NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia

Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia

(2010) F. Chiarini et al.   CANCER RESEARCH

Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy

(2010) Robert Zeiser et al.   CELL CYCLE

Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis

(2010) Ling Gu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

(2009) T. Sanda et al.   BLOOD

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

(2009) K. Cullion et al.   BLOOD

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-  and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

(2009) M. Remke et al.   BLOOD

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

(2009) H. Medyouf et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia

(2009) F. Chiarini et al.   CANCER RESEARCH

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and  -secretase inhibitors

(2009) A. Silva et al.   HAEMATOLOGICA

Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway

(2009) Kuen-Feng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway Are Associated With Clinical Outcomes in Esophageal Cancer Patients Treated With Chemoradiotherapy

(2009) Michelle A.T. Hildebrandt et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction of Akt Activity by Chemotherapy Confers Acquired Resistance

(2009) Wei-Chien Huang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

(2009) P Y Jotta et al.   LEUKEMIA

The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

(2009) Ledu Zhou et al.   MEDICAL ONCOLOGY

Regulation of Notch1/NICD and Hes1 expressions by GSK-3α/β

(2009) Yun Hye Jin et al.   MOLECULES AND CELLS

Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling

(2008) S.-F. Wang et al.   BLOOD

K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to  -secretase inhibitors

(2008) T. Kindler et al.   BLOOD

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

(2008) N. Harir et al.   BLOOD

PTEN expression is a strong predictor of survival in mesothelioma patients☆

(2008) Isabelle Opitz et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

The role of the PI3K-AKT kinase pathway in T-cell development beyond the β checkpoint

(2008) Ling Xue et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chemoinhibitory Effect of Mulberry Anthocyanins on Melanoma Metastasis Involved in the Ras/PI3K Pathway

(2008) Hui-Pei Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Notch1 is an effector of Akt and hypoxia in melanoma development

(2008) Barbara Bedogni et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines

(2008) Dongmei Guo et al.   LEUKEMIA RESEARCH

Regulation of Lymphocyte Development by Cell-Type-Specific Interpretation of Notch Signals

(2008) L. Nie et al.   MOLECULAR AND CELLULAR BIOLOGY

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development

(2008) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors

(2008) Z. Wu et al.   PROSTATE

Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells In Vitro

(2007) Elisabetta Calzavara et al.   JOURNAL OF CELLULAR BIOCHEMISTRY