Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML

c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1

(2012) Francesca Anselmi et al.   ANGIOGENESIS

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

Janus Kinase Deregulation in Leukemia and Lymphoma

(2012) Edwin Chen et al.   IMMUNITY

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling

(2012) Amy Young et al.   Cancer Discovery

Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia

(2011) B. V. Balgobind et al.   HAEMATOLOGICA

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

I B kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia

(2010) N. Chapuis et al.   BLOOD

GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis

(2010) Zhong Wang et al.   CANCER CELL

Identification of new possible targets for leukemia treatment by kinase activity profiling

(2010) Arja Ter Elst et al.   LEUKEMIA & LYMPHOMA

Therapeutic targeting of MLL

(2009) M. Liedtke et al.   BLOOD

The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia

(2009) N Gallay et al.   LEUKEMIA

Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

(2009) Tomasz Cierpicki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD