Article
Oncology
Rongqin Dai, Meirong Wu, Yin Zhang, Zunmin Zhu, Jie Shi
Summary: GNL3 functions as an oncogenic driver in non-Hodgkin lymphoma through the Wnt/β-catenin pathway, promoting tumor progression.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tingling Zou, Lan Ma, Lili Gu, Shuhua Xi, Kaiqiang Zhang, Xiaoying Guo
Summary: This study found that excessive consumption of fluoride leads to dental fluorosis, inhibiting ameloblast differentiation and matrix degradation through the regulation of clock genes, PPAR gamma, and Wnt/beta-catenin signaling pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Zhenhui Lv, Xueqiong Wu, Ping Lu, Xinxin Xu, Jiaju Wang, Cui Zhang, Wenting Liu, Yan Gao, Cong Lu, Yinqiang Zhang, Haiming Kou
Summary: POLE2 is significantly upregulated in lymphoma tissues and cells. Knockdown of POLE2 inhibits proliferation and migration, induces apoptosis and cycle arrest in lymphoma cells, and impairs tumor growth in mice. POLE2 may serve as a novel therapeutic target for lymphoma by inhibiting Wnt/β-catenin signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Liya Shi, Xue Xue, Hui Tian, Hongjuan Ye, Hui Wang, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Lihua Sun
Summary: Endometriosis, common in women of childbearing age, involves the presence of endometrial tissue outside the uterine cavity. Research shows that WEE1 promotes migration and fibrosis in endometrial stromal cells through the Wnt/β-catenin signaling pathway, suggesting it may be a potential therapeutic target for endometriosis treatment.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Oncology
Aftab Nadeem, Kyaw Min Aung, Tanusree Ray, Athar Alam, Karina Persson, Amit Pal, Bernt Eric Uhlin, Sun Nyunt Wai
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, with APC gene mutations playing a key role in tumor development. The novel cytotoxin MakA induces apoptosis in cancer cells, with potent cytotoxic activity against cancer cell lines while sparing nontransformed cells. MakA inhibits beta-catenin-mediated tumor cell proliferation, making it a promising candidate for therapeutic development against colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Immunology
Xiaoyue Guan, Yani He, Zhichen Wei, Chen Shi, Yingxue Li, Rui Zhao, Lifei Pan, Yue Han, Tiezhou Hou, Jianmin Yang
Summary: The crosstalk between Wnt3a/beta-catenin and NF-kappa B signaling pathways plays a crucial role in the development of apical periodontitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yan-Jun Cao, Jing-Yan Li, Pan-Xia Wang, Zhi-Rong Lin, Wen-Jing Yu, Ji-Guo Zhang, Jing Lu, Pei-Qing Liu
Summary: Inhibition of protein kinase C-zeta (PKC-zeta) activity may serve as a potential approach to prevent doxorubicin-induced cardiac injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hongyan Mo, Qian Ren, Dongyan Song, Bo Xu, Dong Zhou, Xue Hong, Fan Fan Hou, Lili Zhou, Youhua Liu
Summary: This study found that CXCR4 and beta-catenin colocalized in glomerular podocytes and that the assembly of CXCR4/beta-arrestin-1/Src signalosome led to beta-catenin activation, promoting podocyte dysfunction and proteinuria.
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
