Article
Cell Biology
Qiudong Yang, Wenhua Zhao, Yuyi Chen, Yue Chen, Jiali Shi, Ran Qin, Hua Wang, Ruixia Wang, Hua Yuan, Wen Sun
Summary: The study reveals that the RelA/miR-30a/NLRP3 signaling axis is involved in rheumatoid arthritis by regulating the NLRP3 inflammasome in macrophages.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Tingting Yuan, Honglin Tang, Xiaojie Xu, Jingjing Shao, Gaojun Wu, Young-Chang Cho, Yuan Ping, Guang Liang
Summary: This study developed an inflammation-inducible CRISPR-Cas9 system by grafting a sequence that binds with NF-KB to the CRISPR-Cas9 framework, named NBS-CRISPR. By targeting the MyD88 gene, a crucial player in the NF-KB signaling pathway, this system successfully reversed inflammatory conditions and achieved impressive therapeutic effects.
Article
Multidisciplinary Sciences
Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx
Summary: This study identifies two fusion transcripts that activate T cell receptor complex signaling and confer therapeutic vulnerability in PTCL-NOS, contributing to the understanding of this poorly characterized subgroup of PTCL at the genetic level.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Barbara Kiesewetter, Christiane Copie-Bergman, Michael Levy, Fangtian Wu, Jehan Dupuis, Caroline Barau, Luca Arcaini, Marco Paulli, Marco Lucioni, Arturo Bonometti, Antonio Salar, Concepcion Fernandez-Rodriguez, Miguel A. Piris, Francesco Cucco, Rachel Dobson, Yan Li, Zi Chen, Cyrielle Robe, Ingrid Simonitsch-Klupp, Andrew Wotherspoon, Markus Raderer, Ming Qing Du
Summary: The study reveals that H. pylori negative gastric MALT lymphoma is characterized by frequent genetic changes in the NF-kappa B signaling pathways. However, these genetic changes do not show significant correlation with clinicopathological parameters, and patients treated with systemic therapy have significantly better progression-free survival compared to those treated with antibiotics.
Review
Integrative & Complementary Medicine
Navid Naghsh, Vali Musazadeh, Omid Nikpayam, Zeynab Kavyani, Amir Hossein Moridpour, Fatemeh Golandam, Amir Hossein Faghfouri, Alireza Ostadrahimi
Summary: The umbrella meta-analysis suggests that curcumin can effectively reduce the levels of inflammatory biomarkers, especially C-reactive protein, interleukin 6, and tumor necrosis factor alpha. It can be used as an adjunctive therapeutic approach in diseases with elevated levels of inflammatory biomarkers.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2023)
Article
Chemistry, Medicinal
Xuewu Liang, Chenxia Sun, Chunpu Li, Haolan Yu, Xiaohui Wei, Xuyi Liu, Wei Bao, Yuqiang Shi, Xiaochen Sun, Mirzadavlat Khamrakulov, Chenghua Yang, Hong Liu
Summary: The study identified a novel class of potent MALT1 inhibitors that showed selective cytotoxicity to activated B cell-like diffuse large B cell lymphoma with low micromolar potency. Compound 20c specifically repressed NF-κB signaling and induced cell apoptosis in MALT1-dependent TMD8 cells in a dose-dependent manner, exhibiting good pharmacokinetic properties and antitumor efficacy in xenograft tumor model. This provides valuable lead compounds for further structural optimization and antitumor mechanism study.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Elizabeth M. Black, Yoon Ki Joo, Lilia Kabeche
Summary: Chk1 is a crucial player in the DNA damage response pathway and its loss can lead to replication stress and genome instability. However, the development of resistance to Chk1 inhibitors remains a major challenge in cancer therapy. Recent studies have shed light on multiple mechanisms underlying the emergence of Chk1 inhibitor resistance in lymphomas, involving dysfunction in NF-kappa B and up-regulation of alternative pathways. Additionally, these studies have discovered a novel role for Claspin in female fertility and cancer development, further deepening our understanding of the impact of dysfunction in the Claspin/Chk1 signaling pathway on disease states.
