induce apoptosis, and do not affect the functionality of other human cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Sunny O. Abarikwu, Guilherme M. J. Costa, Nathalia de Lima e Martins Lara, Samyra M. S. N. Lacerda, Luiz R. de Franca
Summary: Several studies have reported the effects of atrazine on the gonads of many experimental models. The short-term effects of in vivo exposure to atrazine on the testes of mice involve decreased numbers of Leydig cells and increased cell apoptosis. Atrazine may directly reduce testosterone-secreting Leydig cells in mice through apoptosis.
Article
Environmental Sciences
Jiongjiong Chang, Chunlai Liang, Wei Wang, Ling Yong, Weifeng Mao, Hui Yang, Xudong Jia, Zhaoping Liu, Yan Song
Summary: The study found that high doses of atrazine had significant adverse effects on mice in terms of body weight, immune cell counts, and organ weights, while low doses had minimal impact on the immune system. Atrazine mainly causes immunotoxicity through cellular and humoral immunity pathways.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Parasitology
Hang Li, Bing-Yi Yang, Ming-Ming Liu, Shao-Wei Zhao, Su-Zhu Xie, Hao Wang, Shuang Zhang, Xue-Nan Xuan, Li-Jun Jia
Summary: Infection of male BALB/c mice with Neospora caninum induced varying degrees of injury to the testis, epididymis and sperm, disrupting spermatogenesis and affecting reproductive capacity.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Shivani Singla, Vinod Kumar, Gopabandhu Jena
Summary: Diabetes and ulcerative colitis are chronic diseases associated with inflammation, dysbiosis, impaired immune function, and infection risk. This study aimed to investigate the role of 3-aminobenzamide (3-AB) in ulcerative colitis-associated diabetes mellitus. The results showed that 3-AB significantly reduced the severity of colitis-associated diabetes mellitus by altering the expression of multiple molecular targets.
Article
Food Science & Technology
Juer Liu, Yuyang Yao, Yanling Cheng, Wei Hua, Xinyue Zhu, Qiming Miao, Guangwei Huang, Shengquan Mi, Roger Ruan
Summary: This study conducted an acute oral toxicity test using almond hull powders from three major almond varieties, and the results demonstrated that almond hull powders were non-toxic, even at high dosages, supporting their safety as an edible food ingredient.
Article
Biochemistry & Molecular Biology
Ibrahim S. Al Nasr, Riadh Hanachi, Ridha B. Said, Seyfeddine Rahali, Bahoueddine Tangour, Siddig Abdelwahab, Abdullah Farasani, Manal M. E. Taha, Anil Bidwai, Waleed S. Koko, Tariq A. Khan, Rainer Schobert, Bernhard Biersack
Summary: A series of curcuminoid compounds with structural variance were tested for their activities against parasites, showing high activity and selectivity. The cyclic ketone hub was found to be crucial for the anti-parasitic activities and selectivities. QSAR calculations and docking studies suggested structural variations for further improving the antiparasitic activity.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
Abdulaziz Alhazmi, Edrous Alamer, Dalia Daws, Mashael Hakami, Majid Darraj, Siddig Abdelwahab, Amani Maghfuri, Abdullah Algaissi
Summary: A study conducted in Saudi Arabia found that side effects reported after receiving Oxford-AstraZeneca and Pfizer-BioNTech vaccines are similar to those reported in clinical trials, indicating the safety of these vaccines. Most participants reported fatigue and pain at the injection site as common side effects. Further research is needed to assess the effectiveness of these vaccines in protecting against SARS-CoV-2 reinfections.
