Glucocorticoid-induced TNFR-related protein (GITR) ligand modulates cytokine release and NK cell reactivity in chronic lymphocytic leukemia (CLL)

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies

(2011) W. Alduaij et al.   BLOOD

CD4+CD25lowGITR+ cells: A novel human CD4+ T-cell population with regulatory activity

(2011) Rodolfo Bianchini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

The clinical application of monoclonal antibodies in chronic lymphocytic leukemia

(2010) S. M. Jaglowski et al.   BLOOD

Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

(2010) Theresa Placke et al.   Clinical & Developmental Immunology

Rituximab

(2010) Gillian M. Keating   DRUGS

Stimulation of the Glucocorticoid-Induced TNF Receptor Family-Related Receptor on CD8 T Cells Induces Protective and High-Avidity T Cell Responses to Tumor-Specific Antigens

(2010) A. L. Cote et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

(2010) Giovanni D’Arena et al.   LEUKEMIA RESEARCH

Evolution of anti- CD20 monoclonal antibody therapeutics in oncology

(2010) Ezogelin Oflazoglu et al.   mAbs

Differential effects of IL-2 and IL-21 on expansion of the CD4+CD25+Foxp3+T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia

(2010) Aruna Gowda et al.   mAbs

Rituximab: Mechanism of Action

(2010) George J. Weiner   SEMINARS IN HEMATOLOGY

CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells

(2009) T. Baessler et al.   BLOOD

Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related Protein Ligand Subverts Immunosurveillance of Acute Myeloid Leukemia in Humans

(2009) T. Baessler et al.   CANCER RESEARCH

Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+T cells with tumor regression

(2009) Naoko Imai et al.   CANCER SCIENCE

Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

(2008) K. M. Baltz et al.   BLOOD

Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity

(2008) John S. Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

(2008) P. Hu et al.   CLINICAL CANCER RESEARCH

Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours

(2008) Jinhua Piao et al.   IMMUNOLOGY

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

(2008) Baoying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Reverse signaling initiated from GITRL induces NF-κB activation through ERK in the inflammatory activation of macrophages

(2007) Eun Mi Bae et al.   MOLECULAR IMMUNOLOGY