Journal
LEUKEMIA RESEARCH
Volume 34, Issue 3, Pages 284-288Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.07.008
Keywords
Chronic lymphocytic leukemia (CLL); Chemoimmunotherapy; Mitoxantroe; Nucleoside analogs
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Funding
- OSI Pharmaceuticals
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Randomized trials demonstrated the superiority of chemoimmunotherapy over chemotherapy in the frontline treatment of CLL. Based on favorable experience with the addition of mitoxantrone (M) to fludarabine (F) plus cyclophosphamide (C), we designed a pilot study testing the combination of FCM plus rituximab (R). Thirty patients with previously untreated, symptomatic CLL, <70 years, and beta-2-microglobulin
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