Article
Environmental Sciences
Abdulaziz Alhazmi, Edrous Alamer, Siddig Abdelwahab, Nizar Khamjan, Abdullah Hamami, Moayad Haddad, Majid Darraj, Anwar M. Hashem, Abdullah Algaissi
Summary: A serological study in Jazan Province, Saudi Arabia revealed a 26% SARS-CoV-2 seropositivity rate, indicating a high prevalence of antibodies but also that majority of the population remains susceptible to infection, with lower seropositivity rates seen in younger and older age groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Nasser Shubayr, Rola Khmees, Ali Alyami, Naif Majrashi, Nada Alomairy, Siddig Abdelwahab
Summary: Breast cancer screening is important for survival, treatment efficacy, and quality of life. This study used the health belief model to assess the impact of health perception and knowledge on breast self-examination intention. The findings suggest that perceived benefit, perceived barriers, and self-efficacy are good predictors of breast self-examination intention.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Anas Elyas Ahmed, Mohammed A. Almarhabi, Mohammed O. Shami, Alhassan Ali Alhazemi, Hassan M. Alsharif, Ali Essa Abu Hayyah, Wessam Ahmed Alhazmi, Mohammed A. Alfaifi, Abdulaziz Q. Abdali, Mohammed S. Alshihri, Ali H. Alhazmi, Halimah A. Qasem, Mazen Ahmed Alhazmi, Siddig Ibrahim Abdelwahab
Summary: This study assessed the knowledge, attitude, and practices towards dengue fever among the population in the Jazan region of Saudi Arabia. The results showed that there is room for improvement in the participants' knowledge, attitude, and practices regarding dengue fever, highlighting the need for increased health education and awareness to reduce the impact of dengue epidemics.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Siddig Ibrahim Abdelwahab, Mohammed Al-Mamary, Khaled Hassanein, Manal Mohamed Elhassan Taha, Abdullah Farasani, Hassan Alhazmi
Summary: A series of chalcones were evaluated for their anti-inflammatory properties, and two compounds showed more significant inhibitory effects on COX-2 compared to the standard drug. Molecular modeling investigations revealed the potential mechanisms of action of these compounds on COX-2. These findings are important for the development of new pharmaceuticals for COX-associated inflammatory disorders.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Rahamat Unissa Syed, Sivakumar S. Moni, Muhammad Nawaz, Mohammed Khaled Bin Break, Nasrin E. Khalifa, Siddig Ibrahim Abdelwahab, Reham Meshal Alharbi, Raghad Huraid Alfaisal, Bayan Naif Al Basher, Entsar Mohammed Alhaidan
Summary: Amikacin sulfate-loaded dextran sulfate sodium nanoparticles (LADNP) were prepared and analyzed. LADNP had a zeta potential of -20.9 +/- 8.35 mV, PDI of 0.256, and % PDI of 67.7. The size of LADNP was 317.9 d. nm, with individual particles measuring 259.3 +/- 73.52 nm. The release kinetics of amikacin from LADNP demonstrated zero order kinetics, with 37% of the drug released in 7 hours.
Article
Health Care Sciences & Services
Yasir Osman Hassan Babiker, Muhannad Hussain Shawkan Najmi, Ibrahim Mohammed A. Muslihi, Ali Fathuldeen Mohammed Amri, Tariq Yahya Mohammed Magafi, Wail Mohammad Hadi Alughbi, Mohammad Refah A. Bashir, Ali Nasser Ahmed Alsharif, Anas Elyas Ahmedand, Siddig Ibrahim Abdelwahab
Summary: This study investigated the knowledge and attitudes towards epidural analgesia (EA) among women in Jazan, Saudi Arabia. The findings showed that a large proportion of participants had limited knowledge about EA. Attitudes played a significant role in determining the knowledge level, while demographics did not. Cognitive intervention is needed to change attitudes and disseminate EA-related knowledge.
Article
Health Care Sciences & Services
Anas Elyas Ahmed, Suhaila Abdelkarim, Maria Zenida, Maisa Ali Hussein Baiti, Atyaf Abbas Yahya Alhazmi, Bushra Ahmed Hussain Alfaifi, Rania Qarmoush Mohammed Majrabi, Nidaa Qasem M. Khormi, Alyaj Alla Ali Hakami, Rafa Abdu Mohammed Alqaari, Raffan Ahmed Alhasani, Ramzi Abdu Alajam, Mohammed M. Alshehri, Aqeel M. Alenazi, Bader Alqahtani, Meshal Alshamrani, Ahmed Alhowimel, Siddig Ibrahim Abdelwahab
Summary: This research aims to evaluate the risk factors and prevalence of urinary tract infections (UTIs) among people with diabetes mellitus (DM) in Saudi Arabia (KSA). The study found that UTIs are common in individuals with DM and are associated with gender. The findings of this study can provide important guidance for the health management of DM patients.