BIOCHEMICAL JOURNAL
(2022)
Article
Critical Care Medicine
Hu Qin, Tao Wu, Jun Liu, Gang Wang, Lei Fan, Boyao Wang, Yajun Shen
Summary: The study showed that inhibiting MALT-1 partially suppressed the inflammatory response in ankylosing spondylitis by regulating CYLD and NF-kappa B, leading to alleviation of arthritis symptoms.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Multidisciplinary Sciences
Maria C. Tanzer, Isabell Bludau, Che A. Stafford, Veit Hornung, Matthias Mann
Summary: By integrating phosphoproteomics, subcellular localization analyses, and kinase inhibitor assays, the authors provide insights into TNF signaling and identify modulators of TNF-induced cell death at the systems level.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zheng Lu, Lu Liu, Shunxin Zhao, Jiangtao Zhao, Sujun Li, Mingyang Li
Summary: Apigenin (APN), a flavone found in plant foods, has various biological properties such as anti-obesity and anti-inflammation. This study investigated the role of NLRP3 in the anti-atherosclerosis and anti-NAFLD effects of APN in mouse models. The results suggest that APN prevents atherosclerosis and NAFLD by inhibiting NLRP3, making it a potential therapeutic agent for these diseases.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Marie Ito, Gloria Michelle Ducasa, Judith David Molina, Javier Varona Santos, Shamroop Kumar Mallela, Jin Ju Kim, Mengyuan Ge, Alla Mitrofanova, Alexis Sloan, Sandra Merscher, Imari Mimura, Alessia Fornoni
Summary: This study investigated the connection between decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution in podocytes in diabetic kidney disease (DKD). The results showed that knockdown of ABCA1 led to increased mRNA and protein levels of IRF1, caspase-4, GSDMD, caspase-1, and IL1 beta. Further experiments revealed that APE1 accumulation and APE1 redox inhibitor could modulate the expression of IRF1 and caspase-4. The in vivo study confirmed the APE1/IRF1/Casp1 axis in BTBR ob/ob mice.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Yu Zhang, Zhuo-Chang Chen, Nan Li, Zhi-Hua Wang, Ya-Li Guo, Cui-Jie Tian, Dong-Jun Cheng, Xue-Yi Tang, Luo-Xian Zhang
Summary: Activated neutrophil-derived CRNDE is transferred to ASMCs through exosomes, activating the NF-kappa B pathway and promoting the proliferation and migration of ASMCs, which contributes to airway remodeling in asthma.
HUMAN MOLECULAR GENETICS
(2022)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Article
Multidisciplinary Sciences
Jugal Kishore Das, Yijie Ren, Anil Kumar, Hao-Yun Peng, Liqing Wang, Xiaofang Xiong, Robert C. Alaniz, Paul de Figueiredo, Xingcong Ren, Xiaoqi Liu, Alexey G. Ryazonov, Jin-Ming Yang, Jianxun Song
Summary: eEF-2K plays a critical role in regulating the fate and function of CD8(+) T cells. Loss of eEF-2K leads to increased proliferation but decreased survival of CD8(+) T cells, along with premature senescence and exhaustion. eEF-2K deficiency also affects the metabolic activity of CD8(+) T cells and the effectiveness of CAR-T therapy against cancer.
