Journal
LEUKEMIA RESEARCH
Volume 32, Issue 10, Pages 1499-1504Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2008.03.001
Keywords
multiple myeloma; SNP; TNF-alpha; lymphotoxin-alpha; ancestral haplotype; 8.1 ancestral haplotype; heat shock protein 70; RAGE
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Allelic distribution of -308 G > A (TNF 1/2) polymorphism of the TNF-alpha, and the +252 A > G promoter polymorphism of the LT-alpha gene, the 1267 A > G polymorphism of the HSP70-2 gene as well as the -429 T > C promoter polymorphism of the RAGE gene were tested in 94 MM cases and 141 controls. Significantly less MM patients than controls carried the TNF2 allele (p = 0.018) and the TNF2-LTA 252G haplotype (p = 0.025). The difference was, however, restricted to the females, as well as the relatively young (< 69 years) subjects. By contrast, we did not find differences with the other SNPs tested. (c) 2008 Elsevier Ltd. All rights reserved.
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