Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1

Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro

(2011) S. Guiducci et al.   ANNALS OF THE RHEUMATIC DISEASES

Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4

(2011) Leonardo Mirandola et al.   BMC CANCER

Notch-ing from T-cell to B-cell lymphoid malignancies

(2011) Leonardo Mirandola et al.   CANCER LETTERS

Advances in the Biology and Treatment of Bone Disease in Multiple Myeloma

(2011) Noopur Raje et al.   CLINICAL CANCER RESEARCH

Galectin-3C Inhibits Tumor Growth and Increases the Anticancer Activity of Bortezomib in a Murine Model of Human Multiple Myeloma

(2011) Leonardo Mirandola et al.   PLoS One

Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma

(2011) Feng Chen et al.   CELLULAR ONCOLOGY

Advances in the understanding of myeloma bone disease and tumour growth

(2010) Shmuel Yaccoby   BRITISH JOURNAL OF HAEMATOLOGY

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

(2010) Taina Taube et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Multiple myeloma: chemotherapy or transplantation in the era of new drugs

(2010) Antonio Palumbo et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth

(2010) Katia Beider et al.   EXPERIMENTAL HEMATOLOGY

Novel therapeutic targets for multiple myeloma

(2010) Anuj Mahindra et al.   Future Oncology

Immunohistochemical analysis of NOTCH1 and JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance

(2010) Anita Škrtić et al.   HUMAN PATHOLOGY

Combined Inhibition of Notch Signaling and Bcl-2/Bcl-xL Results in Synergistic Antimyeloma Effect

(2010) M. Li et al.   MOLECULAR CANCER THERAPEUTICS

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

(2009) A. K. Azab et al.   BLOOD

Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma

(2009) P. Ghoshal et al.   CANCER RESEARCH

Targeted Disruption of the CXCL12/CXCR4 Axis Inhibits Osteolysis in a Murine Model of Myeloma-Associated Bone Loss

(2009) Peter Diamond et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The molecular characterization and clinical management of multiple myeloma in the post-genome era

(2009) Y Zhou et al.   LEUKEMIA

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

(2009) Silvia Buonamici et al.   NATURE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch-RBP-J Signaling Regulates the Mobilization and Function of Endothelial Progenitor Cells by Dynamic Modulation of CXCR4 Expression in Mice

(2009) Lin Wang et al.   PLoS One

Treatment of relapsed and refractory myeloma

(2009) Jonathan Kaufman et al.   Current Hematologic Malignancy Reports

Regulation of CXCR4 by the Notch Ligand Delta-like 4 in Endothelial Cells

(2008) C. K. Williams et al.   CANCER RESEARCH

Notch inhibition blocks multiple myeloma cell-induced osteoclast activation

(2008) R Schwarzer et al.   LEUKEMIA