Article
Biochemistry & Molecular Biology
Alya R. Alnuaimi, Justus Bottner, Vidhya A. Nair, Nival Ali, Razaz Alnakhli, Eva Dreyer, Iman M. Talaat, Hauke Busch, Sven Perner, Jutta Kirfel, Rifat Hamoudi, Wael M. Abdel-Rahman
Summary: Colorectal cancer is a deadly disease with increasing rates worldwide. Caldesmon (CaD) has emerged as a promising biomarker for diagnosis and therapy. It was found that l-CaD is overexpressed in colorectal cancer and associated with preinvasive stages, while h-CaD is expressed in smooth muscle cells but not in cancer cells or normal colon mucosal epithelial cells. These findings have significant implications for the management of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Come Sesboue, Jean Galtier, Marie Jeanneau, Annick Chauvel, Elodie Laharanne, Samuel Amintas, Jean-Philippe Merlio, Krimo Bouabdallah, Francois-Xavier Gros, Laurence de Leval, Audrey Gros, Marie Parrens
Summary: Distinguishing FL from NMZL can be difficult in cases with unusual morphologic and phenotypic features and without characteristic cytogenetic rearrangements. Ancillary techniques, such as FISH, RT-MLPA, and NGS, can provide diagnostic contributions for unclassified tumors. In this study, FISH detected 1p36 deletion in some FLs and unclassified tumors, while RT-MLPA signatures were associated with FL and NMZL subtypes. Combining RT-MLPA and NGS findings successfully discriminated most unclassified tumors towards FL or NMZL diagnosis.
Article
Pathology
Rita Sarkis, Olivier Burri, Claire Royer-Chardon, Frederica Schyrr, Sophie Blum, Mariangela Costanza, Stephane Cherix, Nathalie Piazzon, Carmen Barcena, Bettina Bisig, Valentina Nardi, Rossella Sarro, Giovanna Ambrosini, Martin Weigert, Olivier Spertini, Sabine Blum, Bart Deplancke, Arne Seitz, Laurence de Leval, Olaia Naveiras
Summary: Bone marrow cellularity assessment is crucial in evaluating bone marrow biopsies for hematologic and nonhematologic disorders. MarrowQuant 2.0 is an efficient digital hematopathology workflow that accurately quantifies the cellularity of human bone marrow biopsies by segmenting different compartments. This tool can be used for clinical research to explore biomarkers related to bone marrow stromal components.
Review
Pathology
Laurence de Leval, Andrew L. Feldman, Stefano Pileri, Shigeo Nakamura, Philippe Gaulard
Summary: Non-cutaneous extranodal NK/T cell lymphoproliferations are a rare group of tumors that primarily occur in the gastrointestinal tract, nasal area, spleen, and liver. Accurate diagnosis is crucial due to the diverse clinical presentations and similarities with other diseases.
Article
Multidisciplinary Sciences
Adel Elmoselhi, Mohamed Seif Allah, Amal Bouzid, Zeinab Ibrahim, Thenmozhi A. Venkatachalam, Ruqaiyyah Siddiqui, Naveed Ahmed Khan, Rifat Hamoudi
Summary: This study aimed to identify circulating miRNA biomarkers as early predictors of cardiovascular diseases (CVDs) in patients with vitamin D3 deficiency, obesity, and diabetes mellitus (DM). The results showed that four specific circulating miRNA signatures can be utilized as non-invasive, diagnostic, and prognostic biomarkers for early vascular damage in high-risk patients for CVDs.
Review
Nutrition & Dietetics
Laila Salameh, Walid Mahmood, Rifat Hamoudi, Khulood Almazrouei, Mahesh Lochanan, Suheyl Seyhoglu, Bassam Mahboub
Summary: Asthma, a common chronic respiratory disease affecting millions of people worldwide, is being increasingly linked to vitamin D deficiency. This systematic review evaluated the effects of vitamin D supplementation on airway remodeling in asthmatic patients. After a thorough search of several databases, 9 experimental studies were included, suggesting that vitamin D inhibits airway smooth muscle cell contraction and remodeling, reduces inflammation, regulates collagen synthesis in the airways, and modulates the action of bronchial fibroblasts. However, the role of TGF-beta 1 in impairing vitamin D-induced airway epithelial host defense mechanisms needs further investigation.
Review
Oncology
Rama Alsabbagh, Munazza Ahmed, Mohammad A. Y. Alqudah, Rifat Hamoudi, Rania Harati
Summary: Brain metastasis (BM) is an incurable end-stage of systemic cancer and the understanding of the molecular mechanisms driving BM, particularly extravasation of cancer cells through the blood-brain barrier (BBB), is limited. In this review, the molecular events that occur during extravasation in breast cancer, melanoma, and lung cancer, which are most likely to develop brain metastasis, are summarized and compared. This review provides valuable information for the development of therapeutic strategies for the prevention or treatment of brain metastases.
