Editorial Material
Clinical Neurology
Lauren Lu, Agnes Zhu, Christopher Y. Itoh, Ryan P. Coburn, Rafid Mustafa
Summary: A 26-year-old man presented with progressive encephalopathy, right inferior quadrantanopia, right hemiparesis, and facial swelling for 2 months. Imaging studies revealed an enhancing left parietal lesion and PET scan showed hypermetabolism in the lesion, face, and abdominal musculature. Biopsies confirmed CD8(+), CD30(-) T-cell lymphoma and the patient responded well to methotrexate and temozolomide treatment.
Article
Immunology
Ailin Zhao, Jinrong Yang, Meng Li, Linfeng Li, Xinai Gan, Jie Wang, He Li, Kai Shen, Yunfan Yang, Ting Niu
Summary: In EBV-positive LAHS patients, those with T/NK cell lymphoma were significantly younger and had lower fibrinogen and C-reactive protein levels compared to those with B cell lymphoma. Patients who received combined anti-HLH and anti-lymphoma treatment had higher ORR and OS. Elevated alanine aminotransferase level was an independent risk factor for the prognosis of EBV-positive LAHS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Na Li, Ming Jiang, Wan-Chun Wu, Wen-Wen Wei, Li-Qun Zou
Summary: The study analyzed risk factors associated with NK/T-LAHS in patients with ENKTL and developed two nomograms, RINK and RINK-E, for predicting disease risk. These nomograms showed good accuracy and consistency in predicting NK/T-LAHS, providing important reference for individualized patient risk assessment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Cheng-Hsien Lin, Yu-Hsuan Shih, Tsung-Chih Chen, Cheng-Wei Chou, Chiann-Yi Hsu, Chieh-Lin Jerry Teng
Summary: The study found that the clinical characteristics of lymphoma-associated HLH have not substantially changed over the past twenty years, but more patients diagnosed in 2013-2021 were tested for Epstein-Barr virus compared to those diagnosed in 2004-2012. In terms of treatment response, patients treated in 2013-2021 had a slightly higher median OS than those treated in 2004-2012.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Na Li, Ming Jiang, Wan-Chun Wu, Hui-Jie Zhou, Li-Qun Zou
Summary: Lymphoma-associated hemophagocytic syndrome (LAHS) is a rare and life-threatening clinical syndrome, and its prognosis is closely associated with patient age, cell lineage, LDH levels, and HPS onset. Specifically, patients with B-LAHS have a higher survival rate compared to those with T/NK-LAHS.
Article
Medicine, General & Internal
Yuxuan Che, Liye Xu, Xian Zhang, Xun Qiu, Jincheng Song, Xiaolei Ding, Xiuhua Sun
Summary: HLH is a severe syndrome of pathological immune activation that can lead to multiorgan failure and high mortality rates. Early screening and effective treatment are crucial, and plasmapheresis and organ support are viable treatment options.
CLINICAL CASE REPORTS
(2022)
Article
Oncology
Ademola S. Ojo, Joseph Asemota, Somtochukwu Ojukwu, Ahmad Rajeh, Amina Bot, Caitlyn J. Smith, Katsiaryna Laziuk, Mohammed Saleh
Summary: HLH is a life-threatening condition characterized by an exaggerated and dysregulated immune response. This study reports the case of a middle-aged man with HLH triggered by B-cell lymphoma, who achieved a good outcome with a combination of different treatment modalities.
Article
Oncology
Liqiang Wei, Lei Yang, Jia Cong, Jin Ye, Xin Li, Na Yao, Jing Yang, Jing Ding, Jingwen Wang
Summary: The study found that the etoposide + dexamethasone-based chemotherapy regimens were effective in treating patients with NK/T-LAHLH, particularly for those with newly diagnosed or early stage disease. Overall survival rates declined after 6 months, but were significantly better for patients with nasal involvement and early-stage disease.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Immunology
Deli Song, Jingshi Wang, Jia Zhang, Junxia Hu, Chaofan Wu, Zhao Wang
Summary: In this article, five cases of HAVCR2 mutation-associated HLH were reported. The study found an elevated level of IL-1RA in the serum of these patients. The potential mechanisms underlying HLH associated with HAVCR2 mutation were also investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Agnieszka Giza, Krystyna Galazka, Marcin Jonca, Malgorzata Razny, Dagmara Zimowska-Curylo, Mateusz Wilk, Sarah Goldman-Mazur, Beata Piatkowska-Jakubas, Tomasz Sacha
Summary: This article presents a case study of a 35-year-old Caucasian man diagnosed with subcutaneous panniculitis-like T-cell lymphoma (SPTL) with hemophagocytic syndrome (HPS). The patient was treated with CHOEP chemotherapy, modified HLH 2014 protocol, high dose chemotherapy (BEAM), and autologous stem cells transplantation. The treatment was complicated by some complications, but the overall outcome was positive.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Oncology
Shuyan Yao, Zhili Jin, Lingbo He, Ruoxi Zhang, Menghan Liu, Zhengjie Hua, Zhao Wang, Yini Wang
Summary: The study showed significant differences in pathological types, clinical characteristics, and prognosis between lymphoma patients with or without LAHS. Age, platelet count, IPI, history of lymphoma, and lack of HLH remission were identified as independent risk factors for the prognosis of NHL-LAHS patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yingdan Huang, Ruolan Zeng, Chang Xue, Qing Huang, Ding Yu, Liang Shao, Hui Zhou, Huijing Wu
Summary: This study suggests that spleen involvement may serve as a prognostic indicator for patients with AITL.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Wenxin Ou, Yunze Zhao, Ang Wei, Honghao Ma, Liping Zhang, Hongyun Lian, Qing Zhang, Dong Wang, Zhigang Li, Tianyou Wang, Rui Zhang
Summary: Subcutaneous panniculitis-like T-cell lymphoma complicated with hemophagocytic lymphohistiocytosis (SPTCL-HLH) has been studied in terms of its clinical features, treatment strategies, and prognosis. The presence of HAVCR2 gene mutation is associated with younger age and positive autoantibodies. Corticosteroid monotherapy has a higher recurrence rate compared to corticosteroids plus other immunoregulatory agents therapy. Intensive anthracycline-based chemotherapy can induce long-term remission. Stem cell transplantation (SCT) is a reliable treatment strategy. A watch and wait approach is recommended for mild SPTCL-HLH caused by drugs.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lingling Xu, Xianqi Liu, Yan Wang, Yanming Wang, Xiaoxia Chu, Liming Chen
Summary: This article reports a case of lymphoma-associated hemophagocytic syndrome (HPS) with bone marrow necrosis. The patient achieved complete remission and long-term survival after receiving combination therapy of rituximab and chemotherapy drugs. This study highlights the presence of lymphoma in patients with HPS and the important role of rituximab in the treatment of HPS.
Article
Multidisciplinary Sciences
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A. Teichmann, Fan Bai, Yang Wang
Summary: Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphoma characterized by clonal malignant T cells. This study analyzed CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
NATURE COMMUNICATIONS
(2022)