Review
Food Science & Technology
Siddig I. Abdelwahab, Manal M. E. Taha, Abdalbasit A. Mariod
Summary: Nigella sativa L. and its active component, thymoquinone, have attracted considerable scientific attention. This review analyzes 2072 studies on thymoquinone from the Scopus database and provides insights into research areas, top authors, publications, journals, institutions, and countries. The review highlights the potential of molecular-based approaches and ethno-knowledge in understanding the cellular mechanisms and therapeutic efficacy of thymoquinone.
FOODS AND RAW MATERIALS
(2023)
Article
Health Care Sciences & Services
Amani Osman Abdelmola, Ahmed Bahari, Ibrahim Gosadi, Khdeeja Shami Aburasain, Njoud Ali Osaisi, Nidaa Sameer Jilan, Sarah Rashad Alsanosy, Haneen Ali Mahnashi, Hadeel Fuad Gadri, Amnah Ahmad Khobrani, Alaa Ahmad Darraj, Mohamed Salih Mahfouz, Hadi Dhafer Hassan Kariri, Siddig Ibrahim Abdelwahab
Summary: This study aimed to investigate the prevalence of postpartum depression (PPD) in the Jazan region, as well as the significant risk factors and likelihood of seeking help among depressed women. The results revealed a high prevalence of PPD (75.7%) in Jazan and identified a lack of family support as a significant association with PPD. Pregnant women need to be aware of PPD and learn how to prevent or manage it.
Article
Health Care Sciences & Services
Yahia Ali Kaabi, Nahla A. Alshaikh, Ahmed A. Jerah, Mustafa A. Halawi, Mahmoud M. Habibullah, Siddig Ibrahim Abdelwahab
Summary: This study validated the Arabic version of the Diabetes Self-Management Scale (DSMS) using Rasch and confirmatory factor analyses. The results showed good fit, reliability, and content validity for the scale, with minor issues in one item. The DSMS was found to be beneficial as a screening tool for patient-reported diabetes self-management, though further improvements are needed.
Review
Immunology
Sivakumar S. Moni, Siddig Ibrahim Abdelwahab, Aamena Jabeen, Mohamed Eltaib Elmobark, Duaa Aqaili, Gassem Ghoal, Bassem Oraibi, Abdulla Mohammed Farasani, Ahmed Ali Jerah, Mahdi Mohammed A. Alnajai, Abdul Majeed Hamad Mohammad Alowayni
Summary: This review provides a thorough analysis of the advances in adjuvant research and explores the evolution and effects of various adjuvants. Alum, as the pioneer, laid the foundation for further research and innovation. The transition from traditional alum-based adjuvants to nano formulations reflects the dynamism and potential of vaccine research. Innovations in adjuvant research, particularly the development of nano formulations, hold great promise for improving vaccine efficacy and safety.
Article
Health Care Sciences & Services
Sami A. Alhazmi, Afnan Q. Maashi, Shahad K. Shabaan, Aisha A. Majrashi, Mawaeed A. Thakir, Safa M. Almetahr, Alanoud M. Qadri, Abdulaziz A. Hakami, Siddig I. Abdelwahab, Abdulaziz H. Alhazmi
Summary: This study aimed to evaluate the factors associated with poor adherence in attending appointments among patients with SCD. The results showed that age, level of education, income, patient residence, and lack of cues to action have significant impacts on the adherence in attending appointments.
Article
Nutrition & Dietetics
Siddig Ibrahim Abdelwahab, Shyam Sunder Pancholi, Syam Mohan, Muhammad Hadi Sultan, Pankaj Tripathi, Saeed Alshahrani, Mohammed Abdul Hakim Sidiqui, Abdullah Farasani, Manal Mohamed Elhassan Taha
Summary: The research evaluated the antinociceptive activity of essential oil obtained from the roots of Saussurea lappa Clarke, showing promising analgesic effects possibly due to its interaction with opioid receptors and involvement of peripheral analgesia. The formulated cream from the essential oil also demonstrated favorable pharmaceutical and pharmacological properties, suggesting potential use as a drug candidate for pain management. Further research is warranted to explore the development of this novel analgesic agent.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2021)