Review
Biochemistry & Molecular Biology
Zaynab Osaid, Mohamed Haider, Rifat Hamoudi, Rania Harati
Summary: This review discusses the role of exosomes in the physiological and pathological modulation of the blood-brain barrier (BBB), including their impact on various cerebral disorders. A better understanding of this regulation will improve our knowledge of cerebral diseases and enable the development of effective treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Summary: Session 3 of the lymphoma workshop at the joint meeting of the European Association for Haematopathology and the Society for Hematopathology discussed splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas. The case review emphasized the challenges in diagnosing marginal zone lymphomas, including distinguishing between different types and the need for molecular studies to establish a final diagnosis. The workshop also addressed the overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma.
Correction
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Review
Pathology
Fina Climent, Alina Nicolae, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Sarah L. Ondrejka, Lorinda Soma, Andrew Wotherspoon, Alberto Zamo, Leticia Quintanilla-Martinez, Siok-Bian Ng
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop discussed cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases. Primary nodal-EBV-TNKL is a newly recognized entity associated with underlying immune deficiency/immune dysregulation. cPTCL-NOS demonstrates the TBX21 phenotype and shows an unexpected association with TFH lymphomas/LPDs.
Review
Cell Biology
Yauhen Statsenko, Nik V. Kuznetsov, Daria Morozova, Katsiaryna Liaonchyk, Gillian Lylian Simiyu, Darya Smetanina, Aidar Kashapov, Sarah Meribout, Klaus Neidl-Van Gorkom, Rifat Hamoudi, Fatima Ismail, Suraiya Anjum Ansari, Bright Starling Emerald, Milos Ljubisavljevic
Summary: Although accelerated aging is a commonly recognized theory, it still has many shortcomings and limitations that require an updated concept.
Article
Biochemistry & Molecular Biology
Waad Kheder, Amal Bouzid, Thenmozhi Venkatachalam, Iman M. Talaat, Noha Mousaad Elemam, Tom Kalathil Raju, Soumya Sheela, Manju Nidagodu Jayakumar, Azzam A. Maghazachi, Abdul Rani Samsudin, Rifat Hamoudi
Summary: This study analyzed the gene expression in peri-implant gingival tissues of patients with failed, successful, or no implants. The results showed that titanium particles modulate lymphocyte and macrophage polarization in peri-implant tissues, which may contribute to implant failure. The presence of titanium particles and infiltration of immune cells, particularly lymphocytes and macrophages, were confirmed in the failed implant samples. In vitro validation also demonstrated increased expression of IL-1 beta, IL-8, and IL-18 by macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nada Alnaqbi, Mohammad G. Mohammad, Rifat Hamoudi, Aloise Mabondzo, Rania Harati
Summary: The blood-brain barrier (BBB) is a neurovascular structure in the brain that maintains brain homeostasis but hinders drug delivery. Despite advances in understanding the BBB, efficiently treating brain diseases by overcoming the BBB remains challenging. Gene and protein expression analysis of the BBB in different brain regions showed variation, indicating the importance of considering the BBB heterogeneity for effective drug delivery and brain disease treatment in future research programs.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Hematology
Joaquim Carreras, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Haruka Ikoma, Yusuke Kondo, Atsushi Ito, Shunsuke Nagase, Hisanobu Miura, Giovanna Roncador, Lluis Colomo, Rifat Hamoudi, Elias Campo, Naoya Nakamura
Summary: We report a rare variant of diffuse large B-cell lymphoma with spindle cell morphology in a 74-year-old male patient who presented with right supraclavicular (lymph) node enlargement. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB), and mutational profiling confirmed mutations in multiple genes associated with aggressive B-cell lymphomas. The immune microenvironment showed infiltration of tumor-associated macrophages and expression of certain markers associated with poor prognosis. The patient achieved a complete response with R-CHOP therapy.
HEMATOLOGY REPORTS
(2023)