Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target

Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia

(2011) B. Lowenberg et al.   BLOOD

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia

(2011) J Dürig et al.   LEUKEMIA

A Phase I study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia

(2011) Kosuke Tsuboi et al.   LEUKEMIA RESEARCH

Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors

(2010) D. S. Boss et al.   ANNALS OF ONCOLOGY

Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection

(2010) Y Zhang et al.   GENE THERAPY

High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia

(2010) Antonio R. Lucena-Araujo et al.   LEUKEMIA RESEARCH

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?

(2010) A. A. Dar et al.   MOLECULAR CANCER THERAPEUTICS

AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

(2009) A. Oke et al.   CANCER RESEARCH

p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells

(2009) Takayuki Ikezoe et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Analysis of Aurora B kinase in non-Hodgkin lymphoma

(2009) Takayuki Ikezoe et al.   LABORATORY INVESTIGATION

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

(2009) C. A. Stein et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients

(2009) Yi-Jen Chen et al.   VIRCHOWS ARCHIV

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

(2008) E. Walsby et al.   HAEMATOLOGICA

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS